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Angelylalkannin, 提取自Alkanna tinctoria根部的一种萘醌类化合物,对人类结肠癌细胞HCT-116和SW-480具有显著的抗增殖效果.其中位抑制浓度(IC50)分别为HCT-116细胞4.76 mM和SW-480细胞7.03 mM.在1-10 mM的浓度范围内,Angelylalkannin与alkannin同样能够引起细胞周期在G1期的停滞并诱导细胞凋亡.
Angelylalkannin, 提取自Alkanna tinctoria根部的一种萘醌类化合物,对人类结肠癌细胞HCT-116和SW-480具有显著的抗增殖效果.其中位抑制浓度(IC50)分别为HCT-116细胞4.76 mM和SW-480细胞7.03 mM.在1-10 mM的浓度范围内,Angelylalkannin与alkannin同样能够引起细胞周期在G1期的停滞并诱导细胞凋亡.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Angelylalkannin, a naphthoquinone compound isolated from the roots of Alkanna tinctoria, exhibits significant antiproliferative effects on human colon cancer cells HCT-116 and SW-480. The median inhibitory concentration (IC50) of Angelylalkannin is 4.76 mM for HCT-116 cells and 7.03 mM for SW-480 cells. Similar to alkannin, Angelylalkannin induces cell cycle arrest in the G1 phase and cell apoptosis at concentrations ranging from 1-10 mM. |
分子量 | 370.4 |
分子式 | C21H22O6 |
CAS No. | 69175-72-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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