Kobusin

Name: Kobusin
Brand: TargetMol
SKU: TN1834
Price: 397 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 TN1834Cas号 36150-23-9

别名 自旋七叶素, 去甲槟郎碱

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells.

Kobusin

还可以

产品编号 TN1834 别名 自旋七叶素, 去甲槟郎碱Cas号 36150-23-9

规格	价格	库存	数量
2 mg	¥ 1,230	5日内发货

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产品介绍

生物活性

产品描述	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells.
体外活性	In this study, we identified major volatile constituents present in different solvent fractions of Z. rhetsa bark using GC-MS analysis and isolated two tetrahydrofuran lignans (yangambin and Kobusin), a berberine alkaloid (columbamine) and a triterpenoid (lupeol) from the bioactive chloroform fraction. The solvent fractions and purified compounds were tested for their cytotoxic potential against human dermal fibroblasts (HDF) and mouse melanoma (B16-F10) cells, using the MTT assay. All the solvent fractions and purified compounds were found to be non-cytotoxic to HDF cells. However, the chloroform fraction and Kobusin exhibited cytotoxic effect against B16-F10 melanoma cells[1]
别名	自旋七叶素, 去甲槟郎碱

化学信息

分子量	370.4
分子式	C₂₁H₂₂O₆
CAS No.	36150-23-9
密度	1.265 g/cm3 (Predicted)

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.

TCMIP相关数据

中药材来源及性味归经

中药材名称	中药材拉丁名	性	味	归经
辛夷	Magnolia biondii Pamp., Magnolia denudata Desr. , Magnolia sprengeri Pamp.	温	辛	肺, 胃
玉兰	Yulania denudata (Desrousseaux) D. L. Fu	温	辛

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