HDAC6-IN-11

Name: HDAC6-IN-11
Brand: TargetMol
SKU: T61044
Rating: 4.5 (1 reviews)

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产品编号 T61044Cas号 2409072-27-9

HDAC6-IN-11 (Compound 9) 对癌细胞具有抗增殖活性。HDAC6-IN-11 是 HDAC6 的选择性抑制剂，IC50值为 20.7 nM。HDAC6-IN-11 的选择性是其他 HDAC 异构体的 300 多倍。

HDAC6-IN-11

还可以

产品编号 T61044Cas号 2409072-27-9

HDAC6-IN-11 (Compound 9) 对癌细胞具有抗增殖活性。HDAC6-IN-11 是 HDAC6 的选择性抑制剂，IC50值为 20.7 nM。HDAC6-IN-11 的选择性是其他 HDAC 异构体的 300 多倍。

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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HDAC6-IN-11 (Compound 9) has anti-proliferative activities against cancer cells. HDAC6-IN-11 is a selective inhibitor of HDAC6 with the IC50 value of 20.7 nM. The selectivity of HDAC6-IN-11 is more than 300-fold over HDAC other isoforms [1].

体外活性

HDAC6-IN-11 (0.44-6.68 μM, 48 h) treatment shows anti-proliferative activities against A549 and HCT116 cells [1]. HDAC6-IN-11 (0-20 μM, 48 h) treatment can increase the acetylation status of H3 and tubulin [1]. Cell Proliferation Assay [1] Cell Line: A549 and HCT116 cells Concentration: 0.44-6.68 μM Incubation Time: 48 hours Result: Showed anti-proliferative activities to A549 and HCT116 cells (GI 50 =3.2 and 1.82 μM, respectively). Western Blot Analysis [1] Cell Line: HCT116 cells Concentration: 0, 0.6, 1.25, 2.5, 5, 10 and 20 μM Incubation Time: 48 hours Result: Led to the increase of acetylation status of H3 and tubulin in a dose-dependent manner, and upregulated acetylated tubulin.