γ-Fibrinogen377-395 TFA is an inhibitory peptide derived from fibrinogen, which also functions as a fibrinogen epitope. It effectively blocks microglial activation and impedes fibrin-Mac-1 interactions in vitro. Additionally, it exhibits in vivo efficacy by suppressing experimental autoimmune encephalomyelitis (EAE) in mice. This compound has applications in researching multiple sclerosis (MS) and other neuroinflammatory diseases linked to blood-brain barrier disruption and microglial activation [1].

γ-Fibrinogen377-395 TFA (200 μM) 可以阻断纤维蛋白与Mac-1的相互作用，进而抑制Mac-1高表达细胞与固定化的纤维蛋白原相互粘附。此外，γ-Fibrinogen377-395 TFA 能够有效抑制小胶质细胞的活化 [1]。

γ-Fibrinogen377-395 TFA（30 μg/小鼠；鼻内给药；每日一次，连续40天）能提升小鼠的运动能力，但不影响其外周免疫响应。研究发现，γ-纤维蛋白原377-395并不改变纤维蛋白原的凝血功能[1]。在实验性自身免疫性脑炎（EAE）诱导前接种γ377-395肽的小鼠，与对照组比较，运动能力和协调性均得到显著改善[1]。