|
TMPH-01370
|
SNCG Protein, Human, Recombinant (His & SUMO)
Breast cancer-specific gene 1 protein,SNCG...
|
Human
|
E. coli
|
|
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. SNCG Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.3 kDa a... |
|
TMPH-01426
|
HEATR6 Protein, Human, Recombinant (His & Myc)
HEATR6,HEAT repeat-containing protein 6,Amplified in bre...
|
Human
|
E. coli
|
|
HEATR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
|
TMPJ-00706
|
SNCG Protein, Human, Recombinant
PRSN,Gamma-Synuclein,SNCG,BCSG1,Breast Cancer
|
Human
|
E. coli
|
|
Gamma-Synuclein (SNCG) is a member of the Synuclein protein family. Gamma-Synuclein is mostly expressed in the peripheral nervous system and retina. Gamma-Synuclein plays a role in neurofilament network integrity and may be involved in modulating axonal architecture during development and in the adult. In addition, it may also function in modulating the keratin network in skin. SNCG expression in breast tumors has been as a marker for tumor progression. SNCG is also believed to be involved in th... |
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TMPJ-00050
|
AG-3 Protein, Human, Recombinant (His)
BCMP11,hAG-3,AG-3,AG3,Anterior Gradient Protein 3 Homolog,
|
Human
|
HEK293 Cells
|
|
Anterior Gradient Protein 2(AG-2) and Anterior Gradient Protein 3 (AG-3) are human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan (hAG-3 protein). AG-3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas. |
|
TMPH-02158
|
SVEP1 Protein, Human, Recombinant (hFc)
Selectin-like osteoblast-derived protein,SVEP1,Polydom,Sushi...
|
Human
|
HEK293 Cells
|
|
May play a role in the cell attachment process. |
|
TMPJ-00155
|
Mucin-1/MUC1 Protein, Human, Recombinant (hFc&Avi), Biotinylated
Polymorphic epithelial mucin,KL-6,Cancer antigen 15...
|
Human
|
HEK293 Cells
|
|
Mucin-1, is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1 exclusively located in the apical domain of the plasma membrane ... |
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TMPH-01705
|
Mucin-1/MUC1 Protein, Human, Recombinant (Isoform 8, His)
Peanut-reactive urinary mucin,Isoform 8 of Mucin-1,Cance...
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Human
|
E. coli
|
|
Mucin-1/MUC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.2 kDa and the accession number is P15941-8. |
|
TMPY-02646
|
NSE/ENO2 Protein, Human, Recombinant (His)
enolase 2 (γ, neuronal),NSE,HEL-S-279,enolase 2 (gamma, neur...
|
Human
|
E. coli
|
|
The combination of silencing ENO2 and 2-deoxyglucose (2-DG) synergistically inhibited leukemia cell survival. ENO2 may be a biological marker for monitoring chemotherapeutic efficacy and relapse in ALL. Reduced ENO2 expression may be a biomarker for a subset of autistic children. Neuron specific enolase (ENO2, gamma-enolase) has been used as a biomarker to help identify neuroendocrine differentiation in breast cancer. |
|
TMPY-00476
|
ITGB1 Protein, Human, Recombinant (His)
VLAB,integrin, beta 1 (fibronectin receptor, beta polypeptid...
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Human
|
HEK293 Cells
|
|
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involved in cell functions such as proliferation, migration, invasion, and survival. ITGB1 has been recognized to play a major role in tumor growth, invasion, and metastasis. Using luciferase assays, the researcher identified ITGB1 as a direct target of miR-134. ITGB1 is a direct targe... |
|
TMPY-03407
|
NQO1 Protein, Human, Recombinant (His)
NAD(P)H dehydrogenase, quinone 1,NMORI,DIA4,QR1,NMOR1,DTD,DH...
|
Human
|
E. coli
|
|
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered ex... |
|
TMPY-02062
|
SULT1A1 Protein, Human, Recombinant (His)
HAST1/HAST2,PST,P-PST,ST1A1,STP,sulfotransferase family, cyt...
|
Human
|
E. coli
|
|
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Pa... |
|
TMPY-02869
|
MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12
|
Human
|
E. coli
|
|
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... |
|
TMPY-00150
|
IGF2/IGF-II Protein, Human, Recombinant
PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2
|
Human
|
P. pastoris (Yeast)
|
|
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br... |
|
TMPY-00203
|
LOXL2 Protein, Mouse, Recombinant (His)
1110004B06Rik,4930526G11Rik,9430067E15Rik,lysyl oxidase-like...
|
Mouse
|
HEK293 Cells
|
|
Lysyl oxidase homolog 2, also known as Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14 and LOXL2, is a secreted protein that belongs to the lysyl oxidase family. LOXL2 contains four SRCR domains. The lysyl oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 ( LOXL1, LOXL2, LOXL3, LOXL4 ). All members share conserved C-terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme act... |
|
TMPY-02028
|
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON
|
Human
|
HEK293 Cells
|
|
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... |
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TMPY-04396
|
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...
|
Human
|
Baculovirus Insect Cells
|
|
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... |
|
TMPY-04205
|
AGR3 Protein, Human, Recombinant (mFc)
hAG-3,AG3,HAG3,anterior gradient 3,PDIA18,BCMP11,AG-3
|
Human
|
HEK293 Cells
|
|
Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. AGR3 was found in breast, ovary, prostate, and liver cancer, it is associated with the level of differentiation, slowly proliferating tumors, and more favorable prognosis of breast cancer patients. AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway. AGR3 had been... |
|
TMPK-00194
|
TFPI Protein, Human, Recombinant (His & Avi)
LACI,EPI,TFPI,convertin,TFI,TFPI1
|
Human
|
HEK293 Cells
|
|
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1. |
|
TMPK-00195
|
TFPI Protein, Human, Recombinant (His & Avi), Biotinylated
convertin,TFI,LACI,EPI,TFPI,TFPI1
|
Human
|
HEK293 Cells
|
|
Oestrogens influence the pathophysiology and development of hormone-sensitive cancers, such as breast cancer. Tissue factor pathway inhibitor (TFPI) is a serine protease inhibitor of the extrinsic coagulation pathway and has recently been associated with breast cancer cell development. TFPI Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 32.1 kDa and the accession number is P10646-1. |
|
TMPK-00007
|
TFF1 Protein, Human, Recombinant (hFc)
Polypeptide P1.A,Trefoil factor 1,Bcei,HP1.A,pNR-2,PS2,HPS2,...
|
Human
|
HEK293 Cells
|
|
Breast cancer (BC) is the most common cancer in women and the second leading cause of their cancer death. Establishing an accurate BC prognosis is very difficult because of its heterogeneity. Elevated TFF1 levels in serum were associated with development of BC, TFF1 expression was upregulated in BC compared to the healthy breast tissue.That expression of TFF1 was related to ER status of BC and that expression of TFF1 was lower in TNBC than in non-TNBC. TFF1 Protein, Human, Recombinant (hFc) is e... |
|
TMPK-00941
|
TFF1 Protein, Mouse, Recombinant (hFc)
HP1.A,D21S21,TFF1,Polypeptide P1.A,PS2,BCEI,pNR-2,HPS2,Trefo...
|
Mouse
|
HEK293 Cells
|
|
Breast cancer (BC) is the most common cancer in women and the second leading cause of their cancer death. Establishing an accurate BC prognosis is very difficult because of its heterogeneity. Elevated TFF1 levels in serum were associated with development of BC, TFF1 expression was upregulated in BC compared to the healthy breast tissue.That expression of TFF1 was related to ER status of BC and that expression of TFF1 was lower in TNBC than in non-TNBC. TFF1 Protein, Mouse, Recombinant (hFc) is e... |
|
TMPY-03979
|
ARHI Protein, Human, Recombinant (mFc)
DIRAS3,DIRAS family, GTP-binding RAS-like 3,ARHI,RHOI,NOEY2
|
Human
|
HEK293 Cells
|
|
ARHI, also known as DIRAS3, belongs to the small GTPase superfamily, Di-Ras family. ARHI gene is a novel tumor suppressor gene located on chromosome 1p31. Downregulation of ARHI expression has been detected in many types of cancer. ARHI is expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers. As a suppressor, ARHI is not only an important factor in the pathogenesis of gastric cancer, but also a potential factor for tumor aggravation. ARHI expression in ga... |
|
TMPY-06226
|
SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His)
solute carrier family 39 member 6
|
Cynomolgus
|
HEK293 Cells
|
|
Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like protein zinc transporters (LZTs). It is involved in maintaining the intracellular homeostasis of zinc, an ion that is essential in the control of cellular growth and differentiation. SLC39A6 plays a critical role in maintaining zinc homeostasis, and was originally identified as a... |
|
TMPY-05160
|
PFKP Protein, Human, Recombinant (His & GST)
PFK-P,PFKF,ATP-PFK,phosphofructokinase, platelet,PFK-C
|
Human
|
Baculovirus Insect Cells
|
|
PFKP plays a critical role in cell proliferation in breast cancer cells. PFKP is necessary for starvation-mediated autophagy, glycolysis, and EMT, thereby promoting the malignant progression of OSCC. The Snail-PFKP axis plays an important role in cancer cell survival via regulation of glucose flux between glycolysis and PPP. |
|
TMPK-01299
|
CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)
Carcinoembryonic,CEA,CEACD66e,DKFZp781M2392,CEACAM-5,CD66e,M...
|
Cynomolgus
|
HEK293 Cells
|
|
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. |
|
TMPK-00945
|
ASPH Protein, Human, Recombinant (His)
Aspartate beta-hydroxylase,ASP beta-hydroxylase,Asph,Bah,Asp...
|
Human
|
E. coli
|
|
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication.Expression profiling of Notch signaling components positively correlates with ASPH expression in breast cancer patients, confirming that ASPH-Notch axis acts functionally in breast tumorigenesis. ASPH... |
|
TMPK-01083
|
ASPH Protein, Mouse, Recombinant (His)
Aspartate β-hydroxylase,ASP β-hydroxylase,Aspartate beta-hyd...
|
Mouse
|
E. coli
|
|
Aspartate β-hydroxylase (ASPH) is silent in normal adult tissues only to re-emerge during oncogenesis where its function is required for generation and maintenance of malignant phenotypes. Exosomes enable prooncogenic secretome delivering and trafficking for long-distance cell-to-cell communication.Expression profiling of Notch signaling components positively correlates with ASPH expression in breast cancer patients, confirming that ASPH-Notch axis acts functionally in breast tumorigenesis. ASPH... |
|
TMPY-02763
|
DEP-1 Protein, Human, Recombinant (aa 997-1337, His)
HPTPeta,SCC1,protein tyrosine phosphatase, receptor type, J,...
|
Human
|
E. coli
|
|
DEP1 / PTPRJ (Receptor-type tyrosine-protein phosphatase eta) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. DEP1 / PTPRJ possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-... |
|
TMPY-02660
|
Resistin Protein, Mouse, Recombinant (hFc)
resistin,Xcp4,ADSF,Fizz3,Rstn
|
Mouse
|
HEK293 Cells
|
|
Resistin is an adipocytokine, which has been studied for its role in insulin resistance and recently in inflammation. The RETN and CAP1 polymorphisms and gene expression may be potential biomarkers for breast cancer risk. Resistin (RETN), recently found to be relevant to inflammation and inflammatory disorders. |
|
TMPK-00868
|
Notch 4 Protein, Mouse, Recombinant (His)
Notch-4,Int-3,Notch4,Int3
|
Mouse
|
HEK293 Cells
|
|
The Notch signaling pathway is important for cell-cell communication; it is involved in gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life. Notch-4 expression correlates with Ki67. Notch-4 also plays a key role in breast cancer stem-like cells. |
|
TMPY-04984
|
CXCL17 Protein, Human, Recombinant (His)
Dcip1,UNQ473,DMC,VCC1,chemokine (C-X-C motif) ligand 17,VCC-...
|
Human
|
P. pastoris (Yeast)
|
|
Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like ski... |
|
TMPY-04203
|
RAB1B Protein, Human, Recombinant (hFc)
RAB1B, member RAS oncogene family
|
Human
|
HEK293 Cells
|
|
RAB1B, a member of the RAS oncogene family, was significantly down-regulated in highly metastatic breast cancer cells. Moreover, down-regulation of RAB1B was also found to promote the proliferation and migration of TNBC cells in vitro and in vivo. Mechanistically, loss of RAB1B resulted in elevated expression of TGF-beta receptor 1 (TbetaR1) through decreased degradation of ubiquitin, increased levels of phosphorylated SMAD3 and TGF-beta-induced epithelial-mesenchymal transition (EMT). Furthermo... |
|
TMPK-00547
|
PRLR Protein, Cynomolgus, Recombinant (His)
Prolactin R,HPRL,MFAB,PRL-R
|
Cynomolgus
|
HEK293 Cells
|
|
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Cynomolgus, Recombinant (His) is expressed in HEK... |
|
TMPJ-00705
|
BCAS2 Protein, Human, Recombinant (His, T7)
BCAS2,DNA Amplified in Mammary Carcinoma 1 Protein,Pre-mRNA-...
|
Human
|
E. coli
|
|
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator ... |
|
TMPJ-01155
|
PDCD4 Protein, Human, Recombinant (His)
Programmed Cell Death Protein 4,Protein 197/15a,Neoplastic T...
|
Human
|
E. coli
|
|
Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation initiation and cap-dependent translation.PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. Overexpression of PDCD4 in carc... |
|
TMPK-01375
|
PRLR Protein, Canine, Recombinant (hFc)
PRL-R,Prolactin R,MFAB,HPRL
|
Canine
|
HEK293 Cells
|
|
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. PRLR Protein, Canine, Recombinant (hFc) is expressed in HEK293 ... |
|
TMPY-00585
|
Annexin A8 Protein, Human, Recombinant (His)
ANX8,annexin A8
|
Human
|
E. coli
|
|
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA8 mRNA is expressed in low-proliferative isolated pubertal mouse mammary ductal epithelium and after enforced involution, but not in isolated highly proliferative terminal end buds (TEB) or during pregnancy. ANXA8 as a potential mediator of quiescence in the normal mouse mammary ... |
|
TMPK-00980
|
EPhA2 Protein, Cynomolgus, Recombinant (hFc)
EC:2.7.10.1,Ephrin type-A receptor 2,EPHA2
|
Cynomolgus
|
HEK293 Cells
|
|
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 83.1 kDa and the accession number is Q1KL86. |
|
TMPK-00979
|
EPhA2 Protein, Cynomolgus, Recombinant (His & Avi)
EPHA2,EC:2.7.10.1,Ephrin type-A receptor 2
|
Cynomolgus
|
HEK293 Cells
|
|
Ephrin type-A receptor 2 (EPHA2) is a receptor tyrosine kinase (RTK), whose over-expression has been observed in a variety of cancers, including breast cancer. EPHA2 expression may be causally related to tumorigenesis; therefore, it is important to understand how EPHA2 gene (EPHA2) expression is regulated. EPhA2 Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59.2 kDa and the accession number is Q1KL86. |
|
TMPY-03398
|
FHIT Protein, Human, Recombinant (His)
FRA3B,AP3Aase,fragile histidine triad
|
Human
|
E. coli
|
|
Fragile histidine triad, also known as FHIT, may play a key role in differentiating humans from apes. Fragile histidine triad gene belongs to the histidine triad gene family. It has been shown that fragile histidine triad synergizes with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer. Fragile histidine triad gene works as a tumor suppressor as it has been demonstrated in animal studies. The exact molecular function of FHIT is still partially unclear. It als... |
|
TMPY-05055
|
GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His)
GGH/Glutamyl hydrolase γ,γ-glutamyl hydrolase (conjugase, fo...
|
Human
|
HEK293 Cells
|
|
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer. |
|
TMPY-02384
|
MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)
metastasis suppressor 1,MIMB,MIM,MIMA
|
Human
|
E. coli
|
|
MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor... |
|
TMPY-02386
|
PTP4A2 Protein, Human, Recombinant (GST)
HNMT-S2,PRL-2,HNMT-S1,protein tyrosine phosphatase type IVA,...
|
Human
|
E. coli
|
|
PRL-2 (Protein-tyrosine phosphatase of regenerating liver 2), also known as PTP4A2 (Protein tyrosine phosphatase type IVA, member 2), is a member of PTP family and has an important function in controlling cell growth. PRL-2 phosphatases may be multifunctional enzymes with diverse roles in a variety of tissue and cell types. The phosphatase of regenerating liver (PRL) family, comprising PRL-1, PRL-2 and PRL-3, is a group of prenylated phosphatases that are candidate cancer biomarkers and therapeu... |
|
TMPY-01583
|
ALDH1A1 Protein, Human, Recombinant (His)
ALDH11,ALDC,PUMB1,ALDH-E1,HEL-S-53e,HEL-9,aldehyde dehydroge...
|
Human
|
E. coli
|
|
Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell function. The retinaldehyde dehydrogenase (RALDH) subfamily of ALDHs, composed of ALDH1A1, ALDH1A2, ALDH1A3, and ALDH8A1, regulate development by catalyzing retinoic acid biosynthesis. The ALDH1A1 protein belongs to the aldehyde dehydrogenases f... |
|
TMPY-04817
|
Syntenin Protein, Human, Recombinant (His)
MDA-9,SYCL,TACIP18,syndecan binding protein (syntenin),ST1,M...
|
Human
|
E. coli
|
|
Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy. |
|
TMPJ-01125
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PEA15 Protein, Human, Recombinant
15 kDa Phosphoprotein Enriched in Astrocytes,PEA15,PED,Astro...
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Human
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E. coli
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Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm... |
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TMPJ-00933
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PRDX5 Protein, Human, Recombinant (His)
Antioxidant enzyme B166,Alu corepressor 1,Peroxiredoxin-5,PL...
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Human
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HEK293 Cells
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Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Peroxiredoxins is overexpressed in breast cancer tissues to a great extent suggesting that they has a proliferative effect and may be related to cancer development or progression. Peroxiredoxin 5 (PRDX5) is a thioredoxin peroxidase that belongs to the atypical 2-Cys class of the TSA/a... |
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TMPJ-00762
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ER alpha Protein, Human, Recombinant (His)
Estrogen Receptor,ER α,estrogen receptor α,ER-Alpha,ER alpha...
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Human
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E. coli
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Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as ... |
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TMPJ-00105
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SOD2 Protein, Human, Recombinant (His)
Superoxide Dismutase [Mn] Mitochondrial,SOD2
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Human
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HEK293 Cells
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Superoxide Dismutase (SOD2) belongs to the iron/manganese superoxide dismutase family. SOD2 is a mitochondrial matrix protein that forms a homotetramer and binds one manganese ion per subunit. SOD2 transforms toxic superoxide, a byproduct of the mitochondrial electron transport chain into hydrogen peroxide and diatomic oxygen. It is reported that oxidative stress plays an essential role in the development of breast cancer, while SOD2 is one of the primary enzymes that directly convert potential ... |
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TMPK-00933
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ADAM8/CD156a Protein, Mouse, Recombinant (His)
CD156a,MGC134985,ADAM 8,Ms2,Adam8
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Mouse
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HEK293 Cells
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A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer. ADAM8/... |
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