677
300
29
36
11
Cat. No. | Product Name | ||
---|---|---|---|
L2150 | 抗癌药物库 | 3080 compounds | |
3080 个具有抗癌活性小分子的独特集合,生物活性已经临床前实验证实,可用于高通量、高内涵筛选; | |||
L2100 | 抗癌化合物库 | 7234 compounds | |
7234 种肿瘤相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2190 | 抗肺癌化合物库 | 1702 compounds | |
1702 种与肺癌相关的化合物,可以用于抗肺癌药物研发和药理研究; | |||
L2192 | 抗胰腺癌化合物库 | 2238 compounds | |
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L2191 | 抗乳腺癌化合物库 | 1939 compounds | |
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究; | |||
L2180 | 抗肿瘤库Plus | 1468 compounds | |
1468 种抗肿瘤相关、结构新颖的化合物; | |||
L2120 | 抗癌临床化合物库 | 2545 compounds | |
2545 个具有抗癌活性小分子的独特集合,可用于高通量高内涵筛选。 | |||
L2160 | 抗癌活性化合物库 | 3188 compounds | |
3188 种具有抗肿瘤活性的化合物的特有集合,用于高通量、高内涵筛选; | |||
L2110 | 抗癌上市药物库 | 1779 compounds | |
1779 个具有抗癌活性小分子的独特集合,所有化合物都经过了严格的临床前研究和临床试验,由FDA、EMA 或NMPA 批准上市,可用于高通量、高内涵筛选。 | |||
L2130 | 抗癌细胞代谢库 | 1268 compounds | |
1268 种癌细胞代谢相关的生物活性小分子化合物的特有集合,用于肿瘤相关的研究以及抗肿瘤药物的筛选,用于高通量、高内涵筛选; | |||
L2195 | 抗前列腺癌化合物库 | 2070 compounds | |
2070 种与前列腺癌相关的化合物,可以用于高通量和高内涵筛选 | |||
L2193 | 抗肝癌化合物库 | 1787 compounds | |
1787 种与肝癌相关的化合物,可以用于抗肝癌药物研发和药理研究; | |||
L2194 | 抗结直肠癌化合物库 | 1545 compounds | |
1545 种与结直肠癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L2196 | 抗卵巢癌化合物库 | 1867 compounds | |
1867 种与卵巢癌相关的化合物,可以用于抗卵巢癌药物研发和药理研究 | |||
L6740 | 抗结直肠癌中药单体化合物库 | 382 compounds | |
382 种抗结直肠癌相关的中药单体集合,是药物开发、药理研究的有效工具; | |||
L6100 | 天然多酚类化合物库 | 635 compounds | |
635 个天然多酚化合物的独特集合,可用于高通量、高内涵筛选; | |||
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; | |||
L6110 | 生物碱类天然产物库 | 500 compounds | |
500 种生物碱类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6120 | 黄酮类天然产物库 | 514 compounds | |
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6810 | 中药单体化合物库 | 2755 compounds | |
2755 种中药来源的单体化合物,是药物开发、药理研究等领域的有力工具; | |||
L6130 | 萜类天然产物库 | 622 compounds | |
622 种萜类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L6200 | 瑶药化合物库 | 221 compounds | |
221 种瑶药来源的天然产物分子集合,可以用于高通量和高内涵筛选; | |||
L6700 | 抗癌天然产物库 | 1772 compounds | |
1772 种已知活性天然产物的独特集合,是肿瘤药物开发、抗癌先导化合物筛选等领域的有力工具,可用于HTS 和HCS。 | |||
L8100 | 细胞周期化合物库 | 677 compounds | |
677 种细胞周期相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L6600 | 胃肠炎天然产物库 | 219 compounds | |
219 种胃肠炎相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9600 | 多肽分子库 | 791 compounds | |
791 种多肽类分子,可用于多肽药物开发及信号转导通路和作用机制研究; | |||
L5510 | 肝脏毒性化合物库 | 1001 compounds | |
1001 个肝脏毒性化合物的特有集合,可用于高通量、高内涵筛选,是毒理学研究的良好工具; | |||
L6500 | 微生物天然产物库 | 550 compounds | |
550 种微生物来源的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
DO2200 | 共价抑制剂库CD | 12000 compounds | |
数量多:超过12000种共价结合化合物,并且数量在持续增加; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9582 |
CLEFMA
|
NF-κB | NF-κB |
CLEFMA 是一种姜黄素,抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关,具有抗肿瘤活性。 | |||
TQ0219 |
MK-8033
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
MK-8033 是一种新型ATP 竞争性c-Met/Ron 双重抑制剂,对野生型c-Met 的IC50=1 nM,对c-Met N1100Y 的IC50=2.0 nM。 | |||
T38699 |
Piperafizine A
|
Others | Others |
Piperafizine A 是从 Streptoverticillium aspergilloides 中分离得到的,可增强 vincristine 的抗肿瘤效力。 | |||
T6540 |
Ibuprofen Lysine
布洛芬赖氨酸盐,Neoprofen |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。 | |||
T4985 |
Neticonazole Hydrochloride
|
Antifungal | Microbiology/Virology |
Neticonazole hydrochloride 是一种咪唑衍生物,具有抗感染和抗癌作用。它也是一种长效抗真菌剂。 | |||
T1394 |
Ibuprofen
Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID),具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂,IC50值分别为 13 和 370 μM,导致前列腺素和血栓素前体的形成减少。 | |||
T8710 |
MSAB
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
MSAB 是一种Wnt/β-catenin 信号传导的选择性抑制剂。它能够与 β-catenin 结合,诱导其降解,并能够下调 Wnt/β-catenin 靶基因。它对 Wnt 依赖性癌细胞表现出有效的抗肿瘤特性。 | |||
T8432 |
ASP4132
|
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
ASP4132 是一种口服活性的 AMPK 激活剂,EC50为 18 nM,具有抗癌活性。 | |||
T12150 |
N-Methylbenzamide
|
PDE | Metabolism |
N-Methylbenzamide 是磷酸二酯酶 10A 抑制剂,具有抗癌作用。 | |||
T11284 |
FIDAS-3
|
Others; Wnt/beta-catenin; Methionine Adenosyltransferase (MAT) | Chromatin/Epigenetic; Cytoskeletal Signaling; Others; Stem Cells |
FIDAS-3 是一种强效Wnt 抑制剂,也是一种二苯乙烯衍生物,对甲硫氨酸腺苷转移酶 2A (MAT2A) 的IC50为 4.9 μM。它能够与 S-腺苷甲硫氨酸有效竞争MAT2A 结合,并具有抗癌作用。 | |||
T6400 |
AZD3514
|
Androgen Receptor | Endocrinology/Hormones |
AZD3514 是一种口服雄激素受体下调剂(Ki :2.2 μM),能够减少 AR 蛋白表达。 | |||
T11285 |
FIDAS-5
|
Others | Others |
FIDAS-5 是甲硫氨酸腺苷转移酶 2A 抑制剂(IC50:2.1 μM),具有口服活性。它能够与 S-腺苷甲硫氨酸有效竞争 MAT2A 结合,并具有抗癌作用。 | |||
T4325 |
COTI-2
COTI 2,COTI2 |
Apoptosis; p53 | Apoptosis |
COTI-2是一种具有口服活性的低毒性抗癌药物,是 p53 突变体激活剂。它通过激活突变型 p53 和抑制PI3K/AKT/mTOR 途径发挥作用,通过 p53 依赖和非依赖机制在 HNSCC 中具有抗肿瘤活性。它诱导多种人肿瘤细胞凋亡,可将突变型 p53 转化为野生型构象。 | |||
T10270 |
BAY 2416964
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
BAY 2416964 是一种可口服的芳基烃受体拮抗剂,IC50为 341 nM,可用于研究实体瘤。 | |||
T21806 |
HNHA
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HNHA 是组蛋白去乙酰化酶抑制剂。它通过 p21诱导将细胞周期阻滞在 G1/S 期,抑制肿瘤生长及肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌药物。 | |||
T12997 |
SR-318
|
p38 MAPK; TNF | Apoptosis; MAPK |
SR-318 是p38 MAPK 的选择性抑制剂,对 p38α,p38β 和 p38α/β 的IC50分别为 5 nM,32 nM 和 6.11 μM。它有效抑制全血中TNF-α的释放,IC50为 283 nM。它显示出抗癌和抗炎活性。 | |||
T8765 |
iGOT1-01
|
Others | Others |
iGOT1-01 是一种天冬氨酸转氨酶 1 (谷氨酸草酰乙酸转氨酶 1;GOT1) 抑制剂,在 GOT1/GLOX/HRP 测定中IC50为 11.3 μM,在 MDH 偶联 GOT1 酶法测定中IC50为 85 μM。它显示出抗癌活性。 | |||
T4425 |
JK-P3
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
JK-P3 是广谱 VEGFR2抑制剂。它能够抑制 VEGF-A 刺激的 VEGFR2 激活和细胞内信号转导,也可阻碍内皮单层细胞迁移和血管生成,影响成纤维细胞生长因子受体激酶在体外的活性。它具有抗血管生成的作用。 | |||
T11793 |
KY-05009
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KY-05009 是 ATP 竞争性的、有效的 TNIK 抑制剂,Ki 为 100 nM。KY-05009抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK 的蛋白表达和Wnt 靶基因的转录活性,并诱导癌细胞凋亡,显示抗癌活性。 | |||
T0797 |
Cimetidine
西米替汀,SKF-92334,西咪替丁 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cimetidine (SKF-92334) 是一种可口服的可逆组胺H2受体拮抗剂,Ki 为 0.6 μM。它抑制胃酸分泌,以及胃蛋白酶和胃泌素的输出,具有抗癌和抗炎活性。 | |||
TP2333 |
cyclo(L-Pro-L-Tyr)
|
Others | Others |
cyclo(L-Pro-L-Tyr) 是真菌和细菌的次生代谢产物。 | |||
T0380 |
Bicalutamide
比卡鲁胺,ICI-176334 |
Androgen Receptor; Autophagy | Autophagy; Endocrinology/Hormones |
Bicalutamide (ICI-176334) 是一种具有口服活性的非甾体雄激素受体拮抗剂,可研究前列腺癌。 | |||
T5125 |
LY3200882
|
TGF-beta/Smad | Stem Cells |
LY3200882 是一种高度选择性的、口服活性的、具有 ATP 竞争性的 TGF-β 受体 1 型 (ALK5) 抑制剂(IC50:38.2 nM)。它能够抑制多种促肿瘤活性,可用作免疫调节剂。 | |||
T9211 |
Mito-LND
Mito-Loidamine |
OXPHOS; Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy | Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Mito-LND (Mito-Loidamine) 是一种有口服活性和靶向线粒体的氧化磷酸化抑制剂。它抑制线粒体生物能,刺激活性氧的形成,并诱导肺癌细胞自噬细胞死亡。 | |||
T9622 |
MF-766
|
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
MF-766 是高效的、具有口服活性的EP4选择性拮抗剂,Ki 为 0.23 nM。它在功能检测中表现为一种完整的拮抗剂,其 IC50为 1.4 nM (在 10% HS 存在时变成 1.8 nM)。它具有用于癌症和炎症疾病研究的价值。 | |||
T14505 |
BAY-524
|
Others | Others |
BAY524 是Bub1抑制剂,当 2 mM ATP 时,其IC50=450 nM。 | |||
T2343 |
AS601245
|
JNK | MAPK |
AS601245 是 c-Jun NH2-末端激酶 (JNK) 的抑制剂,具有神经保护特性。 | |||
T11529 |
H3B-120
|
Others; Potassium Channel | Membrane transporter/Ion channel; Others |
H3B-120 是高选择性,竞争性的氨基甲酰磷酸合成酶 1 变构抑制剂,IC50为 1.5 μM,Ki 为 1.4 μM。它具有抗癌活性。 | |||
T24706 |
RBC10
RBC 10,RBC-10 |
GTPase | GPCR/G Protein |
RBC10 抑制 Ral 与其效应物 RALBP1 的结合,以及抑制 Ral 介导的鼠胚胎成纤维细胞的细胞扩散和人类癌细胞系的非贴壁依赖性生长。 | |||
T8310 |
MMP-9-IN-1
|
MMP | Proteases/Proteasome |
MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂,选择性靶向 MMP-9 的血红素域,对其他 MMP 无影响。 | |||
T6275 |
Obatoclax Mesylate
Obatoclax,GX15-070,奥巴克拉甲磺酸盐 |
BCL; Parasite; Autophagy | Apoptosis; Autophagy; Microbiology/Virology |
Obatoclax Mesylate (GX15-070) 是泛 BCL-2家族蛋白抑制剂,对 BCL-2 的 Ki 值为 220 nM。它是 BH3 模拟物,具有抗癌和广谱抗寄生虫活性。它诱导自噬依赖性细胞死亡,并靶向细胞周期蛋白 D1 进行蛋白酶体降解。 | |||
T7835 |
CM10
CM 10 |
Dehydrogenase | Metabolism |
CM10是一种有效的乙醛脱氢酶 1A (ALDH1A) 家族选择性抑制剂,对于 ALDH1A1,ALDH1A2 和 ALDH1A3 的IC50分别为 1700、740 和 640 nM。CM 10 可以调节新陈代谢并具有抗癌活性。 | |||
T8308 |
NL-1
|
Mitochondrial Metabolism; Autophagy | Autophagy; Metabolism |
NL-1 是一种mitoNEET 抑制剂,具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长,IC50分别为 47.35 µM 和 56.26 µM。 | |||
T6207 |
SC144
|
Apoptosis; Interleukin | Apoptosis; Immunology/Inflammation |
SC144 是一种口服活性 gp130 抑制剂。它结合 gp130,诱导 gp130 磷酸化(S782) 和去糖基化,消除 Stat3 磷酸化和核易位,进一步抑制下游靶基因的表达。它对 gp130 配体触发的信号转导有明显的抑制作用,可诱导人卵巢癌细胞凋亡。 | |||
T34603 |
L-Selenocystine
L-Selenocystine,L-硒代胱胺基乙酸 |
Others | Others |
L-Selenocystine (L-Selenocystine) 可用作生物活性硒醇化合物的组成部分。 | |||
T2345 |
PTC-209
PTC209,PTC 209 |
BMI-1; Autophagy | Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
PTC-209 是特定的BMI-1抑制剂,不可逆转地损害结直肠癌起始细胞,在 HEK293T 细胞系中的IC50为 0.5 μM。它有抗骨髓瘤活性并损害肿瘤微环境。 | |||
T12642L |
Simurosertib
TAK-931 |
CDK | Cell Cycle/Checkpoint |
Simurosertib (TAK-931) 是一种选择性和 ATP 竞争性细胞分裂周期 7 激酶抑制剂,具有抗癌活性,IC50值小于 0.3 nM。 | |||
T7698 |
BS194
(2S,3S)-3-[[3-(异丙基)-7-[(苯基甲基)氨基]吡唑并[1,5-A]嘧啶-5-基]氨基]-1,2,4-丁三醇 |
CDK | Cell Cycle/Checkpoint |
BS194 是一种有效的细胞周期蛋白依赖性蛋白激酶 (CDK) 抑制剂。 | |||
T9497 |
Niraparib tosylate monohyrate
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Niraparib tosylate monohyrate 也称为 MK-4827,是一种聚 (ADP-核糖) 聚合酶 (PARP) 抑制剂,具有潜在的抗肿瘤活性。 MK4827 抑制 PARP 活性,增强 DNA 链断裂的积累,促进基因组不稳定性和细胞凋亡。 PARP 蛋白家族通过碱基切除修复 (BER) 途径检测和修复单链 DNA 断裂。 | |||
T2301 |
SB 202190
FHPI,SB202190 |
Apoptosis; p38 MAPK; Autophagy | Apoptosis; Autophagy; MAPK |
SB 202190 (FHPI) 是一种 p38 MAPK 抑制剂,可以抑制 p38α 和 p38β2 (IC50=50/100 nM),具有选择性和细胞渗透性。SB 202190 具有抗肿瘤活性,还可以诱导人胚胎干细胞向心肌细胞分化。 | |||
T2029 |
Bohemine
|
ERK; CDK | Cell Cycle/Checkpoint; MAPK |
Bohemine 是一种合成的选择性CDK 抑制剂,是嘌呤类似物,具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。 | |||
T1995 |
Fedratinib
TG-101348,SAR 302503 |
Apoptosis; FLT; c-RET; JAK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Fedratinib (TG-101348) 是一种 JAK2 抑制剂,具有选择性、ATP 竞争性和具有口服活性,抑制 JAK2 和 JAK2V617F 激酶 (IC50=3 nM)。Fedratinib 可诱导肿瘤细胞凋亡,并可用于骨髓增生性疾病的研究。 | |||
T9595 |
LP-261
|
Microtubule Associated | Cytoskeletal Signaling |
LP-261 是一种新型的微管蛋白靶向抗癌剂,可与微管蛋白上的秋水仙碱位点结合,诱导 G2/M 期阻滞,其EC50为 3.2 μM。它可抑制人非小细胞肺癌的生长,可用于癌症研究。 | |||
T60024 |
CFT7455
Cemsidomide |
Ligand for E3 Ligase | PROTAC |
CFT7455 (Cemsidomide) 是一种抗癌剂,对 cereblon E3 连接酶具有高亲和力,Kd 为 0.9 nM。 CFT7455 是锌指转录因子 Ikaros (IKZF1) 和 Aiolos (IKZF3) 的口服活性降解剂。 | |||
T9705 |
TL-895
|
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
TL-895 是口服有效的,ATP 竞争性的,以及高度选择性和不可逆的BTK 抑制剂,IC50和Ki 分别为 1.5 nM 和 11.9 nM。TL-895在 JAKi 复发/难治性骨髓纤维化、急性髓系白血病、COVID-19 和癌症方面有研究的价值。 | |||
T4552 |
Fursultiamine
Diteftin,呋喃硫胺,Judolor,Alinamin F |
Others | Others |
Fursultiamine (Alinamin F) 是维生素 B1衍生物,具有抗伤害和抗肿瘤作用。它可用于研究维生素 B1缺乏病、骨关节炎和癌症。 | |||
T7611 |
ODM-203
|
VEGFR; FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
ODM-203 是 FGFR 和 VEGFR 家族的抑制剂,具有显著的抗肿瘤活性,能够诱导抗肿瘤免疫。 | |||
T8656 |
CAY10404
3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T |
Apoptosis; Akt; COX | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling |
CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。 它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂,可诱导 NSC-LC 细胞凋亡,具有镇痛、抗炎和抗癌活性。 | |||
T3278 |
Piribedil
EU-4200,Trivastan,ET-495,Trivastal |
Dopamine Receptor; Histone Methyltransferase; Adrenergic Receptor | Chromatin/Epigenetic; GPCR/G Protein; Neuroscience |
Piribedil (Trivastan) 是多巴胺 D2受体激动剂,对 hα1A-肾上腺素受体也显示出拮抗作用。 | |||
T8375 |
ML-210
CID 49766530 |
Ferroptosis; GPX; Glutathione Peroxidase; Ras | Apoptosis; GPCR/G Protein; MAPK; Metabolism; oxidation-reduction |
ML-210 (CID 49766530) 是一种共价的选择性谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂,EC50为 30 nM。它与 GPX4 硒代半胱氨酸残基结合,具有抗癌活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN7020 |
Astragenol
|
Others | Others |
Astragenol 是合成黄芪醇衍生物的中间体。它的衍生物具有抗炎作用,可用于前列腺癌的研究。 | |||
T6S0139 |
Neobavaisoflavone
|
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎,抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶,也可抑制血小板聚集。 | |||
T11366 |
Garcinol
|
Apoptosis; Endogenous Metabolite; Histone Acetyltransferase; AChR; AChE | Apoptosis; Chromatin/Epigenetic; Metabolism; Neuroscience |
Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮,对乙酰胆碱酯酶和丁酰胆碱酯酶具有抗胆碱酯酶的特性,IC50分别为 0.66 µM 和 7.39 µM。它还抑制组蛋白乙酰转移酶和 p300/CPB 相关因子,具有抗炎和抗癌活性。 | |||
TN2082 |
Pinostrobin
|
Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience |
Pinostrobin 是一种 PCSK9抑制剂,可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物,并具有抗氧化,抗炎,抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。 | |||
T6S1369 |
Vitexin
牡荆素,Apigenin-8-C-glucoside |
Antioxidant | oxidation-reduction |
Vitexin 是一种存在于多种药用植物(如榕树、螺旋藻)中的 c-糖基化的黄酮。 它具有广泛的药理作用,包括抗氧化,抗癌,抗炎,抗痛觉过敏和神经保护作用。 | |||
T3866 |
Macelignan
安五脂素,Anwuligan,(+)-Anwulignan |
Others; COX | Immunology/Inflammation; Neuroscience; Others |
Macelignan (Anwuligan) 是一种从肉豆蔻中分离得到的木脂素,具有抗炎、抗癌、抗糖尿病和神经保护活性。 | |||
T5712 |
zerumbone
花薑酮,球姜酮 |
Antioxidant; HSV | Microbiology/Virology; oxidation-reduction |
Zerumbone 是从Zingiber zerumbetSmith 的根茎中分离的一种单环倍半萜烯,可有效抑制Epstein-Barr 病毒的激活,IC50为 0.14 mM,具有抗癌、抗炎、抗氧化和抗增殖的作用。 | |||
TN2883 |
3',4'-Dimethoxyflavone
|
Others; PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair; Others |
3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准,类黄酮化合物具有多种药用活性。 | |||
TN2054 |
Periplocymarin
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Periplocymarin 是一种强心苷,从 Periploca sepium 和 Periploca graeca 中分离得到,具有抗癌潜力。 | |||
T0724 |
Formononetin
Biochanin B,Flavosil,刺芒柄花素,Formononetol |
Apoptosis; FGFR | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
Formononetin (Flavosil) 是一种 FGFR2抑制剂,IC50约为4.31 μM。 它是一种 O-甲基化的异黄酮,是来自黄芪根的植物雌激素,可有效抑制血管生成和肿瘤生长。 | |||
T2780 |
Catalpol
梓醇,Catalpinoside,Digitalis purpurea L |
Others; HBV | Microbiology/Virology; Others |
Catalpol (Catalpinoside) 是一种在Rehmannia glutinosa 中发现的鸢尾花苷,具有神经保护、降血糖、抗癌、抗痉挛、抗氧化、抗HBV 和抗肝炎病毒作用。 | |||
T7792 |
Hispidin
6-[(1E)-2-(3,4-二羟基苯基)乙烯基]-4-羟基-2H-吡喃-2-酮 |
Endogenous Metabolite; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism |
Hispidin 是来自裂蹄木层孔菌的酚类天然产物,是一种 PKC 抑制剂,具有很强的抗氧化、抗癌、抗糖尿病和抗痴呆作用。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T5755 |
Aloesin
|
Tyrosinase | Proteases/Proteasome |
Aloesin 是芦荟的活性成分之一,能够通过 MAPK 信号通路发挥抗癌作用,并具有抗炎、紫外线保护和抗菌作用。 | |||
TN1493 |
Chrysosplenol D
猫眼草酚D |
IL Receptor; NF-κB; JNK | Immunology/Inflammation; MAPK; NF-κB |
Chrysosplenol D 属于甲氧基黄酮类化合物,可诱导 ERK1/2 介导的三阴性人乳腺癌细胞凋亡。它还显示出抗炎和中等抗锥虫活性。 | |||
T4S1999 |
Valepotriate
戊曲酯/缬草素,Valtrate |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Valepotriate (Valtrate) 是从蜘蛛香分离而来的一种天然产物,是一类新的细胞毒剂和抗肿瘤剂,对 HTC 肝癌细胞是非常有效的细胞毒剂。 它可能对焦虑的精神症状具有潜在的抗焦虑作用。 | |||
T6917 |
Oleuropein
洋橄榄苦甙,橄榄苦苷 |
Apoptosis; Aromatase; ROS; PPAR | Apoptosis; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism |
Oleuropein 在橄榄叶和油中发现的天然产物,通过 p53 依赖性途径以及 Bax 和 Bcl2基因的调控来诱导乳腺癌细胞凋亡,还抑制芳香化酶。它可通过直接抑制 PPARγ转录活性来发挥抗氧化,抗炎和抗动脉粥样硬化作用。 | |||
TN1465 |
Cannabigerol
|
NOS; 5-HT Receptor; ROS | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cannabigerol 是一种植物大麻素,是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压,有潜力治疗青光眼。 | |||
T13229 |
Tunicamycin
|
Influenza Virus; Antibacterial; Antibiotic; Antifungal | Microbiology/Virology |
Tunicamycin 是一种抗生素的混合物,通过阻断 GlcNAc 磷酸转移酶 (GPT),抑制 N-连接糖基化。Tunicamycin 具有抗肿瘤活性,还具有抗细菌、抗真菌和抗病毒活性。 | |||
TN2269 |
Tetramethylcurcumin
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
Tetramethylcurcumin 是一种新型姜黄素类似物,是一种有效的 STAT3 磷酸化、DNA 结合活性和体外反式激活抑制剂。它具有抗炎和抗癌作用。 | |||
T2899 |
Liquiritin
Liquiritigenin-4'-O-glucoside,Liquiritoside,甘草苷 |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Liquiritin (Liquiritigenin-4'-O-glucoside) 是一种从甘草中分离出的类黄酮,是一种竞争性的 AKR1C1 抑制剂,对 AKR1C1,AKR1C2 和 AKR1C3 的 IC50分别为 0.62 μM,0.61 μM 和 3.72 μM,在体内有效抑制 AKR1C1 介导的孕酮代谢。它是一种抗氧化剂,具有神经保护、抗癌、抗炎的活性。 | |||
T6569 |
Mimosine
Leucenine,NSC 69188,含羞草素,Leucenol,L-Mimosine |
Others | Others |
Mimosine (Leucenol) 是一种酪氨酸类似物,具有抗癌和抗炎等活性。它可通过其强大的铁结合活性作为抗氧化剂,是一种 Fe(III) 螯合剂。它作用于人类白血病细胞,通过金属离子螯合、线粒体激活和诱导活性氧产生来诱导细胞凋亡。 | |||
T2217 |
Cephalomannine
Baccatin III,三尖杉宁碱 |
Microtubule Associated | Cytoskeletal Signaling |
Cephalomannine (Baccatin III) 是一种从云南红豆杉中提取的紫杉醇衍生物,具有抗肿瘤活性,可用于癌症研究。 | |||
TN1788 |
Isookanin
|
Amylase | Metabolism |
Isookanin 在多种疾病领域有研究价值,包括肿瘤,皮疹,蛇和昆虫叮咬,糖尿病,腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。 | |||
T4S1173 |
Agrimol B
仙鹤草酚B,仙鹤草酚 B |
Sirtuin; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物,可抑制脂肪形成,降低PPARγ的表达,诱导SIRT1易位和表达。 | |||
T7024 |
Qingyangshengenin
青阳参甙元,Qingyangshengenin A,Cynanchagenin |
Others | Others |
Qingyangshengenin (Cynanchagenin) 是一种孕烷糖苷,是一种分离自Cychuchumot ophyllum(Asclepiadaceae) 的根中的 C21 类固醇糖苷配基。它具有抗癌作用。 | |||
TN1237 |
3-O-Methylgallic acid
3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸 |
Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Membrane transporter/Ion channel; NF-κB; Stem Cells |
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) 是一种花青素代谢产物,具有强大的抗氧化能力。它还诱导细胞凋亡并具有抗癌作用,可抑制 Caco-2 细胞增殖,IC50值为 24.1 μM。 | |||
T3739 |
2,6-Dimethoxyquinone
2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone,2,6-二甲氧基-1,4-苯醌 |
Others; Antibacterial; Parasite | Microbiology/Virology; Others |
2,6-Dimethoxyquinone 是一种植物中提取吸脂诱导因子。它具有抗脂肪、抗癌、抗菌、抗疟疾和抗炎的作用。 | |||
T2895 |
Lupeol
Fagarasterol,羽扇豆醇,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol |
Apoptosis; Androgen Receptor; Akt | Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; PI3K/Akt/mTOR signaling |
Lupeol (Monogynol B) 是一个活跃的五环三萜,具有抗氧化剂、抗肿瘤和抗炎活性。它是一种雄激素受体抑制剂,可研究癌症,特别是雄激素依赖表型和去势抵抗表型的前列腺癌。 | |||
T2950 |
Schisandrin
Wuweizi alcohol-A,Wuweizichun-A,Schizandrol-A,Schizandrol,五味子醇甲 |
Autophagy | Autophagy |
Schisandrin (Wuweizi alcohol-A) 是一种从五味子中分离出来的联苯环辛烯类木脂素,可逆转大鼠的记忆障碍,具有保肝、抗氧化、抗哮喘、抗癌和抗炎作用。 | |||
T3416 |
Aucubin
Aucuboside,桃叶珊瑚苷,Rhinanthin |
IL Receptor; NF-κB; Antibacterial | Immunology/Inflammation; Microbiology/Virology; NF-κB |
Aucubin (Rhinanthin) 是一种可从许多传统的草药中提取的环烯醚萜苷,有许多生物学活性。 | |||
T8293 |
γ-Tocopherol
D-gamma-生育酚,γ-生育酚,(+)-γ-Tocopherol |
COX | Immunology/Inflammation; Neuroscience |
γ-Tocopherol ((+)-γ-Tocopherol) 是有效的环氧合酶抑制剂,是存在于玉米油和大豆中的维生素 E,具有抗炎特性和抗癌活性。 | |||
TN1926 |
Methyl caffeate
Methyl caffeate acid,金银花,咖啡酸甲酯 |
Others; Antibacterial | Microbiology/Virology; Others |
Methyl caffeate (Methyl caffeate acid) acid 是一种抗微生物剂,有抗菌和抗分枝杆菌活性。它还抑制 α-葡萄糖苷酶,有氧化应激抑制活性,抗血小板活性,子宫颈癌的抗增殖活性以及肺和白细胞的抗癌活性。 | |||
T5S1923 |
Schisandrin C
五味子丙素,Schizandrin-C,Wuweizisu-C |
Apoptosis; Others; Virus Protease | Apoptosis; Microbiology/Virology; Others |
Schisandrin C (Wuweizisu-C) 是从五味子中分离得到的一种植物化学木脂素。它具有抗癌、抗炎和抗氧化等多种生物活性,可研究癌症、阿尔茨海默病、肝病。 | |||
TN2064 |
Physcion 8-O-β-D-glucopyranoside
大黄素甲醚-8-O-Β-D-葡萄糖苷,Physcion 8-O-beta-D-monoglucoside |
TNF | Apoptosis |
Physcion 8-O-β-D-glucopyranoside (Physcion 8-O-beta-D-monoglucoside) 具有抗炎和抗癌活性。Physcion 8-O-β-D-glucopyranoside 可用于常见恶性肿瘤的研究。 | |||
T3248 |
alpha-Boswellic acid
α-Boswellic acid,α-乳香酸 |
Others | Others |
alpha-Boswellic acid 是一种从乳香中提取得到的五环三萜类化合物,具有抗惊厥和抗癌作用。在动物体内,它是预防和减少阿尔茨海默病标志物,可用于阿尔茨海默病的研究。 | |||
T0314 |
Hexylresorcinol
己雷锁辛,4-己基间苯二酚,4-Hexylresorcinol |
Apoptosis; Tyrosinase; Antibacterial; Parasite | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Hexylresorcinol (4-Hexylresorcinol) 是在植物中发现的一种天然产物,具有抗菌、驱虫、防腐和抗肿瘤活性。它是一种可逆、非竞争性的 α-葡萄糖苷酶抑制剂,有抗 DNA 氧化损伤的保护作用。它可诱导鳞癌细胞凋亡。 | |||
T2S1158 |
4,5-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C |
Others; HBV; Endogenous Metabolite | Metabolism; Microbiology/Virology; Others |
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物,有抗病毒、抗肝毒性活性。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T0132 |
Etoposide
VP-16,依托泊苷,依托泊甙,VP-16-213 |
Apoptosis; Mitophagy; Topoisomerase; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Microbiology/Virology |
Etoposide (VP-16-213) 是一种拓扑异构酶 II 的抑制剂,通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成 (IC50=60.3 μM)。Etoposide 具有抗肿瘤活性,可以诱导细胞凋亡、自噬。 | |||
T5S1058 |
Triptonide
雷公藤内酯酮,PG 492,NSC 165677 |
Apoptosis; Wnt/beta-catenin; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Stem Cells |
Triptonide (PG 492) 是从雷公藤中鉴定出的一种天然产物,是一种 Wnt 信号抑制剂,其 IC50约为 0.3 nM。它具有免疫抑制、抗炎、避育、神经保护和抗淋巴瘤作用。 | |||
T2882 |
Genistin
染料木甙,Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside,染料木苷 |
Apoptosis; Estrogen Receptor/ERR; Others | Apoptosis; Endocrinology/Hormones; Others |
Genistin (Genistoside) 是一种植物雌激素家族的异黄酮,是一种抗脂肪生成剂。它通过调节ERalpha 信号通路抑制乳腺癌细胞生长和促进凋亡细胞死亡。 | |||
T3P2904 |
α-Linolenic acid
Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸 |
Akt; PI3K | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸,人体无法合成,从种子油中分离得到。它可调节 PI3K/Akt 信号传导,影响血栓形成过程。它具有抗心律失常的特性,并且与心血管疾病和癌症等有关。 | |||
T3324 |
Lycorine
Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱 |
Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase | Apoptosis; Metabolism; Microbiology/Virology; Neuroscience |
Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂,Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂,有用于前列腺癌和代谢疾病的研究潜力。 | |||
T2870 |
Matrine
Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine |
Mitophagy; Ferroptosis; Opioid Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱,可作为一种κ阿片受体激动剂,有抗肿瘤活性。 | |||
T2S2104 |
Sinigrin hydrate
黑芥子苷,Sinigrin monohydrate,芥子甙单水合物,Allylglucosinolate monohydrate |
Antibacterial | Microbiology/Virology |
Sinigrin hydrate (Allylglucosinolate monohydrate) 是一种天然脂肪族芥子油苷,存在于十字花科植物中。它具有消炎、抗癌、抗真菌、抗菌、抗氧化作用。 | |||
T2S0618 |
β-Elemonic Acid
3-oxo Tirucallic Acid,β-岚香酮酸,Beta-Elemonic acid,3-Oxotirucallenoic Acid,β-榄香酮酸,Elemadienonic Acid |
Apoptosis; Reactive Oxygen Species; COX | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
β-Elemonic Acid (3-Oxotirucallenoic Acid) 是从乳香树中分离得到的一种三萜,具有抗癌和抗炎作用。它抑制脯氨酰内肽酶,诱导细胞凋亡,活性氧和COX-2表达。 | |||
TN1142 |
8-Oxocoptisine
8-Oxycoptisine,8-氧黄连碱 |
Others | Others |
8-Oxocoptisine (8-Oxycoptisine) 是天然原小檗碱生物碱,具有抗癌作用。 | |||
T2321 |
Protodioscin
Furostanol I,原薯蓣皂苷 |
Androgen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Protodioscin (Furostanol I) 是一种山药根茎中的主要甾体皂苷,具有抗高血脂、抗癌活性。 | |||
TN1579 |
Dihydrocucurbitacin B
二氢葫芦素 B,23,24-dihydrocucurbitacin B |
IL Receptor; TNF; COX | Apoptosis; Immunology/Inflammation; Neuroscience |
Dihydrocucurbitacin B (23,24-dihydrocucurbitacin B) 是从 Cayaponia tayuya 的根中分离得到的,具有抗癌活性。 | |||
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Cat. No. | Product Name | Species | Expression System |
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TMPY-00566 |
CCL18 Protein, Human, Recombinant (His)
PARC,CCL18,CKb7,DC-CK1,chemokine (C-C motif) ligand 18,MIP-4... |
Human | P. pastoris (Yeast) |
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a... | |||
TMPY-00150 |
IGF2/IGF-II Protein, Human, Recombinant
PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2 |
Human | P. pastoris (Yeast) |
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br... | |||
TMPY-02219 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
NS1 Protein |
H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As... | |||
TMPY-04936 |
BCL2A1 Protein, Human, Recombinant (His)
BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 related protein A1,BCL2... |
Human | E. coli |
B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der... | |||
TMPK-00906 |
PSCA Protein, Mouse, Recombinant (hFc)
UNQ206,PSCA,PRO232 |
Mouse | HEK293 Cells |
Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Mouse, Recomb... | |||
TMPK-00728 |
PSCA Protein, Human, Recombinant (hFc)
UNQ206,PRO232,PSCA |
Human | HEK293 Cells |
Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Human, Recomb... | |||
TMPK-01248 |
CXCL4 Protein, Mouse, Recombinant (hFc)
PF-4,CXCL4,SCYB4,Oncostatin-A,Iroplact,MGC138298 |
Mouse | HEK293 Cells |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Mouse, Recombinant (hFc) is expressed in H... | |||
TMPK-00170 |
CD40 Protein, Human, Recombinant (aa 21-193, His & Avi), Biotinylated
CD40 antigen, TNFRSF5,CD40 molecule,CD40,MGC9013,C... |
Human | HEK293 Cells |
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. | |||
TMPY-04480 |
UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)
CMPK,UMPK,UMK,CK,UMP-CMPK,CMK,cytidine monophosphate (UMP-CM... |
Human | Baculovirus Insect Cells |
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid bi... | |||
TMPK-00491 |
IL-18BP Protein, Cynomolgus, Recombinant (His)
Igifbp,Interleukin-18-binding protein,IL-18BP |
Cynomolgus | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein, Cynomolgus, Recombinant (His) is expressed i... | |||
TMPK-00012 |
CXCL4 Protein, Human, Recombinant (His & Avi)
PF-4,CXCL4,SCYB4,Oncostatin-A,MGC138298,Iroplact |
Human | E. coli |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (His & Avi) is expresse... | |||
TMPK-00014 |
CXCL4 Protein, Human, Recombinant (hFc)
Iroplact,CXCL4,Oncostatin-A,PF-4,MGC138298,SCYB4 |
Human | HEK293 Cells |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (hFc) is expressed in H... | |||
TMPY-01561 |
PIG3 Protein, Human, Recombinant (His)
TP53I3,PIG3,tumor protein p53 inducible protein 3 |
Human | E. coli |
Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of... | |||
TMPK-00082 |
IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated
Igifbp,IL-18BP,IL-18BPA |
Human | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein, Human, Recombinant (His & Avi), Biotinylated... | |||
TMPK-00013 |
CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylated
SCYB4,MGC138298,PF-4,Iroplact,Oncostatin-A,CXCL4 |
Human | E. coli |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. CXCL4 Protein, Human, Recombinant (His & Avi), Biotinylat... | |||
TMPK-00492 |
IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
Igifbp,Interleukin-18-binding protein,IL-18BP |
Cynomolgus | HEK293 Cells |
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice. IL-18BP Protein (Primary Amine Labeling), Cynomolgus, Recombi... | |||
TMPY-04003 |
UNC5B Protein, Rat, Recombinant (hFc)
unc-5 homolog B (C. elegans) |
Rat | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular we... | |||
TMPY-03416 |
TNFAIP8 Protein, Human, Recombinant (His)
GG2-1,tumor necrosis factor, alpha-induced protein 8,SCCS2,S... |
Human | E. coli |
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom... | |||
TMPY-00507 |
UNC5B Protein, Human, Recombinant (hFc)
unc-5 homolog B (C. elegans),UNC5H2,p53RDL1 |
Human | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular ... | |||
TMPY-04133 |
UNC5B Protein, Human, Recombinant (His)
UNC5H2,p53RDL1,unc-5 homolog B (C. elegans) |
Human | HEK293 Cells |
The netrin-1 receptor, UNC-5 Homology B, or UNC5B plays vital roles in angiogenesis, inflammation, embryonic development and carcinogenesis. Overexpression of UNC5B human colon epithelial cells suppressed dextran sodium sulfate, or DSS-induced apoptosis and caspase-3 activity. Besides, is a potential anti-neoplastic target in bladder cancer progression and inflammatory arthritis. UNC5B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular ... | |||
TMPK-01137 |
FAM3D Protein, Human, Recombinant (hFc)
OIT1,EF7,FAM3D |
Human | HEK293 Cells |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity t... | |||
TMPK-00336 |
GPC3 Protein-VLP, Human, Recombinant
Glypican 3,SGB,SGBS1SDYS,DGSX,OCI-5,OCI5,GTR2-2,GPC3,SGBS1,S... |
Human | E. coli |
Glypican-3 is a protein ,which is encoded by the GPC3 gene in humans.The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal subunit is ~30 kDa.Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers. Several therapeutic anti-GPC3 antibodies have been developed. GPC3 Protein-VLP, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14 kDa and the accession ... | |||
TMPY-04984 |
CXCL17 Protein, Human, Recombinant (His)
Dcip1,UNQ473,DMC,VCC1,chemokine (C-X-C motif) ligand 17,VCC-... |
Human | P. pastoris (Yeast) |
Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski... | |||
TMPK-00337 |
GPC3 Protein-VLP, Human, Recombinant (aa 438-554)
OCI-5,SDYS,SGB,OCI5,MXR7,GTR2-2,GPC3,Glypican 3,SGBS,SGBS1SD... |
Human | HEK293 Cells |
Glypican-3 is a protein ,which is encoded by the GPC3 gene in humans.The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal subunit is ~30 kDa.Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers. Several therapeutic anti-GPC3 antibodies have been developed. GPC3 Protein-VLP, Human, Recombinant (aa 438-554) is expressed in HEK293 mammalian cells. The predicted molecular weight is 21.5 kDa and th... | |||
TMPK-00456 |
IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
CD221,MGC142172,IGFIR,IGFR,MGC18216,JTK13,IGF-I R,IGF-1R,IGF... |
Human | HEK293 Cells |
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated is expressed in ... | |||
TMPY-00151 |
Alpha SNAP Protein, Human, Recombinant (His)
N-ethylmaleimide-sensitive factor attachment protein, alpha,... |
Human | E. coli |
NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. NAPA represents an anti-apoptotic protein that promotes resistance to cisplatin in cancer cells by inducing the degradation of the tumor suppressor p53. NAPA overexpression decreased the ubiquitination and degradation of s... | |||
TMPY-04203 |
RAB1B Protein, Human, Recombinant (hFc)
RAB1B, member RAS oncogene family |
Human | HEK293 Cells |
RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC cells in vitro and in vivo. Mechanistically, loss of RAB1B resulted in elevated expression of TGF-beta receptor 1 (TbetaR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-beta-induced epithelial-mesenchymal transition (EMT). Furthermo... | |||
TMPJ-00766 |
ANXA1 Protein, Human, Recombinant
Chromobindin-9,Phospholipase A2 Inhibitory Protein,Annexin-1... |
Human | E. coli |
Annexin A1 is the first characterized member of the annexin family of proteins and is able to bind to cellular membranes in a calcium-dependent manner, promoting membrane fusion and endocytosis. Annexin A1 has anti-inflammatory properties and inhibits phospholipase A2 activity. Annexin A1 also has roles in many diverse cellular functions, such as membrane aggregation, inflammation, phagocytosis, proliferation, apoptosis, and tumorigenesis and cancer development. ANXA1 is strongly expressed on th... | |||
TMPK-00658 |
IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
CD221,IGFR,IGF1R,MGC142172,MGC18216,IGF-1R,IGF-I receptor,MG... |
Cynomolgus | HEK293 Cells |
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells wit... | |||
TMPK-00455 |
IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
MGC142172,IGF-I receptor,IGF-I R,IGF-1R,MGC18216,MGC142170,I... |
Human | HEK293 Cells |
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. IGF1R/CD221 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells wi... | |||
TMPY-02597 |
IL-37 Protein, Human, Recombinant
FIL1Z,IL-37,白细胞介素,IL37,IL1F7,IL-1RP1,FIL1(ζ),IL1RP1,FIL1,白介素... |
Human | E. coli |
Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression i... | |||
TMPJ-00247 |
METAP1 Protein, Human, Recombinant
METAP1,Methionine aminopeptidase 1,MAP 1,MetAP 1,Peptidase M... |
Human | E. coli |
Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine... | |||
TMPJ-01106 |
NAD(P) transhydrogenase/NNT Protein, Human, Recombinant (His)
NAD(P) transhydrogenase,NNT |
Human | E. coli |
NAD(P)+transhydrogenase (NNT) is located in the inner mitochondrial membrane and catalyzes a reversible hydride transfer between NAD(H) and NADP(H) that is coupled to proton translocation between the intermembrane space and mitochondrial matrix. NNT activity has an essential role in maintaining the NADPH supply for antioxidant defense and biosynthetic pathways. Structurally, NNT is composed of three domains; domains I and III are hydrophilic and have binding sites for NAD and NADP, respectively,... | |||
TMPY-00186 |
GHRH Protein, Human, Recombinant (hFc)
GRF,INN,growth hormone releasing hormone,GHRF |
Human | HEK293 Cells |
The role of hypothalamic growth hormone-releasing hormone (GHRH) in the release of growth hormone (GH) from the pituitary is well established. Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in infertility. Growth hormone releasing hormone (GHRH) has recently been shown to increase the level of gamma-aminobutyric acid (GABA) and activate GABA receptors (GABARs) in the cerebral cortex. GABA is an inhibitory neurotransmitter that can inhibit seizures. GHRH may pl... | |||
TMPY-05252 |
Myeloperoxidase/MPO Protein, Human, Recombinant (His)
myeloperoxidase |
Human | HEK293 Cells |
MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important enzyme, which is one of the components of the antibacterial system in neutrophils and monocytes. MPO participates in the inflammatory response in multiple locations in the body, including the mammary glands. Myeloperoxidase (MPO), a specific polymorphonuclear leukocyte enzyme, has ... | |||
TMPH-03753 |
MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase... |
Human | E. coli |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T13141 |
Thalidomide D4
|
Others | Others |
Thalidomide D4 is a deuterium labeled Thalidomide, has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. | |||
T27982 |
MBRI-001
MBRI 001,MBRI001. BPI-2358-d,plinabulin-d,NPI-2358-d |
||
MBRI-001 is a deuterium-substituted plinabulin derivative and a potent anti-cancer agent with better pharmacokinetic characteristics tand lower toxicity. | |||
TMIH-0120 |
Bisdesmethoxy Curcumin-d8
|
||
Bisdesmethoxy Curcumin-d8 是 Bisdesmethoxy Curcumin 的氘代化合物。Bisdesmethoxy Curcumin 的 CAS 号为 33171-05-0。Bisdemethoxycurcumin是姜黄素的天然去甲氧基衍生物,具有抗炎和抗癌活性。 | |||
TMIH-0089 |
Androstenedione-d7
|
||
Androstenedione-d7 是 Androstenedione 的氘代化合物。Androstenedione 的 CAS 号为 560-62-3。9-hydroxy-4-androstene-3,17-dione 是一种类固醇激素,具有抗肿瘤活性,可以抑制多种癌症细胞的生长,包括乳腺癌、前列腺癌和肺癌细胞。 | |||
TMIH-0181 |
Demethoxy Curcumin-d4
|
||
Demethoxy Curcumin-d4 是 Demethoxy Curcumin 的氘代化合物。Demethoxy Curcumin 的 CAS 号为 22608-11-3。Demethoxycurcumin是姜黄素的主要活性成分,有抗炎和抗癌作用。 | |||
T72818 |
Dosimertinib-d3
|
||
Dosimertinib-d3是一种有效的口服活性EGFR 抑制剂。Dosimertinib-d3降低 p-EGFR 和 p-ERK 蛋白水平的表达。Dosimertinib-d3显示出抗增殖和抗肿瘤活性。Dosimertinib-d3具有非小细胞肺癌 (NSCLC) 研究的潜力。 | |||
TMIH-0521 |
Silibinin-d3
|
||
Silibinin-d3 是 Silibinin 的氘代化合物。Silibinin 的 CAS 号为 22888-70-6。Silibinin 是水飞蓟的主要活性成分,具有抗癌和化疗预防作用,能抑制细胞增殖和迁移。 | |||
TMIJ-0025 |
Megestrol Acetate-d3
|
||
Megestrol Acetate-d3 是 Megestrol Acetate 的氘代化合物。Megestrol Acetate 的 CAS 号为 595-33-5。Megestrol acetate 是具有口服活性的合成孕激素。它还具有抗雄激素特性,可用于治疗厌食症和恶病质。 | |||
T36408 |
Rhein-13C4
Rhein-13C4 |
||
Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i... | |||
T71141 |
Fenspiride-d5
|
||
Fenspiride-d5 is intended for use as an internal standard for the quantification of fenspiride by GC- or LC-MS. Fenspiride is an antagonist of histamine H1 receptors and a non-steroidal anti-inflammatory drug (NSAID). It inhibits histamine-induced contraction of isolated guinea pig trachea but not histamine-induced inotropy of isolated guinea pig heart. It also inhibits phosphodiesterase 4 (PDE4), PDE5, and PDE3 (IC50s = 69, ~158, and 363 µM, respectively, in isolated human bronchi derived from ... | |||
T71303 |
Flufenamic Acid-d4
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Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear... |