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CCG-203971

Name: CCG-203971
Brand: TargetMol
SKU: T4306
Price: 126 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: CCG203971

货号 T4306Cas号 1443437-74-8 一键复制产品信息纯度: 99.50%

很棒

CCG-203971 是一种Rho/MRTF/SRF 通路抑制剂，具有潜在的抗转移作用。它有效靶向 RhoA/C 激活的 SRE 荧光素酶，IC50为 6.4 μM。它抑制 PC-3 细胞迁移，IC50为 4.2 μM。

CCG-203971

一键复制产品信息

很棒

纯度: 99.50%

货号 T4306Cas号 1443437-74-8

别名 CCG203971

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
1 mg	¥ 126	现货
5 mg	¥ 246	现货
10 mg	¥ 463	现货
25 mg	¥ 913	现货
50 mg	¥ 1,490	现货
100 mg	¥ 2,380	现货
500 mg	¥ 5,650	现货
1 mL x 10 mM (in DMSO)	¥ 273	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.50%

颜色: 白色

资源下载: COA HNMR LCMS产品操作手册

产品介绍

CCG-203971 AI Summary

CCG-203971 exhibits multifaceted bioactivities and has shown effectiveness in various assays and cell lines. It inhibits the RhoC-mediated pathway in human SK-Mel-147 cells and human PC3 cells, leading to the inhibition of SRE-regulated gene transcription, with respective IC50 values of 5300.0 nM and 6400.0 nM. Additionally, it inhibits a related pathway in both HEK293T cells and human primary dermal fibroblasts, showing suppression of TGF-beta-stimulated gene expression and reduction in Galpha12-stimulated luciferase activity. The compound demonstrates antimetastatic activity against human PC3 cells with an IC50 of 4200.0 nM and 70% inhibition at 10 μM by scratch wound assay after 24 hours. Furthermore, it shows no cytotoxicity against human PC3 cells at 100 μM in a WST1 assay. It has an effective permeability, determined by PAMPA (logPeff of -8.3), and a kinetic solubility of 3.09 μg.mL-1. CCG-203971 also reduces fibrosis markers in mouse NIH/3T3 cells and suppresses myofibroblast activation in human dermal fibroblasts. In assays, it shows strong inhibition with fold changes of 100.0 and has a moderate thermodynamic aqueous solubility, with a short half-life in CD-1 mouse liver microsomes..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50: 4.2 μM), as determined by a scratch wound assay. CCG-203971(CCG203971) causes no cytotoxicity when evaluated by the WST-1 assay. It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.
靶点活性	SRE.L:0.64 μM
别名	CCG203971

化学信息

分子量	408.88
分子式	C₂₃H₂₁ClN₂O₃
CAS No.	1443437-74-8
Smiles	Clc1ccc(NC(=O)C2CCCN(C2)C(=O)c2cccc(c2)-c2ccco2)cc1
密度	1.305 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 50 mg/mL (122.29 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.89 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4457 mL	12.2285 mL	24.4571 mL	122.2853 mL
5 mM	0.4891 mL	2.4457 mL	4.8914 mL	24.4571 mL
10 mM	0.2446 mL	1.2229 mL	2.4457 mL	12.2285 mL
20 mM	0.1223 mL	0.6114 mL	1.2229 mL	6.1143 mL
50 mM	0.0489 mL	0.2446 mL	0.4891 mL	2.4457 mL
100 mM	0.0245 mL	0.1223 mL	0.2446 mL	1.2229 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。