Laccase-IN-1 (compound 4b) is an orally active laccase inhibitor, demonstrating an IC50 of 11.3 μM. It exhibits both protective and curative effects against B. dothidea infections in apple fruits. The compound increases cell membrane permeability, disrupts mycelial surface morphology, alters cell ultrastructure, and decreases the ergosterol and exopolysaccharide levels in B. dothidea [1].