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SLC7A11-IN-2 (Compound 1) 是一种有效的SLC7A11/xCT抑制剂,通过下调细胞内谷胱甘肽水平并增加氧化应激来破坏 HeLa 细胞的氧化稳态,从而诱导细胞死亡,其 IC50 值为 10.23 μM。分子动力学模拟表明,该化合物的 SLC7A11 结合能力优于 Erastin。SLC7A11-IN-2 主要应用于宫颈癌的研究领域。
SLC7A11-IN-2 (Compound 1) 是一种有效的SLC7A11/xCT抑制剂,通过下调细胞内谷胱甘肽水平并增加氧化应激来破坏 HeLa 细胞的氧化稳态,从而诱导细胞死亡,其 IC50 值为 10.23 μM。分子动力学模拟表明,该化合物的 SLC7A11 结合能力优于 Erastin。SLC7A11-IN-2 主要应用于宫颈癌的研究领域。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer. |
分子量 | 356.42 |
分子式 | C19H24N4O3 |
CAS No. | 14668-59-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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