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3-sucCA(3-Succinylated cholic acid)是一款由微生物产生的胆汁酸。这种代谢物主要限制于管腔内,其作用机制包括通过改变肠道内的微生态环境来发挥效应,特别是促进Akkermansia muciniphila的增长,进而在小鼠模型中缓解MAFL-MASH的进展。研究表明,经活检确认的MAFLD患者体内的3-sucCA含量偏低。
3-sucCA(3-Succinylated cholic acid)是一款由微生物产生的胆汁酸。这种代谢物主要限制于管腔内,其作用机制包括通过改变肠道内的微生态环境来发挥效应,特别是促进Akkermansia muciniphila的增长,进而在小鼠模型中缓解MAFL-MASH的进展。研究表明,经活检确认的MAFLD患者体内的3-sucCA含量偏低。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | 3-SucCA (3-Succinylated cholic acid), a bile acid derived from microbial sources, primarily functions as a lumen-restricted metabolite. It plays a crucial role in mitigating the progression of MAFL-MASH in mouse models by altering the gut microbiota composition, notably by enhancing the proliferation of Akkermansia muciniphila. Notably, lower levels of 3-sucCA have been observed in patients with biopsy-proven MAFLD . |
别名 | 3-Succinylated cholic acid |
分子量 | 508.64 |
分子式 | C28H44O8 |
CAS No. | 94159-47-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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