|
TMPK-00369
|
HGF Protein, Human, Recombinant (hFc)
HGF,F-TCF,HGFB,SF,F-TCFB,肝细胞生长因子,DFNB39,Hepatopoietin-A,HPTA
|
Human
|
HEK293 Cells
|
|
Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity. HGF has a role in the metabolic flux of glucose in different insulin sensitive cell types; plays a key role in β-cell homeostasis; and is capable of modulating the inflammatory response.HGF plays a central role in these metabolic disorders,HGF levels could be employed as a biomarker for disease status/progression, and HGF/c-Met signaling pa... |
|
TMPY-04310
|
Apolipoprotein A-IV/APOA4 Protein, Human, Recombinant (His)
apolipoprotein A-IV
|
Human
|
HEK293 Cells
|
|
Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients. CONCLUSION: Low levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drugs for the therapy of AD. SNP(single nucleotide polymorphisms)in APOA1and APOA4 genes influences atherog... |
|
TMPY-03274
|
CXCL11 Protein, Human, Recombinant
SCYB9B,I-TAC,chemokine (C-X-C motif) ligand 11,H174,SCYB11,I...
|
Human
|
E. coli
|
|
I-TAC, also known as CXCL11, is a small cytokine belonging to the CXC chemokine family. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. The I-TAC chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC ... |
|
TMPY-04853
|
TSHR Protein, Human, Recombinant (His)
TSHR,hTSHR-I,TSH Receptor,LGR3,CHNG1
|
Human
|
Baculovirus Insect Cells
|
|
Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis. |
|
TMPJ-01204
|
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1...
|
Human
|
HEK293 Cells
|
|
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... |
|
TMPY-04826
|
LILRB5/CD85c Protein, Human, Recombinant (His)
leukocyte immunoglobulin like receptor B5,LIR8,LIR-8,CD85C
|
Human
|
HEK293 Cells
|
|
A genetic variant in LILRB5 (leukocyte immunoglobulin-like receptor subfamily-B) (rs12975366: T > C: Asp247Gly) has been reported to be associated with lower creatine phosphokinase (CK) and lactate dehydrogenase (LDH) levels. Both biomarkers are released from injured muscle tissue, making this variant a potential candidate for susceptibility to muscle-related symptoms. LILRB5/CD85c Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weig... |
|
TMPJ-00071
|
EPO/Erythropoietin Protein, Human, Recombinant (His)
Erythropoietin,EPO,红细胞生长素,Epoetin
|
Human
|
HEK293 Cells
|
|
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP... |
|
TMPY-04483
|
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...
|
Human
|
Baculovirus Insect Cells
|
|
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... |
|
TMPY-00539
|
GSTA1 Protein, Human, Recombinant (His)
glutathione S-transferase alpha 1,GTH1,GST2,glutathione S-tr...
|
Human
|
HEK293 Cells
|
|
GSTA1 (Glutathione S-Transferase Alpha 1) is a Protein Coding gene. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds. Glutathione S-transferases (GSTs) are involved in the detoxification of carcinogens and may be linked to carcinogenesis. As a vital component of GSTs, GSTA1 plays an important role in carcinogenesis. GSTA1 expression may be a target molecule in the early diagnosis and treatment of lung cancer. Human colonic adeno... |
|
TMPY-03425
|
Tau Protein, Human, Recombinant (His)
PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-associated ...
|
Human
|
E. coli
|
|
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP... |
|
TMPJ-01466
|
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC...
|
Human
|
HEK293 Cells
|
|
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... |
|
TMPY-03962
|
AFM Protein, Human, Recombinant (His)
afamin,ALBA,ALB2,ALF
|
Human
|
HEK293 Cells
|
|
Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of... |
|
TMPJ-00137
|
APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)
TRDL-1,TNF- and APOL-related leukocyte expressed ligand 2,Tu...
|
Human
|
HEK293 Cells
|
|
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily recept... |
|
TMPY-01964
|
CD16a Protein, Human, Recombinant (F176V, His)
FCGRIII,Fc gamma RIIIa,FCR-10,FCRIII,FCRIIIA,FCGR3,CD16A,Fc...
|
Human
|
HEK293 Cells
|
|
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.
CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the... |
|
TMPY-00566
|
CCL18 Protein, Human, Recombinant (His)
PARC,CCL18,CKb7,DC-CK1,chemokine (C-C motif) ligand 18,MIP-4...
|
Human
|
P. pastoris (Yeast)
|
|
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its potential as a circulating biomarker. CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. (CCL18) is predominantly secreted by M2-tumor associated macrophages (TAMs) a... |
|
TMPY-02550
|
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C motif) ligand 11
|
Human
|
E. coli
|
|
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... |
|
TMPY-00021
|
PADI4 Protein, Human, Recombinant (His)
PADI5,PAD4,PDI4,peptidyl arginine deiminase, type IV,PAD,PDI...
|
Human
|
Baculovirus Insect Cells
|
|
Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase family. PADI4 is expressed in CD34+stem cells in normal tissues, and many more CD34+ cells expressing PADI4 are present in tumour tissues. PADI4 post-translationally converts peptidylarginine to citrulline, a process called citrullination. Studies have demonstrated the high expres... |
|
TMPY-01101
|
Coagulation factor X/F10 Protein, Human, Recombinant (His)
FXA,FX,coagulation factor X,coagulation factor 10
|
Human
|
Baculovirus Insect Cells
|
|
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema... |
|
TMPH-00633
|
Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO)
sta2,Heat-stable enterotoxin A2
|
E. coli
|
E. coli
|
|
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. |
|
TMPH-00635
|
Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST)
STh,sta1,Heat-stable enterotoxin ST-IA/ST-P,STp
|
E. coli
|
E. coli
|
|
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. |
|
TMPK-01202
|
CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated
C1QR1,C1q/MBL/SPA receptor,ECSM3,C1qRp,C1qR(p),C1qR,dJ737E23...
|
Human
|
HEK293 Cells
|
|
CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperresponsiveness and inflammation with Th2 cytokine activation, along with decreased CD93 expression in bronchial epithelial cells and lung homogenates but increased serum CD93 levels. |
|
TMPK-01117
|
OSCAR Protein, Mouse, Recombinant (hFc)
PIgR-3,Poly-Ig receptor 3,OSCAR,MGC33613,mOSCAR,PIGR3
|
Mouse
|
HEK293 Cells
|
|
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p... |
|
TMPJ-00978
|
PIP4K2A Protein, Human, Recombinant (His)
Diphosphoinositide kinase 2-α,PtdIns(5)P-4-kinase isoform 2-...
|
Human
|
HEK293 Cells
|
|
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A) is a member of the phosphatidylinositol-4-phosphate 5-kinase family. It contains 1 PIPK domain and is expressed ubiquitously, with high levels in the brain. It catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). It may exert its function by regulating the levels of PtdIns5P, which functions in the... |
|
TMPH-02371
|
SHV-5 Protein, Klebsiella pneumoniae, Recombinant (His & Myc)
Beta-lactamase SHV-5,bla
|
Klebsiella pneumoniae
|
E. coli
|
|
SHV enzymes hydrolyze broad spectrum cephalosporins notably cefotaxime and ceftazidime. SHV-5 causes particularly high levels of resistance to aztreonam and ceftazidime. |
|
TMPK-00149
|
Fc epsilon RI alpha/FCER1a Protein, Human, Recombinant (His)
Fc-ε RI-α,Fc-epsilon RI-alpha,FCER1A,Fc-epsilon RI-α,FCE1A,F...
|
Human
|
HEK293 Cells
|
|
Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic dis... |
|
TMPK-01092
|
OSCAR Protein, Human, Recombinant (hFc)
Poly-Ig receptor 3,PIGR3,OSCAR,PIgR-3,MGC33613,mOSCAR
|
Human
|
HEK293 Cells
|
|
Osteoclast-associated receptor (OSCAR) is a co-stimulatory receptor in osteoclastogenesis. Synovial tissues from active rheumatoid arthritis (RA) patients express higher levels of OSCAR compared with osteoarthritic and normal patients. OSCAR and tartrate-resistant acid phosphatase (TRAP) expression levels did not differ between the cartilage pannus junction (CPJ) and non-CPJ regions in active RA. OSCAR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The p... |
|
TMPH-01549
|
Interferon epsilon/IFNE Protein, Human, Recombinant (His)
IFNE,Interferon epsilon,Interferon epsilon-1
|
Human
|
E. coli
|
|
Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections. |
|
TMPH-03715
|
Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO)
Y-STB,ystB,Heat-stable enterotoxin B
|
Yersinia enterocolitica
|
E. coli
|
|
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis. |
|
TMPK-01069
|
TMEM106B Protein, Mouse, Recombinant (hFc)
Transmembrane protein 106B,Tmem106b
|
Mouse
|
HEK293 Cells
|
|
TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dys... |
|
TMPK-00298
|
ANGPTL2 Protein, Human, Recombinant (His & Avi)
ANGRP2,ANGPTL2,angiopoietin-like 2,HARP,MGC8889,ARP2
|
Human
|
HEK293 Cells
|
|
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... |
|
TMPJ-01142
|
CDO1 Protein, Human, Recombinant (His)
CDO-I,CDO,Cysteine Dioxygenase Type I,CDO1,Cysteine Dioxygen...
|
Human
|
E. coli
|
|
Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells. CDO1 catalyzes the conversion of L-cysteine to cysteine sulfinic acid by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic c... |
|
TMPY-03461
|
GABARAPL2 Protein, Human, Recombinant (His)
GATE16,ATG8,ATG8C,GEF-2,GATE-16,GEF2,GABA(A) receptor-associ...
|
Human
|
E. coli
|
|
GATE-16, also known as ATG8, belongs to the MAP1 LC3 family. It is expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. GATE-16 is expressed at very low levels in lung, thymus and small intestine. GATE-16 is involved in intra-Golgi traffic. It modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1. |
|
TMPK-00299
|
ANGPTL2 Protein, Human, Recombinant (His & Avi), Biotinylated
MGC8889,ANGRP2,angiopoietin-like 2,ANGPTL2,HARP,ARP2
|
Human
|
HEK293 Cells
|
|
Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... |
|
TMPY-03491
|
Lysozyme 2 Protein, Human, Recombinant (His)
lysozyme like 2,LYZL2
|
Human
|
Baculovirus Insect Cells
|
|
The lysozyme 2 gene is a member of a family of lysozyme-like genes. Lysozymes, especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. Lysozymes damage bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. Lysozyme is part of the ... |
|
TMPY-02757
|
TWEAKR/TNFRSF12A Protein, Human, Recombinant (hFc)
FN14,CD266,TWEAKR,tumor necrosis factor receptor superfamily...
|
Human
|
HEK293 Cells
|
|
Fn14 (tumor necrosis factor receptor superfamily, member 12A), also known as TNFRSF12A, is the receptor for TNFSF12/TWEAK. Fn14 shares 82% amino acid identity with the mouse sequence. It contains a signal peptide, an extracellular domain, a membrane-anchoring domain, and a cytoplasmic domain. In response to FGF1, calf serum, or phorbol ester stimulation of human quiescent fibroblasts in vitro, the level of Fn14 is increased. A 1.2-kb FN14 transcript was expressed at high levels in heart, placent... |
|
TMPH-02198
|
TXNRD2 Protein, Human, Recombinant (His & SUMO)
TR-beta,Thioredoxin reductase 2, mitochondrial,Thioredoxin r...
|
Human
|
E. coli
|
|
Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis. Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling. |
|
TMPJ-00902
|
Kell Protein, Human, Recombinant (His)
CD238,KEL,Kell blood group glycoprotein
|
Human
|
HEK293 Cells
|
|
Kell blood group glycoprotein (KEL) is a single-pass type II membrane protein which belongs to the peptidase M13 family. It is expressed in Expressed at high levels in erythrocytes and testis, and, at lower levels, in skeletal muscle, tonsils, lymph node, spleen and appendix. KEL has been shown zinc endopeptidase with endothelin-3-converting enzyme activity. It cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. It links via a single disulfide bond to the XK membrane protein that car... |
|
TMPH-02331
|
GLRA1 Protein, Human, Recombinant (His & Myc)
Glycine receptor subunit alpha-1,GLRA1,Glycine receptor stry...
|
Human
|
E. coli
|
|
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiat... |
|
TMPJ-01258
|
RNASE6 Protein, Human, Recombinant (His)
RNS6,Ribonuclease K6,RNase K6,RNASE6
|
Human
|
HEK293 Cells
|
|
Ribonuclease K6 (RNASE6) is a secreted protein that belongs to the pancreatic ribonuclease family. Human RNASE6 is synthesized as a 150 amino acid precursor that contains a 23 amino acid signal sequence, and a 127 amino acid mature chain. RNASE6 is expressed in many tissues, with high expression levels in the lung, with lower expression levels in the heart, placenta, kidney, pancreas, liver, brain, and skeletal muscle. It is also detected in monocytes and neutrophils. RNASE6 may have a role in h... |
|
TMPH-03293
|
FGF-23 Protein, Rat, Recombinant (E. coli, His)
Fgf23,Fibroblast growth factor 23
|
Rat
|
E. coli
|
|
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. |
|
TMPH-02851
|
PDIA2 Protein, Mouse, Recombinant (His & SUMO)
PDIp,Pdia2,Protein disulfide-isomerase A2
|
Mouse
|
E. coli
|
|
Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. |
|
TMPJ-01390
|
MINPP1 Protein, Human, Recombinant (His)
3,4,5)-Tetrakisphosphate 3-Phosphatase,2,5)P(4) 3-Phosphatas...
|
Human
|
HEK293 Cells
|
|
Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and re... |
|
TMPJ-01044
|
NCALD Protein, Human, Recombinant (His)
Neurocalcin-δ,Neurocalcin-Delta,NCALD
|
Human
|
E. coli
|
|
Neurocalcin-delta (NCALD) is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family. It expressed in mammalian brains. NCALD contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein possesses a Ca2+ /myristoyl switch. It is cytosolic at resting calcium levels. However, elevated intracellular calcium levels induce a conformational change which exposes the myristoyl group, resulting in protein association with membranes a... |
|
TMPJ-01185
|
SULT1C4 Protein, Human, Recombinant (His)
SULT1C4,Sulfotransferase,hCG_27301,SULT1C2
|
Human
|
E. coli
|
|
Human Sulfotransferase (SULT1C4) is an enzyme that in humans is encoded by the SULT1C4 gene, belongs to the sulfotransferase 1 family. SULT1C4 is expressed at high levels in fetal lung and kidney and at low levels in fetal heart, adult kidney, ovary and spinal chord. Sulfotransferase utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. It shows activity towards p-nitrophenol and N-hy... |
|
TMPH-00574
|
Adenylate cyclase Protein, E. coli, Recombinant (His)
cyaA,EC:4.6.1.1,Adenylyl cyclase,ATP pyrophosphate-lyase
|
E. coli
|
E. coli
|
|
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp-cAMP, which then induces its own transcription again. |
|
TMPH-00634
|
Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant
Heat-stable enterotoxin ST-2
|
E. coli
|
E. coli
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Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 2.0 kDa and the accession number is P01560. |
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TMPH-00844
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HSD11B2 Protein, Human, Recombinant (His)
HSD11B2,11-beta-hydroxysteroid dehydrogenase type 2,Short ch...
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Human
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P. pastoris (Yeast)
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Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. HSD11B2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession number is P80365. |
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TMPY-00386
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GLT8D2 Protein, Human, Recombinant (His)
glycosyltransferase 8 domain containing 2,UNQ1901/PRO4347
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Human
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Baculovirus Insect Cells
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GLT8D2 is a glycosyltransferase of apoB100 that regulates apoB100 levels in hepatocytes. GLT8D2 expression increased in steatosis HepG2 cells compared with that in normal HepG2 cells. GLT8D2 participated in nonalcoholic fatty liver disease (NAFLD) pathogenesis possibly by negatively regulating MTP expression. |
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TMPK-00050
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Leptin Protein, Mouse, Recombinant (hFc)
LEP,Obesity factor,Leptin,LEPD,Obese protein,OBS,OB
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Mouse
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HEK293 Cells
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Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene. |
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TMPK-01028
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BSPII Protein, Mouse, Recombinant (His)
IBSP,SP II,BSP,BSP II,BNSP,BSP-II,BSP 2,SPII,SP-II
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Mouse
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HEK293 Cells
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Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and progression. Here, we report on the selection of antisense oligonucleotides (ASOs), which are effective in reducing their protein levels. |
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