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PROTAC 20S proteasomesubunit β5 degrader 1 (compound 12f),一种针对20S蛋白酶体亚基β5的靶向降解剂,在FaDu细胞中表现出0.11 μM的DC50值。此化合物能在FaDu和KM3/BTZ细胞中干扰细胞周期,促进细胞凋亡(apoptosis),并有效抑制细胞的增殖与迁移。此外,PROTAC 20S proteasomesubunit β5 degrader 1 还可用于研究咽癌和多发性骨髓瘤中对Bortezomib的耐药性。
PROTAC 20S proteasomesubunit β5 degrader 1 (compound 12f),一种针对20S蛋白酶体亚基β5的靶向降解剂,在FaDu细胞中表现出0.11 μM的DC50值。此化合物能在FaDu和KM3/BTZ细胞中干扰细胞周期,促进细胞凋亡(apoptosis),并有效抑制细胞的增殖与迁移。此外,PROTAC 20S proteasomesubunit β5 degrader 1 还可用于研究咽癌和多发性骨髓瘤中对Bortezomib的耐药性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) serves as a targeted degrader of the 20S proteasome subunit β5, exhibiting a DC50 value of 0.11 μM in FaDu cells. This compound disrupts the cell cycle and promotes apoptosis (apoptosis), while inhibiting cell proliferation and migration in both FaDu and KM3/BTZ cells. It is applicable for research into resistance to Bortezomib in pharyngeal carcinoma and multiple myeloma. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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