TD-0212

Name: TD-0212
Brand: TargetMol
SKU: T13125
Rating: 4.5 (1 reviews)

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产品编号 T13125Cas号 1073549-10-6

TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

TD-0212

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产品编号 T13125Cas号 1073549-10-6

TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).

规格	价格	库存
25 mg	¥ 19,400	10-14周
50 mg	¥ 25,800	10-14周
100 mg	¥ 33,500	10-14周

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产品描述	TD-0212 is an orally active dual pharmacology antagonist of angiotensin II type 1 receptor (AT1) and inhibitor of neprilysin (NEP)(pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP).
靶点活性	NEP:9.2(pIC50), AT1:(pKi)8.9
体外活性	TD-0212 is a AT1/NEP dual inhibitor, with a potentially lower risk of angioedema relative to dual ACE/NEP inhibition.
体内活性	In models of renin-dependent and –independent hypertension, TD-0212 produces blood pressure reductions similar to omapatrilat and combinations of AT1 receptor antagonists and NEP inhibitors .