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VU534 是一种 NAPE-PLD 激动剂,EC50 为 0.30 μM。VU534 是 FAAH 和 sEH 的双重抑制剂,对 sEH 的 IC50 值为 1.2 μM。VU534 可用于与心脏代谢相关的疾病。
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VU534 是一种 NAPE-PLD 激动剂,EC50 为 0.30 μM。VU534 是 FAAH 和 sEH 的双重抑制剂,对 sEH 的 IC50 值为 1.2 μM。VU534 可用于与心脏代谢相关的疾病。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 362 | 现货 | |
5 mg | ¥ 872 | 现货 | |
10 mg | ¥ 1,390 | 现货 | |
25 mg | ¥ 2,380 | 现货 | |
50 mg | ¥ 3,530 | 现货 | |
100 mg | ¥ 4,930 | 现货 | |
500 mg | ¥ 9,870 | 现货 |
产品描述 | VU534 is a NAPE-PLD agonist with an EC50 of 0.30 μM.VU534 is a dual inhibitor of FAAH and sEH, with an IC50 of 1.2 μM for sEH.VU534 is used in diseases related to cardiometabolism. |
靶点活性 | NAPE-PLD:0.30 μM(EC50), FAAH:1.2 μM, sEH:1.2 μM |
体外活性 | VU534 (30 μM; 24 h) is less cytotoxic to HepG2 and Raw264.7 cell lines.[1] VU534 (3~30 μM; 1 h) can increase NAPE-PLD activity in Raw264.7 cells.[1] VU534 (1 h) can increase NAPE-PLD activity in HepG2 cells with an EC50 value of 1.5 μM.[1] VU534 (5 μM, 1 h) increased NAPE-PLD activity 1.5-fold but did not reverse NAPE-PLD activity inhibited by LEI–401.[1] VU534 (10 μM; 6 h) significantly enhances efferocytosis of bone marrow-derived macrophages but cannot exert this effect when Napepld is knocked out.[1] |
分子量 | 447.55 |
分子式 | C21H22FN3O3S2 |
CAS No. | 923509-20-0 |
存储 | Shipping with blue ice. |
溶解度信息 | DMSO: <1 mg/mL (insoluble or slightly soluble), Sonication is recommended. |
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