NPD8790 is a selective inhibitor of mitochondrial respiratory complex I, with an IC50 of 2.4 µM for the complex I in Caenorhabditis elegans. It demonstrates greater selectivity for nematode species mitochondria compared to those of humans, cattle, and mice. NPD8790 acts as an anthelmintic, effectively eliminating adult soil-transmitted worms.

NPD8790 展现出显著的物种选择性，其对秀丽隐杆线虫复合物 I 的抑制效果 (IC 50 = 2.4 µM) 远强于对牛 (IC 50 = 27.2 µM)、鼠心脏线粒体 (IC 50 = 28.8 µM) 或人类线粒体 (IC 50 >75 μM) 的抑制效果 [1]。NPD8790 对所有线虫物种的复合物 I 均表现出相似的抑制作用 (C. briggsae，IC 50 = 1.6 µM；P. pacificus，IC 50 = 2.1 µM；P. hermaphrodita，IC 50 = 1.1 µM) [1]。