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IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given its properties, IQZ23 holds potential for research related to obesity and metabolic disorders.
IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given its properties, IQZ23 holds potential for research related to obesity and metabolic disorders.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 期货 |
产品描述 | IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given its properties, IQZ23 holds potential for research related to obesity and metabolic disorders. |
体外活性 | IQZ23 activates AMPK pathway by modulating ATP synthase activity[1]. IQZ23 (0.3 and 1.0 μM) markedly decreases the protein level of adipogenic factors C/EBPα, PPARγ, and sterol regulatory element-binding protein 1c (SREBP-1c)) after 24 h treatment as well as the level of fatty acid synthesis related proteins fatty acid synthase (FAS), acetyl CoA carboxylase (ACC), stearoyl-CoA desaturase 1 (SCD1) after 6 days of treatment in 3T3-L1 adipocytes[1]. Western Blot Analysis[1]Cell Line: 3T3-L1 adipocytes Concentration: 0.3 and 1.0 μM Incubation Time: 24 hours Result: Decreased the protein level of adipogenic factors C/EBPα, PPARγ, and SREBP-1c. |
体内活性 | IQZ23 (20 mg/kg, i.p.) treatment significantly reverses high fat and cholesterol diet (HFC)- induced body weight increases and accompanying clinical symptoms of obesity in mice but without indicative toxicity[1]. IQZ23 exhibits moderate terminal elimination half-lives (rat 4.2±0.3 h) and Cmax (rat 37.1±7.0 ng/mL) following oral administration (rat 5 mg/kg)[1]. IQZ23 exhibits terminal elimination half-lives (rat 4.4±0.4 h) following intravenous administration (rat 2 mg/kg)[1]. |
别名 | IQZ23 |
分子量 | 443.551 |
分子式 | C26H29N5O2 |
CAS No. | 2415643-79-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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