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KPT185 (KPT 185) 是一种选择性 CRM1 抑制剂,可诱导细胞凋亡、细胞周期停滞。
KPT185 (KPT 185) 是一种选择性 CRM1 抑制剂,可诱导细胞凋亡、细胞周期停滞。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 175 | 现货 | |
2 mg | ¥ 223 | 现货 |
产品描述 | KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest. |
靶点活性 | CRM1:100-500nM |
体内活性 | 在白血病细胞中(IC50=100 nM-500 nM),KPT-185显着抑制细胞增殖。在AML细胞系和原发性AML母细胞中,KPT-185能够使细胞周期停滞,并诱导细胞凋亡。对于胰腺癌细胞,KPT-185抑制细胞的增殖,诱导细胞凋亡,但KPT-185不会影响人胰腺导管上皮细胞的生长。 |
细胞实验 | Cells are seeded into 96-well plates and treated for 24, 48, and 72 hours with KPT-SINE at various concentrations ranging from 10 nM to 10 μM. Cell viability is evaluated using the cell proliferation reagent WST-1 according to the manufacturer's protocol. The absorbance of wells at 450 nm (reference wavelength, 650 nm) is measured with a microplate reader. (Only for Reference) |
别名 | KPT-185, KPT 185 |
分子量 | 355.31 |
分子式 | C16H16F3N3O3 |
CAS No. | 1333151-73-7 |
Smiles | COc1cc(cc(c1)C(F)(F)F)-c1ncn(C=CC(=O)OC(C)C)n1 |
密度 | 1.29 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: <1 mg/mL DMSO: 66 mg/mL (185.8 mM) Ethanol: 66 mg/mL (185.8 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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