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244cis为含哌嗪基可电离阳离子脂质,用以制备脂质纳米颗粒(LNPs)。与SM-102含量的LNPs相较,富含244cis且包裹mRNA报告基因的LNPs特异性积累于小鼠肺部,能够降低血清中趋化因子(C-C motif)配体2(CCL2)的水平。
244cis为含哌嗪基可电离阳离子脂质,用以制备脂质纳米颗粒(LNPs)。与SM-102含量的LNPs相较,富含244cis且包裹mRNA报告基因的LNPs特异性积累于小鼠肺部,能够降低血清中趋化因子(C-C motif)配体2(CCL2)的水平。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 8-10周 | |
50 mg | 询价 | 8-10周 |
产品描述 | 244cis, an ionizable cationic lipid incorporating a piperazine structure, facilitates the creation of lipid nanoparticles (LNPs). These LNPs, when formulated with 244cis and coated with an mRNA reporter gene, exhibit preferential accumulation in the lungs of mice, in contrast to those formulated with SM-102. Additionally, it leads to a reduction in the levels of serum chemokine (C-C motif) ligand 2 (CCL2) [1]. |
分子量 | 970.54 |
分子式 | C60H111N3O6 |
CAS No. | 2956402-64-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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