Hepcidin-1 (mouse) is a peptide hormone that regulates iron balance, elevates mRNA for TRAP, cathepsin K, and MMP-9, and promotes TRAP-5b protein secretion. This compound also reduces FPN1 protein levels and boosts intracellular iron, ultimately aiding in osteoclast differentiation [1].

Hepcidin-1 mouse 在浓度为200-800 nM，作用时间为4天时，加强了50 ng/mL的RANKL对raw264.7细胞诱导分化的效果[1]。此外，在0-800 nM范围内，Hepcidin-1 mouse 的处理同样在4天的时间内提高了TRAP、CTK和MMP-9 mRNA的表达[1]。并且，当Hepcidin-1 mouse 浓度在0-800 nM，并作用20小时后，能够在RAW264.7细胞中提升Trap-5b蛋白水平，同时降低铁转运蛋白1 (FPN1)的含量[1]。