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Gcase activator 2是一种β-葡萄糖脑苷酶(glucocerebrosidase)激活剂,能够诱导在内质网(ER)和溶酶体pH上发生GCase的二聚化, 增加溶酶体的底物代谢,具有治疗帕金森病和戈谢病的潜力。
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Gcase activator 2是一种β-葡萄糖脑苷酶(glucocerebrosidase)激活剂,能够诱导在内质网(ER)和溶酶体pH上发生GCase的二聚化, 增加溶酶体的底物代谢,具有治疗帕金森病和戈谢病的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,290 | 现货 | |
5 mg | ¥ 2,880 | 现货 | |
10 mg | ¥ 4,970 | 现货 | |
25 mg | ¥ 7,570 | 现货 | |
50 mg | ¥ 9,870 | 现货 | |
100 mg | ¥ 13,700 | 现货 | |
200 mg | ¥ 18,500 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 2,320 | 现货 |
产品描述 | Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase at the endoplasmic reticulum (ER) and lysosomal pHs, increases lysosomal substrate metabolism, and has therapeutic potential for the treatment of Parkinson's and Gosheimer's diseases. |
体外活性 | Gcase activator 2在人和小鼠体内的代谢清除率较低,CL值分别为10和12 μL/min/mg [1]。 |
分子量 | 364.44 |
分子式 | C21H24N4O2 |
CAS No. | 2759897-35-1 |
Smiles | O=C(N1CCC(C2=CC=3N=C(C=NC3N2C)C4=CC=C(OC)C=C4)CC1)C |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 80 mg/mL (219.51 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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