Tubulin polymerization-IN-2

Name: Tubulin polymerization-IN-2
Brand: TargetMol
SKU: T60802
Rating: 4.5 (1 reviews)

还可以

产品编号 T60802Cas号 2873399-22-3

Tubulin polymerization-IN-2 为针对β-微管蛋白的强效抗癌分子，IC50 值为0.92 μM。该分子在多种细胞系中，包括白血病、非小细胞肺癌、肾癌、前列腺癌及乳腺癌细胞中展现出显著的抑制效果。

Tubulin polymerization-IN-2

还可以

产品编号 T60802Cas号 2873399-22-3

规格	价格	库存
25 mg	¥ 10,600	10-14周
50 mg	¥ 13,800	10-14周
100 mg	¥ 17,500	10-14周

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

联系我们获取更多批次信息

资源下载

产品操作手册

产品介绍

生物活性

产品描述

Tubulin Polymerization-IN-2 is a powerful anticancer agent that targets β-tubulin, exhibiting an IC 50 of 0.92 μM. It demonstrates promising efficacy against a range of cancer cell lines including leukemia, non-small cell lung, renal, prostate, and breast cancers [1].

体外活性

Tubulin polymerization-IN-2 (compound 2b) shows anti-cancer activity against epidermal carcinoma and breast carcinoma with IC 50 s of 2.3 μM (KB) and 2.2 μM (BT-549), respectively [1]. Tubulin polymerization-IN-2 (0.342 μM; 24 h) inhibits DNA synthesis or repair, arrests cell cycle at S phase in MCF-7 cells [1]. Tubulin polymerization-IN-2 (0.342 μM; 24 h) induces cell apoptosis by decreasing Bax, APAF-1, and caspase-3 expression and increasing BCL-2 mRNA abundance [1]. Tubulin polymerization-IN-2 (0.01, 0.1, 1, 10 μM; 1 h) has strong interactions on β-tubulin polymerization, with K i value of 0.09 μM [1].