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119-23是一种电离性阳离子脂质,主要用于制备体内mRNA传递的脂质纳米粒子(LNPs)。与SM-102或DLin-MC3-DMA的LNPs相比,119-23的LNPs在包裹mRNA报告分子后,显示出在小鼠肌肉中的转染效率更高。此类LNPs在肝脏和脾脏免疫细胞的积累也明显高于含SM-102的LNPs。此外,这种LNPs还能够有效包裹编码人类红细胞生成素(hEPO) mRNA,从而显著提高小鼠血清中hEPO的水平。
119-23是一种电离性阳离子脂质,主要用于制备体内mRNA传递的脂质纳米粒子(LNPs)。与SM-102或DLin-MC3-DMA的LNPs相比,119-23的LNPs在包裹mRNA报告分子后,显示出在小鼠肌肉中的转染效率更高。此类LNPs在肝脏和脾脏免疫细胞的积累也明显高于含SM-102的LNPs。此外,这种LNPs还能够有效包裹编码人类红细胞生成素(hEPO) mRNA,从而显著提高小鼠血清中hEPO的水平。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | 119-23 is an ionizable cationic lipid frequently utilized in the preparation of lipid nanoparticles (LNPs) for in vivo mRNA delivery. Lipid nanoparticles that include 119-23 and encapsulate mRNA reporter molecules demonstrate a higher transfection efficiency in mouse muscle compared to LNPs containing SM-102 or DLin-MC3-DMA. Additionally, the accumulation of 119-23-containing LNPs in immune cells within the liver and spleen of mice is significantly greater than that of LNPs with SM-102. Furthermore, LNPs containing 119-23 and encoding human erythropoietin (hEPO) mRNA can elevate serum hEPO levels in mice. |
分子量 | 908.47 |
分子式 | C58H105N3O4 |
CAS No. | 2953044-98-7 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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