ω-Conotoxin SVIB, a peptide toxin derived from Conus venoms, exhibits inhibition of the twitch response with an IC50 value of 37 nM and can induce respiratory distress. At high concentrations, it has been shown to be lethal to mice [1] [2].

ω-Conotoxin SVIB (0.1-1000 nM；20分钟)以37 nM的IC50值抑制0.1 Hz的肌肉抽搐反应[2]。

ω-Conotoxin SVIB（20 pmol/g；皮下注射一次）能导致鱼类瘫痪并死亡[1]。在小鼠中，ω-Conotoxin SVIB可引起约70 pmol/g时的呼吸困难，并在约300 pmol/g时对小鼠致命[1]。