SEC

Name: SEC
Brand: TargetMol
SKU: T36535
Rating: 4.5 (1 reviews)

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产品编号 T36535Cas号 1802997-81-4

SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].

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SEC

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产品编号 T36535Cas号 1802997-81-4

规格	价格	库存
2 mg	¥ 1,470	5日内发货
5 mg	¥ 2,490	5日内发货
25 mg	¥ 9,930	6-8周
50 mg	¥ 12,900	6-8周
100 mg	¥ 17,500	6-8周
1 mL x 10 mM (in DMSO)	¥ 2,730	5日内发货

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产品描述	SEC activates ANXA7 GTPase through the AMPK/mTORC1/STAT3 signaling pathway. It selectively induces apoptosis in cancer cells expressing high levels of ITGB4 by promoting ITGB4 nuclear translocation [1][2].
体外活性	SEC (20 μM) inhibits the cell migration of HEK 293T RKIP-/- cells and PC3 prostate cancer cells[1].SEC (20 μM) significantly increases AMPK phosphorylation in PC3 cells, which is inverted by ANXA7 GTPase specific inhibitor ABO, indicating that activated ANXA7 with enhanced phosphorylation level promotes AMPK phosphorylation (cell selectively)[1]. Cell Viability Assay[1] Cell Line: HEK293T RKIP-/- cells.[1]
体内活性	SEC (3 mg/kg/day or 18 mg/kg/day) suppresses metastasis in PC-3M-Luc orthotopic implantation nude mice model[1]. Animal Model: Luciferase-labeled PC-3M-Luc cells (2×106 per 50 μL sterile HBSS-/-) are orthotopically inoculated into the prostates of 8-week-old nude mice[1].