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URAT1&XO inhibitor 2 (Compound BDEO)是一种针对xanthine oxidase (黄嘌呤氧化酶) 及URAT1的双重抑制剂,对xanthine oxidase展现出优异的抑制效果,IC50值为3.3 μM。该化合物在表达URAT1的HEK293细胞中显著抑制尿酸的摄取,其Ki值达到0.145 μM。在动物模型中,URAT1&XO inhibitor 2有效降低高尿酸血症小鼠的血清尿酸水平,并增加尿酸的排泄。该化合物主要用于高尿酸血症的研究。
URAT1&XO inhibitor 2 (Compound BDEO)是一种针对xanthine oxidase (黄嘌呤氧化酶) 及URAT1的双重抑制剂,对xanthine oxidase展现出优异的抑制效果,IC50值为3.3 μM。该化合物在表达URAT1的HEK293细胞中显著抑制尿酸的摄取,其Ki值达到0.145 μM。在动物模型中,URAT1&XO inhibitor 2有效降低高尿酸血症小鼠的血清尿酸水平,并增加尿酸的排泄。该化合物主要用于高尿酸血症的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | |
50 mg | ¥ 13,800 | 6-8周 | |
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM for XO inhibition. It effectively impedes uric acid uptake in HEK293 cells with URAT1 expression, evidenced by a Ki of 0.145 μM. In hyperuricemic mice models, the compound has been shown to reduce serum urate levels and uric acid excretion, indicating potential utility for hyperuricemia research [1]. |
分子量 | 322.15 |
分子式 | C14H12BrNO3 |
CAS No. | 1239488-96-0 |
存储 | Shipping with blue ice. |
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