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Search Results for " cycle "

Targets Recommended: cell cycle arrest Antifection

664

抑制剂 & 化合物

166

天然产物

12

化合物库

174

重组蛋白

9

同位素标记化合物

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Cat. No.	Product Name
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L2151	化疗药物库		48 compounds
	48 个肿瘤化疗药物，可以用于高通量和高内涵筛选；
L8710	铜死亡化合物库		400 compounds
	TargetMol 铜死亡化合物库集合了 400 种与铜死亡相关的化合物，可以用于铜死亡机制及相关疾病研究
L1380	转录因子库		695 compounds
	695 种转录因子靶向、结构新颖的化合物；
L6100	天然多酚类化合物库		635 compounds
	635 个天然多酚化合物的独特集合，可用于高通量、高内涵筛选；
L8600	泛素化化合物库		210 compounds
	210 种泛素化相关的小分子，用于高通量和高内涵筛选；
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；
L1110	微管靶向化合物库		142 compounds
	142 种靶向微管的分子集合，用于高通量筛选和高内涵筛选；
L1300	PI3K/Akt/mTOR 化合物库		420 compounds
	420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合，用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选；
L6120	黄酮类天然产物库		514 compounds
	514 种黄酮类天然产物的独特集合，可用于高通量筛选和高内涵筛选；
L2570	人代谢物化合物库		4454 compounds
	4454 种人代谢物的独特集合，用于高通量、高内涵筛选；
L2550	谷氨酰胺代谢化合物库		565 compounds
	565 种谷氨酰胺代谢相关的分子，可以用于高通量和高内涵筛选；

化合物库

细胞周期化合物库

Cat.No: L8100

Compounds: 677

化疗药物库

Cat.No: L2151

Compounds: 48

铜死亡化合物库

Cat.No: L8710

Compounds: 400

转录因子库

Cat.No: L1380

Compounds: 695

天然多酚类化合物库

Cat.No: L6100

Compounds: 635

泛素化化合物库

Cat.No: L8600

Compounds: 210

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

微管靶向化合物库

Cat.No: L1110

Compounds: 142

PI3K/Akt/mTOR 化合物库

Cat.No: L1300

Compounds: 420

黄酮类天然产物库

Cat.No: L6120

Compounds: 514

人代谢物化合物库

Cat.No: L2570

Compounds: 4454

谷氨酰胺代谢化合物库

Cat.No: L2550

Compounds: 565

Cat. No.	Product Name	Target	Signaling Pathways
T77753	EBV lytic cycle inducer-1 Dp44mT	Antifection	Microbiology/Virology
	EBV lytic cycle inducer-1 是一种铁螯合类似物，可诱导EBV 裂解循环。
T9628	10074-A4	c-Myc	Cell Cycle/Checkpoint
	10074-A4 是与 c-Myc370-409 结合的 c-Myc 结合化合物，具有抗癌作用，其行为类似于“蛋白质云”周围的“配体云”，具有与非结合配体不同的特征。
T22336	Galloflavin	Dehydrogenase	Metabolism
	Galloflavin 是乳酸脱氢酶抑制剂。用 Pyruvate 法得到的 Ki 为 5.46 µM (LDH-A) 以及15.06 µM (LDH-B)。它能够阻断 ATP 的生成和糖酵解，从而抑制癌细胞的增殖。
T60037	SR15006	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SR15006 是 Krüppel 样因子 5 (KLF5) 抑制剂 (IC50 = 41.6 nM)。
T8762	SW106065 SW-106065	Apoptosis	Apoptosis
	SW106065 是一种恶性外周神经鞘瘤（MPNST）细胞凋亡诱导剂。它抑制 sMPNST 和其他 MPNST 模型的 ATP 消耗，EC50 为 1 µM。
T8916	WEE1-IN-3 JUN76288	Wee1	Cell Cycle/Checkpoint
	WEE1-IN-3 (JUN76288) 是一种有效的 Wee1激酶抑制剂，IC50小于 10 nM。它治疗癌症和其他增殖性疾病。
T11960	MBM-55	GSK-3; MAPK; DYRK; Akt; Chk; Bcr-Abl; CDK; S6 Kinase; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂，IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
T14066	9-ING-41	Apoptosis; GSK-3; Autophagy	Apoptosis; Autophagy; PI3K/Akt/mTOR signaling; Stem Cells
	9-ING-41 是基于马来酰亚胺的 ATP 竞争性和选择性的糖原合酶激酶-3β 抑制剂，IC50为 0.71 μM。它显著导致癌细胞的细胞周期停滞，自噬和凋亡，具有增强化疗药物抗肿瘤作用的潜力，有抗癌活性。
T4470	Pyridostatin TFA	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Pyridostatin TFA 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。
T21970	ML-097	GTPase	GPCR/G Protein
	ML-097 是 Ras 相关 GTP 酶的泛激活剂。
T12642L	Simurosertib TAK-931	CDK	Cell Cycle/Checkpoint
	Simurosertib (TAK-931) 是一种选择性和 ATP 竞争性细胞分裂周期 7 激酶抑制剂，具有抗癌活性，IC50值小于 0.3 nM。
T23133	Pentamidine	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine 是抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T21679	4'-bromo-Resveratrol	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	4'-Bromo-resveratrol 是Sirtuin-1和Sirtuin-3的双重抑制剂。它通过线粒体代谢重编程，使黑色素瘤细胞的生长受到抑制。它通过代谢重编程、影响细胞周期以及细胞凋亡的信号传导，使其在黑色素瘤细胞中发挥抗增殖作用。
T2326	Tolvaptan 托伐普坦,OPC-41061	Vasopressin Receptor; Autophagy	Autophagy; GPCR/G Protein
	Tolvaptan (OPC-41061) 是一种可口服的选择性精氨酸加压素受体 2 拮抗剂，可用于治疗低钠血症。
T10760	Ceramides Mixture 神经酰胺混合物,神经酰胺	Telomerase	DNA Damage/DNA Repair
	Ceramides Mixture 是表皮渗透屏障的主要脂质成分，参与生长抑制，细胞周期停滞和端粒酶活性的调节。它是一种内源性神经酰胺，由含羟基和非羟基脂肪酸的神经酰胺组成。
T21331	SAR-020106	Chk	Cell Cycle/Checkpoint
	SAR-020106 是一种强效、ATP 竞争性和选择性 CHK1 抑制剂，IC50为 13.3 nM。它对 CHK2 具有良好的选择性，可通过选择抗癌药物增强抗肿瘤活性。
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T6207	SC144	Apoptosis; Interleukin	Apoptosis; Immunology/Inflammation
	SC144 是一种口服活性 gp130 抑制剂。它结合 gp130，诱导 gp130 磷酸化(S782) 和去糖基化，消除 Stat3 磷酸化和核易位，进一步抑制下游靶基因的表达。它对 gp130 配体触发的信号转导有明显的抑制作用，可诱导人卵巢癌细胞凋亡。
T22461	YKL-5-124	CDK	Cell Cycle/Checkpoint
	YKL-5-124 是选择性不可逆CDK7共价抑制剂，对CDK7和CDK7/Mat1/CycH 的IC50分别为 53.5 nM 和 9.7 nM。它诱导强烈的细胞周期停滞，并抑制 E2F 驱动的基因表达。它对 CDK7 的生化和细胞选择性优于 CDK12/13。它对CDK7的选择性比 CDK9 和 CDK2 高 100 倍以上。
T9244	σ1 Receptor antagonist-1	Sigma receptor	GPCR/G Protein
	σ1 Receptor antagonist-1 是高选择性的 sigma 1受体拮抗剂，pKi 为10.28。它抑制细胞生长，在 G0/G1 期阻滞细胞周期并诱导 MCF-7/ADR 细胞凋亡。
T15771	Lobaplatin D-19466,络铂	DNA Alkylation	DNA Damage/DNA Repair
	Lobaplatin (D-19466) 是一种铂 (II) 复合物的非对映混合物，是一种有前途的抗肿瘤化疗药物，在多种肿瘤类型的患者中具有活性。
T4014	CP-724714 CP724714,CP 724714	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	CP-724714 (CP724714) 是一种高效、选择性口服活性的 ErbB2 (HER2)酪氨酸激酶抑制剂，IC50为 10 nM。它能抑制完整细胞中 ErbB2 受体的自磷酸化，具有抗肿瘤活性。它对 EGFR 激酶有明显的选择性，IC50值为6400 nM。
T36816	S-trityl-L-Cysteine STLC	Kinesin	Cytoskeletal Signaling
	S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM，抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。
T15012	Crolibulin EPC2407	Microtubule Associated	Cytoskeletal Signaling
	Crolibulin (EPC2407) 是一种微管蛋白聚合抑制剂，具有诱导凋亡和抑制细胞生长的作用。它有抗肿瘤活性，还具有心血管毒性和神经毒性。
T13224	Tubulin inhibitor 6 iHAP1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂，抑制微管蛋白聚合，IC50为 0.87 μM。它抑制多种癌细胞系，抑制 K562 细胞生长，IC50为 840 nM。
T10460	Batabulin 巴他布林,T138067	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Batabulin (T138067) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管聚合。它影响细胞形态并导致细胞周期停滞，最终诱导细胞凋亡。
T7055	Bz-RS-ISer(3-Ph)-Ome Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物，在低细胞毒性下抑制 HSV 复制周期，阻断 Vero 细胞的有丝分裂，影响 M-MSV 诱导的肿瘤大小，并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。
T8742	G5-7 JAK2 inhibitor G5-7	Apoptosis; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) 是具有口服活性的JAK2变构抑制剂，可通过结合到 JAK2，选择性的抑制JAK2介导的 EGFR 和 STAT3 的磷酸化和激活。它诱导细胞周阻滞和诱导凋亡、具有抗血管生成活性。它有用于胶质瘤研究的潜能。
T1785	Palbociclib PD 0332991,帕博西尼,帕布昔利布	CDK	Cell Cycle/Checkpoint
	Palbociclib (PD 0332991) 是一种 CDK 抑制剂，抑制 CDK4 和 CDK6 (IC50=11/16 nM)，具有口服活性。Palbociclib 具有抗肿瘤活性，有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T1654	Pentamidine isethionate Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine isethionate (Pentamidine diisethionate) 是抗微生物剂，会干扰 DNA 的生物合成。它抑制寄生虫Leishmania infantum，IC50为 2.5 μM。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它有抗肿瘤和抗菌活性。
T2641	KRCA-0008 KRCA 0008,KRCA0008	ACK; ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	KRCA-0008 是高效的、选择性的 ALK/Ack1 抑制剂，对ALK 和Ack1的IC50值分别为12nM 和4nM，显示出非hERG 依赖性药物活性。
T6941	PI-1840 PI 1840	PARP; Proteasome	Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome; Ubiquitination
	PI-1840 是一种高效的、选择性的蛋白酶体chymotrypsin-like (CT-L)抑制剂，IC50=27nM。
T4134	OTS514 hydrochloride OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))	Apoptosis; TOPK	Apoptosis; MAPK
	OTS514 hydrochloride 是一种高效的TOPK 抑制剂，IC50为 2.6 nM。它可强效抑制 TOPK 阳性的肿瘤细胞生长，诱导细胞周期停滞和凋亡。
T4215	TCS-PIM-1-4a 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a	Apoptosis; Pim	Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling
	TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂，可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系，IC50值为 0.8 μM 至 40 μM。
T23132	Pentamidine dihydrochloride 喷他脒二盐酸盐,MP-601205 dihydrochloride	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T3977	Lifitegrast SHP-606,SAR 1118,立他司特,利非司特	Integrin	Cytoskeletal Signaling
	Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂，抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
T2241	Alisertib MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸	Apoptosis; Aurora Kinase; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Alisertib (MLN 8237) 是一种 Aurora A 激酶抑制剂 (IC50=1.2 nM)，具有口服活性和选择性。Alisertib 具有抗肿瘤活性，可以诱导细胞凋亡和自噬，诱导细胞周期阻滞。
T6303L	CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis; Akt; PKA; mTOR; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 hydrochloride (CCT128930 hydrochloride) 是一种选择性 AKT 抑制剂，具有抗肿瘤活性。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性。
T10898	Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) 是一种具有选择性，ATP 竞争性和口服活性的CDK7抑制剂，IC50为 41 nM。它以 GI50值为 0.2-0.3 µM 来抑制乳腺癌细胞系的生长，具有抗肿瘤作用。
T6240	Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐	CDK	Cell Cycle/Checkpoint
	Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。
T6239	Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl	CDK	Cell Cycle/Checkpoint
	Palbociclib monohydrochloride (PD 0332991 hydrochloride) 是一种口服的细胞周期蛋白依赖性激酶 (CDK) 抑制剂，具有潜在的抗肿瘤活性。它抑制 CDK4和 CDK6，IC50分别为11 nM，16 nM。它有用于 ER 阳性和 HER2 阴性乳腺癌的研究潜力。
T2170	SKF-96365 hydrochloride 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365	Apoptosis; Potassium Channel; Calcium Channel; TRP/TRPV Channel; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel; Metabolism
	SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂，也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流，延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。
T6303	CCT128930	Akt; PKA; S6 Kinase; Autophagy	Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	CCT128930 是一种 ATP 竞争性，选择性 AKT 抑制剂。它通过靶向 AKT 的 Met282 (PKA-AKT 嵌合体的 Met173)，对 PKA 激酶具有 28 倍的选择性，对 p70S6K 具有 20 倍的选择性，具有抗肿瘤活性。
T1899	Pyridostatin RR82,Pyridostatin Trifluoroacetate Salt	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Pyridostatin (RR82) 是一种 G-四链体稳定剂，靶向原癌基因 Src，降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。它通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。
T4134L	OTS514 OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis; TOPK	Apoptosis; MAPK
	OTS514 (OTS514 Hydrochloride) 是一种高效的 TOPK 抑制剂，IC50为 2.6 nM。它强效抑制 TOPK 阳性的肿瘤细胞生长，还可诱导细胞周期停滞和凋亡。
T67241	SPhos Palladacycle Gen. 4	Others	Others
	Methanesulfonato(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II) 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67241。
T20053	Jasmacyclen EC 226-501-6,NSC-6598,Verdyl acetate,Greenyl acetate,NS 6598,NSC 6598	Others	Others
	Jasmacyclen is a compound in which has an aroma.
T67250	SingaCycle(TM)-A1	Others	Others
	SingaCycle(TM)-A1 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T67250。
T84874	Hexacyclen 1,4,7,10,13,16-Hexazacyclooctadecane	Others	Others
	Hexacyclen（亦称环烯）是一种由六个含氮环构成的具有特异性大环结构的有机化合物。作为一种螯合剂，它在化学及生物化学领域有着广泛的应用，特别是作为金属离子的结合剂，进而在抑制某些疾病包括癌症方面显示出潜力。在生物化学研究中，其主要用途在于通过与金属离子的选择性结合来探讨蛋白质或酶的结构与功能。尽管Hexacyclen拥有独特的结构，但由于其较大的体积和复杂性，在日常产品和应用中较少见。
T21067	Decacyclene NSC 60676	Others	Others
	Decacyclene is a biochemical.

化合物

EBV lytic cycle inducer-1

Cat.No: T77753

Synonym: Dp44mT

Target: Antifection

Cat.No: T9628

Target: c-Myc

Cat.No: T22336

Target: Dehydrogenase

Cat.No: T60037

Target: DNA/RNA Synthesis

Cat.No: T8762

Synonym: SW-106065

Target: Apoptosis

Cat.No: T8916

Synonym: JUN76288

Target: Wee1

Cat.No: T11960

Target: GSK-3, MAPK, DYRK, Akt, Chk, Bcr-Abl, CDK, S6 Kinase, Aurora Kinase

Cat.No: T14066

Target: Apoptosis, GSK-3, Autophagy

Pyridostatin TFA

Cat.No: T4470

Target: DNA/RNA Synthesis

Cat.No: T21970

Target: GTPase

Cat.No: T12642L

Synonym: TAK-931

Target: CDK

Cat.No: T23133

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

4'-bromo-Resveratrol

Cat.No: T21679

Target: Sirtuin

Cat.No: T2326

Synonym: 托伐普坦,OPC-41061

Target: Vasopressin Receptor, Autophagy

Ceramides Mixture

Cat.No: T10760

Synonym: 神经酰胺混合物,神经酰胺

Target: Telomerase

Cat.No: T21331

Target: Chk

Cat.No: T21588

Target: ERK, CDK

Cat.No: T6207

Target: Apoptosis, Interleukin

Cat.No: T22461

Target: CDK

σ1 Receptor antagonist-1

Cat.No: T9244

Target: Sigma receptor

Cat.No: T15771

Synonym: D-19466,络铂

Target: DNA Alkylation

Cat.No: T4014

Synonym: CP724714,CP 724714

Target: Apoptosis, EGFR

S-trityl-L-Cysteine

Cat.No: T36816

Synonym: STLC

Target: Kinesin

Cat.No: T15012

Synonym: EPC2407

Target: Microtubule Associated

Tubulin inhibitor 6

Cat.No: T13224

Synonym: iHAP1

Target: Microtubule Associated

Cat.No: T10460

Synonym: 巴他布林,T138067

Target: Apoptosis, Microtubule Associated

Bz-RS-ISer(3-Ph)-Ome

Cat.No: T7055

Synonym: Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate

Target: Others, HIV Protease

Cat.No: T8742

Synonym: JAK2 inhibitor G5-7

Target: Apoptosis, JAK

Cat.No: T1785

Synonym: PD 0332991,帕博西尼,帕布昔利布

Target: CDK

Pentamidine isethionate

Cat.No: T1654

Synonym: Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Cat.No: T2641

Synonym: KRCA 0008,KRCA0008

Target: ACK, ALK

Cat.No: T6941

Synonym: PI 1840

Target: PARP, Proteasome

OTS514 hydrochloride

Cat.No: T4134

Synonym: OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))

Target: Apoptosis, TOPK

Cat.No: T4215

Synonym: 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a

Target: Apoptosis, Pim

Pentamidine dihydrochloride

Cat.No: T23132

Synonym: 喷他脒二盐酸盐,MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Cat.No: T3977

Synonym: SHP-606,SAR 1118,立他司特,利非司特

Target: Integrin

Cat.No: T2241

Synonym: MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸

Target: Apoptosis, Aurora Kinase, Autophagy

CCT128930 hydrochloride

Cat.No: T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Samuraciclib hydrochloride

Cat.No: T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

Palbociclib Isethionate

Cat.No: T6240

Synonym: Palbociclib (PD0332991) Isethionate,帕博西尼羟乙基磺酸盐,PD 0332991 isethionate,帕布昔利布羟乙基磺酸盐

Target: CDK

Palbociclib monohydrochloride

Cat.No: T6239

Synonym: PD 0332991 hydrochloride,Palbociclib hydrochloride,帕布昔利布盐酸盐,Palbociclib (PD-0332991) HCl

Target: CDK

SKF-96365 hydrochloride

Cat.No: T2170

Synonym: 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365

Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy

Cat.No: T6303

Target: Akt, PKA, S6 Kinase, Autophagy

Cat.No: T1899

Synonym: RR82,Pyridostatin Trifluoroacetate Salt

Target: DNA/RNA Synthesis

Cat.No: T4134L

Synonym: OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514

Target: Apoptosis, TOPK

SPhos Palladacycle Gen. 4

Cat.No: T67241

Target: Others

Cat.No: T20053

Synonym: EC 226-501-6,NSC-6598,Verdyl acetate,Greenyl acetate,NS 6598,NSC 6598

Target: Others

SingaCycle(TM)-A1

Cat.No: T67250

Target: Others

Cat.No: T84874

Synonym: 1,4,7,10,13,16-Hexazacyclooctadecane

Target: Others

Cat.No: T21067

Synonym: NSC 60676

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4862	Oxaloacetic acid	Endogenous Metabolite	Metabolism
	Oxaloacetic acid 是一种代谢中间体，涉及多种途径，如葡萄糖异生、柠檬酸循环、乙醛酸循环、尿素循环、氨基酸合成和脂肪酸合成。
T10857	Coenzyme A	Endogenous Metabolite	Metabolism
	Coenzyme A 是所有活细胞中必需的辅助因子，由泛酸，三磷酸腺苷和半胱氨酸合成的。Coenzyme A 与过氧化物酶 5 共价结合导致其过氧化物酶活性完全抑制，通过 DTT 还原能够逆转。Coenzyme A 及其硫酯衍生物是主要分解代谢，合成代谢途径和基因表达调控的关键参与者。
TN2069	Picrocrocin 藏红花,苦番紅花素	Apoptosis	Apoptosis
	Picrocrocin 是一种从椰菜花中发现的类胡萝卜素，对 SKMEL-2 人恶性黑色素瘤细胞具有生长抑制作用，具有抗癌作用。
TN2190	Scoulerine	Apoptosis; Beta-Secretase; BACE; Parasite	Apoptosis; Microbiology/Virology; Neuroscience
	Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。
TN1727	Helichrysetin 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Helichrysetin 是从豆蔻果实中分离出的一种天然产物，是一种 DNA 结合抑制剂，可抑制原位导管癌DCIS 的形成。它抑制细胞生长，可诱导 A549 细胞凋亡。
T17155	Trabectedin Ecteinascidin 743,曲贝替定,ET-743	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱，有抗肿瘤的活性，通过与 DNA 的小沟结合，阻断应激诱导的蛋白质的转录，诱导 DNA 骨架裂解和癌细胞凋亡，并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
T2764	(S)-10-Hydroxycamptothecin 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT	Apoptosis; Topoisomerase	Apoptosis; DNA Damage/DNA Repair
	(S)-10-Hydroxycamptothecin (10-HCPT) 是一种从喜树中分离的 DNA 拓扑异构酶 I 抑制剂。它显著诱导细胞凋亡，可研究肝癌、胃癌、结肠癌和白血病。
T3322	trans-Chalcone Chalcone,反-查耳酮,查尔酮,Cinnamophenone,Chalkone	Apoptosis; Others; Antifungal; Fatty Acid Synthase	Apoptosis; Metabolism; Microbiology/Virology; Others
	trans-Chalcone (Chalkone) 是从 Aronia melanocarpa 果皮中分离出来的一种天然产物，是类黄酮前体的双酚核心结构。它是脂肪酸合酶和 α-淀粉酶的抑制剂，具有抗真菌和抗癌活性。
T3981	Acacetin 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin	Apoptosis; IAP; COX; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Neuroscience
	Acacetin (5,7-Dihydroxy-4'-methoxyflavone) 是一种来自狗舌草的口服有效类黄酮。它停在 PI3Kγ 的 ATP 结合口袋中，可导致癌细胞周期停滞，并诱导细胞凋亡和自噬。它有抗癌和抗炎活性，有潜力研究疼痛相关疾病。
T5087	DL-Isocitric acid trisodium salt 异柠檬酸三钠盐,Isocitric acid trisodium salt	Others; Endogenous Metabolite	Metabolism; Others
	DL-Isocitric acid trisodium salt 是内源性代谢产物的一种。
T2O2701	L-Ornithine hydrochloride L(+)-Ornithine hydrochloride,(S)-2,5-Diaminopentanoic acid,L-鸟氨酸盐酸盐;L-2,5-二氨基戊酸盐酸盐;L-鸟氨酸单盐酸盐;鸟氨酸盐酸盐;L-盐酸鸟氨酸;L-鸟粪氨基酸盐酸盐	Others; Endogenous Metabolite	Metabolism; Others
	L-Ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) 通过提高能量消耗效率和促进氨的排泄而具有抗疲劳作用。它是尿素循环中的关键反应物之一。
TJS1183	Cyclen 轮环藤宁,1,4,7,10-tetraazacyclododecane	Others	Others
	Cyclen (1,4,7,10-tetraazacyclododecane) 是一种氮杂冠醚的类似物，是制备有效的大环螯合物的中间体，是制备磁共振造影剂的前体物质。
T8206	Cycleanine	Others	Others
	Cycleanine 是一种高效血管选择性Ca- 拮抗剂，具有缓解疼痛、肌肉松弛和抗炎作用。它还具有有效的抗菌、抗真菌、抗疟原虫和细胞毒活性。
TN7511	Tricyclene NSC 86978	Others	Others
	Tricyclene, a monoterpene identified in various conifers such as Abies, Pinus, Picea, and Tsuga, exhibits notable presence across these species.
T19121	3-Hydroxyvaleric acid	Endogenous Metabolite	Metabolism
	3-Hydroxyvaleric acid 参与三羧酸循环的补充途径。
T19127	3-Phosphoglyceric acid	Others	Others
	3-Phosphoglyceric acid is a metabolic intermediate in both glycolysis and the Calvin cycle. It is involved in alveolar macrophage epigenetic regulation.
T6S1435	Notopterol	Apoptosis; Others	Apoptosis; Others
	Notopterol 是从羌活提取的一种香豆素，可诱导细胞凋亡，具有解热、缓解疼痛和抗炎作用。它有用于急性髓细胞性白血病的潜力。
T6S1844	Tenacissoside H Tenacissimoside C,通关藤苷H	Others	Others
	Tenacissoside H (Tenacissimoside C) 是一种分离自通关藤中的天然产物，具有抗肿瘤作用。
TN2058	Persicogenin	Anti-infection	Microbiology/Virology
	Persicogenin 是分离自 Rhus retinorrhoea 中，具有抗癌作用。
T34398	Rotundifuran	Others	Others
	Rotundifuran 是从 Vitex rotundifolia 的果实中提取的。 Rotundifuran 抑制细胞周期进程并诱导人髓性白血病细胞凋亡。
T4921	Oxoadipic acid 2-氧代己二酸,2-Oxoadipic acid	Endogenous Metabolite	Metabolism
	Oxoadipic acid (2-Oxoadipic acid) 是必需氨基酸色氨酸和赖氨酸的一种代谢物。
T5257	L-Homocitrulline 高瓜氨酸,Homo-L-citrulline,Homocitrulline	Others; Endogenous Metabolite	Metabolism; Others
	L-Homocitrulline (Homocitrulline) 是一种代谢物，可在尿素循环障碍患者的尿液中大量检测到。在某些情况下，由于尿素循环的鸟氨酸供应耗尽而导致的氨甲酰磷酸酯的积累可能是 L-Homocitrulline 和高精氨酸合成增强的原因。
T5267	N-Acetyl-L-glutamic acid Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸，是动物细胞培养基的组成成分，是一种酿酒酵母和人类的代谢物。
T8137	(Z)-Aconitic acid 顺乌头酸,顺式乌头酸,Cls-Aconitic acid	Others; Endogenous Metabolite	Metabolism; Others
	(Z)-Aconitic acid 是 Aconitic acid 的顺式异构体。它是三羧酸循环中柠檬酸盐异构化为异柠檬酸盐的中间产物。
TN1369	Alloimperatorin Prangenidin,别欧前胡素	Others	Others
	Alloimperatorin (Prangenidin) 是一种从Angelica dahurica 的提取得到的香豆素类化合物，具有抗肿瘤作用。
T5S2306	Hosenkoside A	Apoptosis; Others	Apoptosis; Others
	Hosenkoside A 是一种糖苷，分离自凤仙花种子。Hosenkoside A 具有抗肿瘤活性，可诱导细胞凋亡和细胞周期停滞。
TN1174	Schinifoline	Apoptosis; cell cycle arrest	Apoptosis; Cell Cycle/Checkpoint
	Schinifoline 是从 Zanthoxylum schinifolium Sieb 中提取出来的一种喹啉酮衍生物，具有细胞毒性活性，可促进癌细胞放射敏感性，影响细胞循环周期和细胞凋亡。
T3909	Pulsatilla saponin D 白头翁皂苷D,Hederacolchiside A,SB365	Apoptosis; Others	Apoptosis; Others
	Pulsatilla saponin D (Hederacolchiside A) 是从朝鲜白头翁根部分离得到的一种天然产物，具有抗癌活性。
T4233	Cysteinylglycine 半胱氨酰甘氨酸,Cys-Gly	Others; Endogenous Metabolite	Metabolism; Others
	Cysteinylglycine (Cys-Gly) 是内源性代谢产物的一种，能够用于疾病诊断。
T4838	(S)-Malic acid L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸	Others; Endogenous Metabolite	Metabolism; Others
	(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸，是水果酸甜味的来源，常用作食品添加剂。
T6S0234	Toosendanin	Others	Others
	Toosendanin 是一种从杜鹃花果实皮中提取的三萜，具有杀虫和抗炎活性，可用于研究缓解疼痛。
T3774	Gracillin 山药,纤细薯蓣皂苷	cell cycle arrest	Cell Cycle/Checkpoint
	Gracillin 是一种甾体皂苷，从植物的根里提取得到，有抗肿瘤作用。
T5980	2-Ketoglutaric acid α-酮戊二酸,alpha-酮戊二酸	Tyrosinase; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	2-Ketoglutaric acid 是 Krebs 循环的中间体，可以产生 ATP 或 GTP 。2-Ketoglutaric acid 还充当氮同化反应的主要碳骨架。2-Ketoglutaric acid 是酪氨酸酶(tyrosinase)的可逆抑制剂 (IC50=15 mM)。
T5283	NADH disodium salt Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠	Others; Endogenous Metabolite	Metabolism; Others
	NADH disodium salt hydrate是氧化还原酶的辅酶。 NADH在分解代谢过程中起到再生电子供体的作用，包括糖酵解，柠檬酸循环和β-氧化。
T1508	Decitabine Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA Methyltransferase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Decitabine (Deoxycytidine) 是脱氧胞苷类似物，一种 DNA 甲基转移酶抑制剂，具有口服活性。Decitabine 具有抗肿瘤活性和抗代谢活性。Decitabine 诱导细胞周期阻滞和凋亡。
T20113	D-(+)-Malic acid (R)-Malic acid,Malic acid, D-,D-(+)-苹果酸,D-Malic acid	Others	Others
	D-(+)-Malic acid ((R)-Malic acid) 一种是Malic acid 活性异构体，是竞争性的 L(--)malic acid 转运的抑制剂。
T2336	Vitamin K2 Menatetrenone,四烯甲萘醌	Endogenous Metabolite	Metabolism
	Vitamin K2 (Menatetrenone) 是内源性代谢产物的一种。
T1272	Cytarabine 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Cytarabine (Ara-C) 是一种核苷类似物，一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶，诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。
TN7087	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone	Others	Others
	2,5-dimethoxycyclohexa-2,5-diene-1,4-dio (Thermophillin) 是一种天然产物。它的氧化还原循环是木材褐腐真菌腐烂中Fe2+和H2O2再生的还原当量来源。
T3008	Lawsone methyl ether 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌	Apoptosis; Antibacterial; Antifungal	Apoptosis; Microbiology/Virology
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和Swertia calycina 中分离出的，有抗真菌和抗菌活性。
T5372	L-SelenoMethionine L-(+)-Selenomethionine,L-硒代蛋氨酸	Apoptosis; Amino Acids and Derivatives; Endogenous Metabolite	Apoptosis; Metabolism
	L-SelenoMethionine (L-(+)-Selenomethionine) 是 Selenomethionine 的 L-异构体，是硒的主要天然食物形式。它是一种癌症化学预防剂，可以增加谷胱甘肽过氧化物酶的表达，还可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。
T7989	Trimethyl phosphate	Others	Others
	Trimethyl phosphate 是一种有机磷化合物，是催化磷酸化化合物水解的酶的抑制剂，已被用作合成肽和其他蛋白质的反应物，用作合成有机和无机化合物的催化剂，以及用作合成药物的试剂。
T2931	2-Amino-5-ureidopentanoic acid DL-Citrulline,Citrulline,瓜氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-5-ureidopentanoic acid (Citrulline) 存在于肝脏中，不是蛋白质的构成成分，为人体脲循环的一个重要中间物，可与鸟氨酸、精氨酸合用治疗高氨血症。
TN1658	Ganoderenic acid D	Apoptosis; Others	Apoptosis; Others
	Ganoderenic acid D 是从灵芝提取物 (GLE) 的有效化合物中分离出来的天然产物。 Ganoderenic acid D 诱导细胞周期停滞和细胞凋亡并抑制癌细胞的增殖。
T5260	2-Methylpentanedioic acid 2-甲基戊二酸,2-Methylglutaric acid,alpha-Methylglutarate	Others; Endogenous Metabolite	Metabolism; Others
	2-Methylpentanedioic acid (alpha-Methylglutarate) 是一种琥珀酸的代谢产物，它通常存在于人体尿液、健康成人和儿童中。其中琥珀酸是一种柠檬酸循环中间体。
T6S2038	Ziyuglycoside II	Apoptosis; Antioxidant; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Ziyuglycoside II 是从地榆中提取的一种三萜皂苷，可诱导活性氧产生和凋亡，具有抗炎和抗癌作用。
T2S0820	Karanjin 干华豆晶 4,水黄皮素	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Karanjin 是干花豆中的主要活性呋喃黄酮醇成分，可通过细胞周期阻滞诱导癌细胞死亡，促进细胞凋亡，还通过提高AMPK 的方式诱导骨骼肌细胞 GLUT4 易位。
T5060	2-Oxobutanoic acid 2-酮丁酸,alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid	Others; Endogenous Metabolite	Metabolism; Others
	2-Oxobutanoic acid (alpha-Ketobutyric Acid) 是一种胱硫醚的酶促裂解产物。它也是苏氨酸的降解产物之一。它能够转化为丙酰辅酶A，从而进入柠檬酸循环。
T2S0886	Terrestrosin D	Apoptosis; Others	Apoptosis; Others
	Terrestrosin D 是从刺蒺藜中提取得到一种的甾体皂苷，可诱导细胞周期阻滞和癌细胞凋亡，具有抗血管生成的活性。
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天然产物

Oxaloacetic acid

Cat.No: T4862

Target: Endogenous Metabolite

Cat.No: T10857

Target: Endogenous Metabolite

Cat.No: TN2069

Synonym: 藏红花,苦番紅花素

Target: Apoptosis

Cat.No: TN2190

Target: Apoptosis, Beta-Secretase, BACE, Parasite

Cat.No: TN1727

Synonym: 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭

Target: Apoptosis, HIV Protease

Cat.No: T17155

Synonym: Ecteinascidin 743,曲贝替定,ET-743

Target: Apoptosis, Reactive Oxygen Species

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

(S)-10-Hydroxycamptothecin

Cat.No: T2764

Synonym: 10-羟喜树碱,10-羟基喜树碱,10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Cat.No: T3322

Synonym: Chalcone,反-查耳酮,查尔酮,Cinnamophenone,Chalkone

Target: Apoptosis, Others, Antifungal, Fatty Acid Synthase

Cat.No: T3981

Synonym: 4'-Methoxyapigenin,金合欢素,5,7-Dihydroxy-4'-methoxyflavone,Linarigenin

Target: Apoptosis, IAP, COX, Autophagy

DL-Isocitric acid trisodium salt

Cat.No: T5087

Synonym: 异柠檬酸三钠盐,Isocitric acid trisodium salt

Target: Others, Endogenous Metabolite

L-Ornithine hydrochloride

Cat.No: T2O2701

Synonym: L(+)-Ornithine hydrochloride,(S)-2,5-Diaminopentanoic acid,L-鸟氨酸盐酸盐;L-2,5-二氨基戊酸盐酸盐;L-鸟氨酸单盐酸盐;鸟氨酸盐酸盐;L-盐酸鸟氨酸;L-鸟粪氨基酸盐酸盐

Target: Others, Endogenous Metabolite

Cat.No: TJS1183

Synonym: 轮环藤宁,1,4,7,10-tetraazacyclododecane

Target: Others

Cat.No: T8206

Target: Others

Cat.No: TN7511

Synonym: NSC 86978

Target: Others

3-Hydroxyvaleric acid

Cat.No: T19121

Target: Endogenous Metabolite

3-Phosphoglyceric acid

Cat.No: T19127

Target: Others

Cat.No: T6S1435

Target: Apoptosis, Others

Tenacissoside H

Cat.No: T6S1844

Synonym: Tenacissimoside C,通关藤苷H

Target: Others

Cat.No: TN2058

Target: Anti-infection

Cat.No: T34398

Target: Others

Cat.No: T4921

Synonym: 2-氧代己二酸,2-Oxoadipic acid

Target: Endogenous Metabolite

L-Homocitrulline

Cat.No: T5257

Synonym: 高瓜氨酸,Homo-L-citrulline,Homocitrulline

Target: Others, Endogenous Metabolite

N-Acetyl-L-glutamic acid

Cat.No: T5267

Synonym: Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid

Target: Others, Endogenous Metabolite

(Z)-Aconitic acid

Cat.No: T8137

Synonym: 顺乌头酸,顺式乌头酸,Cls-Aconitic acid

Target: Others, Endogenous Metabolite

Alloimperatorin

Cat.No: TN1369

Synonym: Prangenidin,别欧前胡素

Target: Others

Cat.No: T5S2306

Target: Apoptosis, Others

Cat.No: TN1174

Target: Apoptosis, cell cycle arrest

Pulsatilla saponin D

Cat.No: T3909

Synonym: 白头翁皂苷D,Hederacolchiside A,SB365

Target: Apoptosis, Others

Cysteinylglycine

Cat.No: T4233

Synonym: 半胱氨酰甘氨酸,Cys-Gly

Target: Others, Endogenous Metabolite

Cat.No: T4838

Synonym: L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸

Target: Others, Endogenous Metabolite

Cat.No: T6S0234

Target: Others

Cat.No: T3774

Synonym: 山药,纤细薯蓣皂苷

Target: cell cycle arrest

2-Ketoglutaric acid

Cat.No: T5980

Synonym: α-酮戊二酸,alpha-酮戊二酸

Target: Tyrosinase, Endogenous Metabolite

NADH disodium salt

Cat.No: T5283

Synonym: Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠

Target: Others, Endogenous Metabolite

Cat.No: T1508

Synonym: Dacogen,NSC 127716,地西他滨,Deoxycytidine,5-Aza-2'-deoxycytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA Methyltransferase

D-(+)-Malic acid

Cat.No: T20113

Synonym: (R)-Malic acid,Malic acid, D-,D-(+)-苹果酸,D-Malic acid

Target: Others

Cat.No: T2336

Synonym: Menatetrenone,四烯甲萘醌

Target: Endogenous Metabolite

Cat.No: T1272

Synonym: 阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

2,5-dimethoxycyclohexa-2,5-diene-1,4-dio

Cat.No: TN7087

Synonym: 2,5-二甲氧基-1,4-苯醌,2,5-DMBQ,Thermophillin,2,5-Dimethoxybenzoquinone,2,5-Dimethoxybenzo-1,4-quinone

Target: Others

Lawsone methyl ether

Cat.No: T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌

Target: Apoptosis, Antibacterial, Antifungal

L-SelenoMethionine

Cat.No: T5372

Synonym: L-(+)-Selenomethionine,L-硒代蛋氨酸

Target: Apoptosis, Amino Acids and Derivatives, Endogenous Metabolite

Trimethyl phosphate

Cat.No: T7989

Target: Others

2-Amino-5-ureidopentanoic acid

Cat.No: T2931

Synonym: DL-Citrulline,Citrulline,瓜氨酸

Target: Others, Endogenous Metabolite

Ganoderenic acid D

Cat.No: TN1658

Target: Apoptosis, Others

2-Methylpentanedioic acid

Cat.No: T5260

Synonym: 2-甲基戊二酸,2-Methylglutaric acid,alpha-Methylglutarate

Target: Others, Endogenous Metabolite

Ziyuglycoside II

Cat.No: T6S2038

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Cat.No: T2S0820

Synonym: 干华豆晶 4,水黄皮素

Target: Apoptosis, AMPK

2-Oxobutanoic acid

Cat.No: T5060

Synonym: 2-酮丁酸,alpha-Ketobutyric Acid,2-Oxobutyric acid,Propionylformic acid

Target: Others, Endogenous Metabolite

Cat.No: T2S0886

Target: Apoptosis, Others

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01715	CDC37 Protein, Human, Recombinant (GST) cell division cycle 37,P50CDC37	Human	Baculovirus Insect Cells
	CDC37 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 70.7 kDa and the accession number is A0A024R7B7.
TMPY-03558	CDC37 Protein, Mouse, Recombinant p50Cdc37,cell division cycle 37,p50	Mouse	Baculovirus Insect Cells
	CDC37 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 44.7 kDa and the accession number is Q61081.
TMPY-03534	CDC37 Protein, Mouse, Recombinant (His & GST) cell division cycle 37,p50,p50Cdc37	Mouse	Baculovirus Insect Cells
	CDC37 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 72.4 kDa and the accession number is Q61081.
TMPY-02308	CDC42 Protein, Human, Recombinant (GST) cell division cycle 42,G25K,CDC42Hs	Human	E. coli
	CDC42 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 48.1 kDa and the accession number is P60953-2.
TMPH-01074	CDC20 Protein, Human, Recombinant (His & Myc) Cell division cycle protein 20 homolog,CDC20,p55CDC	Human	E. coli
	CDC20 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 62.2 kDa and the accession number is Q12834.
TMPY-03980	ECD Protein, Human, Recombinant (His & GST) HSGT1,ECD,GCR2,ecdysoneless cell cycle regulator	Human	Baculovirus Insect Cells
	ECD, also known as ecdysoneless homolog, belongs to the SGT1 family. It is highly expressed in muscle and heart. ECD is a novel promoter of mammalian cell cycle progression. This function is related to its ability to remove the repressive effects of Rb-family tumor suppressors on E2F transcription factors. It is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. ECD may also be a transcriptional ...
TMPH-02144	Striatin-3 Protein, Human, Recombinant (His) STRN3,S/G2 antigen,Cell cycle autoantigen SG2NA,Str...	Human	E. coli
	Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Striatin-3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 93.2 kDa and the accession number is Q13033.
TMPH-01036	Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) GPI-anchored membrane protein 1,CAPRIN1,GPIP137,M11S1,GPI-an...	Human	Baculovirus Insect Cells
	May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs. Caprin-1/CAPRIN1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells ...
TMPY-02543	PCNA Protein, Human, Recombinant (His) ATLD2,proliferating cell nuclear antigen	Human	Baculovirus Insect Cells
	Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replic...
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-04125	PTP1B Protein, Human, Recombinant (His) protein tyrosine phosphatase, non-receptor type 1,PTP1B,PTPN...	Human	E. coli
	PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p...
TMPY-01355	Transglutaminase 2/TGM2 Protein, Human, Recombinant (His) G-α-h,HEL-S-45,TGC,transglutaminase 2,TG2,GNAH,G-ALPHA-h	Human	Baculovirus Insect Cells
	Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth and survival through the anti-apoptosis signaling pathway. It is a calcium-dependent acyltransferase that also undergoes a GTP-binding/GTPase cycle even though it lacks any obvious sequence similarity with canonical GTP-binding (G) proteins. TGM2 is a multi-functional protein which...
TMPY-05176	AMH Protein, Human, Recombinant (His) MIS,anti-Mullerian hormone,MIF	Human	HEK293 Cells
	Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. BMP15 up-regulates the transcription of AMH and that the inhibition of p38 MAPK decreases the BMP15-induced expression of AMH and SOX9, suggesting that BMP15 up-regulates the expression of AMH via the p38 MAPK signaling pathway, and thi...
TMPY-02219	Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) NS1 Protein	H1N1	E. coli
	The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As...
TMPH-02817	OTCase Protein, Mouse, Recombinant (His & SUMO) Ornithine carbamoyltransferase, mitochondrial,Otc,Ornithine ...	Mouse	E. coli
	Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.
TMPH-00548	Epstein-Barr virus (strain B95-8) BZLF1 Protein (His & SUMO) Zta,Trans-activator protein BZLF1,Lytic switch protein BZLF1...	EBV	E. coli
	Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).
TMPH-00549	Epstein-Barr virus (strain GD1) BZLF1 Protein (His & Myc) bZIP transcription factor ZEBRA,Lytic switch protein BZLF1,T...	EBV	E. coli
	Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).
TMPH-01817	OTCase Protein, Human, Recombinant (His & SUMO) Ornithine carbamoyltransferase, mitochondrial,OTC,Ornithine ...	Human	E. coli
	Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion. OTCase Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.1 kDa and the accession number is P00480.
TMPH-02234	TMPRSS11A Protein, Human, Recombinant (His) Epidermal type-II transmembrane serine protease,Transmembran...	Human	E. coli
	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
TMPH-01658	MAGEA4 Protein, Human, Recombinant (His) MAGEA4,Melanoma-associated antigen 4,MAGE-4 antigen,MAGE-41 ...	Human	HEK293 Cells
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-02626	DLAT Protein, Mouse, Recombinant (His) Pyruvate dehydrogenase complex component E2,Dlat,Dihydrolipo...	Mouse	HEK293 Cells
	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
TMPH-00564	FabG Protein, E. coli, Recombinant (His & Myc) Beta-Ketoacyl-acyl carrier protein reductase,fabG,Beta-ketoa...	E. coli	E. coli
	Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
TMPH-01659	MAGEA4 Protein, Human, Recombinant (A173T, His & Myc) MAGE-41 antigen,MAGE-4 antigen,Melanoma-associated antigen 4...	Human	E. coli
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-02560	CPS1 Protein, Mouse, Recombinant (His) Carbamoyl-phosphate synthetase I,CPS1,CPSase I,Carbamoyl-pho...	Mouse	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
TMPH-03511	Simian virus 40 (SV40) SV40 early leader Protein (His & KSI) SV40 early leader protein	SV40	E. coli
	May play a role in the lytic cycle. Simian virus 40 (SV40) SV40 early leader Protein (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.0 kDa and the accession number is P0C6L2.
TMPH-00367	Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) Apoptin,VP3	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.3 kDa and the accession number is Q99152.
TMPJ-00732	ASS1 Protein, Human, Recombinant (His) Citrulline--Aspartate Ligase,Argininosuccinate Synthase,ASS1...	Human	E. coli
	Argininosuccinate Synthase (ASS1) is an urea cycle enzyme with a tetrameric structure composed of identical subunits. ASS1 is involved in the synthesis of arginine and catalyzes that condensation of citrulline and aspartate to argininosuccinate using ATP. ASS1 is important to the urea cycle as it catalyzes the important second last step in the arginine biosynthetic pathway. ASS1 mainly expressed in periportal hepatocytes, but also in most other body tissues. A deficiency of ASS1 causes citrullin...
TMPH-03510	Simian virus 40 (SV40) SV40 early leader Protein (hFc) SV40 early leader protein	SV40	HEK293 Cells
	May play a role in the lytic cycle. Simian virus 40 (SV40) SV40 early leader Protein (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 31.6 kDa and the accession number is P0C6L2.
TMPH-01526	KMT2E Protein, Human, Recombinant (His & Myc) Inactive histone-lysine N-methyltransferase 2E,Myeloid/lymph...	Human	E. coli
	Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r...
TMPY-02375	acnB Protein, E. coli, Recombinant yacI,yacJ	E. coli	E. coli
	Escherichia coli contains two major aconitases (Acns), AcnA and AcnB. They are distantly related monomeric Fe-S proteins that contain different arrangements of four structural domains. acnA is specifically subject to SoxRS-mediated activation, whereas acnB encodes the major aconitase that is synthesized earlier in the growth cycle than AcnA. It is concluded that AcnB is the major citric acid cycle enzyme. Aconitate hydratase 2 (acnB) catalyzes the isomerization of citrate to isocitrate via cis-a...
TMPH-00366	Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) VP3,Apoptin	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 40.3 kDa and the accession number is Q99152.
TMPH-01037	CPS1 Protein, Human, Recombinant (His) CPS1,CPSase I,Carbamoyl-phosphate synthetase I,Carbamoyl-pho...	Human	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. CPS1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.5 kDa and the accession number is P31327.
TMPH-00133	AcMNPV Major capsid Protein (His & Myc) VP39,P39	AcMNPV	E. coli
	Most abundant structural protein of the nucleocapsid produced during the infection cycle. The monomers are arranged in stacked rings around the nucleoprotein core. AcMNPV Major capsid Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.4 kDa and the accession number is P17499.
TMPK-01386	TK1 Potein, Canine, Recombinant (His) thymidine kinase-1,EC 2.7.1.21,Thymidine kinase	Canine	E. coli
	Thymidine kinase 1 (TK1) catalyzes the initial phosphorylation of thymidine in the salvage pathway synthesis of dTTP, an essential building block of DNA. TK1 is a cytosolic enzyme with its highest level during the S-phase of the cell cycle.
TMPH-03257	CPS1 Protein, Rat, Recombinant (His & Myc) Carbamoyl-phosphate synthase [ammonia], mitochondrial,CPSase...	Rat	E. coli
	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. CPS1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 23.7 kDa and the accession number is P07756.
TMPY-03225	VSIG8 Protein, Human, Recombinant (hFc) C1orf204,V-set and immunoglobulin domain containing 8	Human	HEK293 Cells
	V-set and immunoglobulin domain containing 8 (VSIG8) is essential in hair cycle, oral mucosa, and the nail matrix. Moreover, VSIG8 also has an important role in proper epithelial differentiation and function in the upper alimentary tract.
TMPH-02625	DLAT Protein, Mouse, Recombinant (E. coli, His) Dihydrolipoyllysine-residue acetyltransferase component of p...	Mouse	E. coli
	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. DLAT Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 62.8 kDa and the accession number is Q8BMF4.
TMPJ-00988	SEPHS1 Protein, Human, Recombinant (His) water dikinase 1,SELD,Selenophosphate synthase 1,SEPHS1,SPS1...	Human	HEK293 Cells
	Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased, which Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased. SEPHS1 can be activated by phosphate ions and by potassium ions. It can synthesize synthesizes selenophosphate from selenide and ATP....
TMPH-00365	Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) VP3,Apoptin	CAV	E. coli
	May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P54095.
TMPJ-00936	CCND2 Protein, Human, Recombinant (His) G1/S-specific cyclin-D2,CCND2	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ...
TMPH-03264	p53 Protein, Rat, Recombinant (His) Tumor suppressor p53,Tp53,Cellular tumor antigen p53	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex...
TMPY-04764	PCK2 Protein, Human, Recombinant (His & GST) PEPCK-M,PEPCK2,PEPCK,phosphoenolpyruvate carboxykinase 2 (mi...	Human	Baculovirus Insect Cells
	PCK2 promotes tumor initiation by lowering acetyl-CoA level through reducing the mitochondrial tricarboxylic acid (TCA) cycle. The levels of phosphoenolpyruvate carboxykinase isoform 2 (PCK2) are critical for the metabolic switch and the maintenance of TICs in prostate cancer. PCK2 is a potential therapeutic target for aggressive prostate tumors.
TMPH-03269	COMMD5 Protein, Rat, Recombinant (His & Myc) COMM domain-containing protein 5,COMMD5,Hypertension-related...	Rat	E. coli
	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPH-03748	KAT14 Protein, Human, Recombinant (His) KAT14,ADA2A-containing complex subunit 2,Cysteine-rich prote...	Human	E. coli
	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle.
TMPH-01703	CDC25C Protein, Human, Recombinant (His) Dual specificity phosphatase Cdc25C,M-phase inducer phosphat...	Human	E. coli
	Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. CDC25C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.4 kDa and the accession number is P30307.
TMPH-00504	Bursicon Protein, Drosophila melanogaster, Recombinant (GST) Bursicon,Cuticle-tanning hormone,Bursicon subunit alpha,burs...	Fruit fly	E. coli
	Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk. Bursicon Protein, Drosophila melanogaster, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.5 kDa and the accession number is Q9VD83.
TMPH-01948	PPP1R3G Protein, Human, Recombinant (His & Myc) PPP1R3G,Protein phosphatase 1 regulatory subunit 3G	Human	E. coli
	Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits. PPP1R3G Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 45.5 kDa and the accession number is B7ZBB8.
TMPH-00095	HDT2 Protein, Arabidopsis thaliana, Recombinant (His) Histone deacetylase HDT2,Histone deacetylase 2b,HD-tuins pro...	Arabidopsis thaliana	P. pastoris (Yeast)
	Probably mediates the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDT2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.3 kDa and the accession number is Q56WH4.
TMPY-02003	FH/Fumarate Hydratase Protein, Human, Recombinant (His) fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLRCC	Human	E. coli
	Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func...
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重组蛋白

CDC37 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01715

Species: Human

Expression System: Baculovirus Insect Cells

CDC37 Protein, Mouse, Recombinant

Cat.No: TMPY-03558

Species: Mouse

Expression System: Baculovirus Insect Cells

CDC37 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-03534

Species: Mouse

Expression System: Baculovirus Insect Cells

CDC42 Protein, Human, Recombinant (GST)

Cat.No: TMPY-02308

Species: Human

Expression System: E. coli

CDC20 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01074

Species: Human

Expression System: E. coli

ECD Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03980

Species: Human

Expression System: Baculovirus Insect Cells

Striatin-3 Protein, Human, Recombinant (His)

Cat.No: TMPH-02144

Species: Human

Expression System: E. coli

Caprin-1/CAPRIN1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01036

Species: Human

Expression System: Baculovirus Insect Cells

PCNA Protein, Human, Recombinant (His)

Cat.No: TMPY-02543

Species: Human

Expression System: Baculovirus Insect Cells

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

PTP1B Protein, Human, Recombinant (His)

Cat.No: TMPY-04125

Species: Human

Expression System: E. coli

Transglutaminase 2/TGM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01355

Species: Human

Expression System: Baculovirus Insect Cells

AMH Protein, Human, Recombinant (His)

Cat.No: TMPY-05176

Species: Human

Expression System: HEK293 Cells

Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)

Cat.No: TMPY-02219

Species: H1N1

Expression System: E. coli

OTCase Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02817

Species: Mouse

Expression System: E. coli

Epstein-Barr virus (strain B95-8) BZLF1 Protein (His & SUMO)

Cat.No: TMPH-00548

Species: EBV

Expression System: E. coli

Epstein-Barr virus (strain GD1) BZLF1 Protein (His & Myc)

Cat.No: TMPH-00549

Species: EBV

Expression System: E. coli

OTCase Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01817

Species: Human

Expression System: E. coli

TMPRSS11A Protein, Human, Recombinant (His)

Cat.No: TMPH-02234

Species: Human

Expression System: E. coli

MAGEA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01658

Species: Human

Expression System: HEK293 Cells

DLAT Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02626

Species: Mouse

Expression System: HEK293 Cells

FabG Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00564

Species: E. coli

Expression System: E. coli

MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)

Cat.No: TMPH-01659

Species: Human

Expression System: E. coli

CPS1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02560

Species: Mouse

Expression System: E. coli

Simian virus 40 (SV40) SV40 early leader Protein (His & KSI)

Cat.No: TMPH-03511

Species: SV40

Expression System: E. coli

Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO)

Cat.No: TMPH-00367

Species: CAV

Expression System: E. coli

ASS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00732

Species: Human

Expression System: E. coli

Simian virus 40 (SV40) SV40 early leader Protein (hFc)

Cat.No: TMPH-03510

Species: SV40

Expression System: HEK293 Cells

KMT2E Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01526

Species: Human

Expression System: E. coli

acnB Protein, E. coli, Recombinant

Cat.No: TMPY-02375

Species: E. coli

Expression System: E. coli

Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST)

Cat.No: TMPH-00366

Species: CAV

Expression System: E. coli

CPS1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01037

Species: Human

Expression System: E. coli

AcMNPV Major capsid Protein (His & Myc)

Cat.No: TMPH-00133

Species: AcMNPV

Expression System: E. coli

TK1 Potein, Canine, Recombinant (His)

Cat.No: TMPK-01386

Species: Canine

Expression System: E. coli

CPS1 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03257

Species: Rat

Expression System: E. coli

VSIG8 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-03225

Species: Human

Expression System: HEK293 Cells

DLAT Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02625

Species: Mouse

Expression System: E. coli

SEPHS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00988

Species: Human

Expression System: HEK293 Cells

Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His)

Cat.No: TMPH-00365

Species: CAV

Expression System: E. coli

CCND2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00936

Species: Human

Expression System: E. coli

p53 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03264

Species: Rat

Expression System: E. coli

PCK2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04764

Species: Human

Expression System: Baculovirus Insect Cells

COMMD5 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03269

Species: Rat

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

KAT14 Protein, Human, Recombinant (His)

Cat.No: TMPH-03748

Species: Human

Expression System: E. coli

CDC25C Protein, Human, Recombinant (His)

Cat.No: TMPH-01703

Species: Human

Expression System: E. coli

Bursicon Protein, Drosophila melanogaster, Recombinant (GST)

Cat.No: TMPH-00504

Species: Fruit fly

Expression System: E. coli

PPP1R3G Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01948

Species: Human

Expression System: E. coli

HDT2 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00095

Species: Arabidopsis thaliana

Expression System: P. pastoris (Yeast)

FH/Fumarate Hydratase Protein, Human, Recombinant (His)

Cat.No: TMPY-02003

Species: Human

Expression System: E. coli

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Cat. No.	Product Name	Target	Signaling Pathways
TMID-0003	Ribociclib-d6
	Ribociclib-d6 是 Ribociclib 的氘代化合物。Ribociclib 的 CAS 号为 1211441-98-3。Ribociclib (LEE011) 是一种细胞周期蛋白依赖性激酶 CDK4/6 抑制剂 (IC50=10/39 nM)，具有特异性和口服活性。Ribociclib 具有抗肿瘤活性，可以阻滞细胞周期，抑制肿瘤细胞增殖。
TMIJ-0443	3-Keto Fenretinide-d4
	3-Keto Fenretinide-d4 是 3-Keto Fenretinide 的氘代化合物。3-Keto Fenretinide 的 CAS 号为 865536-65-8。4-Oxofenretinide 是一种最近发现的 fenretinide 代谢物，可诱导显着的 G2-M 细胞周期停滞和细胞凋亡。
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
TMIJ-0375	Levomefolic Acid-13C-d3
	Levomefolic Acid-13C-d3 是 Levomefolic Acid 的 13C 和氘代化合物。Levomefolic Acid 的 CAS 号为 31690-09-2。Levomefolic acid是一种具有口服活性、可穿过血脑屏障的天然活性叶酸，是广泛使用的叶酸食品补充剂。
TMIJ-0050	Butyricacid-d7
	Butyricacid-d7 是 Butyricacid 的氘代化合物。Butyricacid 的 CAS 号为 107-92-6。Butyric acid 是一种从许多乳制品中分离出来的脂肪酸，具有抗癌活性。它抑制组蛋白去乙酰化酶 (HDAC) 并诱导胶质瘤细胞凋亡和 G1 期细胞周期停滞。此外，它在低剂量时刺激上皮细胞增殖，在高剂量时抑制增殖。
T35778	Ochratoxin A-13C20 Ochratoxin A-13C20
	Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse ...
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...
TMIJ-0101	DL-Alanine-2,3,3,3-d4
	DL-Alanine-2,3,3,3-d4 是 DL-Alanine 的氘代化合物。DL-Alanine 的 CAS 号为 302-72-7。DL-Alanine 是一种氨基酸，是L-和D-丙氨酸的外消旋化合物。DL-Alanine 与硝酸银水溶液一起用于纳米颗粒生成时常作为还原剂和封端剂。DL-Alanine 是一种甜味剂，可把它位与甘氨酸和糖精钠归为一类。DL-Alanine 在组织和肝脏之间的葡萄糖-丙氨酸循环中起重要作用。DL-Alanine 可用于研究 Cu、Zn、Cd 等过渡金属螯合。
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...

同位素标记化合物

Cat.No: TMID-0003

3-Keto Fenretinide-d4

Cat.No: TMIJ-0443

Cat.No: T70808

Levomefolic Acid-13C-d3

Cat.No: TMIJ-0375

Cat.No: TMIJ-0050

Ochratoxin A-13C20

Cat.No: T35778

Synonym: Ochratoxin A-13C20

Cat.No: T71055

DL-Alanine-2,3,3,3-d4

Cat.No: TMIJ-0101

Cat.No: T35915

Synonym: Erlotinib-13C6

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