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Cat. No. | Product Name | ||
---|---|---|---|
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38514 |
PMEDAP
|
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
PMEDAP 是有效的人类免疫缺陷病毒 (HIV) 复制抑制剂。它具有抗小鼠巨细胞病毒活性。它有效抑制莫罗尼鼠肉瘤病毒诱导的肿瘤形成和相关死亡率。 | |||
T40187 |
GNF2133
|
DYRK | Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
GNF2133 是一种有效的特异性 DYRK1A 抑制剂,IC50 为 6.2 nM。 GNF2133 可用于关于 1 型糖尿病的研究。 | |||
T36692 |
Fanotaprim
|
DHFR | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Fanotaprim 是二氢叶酸还原酶的有效抑制剂,抑制 tgDHFR (Toxoplasma gondiiDHFR) 和 hDHFR (human DHFR)的 IC50分别为 1.57 和 308 nM。Fanotaprim 在研究弓形虫病方面具有价值。 | |||
T5477 |
ELQ-300
|
Parasite | Microbiology/Virology |
ELQ-300 是一种有口服生物活性的抗疟疾剂,可作为细胞色素 bc1 复合物的还原位点的抑制剂 | |||
T8574 |
SPHINX
|
Others | Others |
SPHINX 是新一代的 SPRK1抑制剂。 | |||
T7149 |
S29434
|
NADPH; Autophagy | Autophagy; Metabolism |
S29434 是一种竞争性、选择性和可透过细胞膜的醌还原酶 2 抑制剂,对人 QR2 的 IC50值为 5-16 nM。它可诱导自噬,抑制 QR2 介导的 ROS 的产生。 | |||
T41277 |
PACMA 31
|
Others | Others |
PACMA 31 是一种不可逆的共价蛋白二硫键异构酶 (PDI) 抑制剂,IC50 为 10 μM。 PACMA 31 显着抑制卵巢肿瘤生长并表现出肿瘤靶向能力。 | |||
T7156 |
NIBR189
|
EBI2/GPR183 | GPCR/G Protein |
NIBR189是 EBI2(GPR183)小分子拮抗剂(IC50:11 nM)。 | |||
T5345 |
V-9302
|
Others | Others |
V-9302 是一种跨膜谷氨酰胺通量的竞争性拮抗剂。它选择性的靶向氨基酸转运体 ASCT2 (SLC1A5),不影响 ASCT1。它能够阻碍 HEK-293 细胞中由 ASCT2 介导的谷氨酰胺摄取 (IC50=9.6 μM)。 | |||
T29126 |
VU0360172
VU-0360172,VU 0360172 |
GluR | Neuroscience |
VU0360172 是 mGlu5 受体的正变构调节剂(EC50 = 16 nM;Ki = 195 nM)。 | |||
T2014 |
CCG-1423
CCG1423 |
LRRK2; Rho; Ras | Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
CCG-1423 是一种选择性 RhoA 通路抑制剂,可抑制 SRF 介导的转录,能抑制细胞的转移前列腺癌PC-3细胞侵袭模型。 | |||
T9266 |
Fatostatin
|
Lipid; Fatty Acid Synthase | Metabolism |
Fatostatin A 是一种SREBP 活化的特异性抑制剂,能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性,能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。 | |||
T8954 |
ML179
ML-179 |
Others | Others |
ML179 是一种有效的选择性肝受体同源物 1 (LRH1, NR5A2) 反向激动剂,IC50 为 320 nM。 | |||
T1115 |
Doxylamine succinate
琥珀酸多西拉敏,Decapryn |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Doxylamine succinate (Decapryn) 是一种吡啶衍生物组胺 H1 拮抗剂,具有明显的镇静特性。它竞争性阻断组胺 H1 受体并限制典型的过敏和过敏反应,可防止组胺引起的皮肤和粘膜疼痛和瘙痒。 | |||
T15249 |
Estrogen receptor modulator 1
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
Estrogen receptor modulator 1 是一种有效的、具有口服活性的、选择性雌激素受体(estrogen receptor)调节剂 (SERM),其 pIC50为 0.46。它能够诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。 | |||
T10717 |
Inobrodib
CBP-IN-1 |
Epigenetic Reader Domain | Chromatin/Epigenetic |
Inobrodib (CBP-IN-1) 是一种口服活性的强选择性p300/CBP 抑制剂,与 p300 和 CBP 结合,Kd 值为 1.3 和 1.7 nM。它抑制前列腺癌细胞系的细胞增殖并降低雄激素受体和 C-MYC 调节的基因表达。 | |||
T12079 |
ML604440
|
Proteasome | Proteases/Proteasome; Ubiquitination |
ML604440 是一种特异性的、有效的、细胞可渗透的蛋白酶体 β1i (LMP2) 亚基抑制剂,能够破坏 MHC I 类细胞表面表达,IL-6 分泌以及 naïve T helper 向 17 T helper 细胞的分化。它可以改善实验性结肠炎和 EAE 疾病。 | |||
T8222 |
Selpercatinib
LOXO-292 |
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
Selpercatinib (LOXO-292) 是 RET 激酶抑制剂,抑制 RET (WT)、RET (V804M) 、RET (G810R)的 IC50分别为 14.0 nM、24.1 nM、530.7 nM,具有抗肿瘤活性。 | |||
T26619 |
Amitivir
LY217896,LY 217896,阿米替韦,LY-217896 |
Others; Influenza Virus | Microbiology/Virology; Others |
Amitivir (LY 217896) 是一种噻二唑衍生物,对 A 和 B 型流感病毒均有效,对正粘病毒和副粘病毒具有广泛的抗病毒活性。 | |||
T4014 |
CP-724714
CP724714,CP 724714 |
Apoptosis; EGFR | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
CP-724714 (CP724714) 是一种高效、选择性口服活性的 ErbB2 (HER2)酪氨酸激酶抑制剂,IC50为 10 nM。它能抑制完整细胞中 ErbB2 受体的自磷酸化,具有抗肿瘤活性。它对 EGFR 激酶有明显的选择性,IC50值为6400 nM。 | |||
T9072 |
Tuxobertinib
BDTX-189 |
EGFR; HER; BTK; RIP kinase | Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors |
Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂,具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。 | |||
T11279 |
FGFR1/DDR2 inhibitor 1
|
Discoidin Domain Receptor (DDR); FGFR; Others | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
FGFR1/DDR2 inhibitor 1 是一种具有口服活性的成纤维细胞生长因子受体 1 和盘状蛋白域受体 2 的抑制剂,能够抑制 FGFR1 (IC50:31.1 nM) 和 DDR2 (IC50:3.2 nM),具有抗肿瘤作用。 | |||
T9521 |
CHR-6494 TFA
|
Others | Others |
CHR 6494 TFA 是一种选择性 haspin 抑制剂,IC50值为 2 nM,可抑制组蛋白 H3T3 的磷酸化。它诱导黑色素瘤、乳腺癌等肿瘤细胞凋亡,可研究癌症。 | |||
T7530 |
PD146176
NSC168807 |
Ferroptosis; Lipoxygenase; Autophagy | Apoptosis; Autophagy; Metabolism |
PD146176 (NSC-168807) 是一种 15-脂氧合酶(15-LO)抑制剂,抑制兔网织红细胞 15-LO,Ki 为 197 nM,IC50 为 0.54 μM。 它通过刺激老年三重转基因小鼠的自噬来逆转认知障碍、脑淀粉样变性和 tau 病理学。 | |||
T1646 |
Famciclovir
泛昔洛韦,BRL 42810 |
DNA/RNA Synthesis; HSV | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。 | |||
T3100 |
GSK-J4
GSK J4 HCl |
Apoptosis; Histone Demethylase | Apoptosis; Chromatin/Epigenetic |
GSK-J4 (GSK J4 HCl) 是 H3K27me3/me2 去甲基化酶JMJD3/KDM6B 和UTX/KDM6A 双抑制剂,IC50分别为 8.6 μM 和 6.6 μM。它是 GSK-J1 的细胞通透性前药,可诱导内质网应激相关的细胞凋亡。它抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α,IC50值为 9 μM。 | |||
T7535 |
RGX-202
胍基丙酸,β-GPA,3-Guanidinopropionic Acid |
AMPK; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
RGX-202 (β-GPA) 是口服有活性的SLC6A8转运蛋白抑制剂。它在体内外均能够强烈地抑制肌酸输入,降低细胞内磷酸肌酸和 ATP 水平,诱导肿瘤凋亡,可于研究肿瘤。 | |||
T1290 |
Oxiconazole nitrate
硝酸奥昔康唑,Ro 13-8996 |
Others; Antibiotic; Antifection; Antifungal | Microbiology/Virology; Others |
Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物,抑制T. tonsurans 和T.rubrum 的生长,MIC90值分别为 0.25 和 0.5 μg/mL。 | |||
T12134 |
MYCMI-6
NSC354961 |
Apoptosis; c-Myc | Apoptosis; Cell Cycle/Checkpoint |
MYCMI-6 (NSC-354961) 是一种内源性MYC:MAX 蛋白相互作用抑制剂,选择性结合 MYC bHLHZip 域,Kd 值为 1.6 μM。它阻断 MYC 驱动的转录,以 MYC 依赖性的方式抑制肿瘤细胞的生长 ,诱导细胞凋亡。 | |||
T0839 |
Ketoprofen
酮基布洛芬,RP-19583,酮洛芬 |
Apoptosis; COX; MRP | Apoptosis; Immunology/Inflammation; Neuroscience |
Ketoprofen (RP-19583) 是一种非甾体抗炎剂,能够有效地抑制COX 的活性,在人血单核细胞中,对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。 | |||
T2275 |
YK-4-279
4,7-二氯-1,3-二氢-3-羟基-3-[2-(4-甲氧基苯基)-2-氧代乙基]-2H-吲哚-2-酮 |
Apoptosis; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
YK 4-279是一种RNA 解旋酶A 与致癌转录因子EWS-FLI1结合抑制剂,能抑制ESFT 细胞增长,诱导凋亡。 | |||
T6832 |
Fatostatin hydrobromide
Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin |
NPC1L1; Fatty Acid Synthase | Membrane transporter/Ion channel; Metabolism |
Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂,可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合,抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用,能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。 | |||
T1824 |
TGR5 Receptor Agonist
|
GPCR19 | GPCR/G Protein |
TGR5 Receptor Agonist 是一种TGR5(GPCR19)激动剂。 | |||
T8825 |
Capmatinib 2HCl.H2O
INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) 是一种具有潜在抗肿瘤活性的原癌基因 c-Met (HGFR) 的口服生物可利用抑制剂。 | |||
T5045 |
GSK4112
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate,SR6452 |
Autophagy | Autophagy |
GSK4112 (SR6452) 是一种 Rev-erbα 激动剂,EC50 为 0.4 μM。它也是一种用于核血红素受体 Rev-erbα 的细胞生物学的小分子化学探针。 | |||
T8416 |
Capmatinib xHCl
INCB28060,Capmatinib hydrochloride(free base),INC280 |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Capmatinib xHCl (INCB28060) 是一种有效的、口服活性的、选择性的和 ATP 竞争性 c-Met 激酶抑制剂,有效地阻断体外激酶活性 (IC50 = 0.13 nM) 以及在细胞中的组成型或 HGF 刺激活性(IC50 值范围从 0.3 到1.1纳米)。 | |||
T7804 |
Garenoxacin mesylate hydrate
Garenoxacin mesylate [USAN],加雷沙星甲磺酸盐,BMS284756 (Mesylate hydrate) |
Antibacterial | Microbiology/Virology |
Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) 是一种新型口服 des-fluoro(6) 喹诺酮,具有强抗菌活性,抗呼吸道病原体。 | |||
T4260 |
Capmatinib 2HCl
INC-280 2HCl,INCB28060盐酸盐,INCB28060 2HCl |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Capmatinib 2HCl (INC-280 2HCl) 是一种新型的 ATP 竞争性 c-MET 激酶抑制剂,IC50 为 0.13 nM。它具有皮摩尔酶效,对 c-MET 具有高度特异性,选择性超过 10, 000 倍一大组人类激酶。该抑制剂在 c-MET 依赖性肿瘤细胞系中有效阻断 c-MET 磷酸化和其关键下游效应子的激活。因此,它在体外有效抑制 c-MET 依赖性肿瘤细胞增殖和迁移,并有效诱导细胞凋亡。 | |||
T1963 |
Capmatinib
NVP-INC280,INC-280,卡马替尼,INCB28060 |
Apoptosis; c-Met/HGFR | Apoptosis; Tyrosine Kinase/Adaptors |
Capmatinib (INCB28060) 是一种具有口服活性的,选择性的,ATP 竞争性的c-Met 激酶抑制剂,IC50值为0.13 nM。它有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移,可诱导细胞凋亡,有抗肿瘤活性。 | |||
T4383 |
GSK-J4 Hydrochloride
GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base) |
Histone Demethylase | Chromatin/Epigenetic |
GSK-J4 Hydrochloride (GSK J4 HCl) 是 H3K27me3/me2 去甲基化酶 JMJD3/KDM6B 和 UTX/KDM6A 双抑制剂,IC50分别为 8.6 和 6.6 μM。它是 GSK-J1 的乙酯衍生物,体外 IC50 值大于 50 μM。它抑制 LPS 诱导的人原代巨噬细胞产生 TNF-α,IC50值为 9 μM。 | |||
TQ0157 |
EIPA
L593754,MH 12-43 |
Sodium Channel; TRP/TRPV Channel | Membrane transporter/Ion channel |
EIPA (L593754) 是一种有效的TRPP3 channel 抑制剂,IC50为 10.5 μM。EIPA 对Na+/H+交换 (NHE) 和巨噬细胞也有抑制作用。 | |||
T7179 |
Garenoxacin
BMS284756,加雷沙星 |
Antibacterial | Microbiology/Virology |
Garenoxacin (BMS284756) 是一种新型的口服 des-fluoro(6) 喹诺酮,有抗菌活性,可抑制呼吸道病原体。 | |||
T76135 |
Hemicellulase
|
Others | Others |
Hemicellulase(半纤维素酶),糖苷水解酶家族成员,广泛应用于生化研究领域。该酶能够分解植物纤维中的葡萄糖及其与水分子的聚合物,是自然界植物生物量及碳流降解的关键酶类。 | |||
T15214 |
Emicerfont
GW876008 |
Others | Others |
Emicerfont is an antagonist of the corticotropin-releasing factor type 1 receptor (IC50: 66 nM). | |||
T21870 |
C-021
4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy- |
CCR | Immunology/Inflammation; Microbiology/Virology |
C 021 dihydrochloride 是一种 CC 趋化因子受体 4 (CCR4) 拮抗剂,抑制人和小鼠的功能趋化性,IC50分别为 140 和 39 nM。C-021 (4-Quinazolinamine, 2-[1,4'-bipiperidin]-1'-yl-N-cycloheptyl-6,7-dimethoxy-) 可有效阻止人 CCL22 衍生的 [35S]GTPγS 与受体结合,IC50为 18 nM。 | |||
T35033 |
Vamicamide
FK 176,FK-176,FK176 |
AChE | Neuroscience |
Vamicamide (FK 176)是一种新型抗胆碱能化合物。Vamicamide 在 32 mg/kg (p.o.)或更高时增加小鼠的自发运动活动,并在 100 mg/kg 时抑制小鼠强直性惊厥。 | |||
T35033L |
(S)-Vamicamide
(S)-Vamicamide (Iso-132373-81-0) |
AChE | Neuroscience |
(S)-Vamicamide 是一种新型抗抗胆碱能化合物。Vamicamide 在 32 mg/kg 或更高 (p.o.) 时增加小鼠的自发运动活动,并在 100 mg/kg 时抑制小鼠强直性惊厥。 | |||
T68166L |
Traxanox TFA
Traxanox TFA(58712-69-9 Free base) |
Others | Others |
Traxanox TFA 是一种可口服的利尿剂。Traxanox TFA 在体外增强小鼠腹膜巨噬细胞或大鼠腹膜多形核白细胞对酵母颗粒的吞噬作用。Traxanox TFA 对抑制BALB/c小鼠抗体产生的恢复作用。 | |||
T26986 |
Cevoglitazar
LBM-642,LBM 642,LBM642 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Cevoglitazar (LBM-642) 是一种 PPARɑ 激动剂和 PPARγ激动剂。Cevoglitazar 能有效减少肥胖小鼠和猴的食物摄入量和体重。 | |||
T12779 |
Ru-32514
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Ru-32514 是一种苯二氮受体激动剂,可部分逆转小鼠应激诱导的觉醒,可用于研究神经系统疾病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5661 |
Methyl isoeugenol
|
Others | Others |
Methyl isoeugenol 是一种天然的食用香精,占石竹叶香精油的 93.7%。该物种的叶子提取物用作镇静剂。作为一种无处不在的食品添加剂,MIE 在治疗情绪障碍方面的应用。 | |||
T2869 |
Emodin
Frangula emodin,大黄素 |
SARS-CoV; Casein Kinase; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Stem Cells |
Emodin (Frangula emodin) 是蒽醌衍生物,有抗SARS-CoV 作用。它阻断 SARS 冠状病毒刺突蛋白和血管紧张素转化酶 2 的相互作用。它抑制酪蛋白激酶 2 ,具有抗炎和抗癌作用。它可改善饮食诱导的肥胖小鼠的代谢紊乱。 | |||
T0983 |
Penicillamine
青霉胺,d-penicillamin,Dimethyl Cysteine,D-青霉胺,Artamine,D-(-)-Penicillamine |
Antibiotic | Microbiology/Virology |
Penicillamine (Artamine) 是一种 penicillin 的代谢降解产物,是一种螯合剂,可作用于威尔逊氏病。 | |||
TN1818 |
Kaempferol 3-O-β-D-glucuronide
Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,山奈酚葡萄糖醛酸苷,Kaempferol-3-glucuronide |
IL Receptor | Immunology/Inflammation |
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide) 具有抗氧化活性。 类黄酮葡糖苷酸可以被来自各种人体细胞的微粒体 α2-葡糖苷酸酶解偶联。 | |||
T4984 |
Cefozopran hydrochloride
SCE-2787 hydrochloride |
Antifungal | Microbiology/Virology |
Cefozopran hydrochloride (SCE-2787 hydrochloride) 是一种半合成的非肠道头孢菌素。它是一种广谱抗菌抗生素,能抑制大多数革兰氏阴性和革兰氏阳性菌。 | |||
T73853 |
Amicetin
|
Others | Others |
Amicetin,一种强效的抗生素,对革兰氏阳性菌表现出显著的抗生活性,主要通过抑制蛋白质合成机制发挥作用。 | |||
T2S0967 |
Sennoside C
|
Others | Others |
Sennoside C 是从番泻叶和豆荚中提取的蒽醌甙,对小鼠的通便作用有辅助作用。 | |||
T4396 |
Officinalisinin I
|
Others | Others |
Officinalisinin I 是一种甾体皂苷,分离自 Anemarrhena asphodeloides。 | |||
T6985 |
Benzo[a]pyrene
苯并[a]芘,3,4-Benzopyrene,苯并(a)芘 |
Others | Others |
Benzo[a]pyrene (3,4-Benzopyrene) 在动物模型中显示肺致癌性,可用于化学预防研究。 | |||
T13903 |
Stearoylethanolamide
N-(2-Hydroxyethyl)octadecanamide |
Apoptosis | Apoptosis |
Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) 是一种存在于人、大鼠和小鼠大脑中的大麻素类化合物,具有促细胞凋亡活性。 | |||
T3698 |
alpha-Asarone
α-Asarone,trans-Asarone,α-细辛脑 |
P450; GABA Receptor; HMG-CoA Reductase | Membrane transporter/Ion channel; Metabolism; Neuroscience |
alpha-Asarone (trans-Asarone) 是来自胡萝卜的一种天然产物,具有抗抑郁等功效。 | |||
T20225 |
Dicentrine, (-)-
L-Dicentrine,荷包牡丹碱,NSC 251699,NSC251699,NSC-251699 |
Others | Others |
Dicentrine, (-)- (NSC-251699) 是一种在几种植物物种中发现的非卟啉生物碱,在小鼠内脏痛的急性模型中显示出显著的镇痛活性。 | |||
T6S1885 |
Benzoylmesaconine
Mesaconine 14-benzoate,苯甲酰新乌头原碱 |
Others | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。 | |||
TN1757 |
Hypophyllanthin
叶下珠次素,(7S,8S,9R)-9-(3,4-二甲氧基苯基)-6,7,8,9-四氢-4-甲氧基-7,8-双(甲氧基甲基)萘并[1,2-D]-1,3-二恶茂 |
Potassium Channel; Calcium Channel; P-gp | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Hypophyllanthin 是珠子草中的一种木脂素,能直接抑制 P-gp 的活性,具有很强的抗炎活性。 | |||
T4588 |
Glycochenodeoxycholic Acid
甘氨鹅脱氧胆酸,Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Glycochenodeoxycholic Acid (Lithocholylglycine) 是一种从脱氧鹅胆酸和甘氨酸在肝脏中形成的胆汁盐,可诱导肝细胞凋亡。它有洗涤剂的作用,可溶解脂肪吸收,并本身被吸收。 | |||
T5S0669 |
Bergamottin
5-Geranoxypsoralen,Bergamotine,Bergaptin,佛手柑素 |
P450 | Metabolism |
Bergamottin (5-Geranoxypsoralen) 是竞争性CYP1A1抑制剂(Ki:10.703 nM)。 | |||
TN2151 |
Rhamnocitrin
|
Others | Others |
Rhamnocitrin 是一种分离自黄芪(沙源子)中的类黄酮,具有抗氧化,抗炎和抗动脉粥样硬化活性。它是 DPPH 的清除剂(IC50:28.38 mM)。 | |||
TN2088 |
Platycodin D2
桔梗皂苷D2 |
IL Receptor; HBV | Immunology/Inflammation; Microbiology/Virology |
Platycodin D2 是分离自桔梗的皂苷类物质,显示除抗癌活性。 | |||
T5735 |
Methyl deacetylasperulosidate
Deacetyl asperulosidic acid methyl ester,6α-Hydroxygeniposide,去乙酰车叶草苷酸甲酯 |
Others | Others |
Methyl deacetylasperulosidate (6α-Hydroxygeniposide) 是环烯醚萜类化合物,能够降低正常小鼠的血糖水平,对小鼠具有通便作用。 | |||
TN1111 |
Arnidiol
|
Immunology/Inflammation related | Immunology/Inflammation |
Arnidiol 是一种五环三萜烯,从Barleria Longiflora LinnF. 中提取得到。 | |||
TN1256 |
3-O-Acetyl-16α-hydroxytrametenolic acid
3-O-乙酰基-16Α-羟基-氢化松苓酸,3-O-Acetyl-16 alpha-hydroxytrametenolic acid |
Immunology/Inflammation related | Immunology/Inflammation |
3-O-Acetyl-16α-hydroxytrametenolic acid 是茯苓中的一种萜类物质,具有抗氧化、抗癌作用。 | |||
TQ0213 |
Bruceantin
鸦胆亭,(-)-Bruceantin,NCI165563,鸦胆停,NSC165563 |
Others | Others |
Bruceantin (NSC-165563) 提取自痢鸦胆子中,显示出对 B16黑色素瘤,结肠癌38,L1210和白血病 P388的抑制活性。 | |||
TN2230 |
Soyasaponin Ba
大豆皂苷 BA,大豆皂苷Ba |
Others | Others |
Soyasaponin Ba 是一种大豆皂苷,分离自菜豆类,可用作醛糖还原酶抑制剂。 | |||
T10822 |
Cirsimarin
Cirsitakaoside |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
Cirsimarin (Cirsitakaoside) 是一种从 Microtea debilis 中分离出来的黄酮类化合物。它具有很强的抗脂肪生成作用,能减少小鼠脂肪组织的沉积。Cirsimarin 对腺苷 A1 受体有拮抗作用,对磷酸二酯酶有抑制作用 | |||
T5S0229 |
Isosakuranetin
4'-Methylnaringenin,异野樱素,异樱花亭 |
Others | Others |
Isosakuranetin (4'-Methylnaringenin) 是一种黄烷酮黄酮类化合物,存在于 Citrus bergamia 果实中。 | |||
T19924 |
Rhododendrol
Betuligenol,Frambinol,杜鹃醇 |
Others | Others |
Rhododendrol (Frambinol) 是一种黑色素合成物,防止雄性小鼠高脂饮食引起的体重升高和增加雄性小鼠白色脂肪细胞的脂肪分解。Rhododendrol 可用作美白/美白化妆品抑制剂。 | |||
T6S0721 |
Orientin
荭草苷,Lutexin,Luteolin-8-glucoside |
Others | Others |
Orientin (Luteolin-8-glucoside) 是天然存在的生物活性类黄酮,是一种有前景的神经保护剂,具有多种生物特性,如抗炎、抗肿瘤、抗氧化、保护心脏等。它有用于神经性疼痛研究潜力。 | |||
T7036 |
2,4'-Dihydroxybenzophenone
|
Antioxidant | oxidation-reduction |
2,4'-Dihydroxybenzophenone 可有效保护 C57BL/6J 小鼠免受 APAP 诱导的肝毒性。它对可卡因诱导的小鼠急性肝毒性和神经毒性具有保护作用。其机制可能与其抗氧化活性有关。 | |||
T5S2083 |
Puerarin 6''-O-Xyloside
|
Apoptosis; Caspase | Apoptosis; Proteases/Proteasome |
Puerarin 6''-O-Xyloside 是从葛根中分离得到的一种天然产物,可诱导线粒体介导的细胞凋亡通路,有抗炎和抗癌活性。 | |||
T3887 |
Rosarin
|
Others | Others |
Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS,IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。 | |||
T30451 |
Biliatresone
|
Others | Others |
Biliatresone 是一种从球藻 Dysphania glomulifera 和 D. littoralis 中分离出来的环境毒素,诱导 C57BL/6J 新生儿胆管病,诱导谷胱甘肽 (GSH) 水平降低,诱导 SOX17 胆管细胞水平显着降低,诱导小鼠肝外胆管细胞损伤和纤维化。 | |||
T0632 |
3,4,5-Trimethoxybenzoic acid
Gallic acid trimethyl ether,Eudesmic acid,3,4,5-三甲氧基苯甲酸,Trimethylgallic Acid,Benzoic acid,Tri-O-methylgallic acid,没食子酸三甲醚 |
Antioxidant | oxidation-reduction |
3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) 是一种苯甲酸衍生物,可用作医药和有机合成中的砌块。 | |||
T5S0733 |
Picroside III
|
Others | Others |
Picroside III 是一种环烯醚萜苷,分离自传统中药胡黄连中。Picroside III 具有修复肠粘膜损伤的潜力,可减轻小鼠肠道炎症。 | |||
T5773 |
Moslosooflavone
5-羟基-7,8-二甲氧基黄酮,5-hydroxy-7,8-dimethoxyflavone |
NF-κB; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) 是一种从雪莲中分离出来的类黄酮,具有抗缺氧和抗炎作用。 | |||
T5S0285 |
Cistanoside A
肉苁蓉苷 A,肉苁蓉苷A |
Others | Others |
Cistanoside A 是一种肉苁蓉中的苯丙素类化合物,能够抑制 NO 的聚集,但不影响诱导型一氧化氮合酶 iNOS 的 mRNA 和蛋白水平及其活性。它具有抗炎作用。 | |||
T2777 |
Ginsenoside Rg1
Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,人参皂苷Rg1,Panaxoside A,人参皂苷 Rg1,Ginsenoside A2 |
Apoptosis; Beta Amyloid; NF-κB | Apoptosis; Neuroscience; NF-κB |
Ginsenoside Rg1 (Panaxoside Rg1) 是人参的主要活性成分之一,可减少NF-κB 核易位。它改善认知功能受损,通过降低大脑Aβ水平来发挥作用。 | |||
T3662 |
Eleutheroside E
|
NF-κB | NF-κB |
Eleutheroside E 是刺五加的重要成分,具有抗炎,保护缺血心脏的功能。 | |||
T3999 |
D(+)-Galactosamine hydrochloride
D-半乳糖胺盐酸盐,D-氨基半乳糖盐酸盐,D-Galactosamine HCl |
Others | Others |
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) 是一种被证实的实验毒素,它能够产生自由基及UTP 核苷酸的消耗导致肝损伤,中毒剂量会造成肾功能不全,而肾功能衰竭通常和终末期肝损伤有关。脂多糖/D-Galactosamine 诱导的急性肝损伤是一种已知的暴发性肝衰竭动物模型。 | |||
T3005 |
4-Hydroxychalcone
P-Cinnamoylphenol,4-羟基查尔酮 |
Others; NF-κB | NF-κB; Others |
4-Hydroxychalcone (P-Cinnamoylphenol) 是一种查尔酮代谢物,具有抗血管生成和消炎作用。它抑制 TNF-α 诱导的 NF-κB 途径活化并激活 BMP 信号传导,通过减轻小鼠的醛固酮过多症和肾脏损伤来降低抵抗性高血压。它通过抑制生长因子途径抑制血管生成,无细胞毒性迹象。 | |||
T5715 |
(E)-Flavokawain A
(E)-1-(2-羟基-4,6-二甲氧基苯基)-3-(4-甲氧基苯基)-2-丙烯-1-酮,FLAVOKAVAIN A(P),卡瓦胡椒素A |
Apoptosis; P450 | Apoptosis; Metabolism |
(E)-Flavokawain A 是一种来自卡瓦提取物的新型查尔酮,通过参与 Bax 蛋白依赖性和线粒体依赖性凋亡途径诱导膀胱癌细胞凋亡,并抑制小鼠肿瘤生长,具有抗癌作用。 | |||
TN2089 |
Platycodin D3
桔梗皂苷D3,桔梗皂苷 D3 |
HCV Protease; NF-κB | Microbiology/Virology; NF-κB; Proteases/Proteasome |
Platycodin D3 是桔梗中有抗HCV 活性的一种三萜皂苷类天然产物。 | |||
T5702 |
Tenuifoliside B
|
Dehydrogenase | Metabolism |
Tenuifoliside B 是一种分离自Polygalae Radix 中的成分,能够抑制氰化钾引起的缺氧和东莨菪碱引起的记忆障碍。它有成为 AD 先导化合物的潜力。它具有潜在的认知改善和脑保护作用。 | |||
TN7235 |
4-methoxylonchocarpin
|
TNF; NF-κB | Apoptosis; NF-κB |
4-methoxylonchocarpin 是从Abrus precatorius 的根中分离出来的以一种有效的抗炎化合物。4-methoxylonchocarpin 通过抑制LPS 与巨噬细胞的TLR4结合来抑制NF-κB 激活TNF 表达,抑制TNBS 引起的小鼠结肠炎。 | |||
T4S2164 |
Narirutin
Naringenin-7-O-rutinoside,Isonaringin,芸香柚皮苷,柚皮芸香苷 |
Others; Antibacterial | Microbiology/Virology; Others |
Narirutin (Naringenin-7-O-rutinoside) 是从Citrus unshiu 中分离的活性成分之一,具有抗氧化和抗炎活性。它是一种具有抗结核效力的shikimate 激酶抑制剂。 | |||
TN1236 |
3',4',7-Trihydroxyisoflavone
|
MAPK; JNK | MAPK |
3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物,是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂,具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用,可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能,可用于研究特应性皮炎。 | |||
T4A2462 |
Telocinobufagin
Telobufotoxin,远华蟾蜍精,Telocinobufogenin |
Others | Others |
Telocinobufagin (Telobufotoxin) 是一种从蟾酥中分离提取获得的组份。 | |||
T78474 |
6PPD-Q
6PPD-Quinone |
Endogenous Metabolite | Metabolism |
6PPD-Q (6PPD-Quinone) 是一种存在于环境和土壤中的污染物,是轮胎抗氧剂N-(1,3-二甲基丁基)-N'-苯基对苯二胺(6PPD)的衍生物,会损害小鼠精子质量并诱发雄性生殖能力的受损。 | |||
TN1420 |
Bacopaside I
|
Others | Others |
Bacopaside I 是一种皂苷,分离自 Bacopa monniera 中,具有抗氧化活性和清除自由基的功能,有抗抑郁作用。 | |||
TN1936 |
Mogroside III-E
罗汉果皂苷ⅢE |
IL Receptor; TNF; TLR | Apoptosis; Immunology/Inflammation |
Mogroside IIIe 是一种葫芦烷型化合物,从罗汉果中分离得到,可抑制 NO 的释放,具有抗肺纤维化作用。 | |||
T2818 |
Methyl Vanillate
|
Reactive Oxygen Species; Wnt/beta-catenin; Endogenous Metabolite | Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB; Stem Cells |
Methyl vanillate 是一种枳椇属植物中的提取物,是Wnt/β-catenin 信号通路活化剂,是一种香草酸的甲酯。它具有抗氧化作用。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03623 |
Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc)
Toxin Tb2-II,P-Mice-Ins-beta* NaTx5.4 |
Tityus bahiensis | Baculovirus Insect Cells |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number is P60276. | |||
TMPH-03624 |
Tb2-II Protein, Tityus bahiensis, Recombinant (E. coli, His & Myc)
Toxin Tb2-II,P-Mice-Ins-beta* NaTx5.4 |
Tityus bahiensis | E. coli |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. Tb2-II Protein, Tityus bahiensis, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.0 kDa and the accession number is P... | |||
TMPH-03625 |
Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc)
Tityustoxin II,TsTX III-8,Toxin II,Tst2,Toxin T1-IV,TsTX-II,... |
Tityus serrulatus | Baculovirus Insect Cells |
Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.9 kDa and the accession number is P68410. | |||
TMPH-03626 |
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc)
Toxin II-11,Beta-like toxin Ts1,Ts7,Beta-mammal/insect toxin... |
Tityus serrulatus | Baculovirus Insect Cells |
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number is P15226. | |||
TMPH-03627 |
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc)
Ts VII,Beta-like toxin Ts1,Toxin II-11,Ts7,Tityustoxin VII,P... |
Tityus serrulatus | E. coli |
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.3 kDa and the accession number is P15226. | |||
TMPH-01433 |
Hemicentin-1 Protein, Human, Recombinant (His)
Fibulin-6,HMCN1,Hemicentin-1 |
Human | E. coli |
Hemicentin-1 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPK-00735 |
CXCL13/BCA-1 Protein, Mouse, Recombinant (His)
ANGIE,BLR1L,ANGIE2,BLC,SCYB13,BCA1,BCA-1 |
Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The pred... | |||
TMPJ-00261 |
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth inhibitor,G... |
Mouse,Rat | HEK293 Cells |
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... | |||
TMPY-03425 |
Tau Protein, Human, Recombinant (His)
PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-associated ... |
Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP... | |||
TMPJ-01172 |
IL-17 Protein, Mouse, Recombinant (His)
CTLA8,IL-17,IL-17A,Interleukin-17A,CTLA-8,Cytotoxic T-Lympho... |
Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato... | |||
TMPY-02447 |
Shiga toxin II subunit B Protein, E. coli, Recombinant (His)
|
E. coli | E. coli |
E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic group of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli (EHEC). A total of 3222 outbreak cases (including 39 deaths) have been reported in northern Germany in May through June 2011. The outbreak strain was typed as an enteroaggregativ... | |||
TMPY-02028 |
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON |
Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... | |||
TMPY-02550 |
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C motif) ligand 11 |
Human | E. coli |
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... | |||
TMPK-00996 |
SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated
BSRPC,BSRP-C,SEZ6,SEZ-6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi... | |||
TMPK-01065 |
SEZ6 Protein, Mouse, Recombinant (His)
BSRP-C,SEZ-6,BSRPC,SEZ6 |
Mouse | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00997 |
SEZ6 Protein, Human, Recombinant (hFc)
SEZ-6,BSRP-C,SEZ6,BSRPC |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is... | |||
TMPK-00541 |
SEZ6 Protein, Cynomolgus, Recombinant (His)
SEZ-6,BSRPC,BSRP-C,SEZ6 |
Cynomolgus | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig... | |||
TMPK-00998 |
SEZ6 Protein, Human, Recombinant (His)
BSRPC,BSRP-C,SEZ-6,SEZ6 |
Human | HEK293 Cells |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... | |||
TMPK-00585 |
FOLR4/Juno Protein, Human, Recombinant (His)
Folate receptor 4,FR-δ,Folbp3,FR-delta,Izumo1r,Juno,FR δ,FOL... |
Human | HEK293 Cells |
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro... | |||
TMPK-01171 |
FOLR4/Juno Protein, Mouse, Recombinant (His)
Juno,FOLR4, LOC390243,Folate receptor 4,FR δ,FR-delta,Folbp3... |
Mouse | HEK293 Cells |
Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor. FOLR4/Juno Pro... | |||
TMPK-00875 |
CD96 Protein, Human, Recombinant (His & Avi), Biotinylated
TACTILE,CD96,DKFZp667E2122,CD96 molecule |
Human | HEK293 Cells |
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for imm... | |||
TMPH-00351 |
Fel d 4 Protein, Feline, Recombinant (His & SUMO)
Allergen Fel d 4 |
Feline | E. coli |
May be a pheromone carrier. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice. Fel d 4 Protein, Feline, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.7 kDa and the accession number is Q5VFH6. | |||
TMPY-02624 |
IL-9R Protein, Rat, Recombinant (His)
interleukin 9 receptor |
Rat | HEK293 Cells |
IL9R (Interleukin 9 Receptor) is a Protein Coding gene. The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). IL9 is involved in mast cell maturation and the enhancement of IgE production by B cells. Furthermore, linkage data in the human and mice have suggested that IL9 may contribute to asthma. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to differe... | |||
TMPY-04373 |
CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST)
calcium/calmodulin-dependent protein kinase II alpha,calcium... |
Human | Baculovirus Insect Cells |
Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily. CaM kinase Ⅱ is thought to be an important mediator of learning and memory and is also necessary for Ca2+homeostasis and reuptake in cardiomyocytes chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CAMKIIA is one of the major forms of CAMKII... | |||
TMPJ-00052 |
Leptin Protein, Mouse, Recombinant
OB,Obesity Factor,OBS,LEP,Obese Protein,Leptin |
Mouse | E. coli |
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin defici... | |||
TMPJ-01083 |
Serpin E2 Protein, Mouse, Recombinant (His)
Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor 4,PI... |
Mouse | HEK293 Cells |
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser... | |||
TMPK-01202 |
CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated
C1QR1,C1q/MBL/SPA receptor,ECSM3,C1qRp,C1qR(p),C1qR,dJ737E23... |
Human | HEK293 Cells |
CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperresponsiveness and inflammation with Th2 cytokine activation, along with decreased CD93 expression in bronchial epithelial cells and lung homogenates but increased serum CD93 levels. | |||
TMPK-00237 |
2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated
NAIL,CD244,SLAMF4,h2B4,NKR2B4,Nmrk,CD244 antigen,2B4 |
Human | HEK293 Cells |
2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports have linked 2B4 with activation of lymphocytes.Engagement of 2B4 on NK cell surfaces with specific antibodies or CD48 can trigger cell mediated cytotoxicity, interferon γ secretion, phosphoinositol turnover and NK cell invasiveness. | |||
TMPK-01387 |
EPhA3 Protein, Canine, Recombinant (His)
HEK4,TYRO4,ETK1,EPHA3,HEK,ETK,EK4 |
Canine | HEK293 Cells |
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. The interaction of AR and SP1 contributes to regulate EPHA3 expression, and the SP1 binding sites (‑295~‑261) in the EPHA3 core promoter region is crucial to the regulation of EPHA3 expression in response to androgen hormone stimuli. | |||
TMPH-02404 |
LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)
Alpha-insect toxin LqhaIT,Lqh-alpha-IT |
Yellow scorpion | E. coli |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and ... | |||
TMPK-00734 |
CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc)
ANGIE,ANGIE2,BCA-1,BLR1L,BLC,BCA1,SCYB13 |
Mouse | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... | |||
TMPJ-00299 |
LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc)
LIMP II,Lysosome membrane protein II,SCARB2,85 kDa lysosomal... |
Mouse | HEK293 Cells |
Lysosome membrane protein II (LIMPII),also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junc... | |||
TMPY-02686 |
PON3 Protein, Human, Recombinant (S50N, His)
paraoxonase 3 |
Human | Baculovirus Insect Cells |
PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expression of inflammatory genes. PON3 deficiency did not influence atherosclerosis development on an apolipoprotein E null hyperlipidemic background, but it did lead to a significant 60% increase in atherosclerotic lesion size in Pon3KO mice on the C57BL/6J background when fed a cholate... | |||
TMPH-03035 |
M-myrmeciitoxin-Mp2b Protein, Myrmecia pilosula, Recombinant (GST & His)
DELTA-myrtoxin-Mp1a B chain,Pilosin-3 subunit b,M-myrmeciito... |
Myrmecia pilosula | Baculovirus Insect Cells |
Heterodimer protein that may serve both defensive (pain-inducing) and predatory (insecticidal) roles. Has membrane-disrupting activity and shows induction of non-specific calcium influx into cells,. Shows broad-spectrum activity against a diverse range of bacteria, and cell lines, as well as hemolytic activity (EC(50)=2.18 uM). In vivo, shows moderate insecticidal activity against D.melanogaster and potent anthelmintic activity against the veterinary nematode H.contortus. In addition, intraplant... | |||
TMPK-00775 |
PRNP/Prion Protein, Mouse, Recombinant (hFc)
Major prion protein,PrP,ALTPRP,PRIP,PRNP |
Mouse | HEK293 Cells |
Prion protein gene (PRNP) variants determine the susceptibility of humans, sheep and mice to prion diseases, whereas polymorphisms in the open reading frame (ORF) of bovine PRNP seem to be unrelated to the incidence of bovine spongiform encephalopathy (BSE). According to the latest reports, the genetic susceptibility of cattle to BSE is associated with polymorphisms ofthe regulatory region of the PRNP gene and the level ofits expression. | |||
TMPK-00057 |
IL-10 Protein, Human, Recombinant (His & Avi), Biotinylated
IL-10,GVHDS,Interleukin-10,白介素,白细胞介素,MGC126451,CSIF,MGC12645... |
Human | HEK293 Cells |
Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life. IL-10 Protein, Human, Rec... | |||
TMPK-00757 |
TGF alpha Protein, Human, Recombinant (hFc)
TGF type 1,TGFA,TGF-alpha,TGF-α,ETGF,转化生长因子 |
Human | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic support for a role of TGFA arises from its presence at high levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in mice. TGF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted ... | |||
TMPK-00651 |
SLAMF6 Protein, Cynomolgus, Recombinant (His)
SF2000,Ly108,KALIb,SLAMF6,NTB-A,KALI,CD352,NK-T-B-antigen,AN... |
Cynomolgus | HEK293 Cells |
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be widely and exclusively expressed on hematopoietic cells. The SLAMF6 intracellular portion is characterized by two ITSMs that act as binding sites for adaptor molecules such as SAP and EAT-2. SLAMF6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-H... | |||
TMPK-00017 |
CXCL13/BCA-1 Protein, Human, Recombinant (hFc)
BCA1,BLR1L,BLC,SCYB13,ANGIE2,BCA-1,ANGIE |
Human | HEK293 Cells |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The pred... | |||
TMPJ-00298 |
CD36 Protein, Human, Recombinant (aa 27-432, His)
LGP85,Scavenger Receptor Class B Member 2,CD36,Lysosome Memb... |
Human | HEK293 Cells |
Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstructio... | |||
TMPK-00113 |
Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc)
APCS,MGC88159,SAP,Pentraxin 2,PTX2 |
Mouse | HEK293 Cells |
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human PTX-2 (rhPTX-2) retards progression of chronic kidney disease in Col4a3 mutant mice with Alport syndrome, reducing blood markers of kidney failure, enhancing lifespan by 20%, and improving histological signs of disease. diseases. Pentraxin 2/SAP Protein, Mouse, Recombinant (hFc) ... | |||
TMPK-00018 |
CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo)
BLC,SCYB13,ANGIE,ANGIE2,BCA-1,BLR1L,BCA1 |
Human | E. coli |
Recent studies have implicated chemokines in microglial activation and pathogenesis of neuropathic pain. C-X-C motif chemokine 13 (CXCL13) is a B lymphocyte chemoattractant that activates CXCR5. Using the spinal nerve ligation (SNL) model of neuropathic pain, CXCL13 was persistently upregulated in spinal cord neurons after SNL, resulting in spinal astrocyte activation via CXCR5 in mice. CXCL13/BCA-1 Protein, Human, Recombinant (His & Sumo) is expressed in E. coli expression system with N-His-Sum... | |||
TMPK-01165 |
MCEMP1 Protein, Mouse, Recombinant (hFc)
MGC132456,C19orf59,MCEMP1 |
Mouse | HEK293 Cells |
A cecal ligation and puncture-induced sepsis mouse model was established to determine the expression of mast cell expression membrane protein 1 (MCEMP1). MCEMP1 in T lymphocytes isolated from sepsis mice were up- or downregulated by exogenous transfection in an attempt to investigate their effects on the release of inflammatory factors, the expression of immunoglobulins, the activity of T cell subsets and natural killer (NK) cells, as well as T lymphocyte apoptosis. | |||
TMPK-01168 |
LOX-1 Protein, Mouse, Recombinant (His)
LOXIN,LOX-1,CLEC8A,Ox-LDL receptor 1,SLOX1,LOX1,SCARE1,SR-E1... |
Mouse | HEK293 Cells |
LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL.LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis. | |||
TMPK-00827 |
CD43 Protein, Mouse, Recombinant (His)
SPN,GPL115,Galgp,Ly-48,CD43,Leukosialin,Sialophorin,A630014B... |
Mouse | HEK293 Cells |
CD43 is a large transmembrane protein involved in T cell activation. Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing, activation of Foxp3 Treg, and T cell apoptosis. CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage. CD43 is directly involved in the contact between cells participating in a series of events such as signaling, adherence and host parasite interactions... | |||
TMPK-01174 |
SLAMF6 Protein, Mouse, Recombinant (aa 31-239, His)
Ly108,ANK-T-B-antigen,NTB-A,KALI,NK-T-B-antigen,KALIb,CD352,... |
Mouse | HEK293 Cells |
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be widely and exclusively expressed on hematopoietic cells. The SLAMF6 intracellular portion is characterized by two ITSMs that act as binding sites for adaptor molecules such as SAP and EAT-2. SLAMF6 Protein, Mouse, Recombinant (aa 31-239, His) is expressed in HEK293 mammalian cells wi... | |||
TMPK-00222 |
SLAMF6 Protein, Human, Recombinant (His & Avi)
ANK-T-B-antigen,Ly108,KALIb,SLAMF6,CD352,NTB-A,SF2000,NK-T-B... |
Human | HEK293 Cells |
SLAMF6 (signaling lymphocyte activation molecule 6) (Ly108 in mice, NTB-A or SF2000 in humans) is a homophilic receptor belonging to the superfamily immunoglobulin (Ig) domain-containing molecules. It is known to be widely and exclusively expressed on hematopoietic cells. The SLAMF6 intracellular portion is characterized by two ITSMs that act as binding sites for adaptor molecules such as SAP and EAT-2. SLAMF6 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-... | |||
TMPY-02651 |
p63 Protein, Human, Recombinant (His & GST)
p40,TP53L,RHS,B(p51A),p51,KET,NBP,B(p51B),OFC8,tumor protein... |
Human | Baculovirus Insect Cells |
Tumor protein p63 is a protein also known as transformation-related protein 63, TP63, and p63. Tumor protein p63 / p63 is a member of the p53 family of transcription factors whose members P53, p63, and p73 have similar features in their gene structures and functions. An animal model, p63-/- mice has been useful in difining the role p63 plays in the development and maintenance of stratified epithelial tissues. This p63 encoding protein p63 has a dramatic impact on replenishment of cutaneous epith... | |||
TMPK-00765 |
Pentraxin 2/SAP Protein, Human, Recombinant (hFc)
PTX2,SAP,Pentraxin 2,MGC88159,APCS |
Human | HEK293 Cells |
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune plasma protein whose circulating level is decreased in chronic human fibrotic recombinant human PTX-2 (rhPTX-2) retards progression of chronic kidney disease in Col4a3 mutant mice with Alport syndrome, reducing blood markers of kidney failure, enhancing lifespan by 20%, and improving histological signs of disease. diseases. Pentraxin 2/SAP Protein, Human, Recombinant (hFc) ... | |||
TMPK-00888 |
TGF alpha Protein, Mouse, Recombinant (hFc)
TGF type 1,转化生长因子,TGF-alpha,TGF-α,ETGF,TGFA |
Mouse | HEK293 Cells |
Transforming growth factor-alpha (TGFA) has been proposed as a candidate gene in the etiology of nonsyndromic cleft lip with or without cleft palate (NS-CL/P) and of nonsyndromic cleft palate only (NS-CPO). Biologic support for a role of TGFA arises from its presence at high levels in the epithelial tissue of the medial edge of the palatal shelves at the time of shelf fusion in mice. TGF alpha Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted ... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T35513 |
13C15-Nivalenol
13C15-Nivalenol |
||
13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026... | |||
T71206 |
Tiagabine-d6 hydrochloride
|
||
Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of ... | |||
T35517 |
4-deoxy Nivalenol-13C15
4-deoxy Nivalenol-13C15 |
||
4-deoxy Nivalenol-13C15is intended for use as an internal standard for the quantification of 4-deoxy nivalenol by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2It induces leth... | |||
T11240 |
Ethacrynic acid D5
|
Others | Others |
Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by... | |||
T71893 |
Clobetasol Propionate-d5
|
||
Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the t... | |||
T36055 |
Nitisinone-13C6
Nitisinone-13C6 |
||
Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F... | |||
T38356 |
1,2-Dipalmitoyl-13C-sn-glycero-3-PC
|
||
1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation... | |||
T71306 |
Gemfibrozil-d6
|
||
Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l... | |||
T68918 |
Phenytoin-d10
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Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal... | |||
T37119 |
1,2,3-Trioctanoyl-rac-glycerol-13C3
1,2,3-Trioctanoyl-rac-glycerol-13C3 |
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1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomo... | |||
T71143 |
Ambroxol-d5
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Ambroxol-d5 is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine. It decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally. Ambroxol decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous part... | |||
T71327 |
Paraxanthine-d6
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Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine. It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist. In vivo, paraxanthine increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agoni... | |||
T38118 |
Zanamivir-13C,15N2
Zanamivir-13C,15N2 |
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Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intra... | |||
TMIJ-0398 |
rac 1,2-Bis-palmitoyl-3-chloropropanediol-d5
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rac 1,2-Bis-palmitoyl-3-chloropropanediol-d5 是 rac 1,2-Bis-palmitoyl-3-chloropropanediol 的氘代化合物。rac 1,2-Bis-palmitoyl-3-chloropropanediol 的 CAS 号为 51930-97-3。 | |||
T70960 |
Maprotiline-d3 hydrochloride
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Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r... | |||
TMID-0116 |
Carbamazepine-10,11-epoxide-d10 (rings-d10)
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Carbamazepine-10,11-epoxide-d10 (rings-d10) 是 Carbamazepine-10,11-epoxide 的氘代化合物。Carbamazepine-10,11-epoxide 的 CAS 号为 36507-30-9。Carbamazepine 10,11-epoxide是抗惊厥药卡马西平 (carbamazepine) 的活性代谢物。它由卡马西平通过微粒体中的细胞色素 P450 (CYP) 同种型 CYP3A4 和 CYP2C8 形成,微粒体分别由表达 CYP3A4 或 CYP2C8 的 HepG2 细胞制备。它对小鼠最大电击诱发的癫痫发作具有抗惊厥活性。 | |||
T71303 |
Flufenamic Acid-d4
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Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear... | |||
T71055 |
Albendazole-d7
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Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben... | |||
TMID-0040 |
Palmitoyl L-Carnitine-d3 Hydrochloride
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Palmitoyl L-Carnitine-d3 Hydrochloride 是 Palmitoyl L-Carnitine Hydrochloride 的氘代化合物。Palmitoyl L-Carnitine Hydrochloride 的 CAS 号为 18877-64-0。L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride)是一种脂肪酸代谢产物,具有抗血栓形成的作用,通过抵消tMCAO模型中的脑内血栓形成来保护小鼠免受缺血性中风。L-Palmitoylcarnitine chloride抑制心脏中的Na/K泵,抑制 FeCl 3诱导的动脉血栓形成,减轻了短暂性大脑中动脉闭塞(tMCAO)小鼠模型的脑内血栓形成和炎症。 | |||
T36383 |
L-Thyroxine-13C9,15N
L-Thyroxine-13C9,15N |
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L-Thyroxine-13C9,15N is intended for use as an internal standard for the quantification of L-thyroxine by GC- or LC-MS. L-Thyroxine is a synthetic form of the thyroid hormone thyroxine. In vivo, L-thyroxine (0.9 and 2.7 μg) inhibits synthesis and release of thyrotropin induced by thyrotropin-releasing hormone from the anterior pituitary in mice. It also reverses decreases in levels of circulating thymic serum factor (FTS) and the number of T rosette-forming cells in an old age-induced mouse mode... | |||
T36903 |
Rasagiline-13C3 (mesylate)
Rasagiline-13C3 (mesylate) |
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Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede... | |||
T35515 |
3-Acetyldeoxy Nivalenol-13C17
3-Acetyldeoxy Nivalenol-13C17 |
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3-Acetyldeoxy nivalenol-13C17is intended for use as an internal standard for the quantification of 3-acetyldeoxy nivalenol by GC- or LC-MS. 3-Acetyldeoxy nivalenol is a mycotoxin that has been found inF. graminearum.1In vivo, 3-acetyldeoxy nivalenol (40 mg/kg) induces duodenal and splenic cell necrosis, as well as lethality (LD50= 70 mg/kg) in mice.2 1.Jiao, F., Kawakami, A., and Nakajima, T.Effects of different carbon sources on trichothecene production and Tri gene expression by Fusarium grami... | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
T37250 |
Cefazolin-13C2,15N
Cefazolin-13C2,15N |
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Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50... |