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PROTAC CDK4/6 degrader 1(Compound 7f)作为一种针对CDK4和CDK6的双重降解剂, 其DC50值分别为10.5 nM和2.5 nM。该化合物能显著抑制Jurkat细胞的增殖,其中IC50为0.18 μM,能够在G1期阻断细胞周期,并引发细胞凋亡(apoptosis)。
PROTAC CDK4/6 degrader 1(Compound 7f)作为一种针对CDK4和CDK6的双重降解剂, 其DC50值分别为10.5 nM和2.5 nM。该化合物能显著抑制Jurkat细胞的增殖,其中IC50为0.18 μM,能够在G1期阻断细胞周期,并引发细胞凋亡(apoptosis)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | PROTAC CDK4/6 degrader 1 (Compound 7f) is a dual degrader of CDK4 and CDK6, with DC50 values of 10.5 nM and 2.5 nM, respectively. This compound effectively inhibits proliferation in Jurkat cells (IC50 of 0.18 μM), induces cell cycle arrest during the G1 phase, and triggers cell apoptosis (apoptosis). |
靶点活性 | CDK6:2.5 nM (DC 50 ), CDK4:10.5 nM (DC 50 ) |
分子量 | 789.88 |
分子式 | C41H47N11O6 |
CAS No. | 3025082-14-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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