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Search Results for " tyrosine kinase "

Targets Recommended: Tyrosine Kinases VEGFR FGFR FLT PDGFR

572

抑制剂 & 化合物

21

天然产物

2

化合物库

319

重组蛋白

20

同位素标记化合物

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Cat. No.	Product Name
L2200	酪氨酸激酶分子库		1016 compounds
	1016 种酪氨酸激酶抑制剂的独特集合，可用于高通量筛选和高内涵筛选；
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；

化合物库

酪氨酸激酶分子库

Cat.No: L2200

Compounds: 1016

共价抑制剂库

Cat.No: L9410

Compounds: 1920

Cat. No.	Product Name	Target	Signaling Pathways
T5466	Tyrosine kinase-IN-1	VEGFR; FGFR; FLT; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂，能够抑制KDR (IC50:4 nM)，Flt-1 (IC50:20 nM)，FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。
T60108	PDGFR Tyrosine Kinase Inhibitor III PDGF Receptor Tyrosine Kinase Inhibitor III	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III)是一种多激酶抑制剂，可抑制 PDGFR、EGFR、FGFR、PKA 和 PKC 等。PDGFR Tyrosine Kinase Inhibitor III 可用于肌萎缩侧索硬化症的研究。
T77746	Tyrosine kinase-IN-7	EGFR; Antiviral	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrosine kinase-IN-7 是一种有效的酪氨酸激酶 EGFR 抑制剂，抑制 EGFR(WT) 和 EGFR(T790M) ，在多种癌细胞系中显示出抗癌和抗肿瘤活性。Tyrosine kinase-IN-7 具有潜在的抗炎和抗病毒活性。
T39178	Tyrosine Kinase Peptide 1
	Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay.
T17184	Tyrosine kinase inhibitor	c-Met/HGFR; Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Tyrosine kinase inhibitor 是酪氨酸激酶的有效抑制剂。
T41099	EGFR Protein Tyrosine Kinase Substrate
	EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate.
T4344	ALW-II-41-27 Eph receptor tyrosine kinase inhibitor	Ephrin Receptor	Tyrosine Kinase/Adaptors
	ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor) 是一种 Eph 受体酪氨酸激酶抑制剂，可用于治疗癌症。
T21761	HNMPA	IGF-1R	Tyrosine Kinase/Adaptors
	HNMPA 是膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 可以抑制人胰岛素受体的酪氨酸和丝氨酸自磷酸化。HNMPA 对环 AMP 依赖性蛋白激酶或蛋白激酶 C 活性没有影响。
TQ0111	LDN-192960	DYRK; Haspin Kinase	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	LDN-192960 是 Haspin 和 DYRK2 的有效抑制剂（IC50：10 nM 和 48 nM）。
T2431	ID-8 ID8	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	ID-8 是 DYRK 抑制剂，长时间培养能够维持胚胎干细胞的自我更新。
T16730	Remibrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Remibrutinib 是有效的、口服具有活力的 bruton tyrosine kinase 抑制剂 (IC50:1 nM)，在血液中抑制 BTK 活性的 IC50的值为 0.23 μM。它具有研究慢性荨麻疹的潜力。
TP1269	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9
	Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491.
T2314	PF-431396	FAK; PYK2	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF 431396 是一种具有口服活性的 FAK (IC50:2 nM) 和 Pyk2 (IC50:11 nM)的抑制剂。
T6257	AZ191	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	AZ191 是特异性 DYRK1B 抑制剂。它对 DYRK1B 的特异性分别是 DYRK1A 和 DYRK2 的 5 倍和 110 倍。
T11447	GNF4877	GSK-3; DYRK	Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	GNF4877 是一种 DYRK1A (IC50:6 nM) 和 GSK3β (IC50:16 nM) 抑制剂。它导致激活 T 细胞核因子核输出的阻断和 β 细胞增殖细胞增加。
T15422	GSK-626616	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GSK-626616 是一种口服具有活力的 DYRK3抑制剂 (IC50:0.7 nM)。它以相似的效力抑制 DYRK 家族的其他成员，可用于研究贫血。
T14692	BMX-IN-1 BMX kinase inhibitor	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	BMX-IN-1 (BMX kinase inhibitor) 是 X 染色体上的骨髓酪氨酸激酶 (BMX, IC50 = 8 nM) 和相关的布鲁顿酪氨酸激酶 (BTK, IC50 = 10.4 nM) 的特异性抑制剂，但 BMX-IN-1 对 Blk、JAK3、EGFR、Itk 或 Tec 活性的效力要低 47-656 倍以上。
T14980	CLK-IN-T3	DYRK; CDK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	CLK-IN-T3 是 CLK1、CLK2 和 CLK3 的抑制剂，IC50 为 0.67、15 和 110 nM。 CLK-IN-T3 具有抗癌活性。
T2655	CEP-37440 CEP37440	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	CEP-37440 是一种新型的 FAK (IC50:2.3 nM) 和 ALK (IC50:120 nM) 双重抑制剂。
T10285	ALK inhibitor 1	FAK; IGF-1R; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	ALK inhibitor 1 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=31 nM) 和粘着斑激酶 (FAK;IC50=2 nM) 抑制剂。
T3041	ALK inhibitor 2	FAK; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	ALK inhibitor 2 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=37 nM) 和粘着斑激酶 (FAK;IC50=5 nM) 抑制剂。
T4209	TAK-659 hydrochloride TAK-659	VEGFR; FLT; Tyrosine Kinases; JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TAK-659 hydrochloride (TAK-659) 是可逆的、高效的、选择性的、口服有效的 SYK/FLT3 双抑制剂，对 SYK 和 FLT3 作用的IC50值分别为 3.2 nM、4.6 nM。它能诱导肿瘤细胞死亡，却不作用于非肿瘤细胞，对慢性淋巴细胞白血病具有潜在的研究价值。
T6217	LFM-A13	PLK; JAK; BTK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	LFM-A13 是一种 BTK，JAK2，PLK 有效抑制剂，可抑制 BTK、Plx1 和 PLK3 的活性，IC50分别为 2.5、10 和 61 μM。
T3079	GSK1838705A	IGF-1R; JNK; S6 Kinase; ALK	Angiogenesis; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	GSK1838705A 是一种高效的、可逆的IGF-IR (IC50:2.0 nM) 和胰岛素受体 (IC50:1.6 nM)抑制剂，也可抑制ALK (IC50:0.5 nM)。
T6177	PF-562271 besylate PF-00562271 Besylate	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 besylate (PF-00562271 Besylate) 是一种可逆的，有效的，ATP 竞争性的 FAK(IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T2465	PF-562271 PF562271,PF 562271	FAK; PYK2; CDK	Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-562271 是一种可逆的，有效的，ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。
T15612	JH-VIII-157-02	Microtubule Associated; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	JH-VIII-157-02 是一种 ALK 抑制剂，可抑制棘皮动物微管相关蛋白样 4-ALK (EML4-ALK)，对EML4-ALK G1202R、EML4-ALKwt、EML4-ALK C1156Y、EML4-ALK F1174L 和 EML4-ALK F1174L 的 IC50 均为 2 nM。
T6115	Fostamatinib R788,福他替尼	FLT; Syk; Monoamine Transporter; Adenosine Receptor	Angiogenesis; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Fostamatinib (R788) 是一种口服具有活力的 R406 前药。其中R406 是具有口服活性的，有效的，ATP 竞争性的Syk/FLT3抑制剂(Ki:30 nM，IC50:41 nM)，也能够抑制 Lyn (IC50:63 nM) 和 Lck (IC50:37 nM)。
T11254	F-1	ROS; ALK; ROS Kinase	Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	F-1 是 ALK 和 ROS1 的双重抑制剂，抑制 ALK 的磷酸化及下游通路，可作用于对 ALKWT (IC50:2.1 nM)，ROS1WT (IC50:2.3 nM)，ALKL1196M (IC50:1.3 nM) 和 ALKG1202R (IC50:3.9 nM)。
T9125	Tolebrutinib PRN2246,SAR442168	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Tolebrutinib (PRN2246) 是一种选择性、有效的、具有口服活性、可透过血脑屏障的布鲁顿氏酪氨酸激酶抑制剂，能够作用于 Ramos B 细胞 (IC50:0.4 nM)、HMC 小胶质细胞 (IC50:0.7 nM)。它对中枢神经系统免疫具有功效。它可用于多发性硬化症的研究。
T9973	FAK-IN-7	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK-IN-7 有潜在的抗增殖活性，是一种 FAK 抑制剂。
T9576	AMP-945	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	AMP-945 是一种粘着斑激酶抑制剂。
T16153	MS4078	ALK; PROTACs	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	MS4078 是一种基于 Cereblon 配体的间变性淋巴瘤激酶 PROTAC ，结合 ALK 的 Kd 为 19 nM。
T6409	ALK kinase inhibitor-1 SAR348830	Others	Others
	SAR348830 是间变性淋巴瘤激酶ALK 抑制剂。
T61730	Tyrosine kinase-IN-4	Others	Others
	Tyrosine kinase-IN-4 (EXAMPLE 107) 是一种酪氨酸激酶 (tyrosine kinase) 抑制剂。
T79612	Tyrosine kinase-IN-6	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Tyrosine kinase-IN-6为RON剪接变异体抑制剂，有效展现抗癌及抗肿瘤活性。
T5138	BMS-986142	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	BMS986142 是一种有效的、具有高选择性的 Bruton's 酪氨酸激酶 (BTK)可逆性抑制剂 (IC50:0.5 nM)。
T6997	SU6656	FAK; Akt; Src	Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	SU6656 是Src 家族激酶抑制剂，抑制 Src，Yes，Lyn，Fyn 的IC50分别为 280，20，130，170 nM。它还能抑制p-AKT。它可抑制FAK Y576/577、 Y925、Y861位点的磷酸化。
T1976	RN486	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	RN486 是选择性的，具有口服活性的Btk 抑制剂 (IC50:4.0 nM;Kd:0.31 nM)，对其他激酶的活性较低。它可用于类风湿关节炎和系统性红斑狼疮的研究。
T14331	Gusacitinib ASN-002	JAK; Syk	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Gusacitinib (ASN-002) 是一种有效的 SYK 激酶和JAK 激酶的双抑制剂，IC50值为 5 到 46 nM 之间，具有抗癌活性。
T1967	AZD-3463 ALK/IGF1R inhibitor	Apoptosis; IGF-1R; ALK; Autophagy	Angiogenesis; Apoptosis; Autophagy; Tyrosine Kinase/Adaptors
	AZD-3463 (ALK/IGF1R inhibitor) 是一种具有口服活性的ALK/IGF1R 抑制剂，对 ALK 作用的Ki 值为 0.75 nM。它可诱导神经母细胞瘤细胞凋亡和自噬。
T1962	ASP3026 ASP 3026	Apoptosis; ALK	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	ASP3026 是一种选择性的，具有口服活性的间变性淋巴瘤激酶抑制剂，可诱导肿瘤细胞凋亡，可研究非小细胞肺癌。
T2620	G-749 G749	Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	G-749 是一种新型 FLT3 抑制剂，对 FLT3 野生型和突变体有持续的抑制作用，IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。
T40187	GNF2133	DYRK	Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	GNF2133 是一种有效的特异性 DYRK1A 抑制剂，IC50 为 6.2 nM。 GNF2133 可用于关于 1 型糖尿病的研究。
T2472	CGI-1746	BTK; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	CGI-1746 是一种有效且高选择性的小分子 Btk 抑制剂，IC50值为 1.9 nM。
T2001	PF-573228 PF 573228	Apoptosis; FAK	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	PF-573228是一种选择性的 FAK 抑制剂，对 FAK 纯化重组催化片段的 IC50值为4 nM。
T36287	Pirtobrutinib	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to tumor regression in BTK-dependent lymphoma tumors in mouse xenograft models. Furthermore, Pirtobrutinib exhibits remarkable selectivity for BTK, with more than a 300-fold difference compared to 370 other kinases tested. Notably, at a concentration of 1 μM, Pirtobrutinib demonstrat...
T6174	R406 R-406 besylate	Apoptosis; FLT; Syk	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	R406 (R-406 besylate) 是一种具有口服活性的 ATP 竞争性 Syk/FLT3抑制剂，Ki 为 30 nM。它有效抑制 Syk 激酶活性，IC50为 41 nM。它还抑制 Lyn 和 Lck，IC50值分别为 63 nM 和 37 nM。它可减轻免疫复合物介导的炎症。
T10626	(Rac)-IBT6A	Others; BTK	Angiogenesis; Others; Tyrosine Kinase/Adaptors
	(Rac)-IBT6A 是 IBT6A 的外消旋体。 IBT6A 是依鲁替尼的杂质，可用于 IBT6A 依鲁替尼二聚体和 IBT6A 加合物的合成。
T3061	Lorlatinib 劳拉替尼,PF-6463922,PF-06463922,Loratinib	Apoptosis; Tyrosine Kinases; ROS; ALK; ROS Kinase	Angiogenesis; Apoptosis; Immunology/Inflammation; Tyrosine Kinase/Adaptors
	Lorlatinib (PF-6463922) 是一种具有口服活性，选择性，脑渗透性和 ATP 竞争性的ROS1/ALK 抑制剂，具有抗癌活性。它对 ROS1、野生型 ALK 和 ALKL1196M 的Ki 值分别为 <0.025 nM、<0.07 nM 和 0.7 nM。

化合物

Tyrosine kinase-IN-1

Cat.No: T5466

Target: VEGFR, FGFR, FLT, PDGFR

PDGFR Tyrosine Kinase Inhibitor III

Cat.No: T60108

Synonym: PDGF Receptor Tyrosine Kinase Inhibitor III

Target: PDGFR

Tyrosine kinase-IN-7

Cat.No: T77746

Target: EGFR, Antiviral

Tyrosine Kinase Peptide 1

Cat.No: T39178

Tyrosine kinase inhibitor

Cat.No: T17184

Target: c-Met/HGFR, Tyrosine Kinases

EGFR Protein Tyrosine Kinase Substrate

Cat.No: T41099

Cat.No: T4344

Synonym: Eph receptor tyrosine kinase inhibitor

Target: Ephrin Receptor

Cat.No: T21761

Target: IGF-1R

Cat.No: TQ0111

Target: DYRK, Haspin Kinase

Cat.No: T2431

Synonym: ID8

Target: DYRK

Cat.No: T16730

Target: BTK

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)

Cat.No: TP1269

Synonym: Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9

Cat.No: T2314

Target: FAK, PYK2

Cat.No: T6257

Target: DYRK

Cat.No: T11447

Target: GSK-3, DYRK

Cat.No: T15422

Target: DYRK

Cat.No: T14692

Synonym: BMX kinase inhibitor

Target: BTK

Cat.No: T14980

Target: DYRK, CDK

Cat.No: T2655

Synonym: CEP37440

Target: FAK, ALK

ALK inhibitor 1

Cat.No: T10285

Target: FAK, IGF-1R, ALK

ALK inhibitor 2

Cat.No: T3041

Target: FAK, ALK

TAK-659 hydrochloride

Cat.No: T4209

Synonym: TAK-659

Target: VEGFR, FLT, Tyrosine Kinases, JAK, Syk

Cat.No: T6217

Target: PLK, JAK, BTK

Cat.No: T3079

Target: IGF-1R, JNK, S6 Kinase, ALK

PF-562271 besylate

Cat.No: T6177

Synonym: PF-00562271 Besylate

Target: FAK, PYK2, CDK

Cat.No: T2465

Synonym: PF562271,PF 562271

Target: FAK, PYK2, CDK

Cat.No: T15612

Target: Microtubule Associated, ALK

Cat.No: T6115

Synonym: R788,福他替尼

Target: FLT, Syk, Monoamine Transporter, Adenosine Receptor

Cat.No: T11254

Target: ROS, ALK, ROS Kinase

Cat.No: T9125

Synonym: PRN2246,SAR442168

Target: BTK

Cat.No: T9973

Target: FAK

Cat.No: T9576

Target: FAK

Cat.No: T16153

Target: ALK, PROTACs

ALK kinase inhibitor-1

Cat.No: T6409

Synonym: SAR348830

Target: Others

Tyrosine kinase-IN-4

Cat.No: T61730

Target: Others

Tyrosine kinase-IN-6

Cat.No: T79612

Target: c-Met/HGFR

Cat.No: T5138

Target: BTK

Cat.No: T6997

Target: FAK, Akt, Src

Cat.No: T1976

Target: BTK

Cat.No: T14331

Synonym: ASN-002

Target: JAK, Syk

Cat.No: T1967

Synonym: ALK/IGF1R inhibitor

Target: Apoptosis, IGF-1R, ALK, Autophagy

Cat.No: T1962

Synonym: ASP 3026

Target: Apoptosis, ALK

Cat.No: T2620

Synonym: G749

Target: Apoptosis, FLT, c-RET, TAM Receptor, Aurora Kinase

Cat.No: T40187

Target: DYRK

Cat.No: T2472

Target: BTK, Autophagy

Cat.No: T2001

Synonym: PF 573228

Target: Apoptosis, FAK

Cat.No: T36287

Target: BTK

Cat.No: T6174

Synonym: R-406 besylate

Target: Apoptosis, FLT, Syk

Cat.No: T10626

Target: Others, BTK

Cat.No: T3061

Synonym: 劳拉替尼,PF-6463922,PF-06463922,Loratinib

Target: Apoptosis, Tyrosine Kinases, ROS, ALK, ROS Kinase

Cat. No.	Product Name	Target	Signaling Pathways
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
T8152	6-Demethoxytangeretin	MAPK; ALK	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	6-Demethoxytangeretin 是一种从柑橘分离的黄酮。它能够促进 CRE 介导的转录 (与海马神经元的学习和记忆相关)。它具有抗炎和抗过敏作用，通过间变性淋巴瘤激酶和丝裂原活化蛋白激酶途径抑制人肥大细胞中 IL-6 的产生和基因表达。
T1711	Harmine Telepathine,去氢骆驼蓬碱	MAO; 5-HT Receptor; DYRK	Cell Cycle/Checkpoint; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Harmine (Telepathine) 是一种从山茱萸种子中分离出来的生物碱，具有抗癌和抗炎活性。它是双特异性酪氨酸磷酸化调节激酶抑制剂，对5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。
T2811	Harmine hydrochloride telepathine hydrochloride,盐酸哈尔明碱	5-HT Receptor; DYRK; GluR	Cell Cycle/Checkpoint; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors
	Harmine hydrochloride (telepathine hydrochloride) 是一种 DYRK 抑制剂，具有抗癌和抗炎活性。它对5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T0610	Piceatannol 白皮杉醇,trans-Piceatannol,Astringenin	Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors
	Piceatannol (Astringenin) 是一种Syk 抑制剂，可降低由 TNF 诱导的 iNOS 表达，可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯，可诱导细胞自噬和凋亡，具有抗癌和抗炎特性。
T3122	Fangchinoline Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline	Apoptosis; FAK; HIV Protease; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Fangchinoline (Tetrandrine B) 是从Stephaniatetrandra 中分离出来的，一种具有广泛生物学活性的天然产物。它是新型HIV-1抑制剂，通过损害 gp160 蛋白水解过程来抑制 HIV-1 复制。它靶向Focal adhesion kinase (FAK)并抑制肿瘤细胞中 FAK 介导的的信号传导途径。
T6S0033	Crotonoside 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE	Others; FLT; HDAC	Angiogenesis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Others; Tyrosine Kinase/Adaptors
	Crotonoside (Isoguanosine) 是从中草药巴豆中分离出来的一种天然产物。它抑制 FLT3 和 HDAC3/6，有治疗急性髓性白血病 (AML)的研究潜力。
T1181	Gefitinib ZD1839,吉非替尼	EGFR; Tyrosine Kinases; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Gefitinib (ZD1839) 是一种 EGFR 一代抑制剂，具有口服活性，抑制 EGFR 19 Del 和 L858R 突变。Gefitinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。Gefitinib 用药会产生 EGFR C797S 耐药突变。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
TQ0065	Pseudobufarenogin 伪异沙蟾毒精,ψ-Bufarenogin	Others	Others
	Pseudobufarenogin (ψ-Bufarenogin) 是一种蟾蜍毒素提取物，活性背景未知。
TN1096	Ginsenoside Ra1 人参皂苷 Ra1,人参皂苷Ra1	Others; Tyrosine Kinases	Others; Tyrosine Kinase/Adaptors
	Ginsenoside Ra1 是来自人参的成分。 Ginsenoside Ra1 对缺氧/复氧诱导的蛋白酪氨酸激酶 (PTK) 活化具有显着抑制作用。
T1238	Daidzein 大豆素,Isoflavone,黄豆苷元	Endogenous Metabolite; PPAR	DNA Damage/DNA Repair; Metabolism
	Daidzein (Isoflavone) 是一种来自大豆的异黄酮提取物，是酪氨酸激酶抑制剂染料木黄酮的无活性类似物，具有抗氧化和植物雌激素特性。
T1737	Genistein NPI 031L,三叶草,染料木素,金雀异黄酮	Apoptosis; EGFR; Endogenous Metabolite; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors
	Genistein (NPI 031L) 是一种大豆异黄酮，是一种多重的酪氨酸激酶抑制剂，通过改变细胞凋亡，细胞周期和血管生成以及抑制转移对多种癌症有化疗作用。
T6427	Butein 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因	Apoptosis; EGFR; Others; PDE; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors
	Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂，也是蛋白酪氨酸激酶抑制剂，还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路，靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。
Fr16741	Oxindole 2-吲哚酮,板蓝根,Indolin-2-one	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Oxindole (Indolin-2-one) 是一种芳族杂环砌块，其衍生物是激酶抑制剂研究中的主要成分。
TN2019	Orobol 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮	BCL; Caspase; PI3K	Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K，对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。
T4183	lavendustin A RG-14355,NSC 678027,薰草菌素	EGFR; Tyrosinase	Angiogenesis; JAK/STAT signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	lavendustin A (RG-14355) 是从链霉菌中分离得到的一种天然产物，是细胞渗透性表皮生长因子受体 (EGFR) 酪氨酸激酶抑制剂，能抑制血管内皮生长因子诱导的血管生成，阻断 LTPGABA-A 的诱导。
TN2504	1,5-Dihydroxyxanthone	EGFR; AChR	Angiogenesis; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzym
T83411	2,3,4,6,8-Pentahydroxy-1-methylxanthone
	2,3,4,6,8-Pentahydroxy-1-methylxanthone，一种源自Wardomyces anomalus的山酮衍生物，展示了显著的抗氧化活性，并作为p56lck酪氨酸激酶的抑制剂发挥作用。它在心血管疾病治疗研究中具备潜在应用价值。

天然产物

Cat.No: TN1433

Target: FAK, Others, Akt

6-Demethoxytangeretin

Cat.No: T8152

Target: MAPK, ALK

Cat.No: T1711

Synonym: Telepathine,去氢骆驼蓬碱

Target: MAO, 5-HT Receptor, DYRK

Harmine hydrochloride

Cat.No: T2811

Synonym: telepathine hydrochloride,盐酸哈尔明碱

Target: 5-HT Receptor, DYRK, GluR

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: T0610

Synonym: 白皮杉醇,trans-Piceatannol,Astringenin

Target: Apoptosis, Serine/threonin kinase, PKA, Syk, PKC, Autophagy

Cat.No: T3122

Synonym: Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline

Target: Apoptosis, FAK, HIV Protease, Autophagy

Cat.No: T6S0033

Synonym: 巴豆苷；异鸟苷,巴豆苷,Isoguanosine,2-HYDROXYADENOSINE

Target: Others, FLT, HDAC

Cat.No: T1181

Synonym: ZD1839,吉非替尼

Target: EGFR, Tyrosine Kinases, Autophagy

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Pseudobufarenogin

Cat.No: TQ0065

Synonym: 伪异沙蟾毒精,ψ-Bufarenogin

Target: Others

Ginsenoside Ra1

Cat.No: TN1096

Synonym: 人参皂苷 Ra1,人参皂苷Ra1

Target: Others, Tyrosine Kinases

Cat.No: T1238

Synonym: 大豆素,Isoflavone,黄豆苷元

Target: Endogenous Metabolite, PPAR

Cat.No: T1737

Synonym: NPI 031L,三叶草,染料木素,金雀异黄酮

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Cat.No: T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone,紫铆因

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Cat.No: Fr16741

Synonym: 2-吲哚酮,板蓝根,Indolin-2-one

Target: Others, HIV Protease

Cat.No: TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮

Target: BCL, Caspase, PI3K

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

Cat.No: T4183

Synonym: RG-14355,NSC 678027,薰草菌素

Target: EGFR, Tyrosinase

1,5-Dihydroxyxanthone

Cat.No: TN2504

Target: EGFR, AChR

2,3,4,6,8-Pentahydroxy-1-methylxanthone

Cat.No: T83411

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02271	BTK Protein, Human, Recombinant (His) BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine...	Human	Baculovirus Insect Cells
	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in...
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) MET proto-oncogene, receptor tyrosine kinase	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.
TMPY-00636	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) erb-b2 receptor tyrosine kinase 2,EGFR2	Cynomolgus	HEK293 Cells
	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.
TMPY-01944	HER2/ERBB2 Protein, Rat, Recombinant (His) EGFR2,erb-b2 receptor tyrosine kinase 2	Rat	HEK293 Cells
	HER2/ERBB2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.2 kDa and the accession number is AAH61863.1.
TMPY-00246	HER3/ERBB3 Protein, Rhesus, Recombinant erb-b2 receptor tyrosine kinase 3	Rhesus	HEK293 Cells
	HER3/ERBB3 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.5 kDa and the accession number is XP_001113953.2.
TMPY-03024	HER3/ERBB3 Protein, Rat, Recombinant (His) erb-b2 receptor tyrosine kinase 3	Rat	HEK293 Cells
	HER3/ERBB3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.9 kDa and the accession number is A6KSF8.
TMPY-02813	ErbB4 Protein, Human, Rhesus, Recombinant (His) erb-b2 receptor tyrosine kinase 4	Human,Rhesus	HEK293 Cells
	ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1.
TMPY-02477	HER3/ERBB3 Protein, Rhesus, Recombinant (His) erb-b2 receptor tyrosine kinase 3	Rhesus	HEK293 Cells
	HER3/ERBB3 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is XP_005571238.1&XP_001113953.2.
TMPY-03719	HER2/ERBB2 Protein, Canine, Recombinant (His) erb-b2 receptor tyrosine kinase 2,EGFR2	Canine	HEK293 Cells
	HER2/ERBB2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is A8WED5.
TMPJ-00412	VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) Vascular endothelial growth factor receptor 1,Vascular perme...	Human	HEK293 Cells
	Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPY-03066	FLT3 Ligand Protein, Mouse, Recombinant (hFc) Ly72L,Flt3lg,fms related tyrosine kinase 3...	Mouse	HEK293 Cells
	FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P49772-1.
TMPY-03215	FLT3 Ligand Protein, Human, Recombinant (His) fms related tyrosine kinase 3 ligand,FLT3L...	Human	Baculovirus Insect Cells
	FLT3 Ligand Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.2 kDa and the accession number is P49771-1.
TMPY-06873	FLT3 Ligand Protein, Human, Recombinant FLT3LG,fms related tyrosine kinase 3 ligan...	Human	E. coli
	FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
TMPY-01601	AXL Protein, Human, Recombinant (His) UFO,ARK,JTK11,AXL receptor tyrosine kinase...	Human	HEK293 Cells
	AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.
TMPY-04649	ROR1 Protein, Human, Recombinant (His) dJ537F10.1,NTRKR1,receptor tyrosine kinase...	Human	HEK293 Cells
	ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973.
TMPY-00930	TIE2 Protein, Human, Recombinant (His & hFc) VMCM1,TIE2,CD202B,TEK tyrosine kinase, end...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
TMPY-01064	TIE2 Protein, Human, Recombinant (His) TIE2,VMCM,CD202B,TEK tyrosine kinase, endo...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-05394	ROR2 Protein, Human, Recombinant (His) BDB,BDB1,NTRKR2,receptor tyrosine kinase-l...	Human	HEK293 Cells
	ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.8 kDa and the accession number is Q01974.
TMPY-00637	FLT1 Protein, Human, Recombinant (aa 1-328, His) VEGFR-1,fms-related tyrosine kinase 1,VEGF...	Human	HEK293 Cells
	FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.6 kDa and the accession number is L7RSL3.
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His) MET proto-oncogene, receptor tyrosine kinase	Mouse	HEK293 Cells
	HGFR/c-Met Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 102 kDa and the accession number is EDL13881.1.
TMPY-01247	FLT3 Protein, Human, Recombinant (T227M, His) FLK2,FLK-2,CD135,STK1,fms-related tyrosine kina...	Human	HEK293 Cells
	FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1.
TMPY-00882	Mer Protein, Human, Recombinant (His & hFc) RP38,c-Eyk,c-mer,Tyro12,MER proto-oncogene, tyrosine	Human	HEK293 Cells
	Mer Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 80 kDa and the accession number is Q12866.
TMPY-04330	Mer Protein, Human, Recombinant MER proto-oncogene, tyrosine kinase,RP38,M...	Human	HEK293 Cells
	Mer Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 54 kDa and the accession number is Q12866.
TMPJ-00778	HER2/ERBB2 Protein, Human, Recombinant (His) TKR1,Metastatic lymph node gene 19 protein,ERBB2,Proto-oncog...	Human	HEK293 Cells
	HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626.
TMPY-02231	TrkB Protein, Mouse, Recombinant (His) trk-B,neurotrophic tyrosine kinase, recept...	Mouse	HEK293 Cells
	TrkB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is P15209-2.
TMPY-01936	VEGFR3/FLT4 Protein, Mouse, Recombinant (His) Flt-4,VEGFR-3,Chy,fms related tyrosine kinase	Mouse	HEK293 Cells
	VEGFR3/FLT4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86.4 kDa and the accession number is P35917-1.
TMPY-04384	Src Protein, Human, Recombinant (His & GST) c-SRC,p60-Src,ASV,SRC1,SRC proto-oncogene, non-receptor ...	Human	Baculovirus Insect Cells
	Src Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 87.7 kDa and the accession number is P12931-1.
TMPY-01084	TrkA Protein, Human, Recombinant (His) TRK1,TRK,TRKA,neurotrophic tyrosine kinase...	Human	HEK293 Cells
	TrkA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 39.5 kDa and the accession number is P04629-1.
TMPY-00751	TrkB Protein, Human, Recombinant (His) trk-B,GP145-TrkB/GP95-TrkB,neurotrophic tyrosine	Human	HEK293 Cells
	TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
TMPY-02365	HER3/ERBB3 Protein, Mouse, Recombinant (His) Erbb-3r,Erbb3r,erb-b2 receptor tyrosine kinase<...	Mouse	HEK293 Cells
	HER3/ERBB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70 kDa and the accession number is Q61526.
TMPY-01296	HGFR/c-Met Protein, Human, Recombinant (His) AUTS9,MET proto-oncogene, receptor tyrosine kin...	Human	HEK293 Cells
	HGFR/c-Met Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103 kDa and the accession number is A0A024R759.
TMPY-02469	HER2/ERBB2 Protein, Mouse, Recombinant (hFc) EGFR2,c-erbB2,l11Jus8,Erbb-2,mKIAA3023,Neu,erb-b2 receptor <...	Mouse	HEK293 Cells
	HER2/ERBB2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 96.7 kDa and the accession number is P70424.
TMPY-02314	HER2/ERBB2 Protein, Mouse, Recombinant (His) HER2,c-erbB2,erb-b2 receptor tyrosine kinase	Mouse	HEK293 Cells
	HER2/ERBB2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is P70424.
TMPY-00949	VEGFR3/FLT4 Protein, Human, Recombinant (His) VEGFR-3,PCL,FLT41,VEGF Receptor 3,VEGFR3,FLT-4,fms related <...	Human	HEK293 Cells
	VEGFR3/FLT4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 86 kDa and the accession number is P35916-1.
TMPY-01289	DDR1 Protein, Human, Recombinant (His) RTK6,DDR,TRKE,PTK3,NTRK4,NEP,PTK3A,MCK10,EDDR1,HGK2,CD167,CA...	Human	HEK293 Cells
	DDR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is A0A024RCQ1.
TMPY-04396	C-ABL/ABL1 Protein, Human, Recombinant (GST) v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosi...	Human	Baculovirus Insect Cells
	c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPY-04956	HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated MDA-BF-1,c-erbB-3,HER3,p85-sErbB3,LCCS2,p180-ErbB3,erbB3-S,e...	Human	HEK293 Cells
	HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
TMPY-02508	TIE2 Protein, Rat, Recombinant (hFc) TEK tyrosine kinase, endothelial	Rat	HEK293 Cells
	TIE2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 108 kDa and the accession number is A6JRG8.
TMPY-05049	TIE2 Protein, Rhesus, Recombinant (His) TEK tyrosine kinase, endothelial	Rhesus	HEK293 Cells
	TIE2 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is G7NFP9.
TMPY-00399	HER3/ERBB3 Protein, Human, Recombinant LCCS2,c-erbB-3,HER3,p180-ErbB3,erbB3-S,MDA-BF-1,erb-b2 recep...	Human	HEK293 Cells
	HER3/ERBB3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.3 kDa and the accession number is P21860-1.
TMPY-01389	HER3/ERBB3 Protein, Human, Recombinant (His) MDA-BF-1,EEBB3,erbB3-S,p45-sErbB3,ErbB-3,LCCS2,p85-sErbB3,p1...	Human	HEK293 Cells
	HER3/ERBB3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.2 kDa and the accession number is P21860-1.
TMPJ-01017	Dtk Protein, Mouse, Recombinant (hFc) tyro3,Tyrosine-protein kinase receptor TYR...	Mouse	HEK293 Cells
	Dtk Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P55144.
TMPJ-01081	Dtk Protein, Human, Recombinant (His) RSE,SKY,DTK,Tyrosine-protein kinase DTK,	Human	HEK293 Cells
	Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th...
TMPJ-01018	Dtk Protein, Mouse, Recombinant (mFc) TK19-2,Tyrosine-protein kinase RSE,Etk2/ty...	Mouse	HEK293 Cells
	Dtk Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is P55144.
TMPY-06552	AXL Protein, Rat, Recombinant (His) AXL receptor tyrosine kinase	Rat	HEK293 Cells
	AXL Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.72 kDa and the accession number is Q8VI99.
TMPY-04383	CSK Protein, Human, Recombinant (GST) c-src tyrosine kinase	Human	Baculovirus Insect Cells
	CSK Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 77 kDa and the accession number is P41240.
TMPY-03563	TIE2 Protein, Cynomolgus, Recombinant (hFc) TEK tyrosine kinase, endothelial	Cynomolgus	HEK293 Cells
	TIE2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 107.6 kDa and the accession number is G7PS68.
TMPY-04377	Brk Protein, Human, Recombinant (GST) BRK,protein tyrosine kinase 6	Human	Baculovirus Insect Cells
	Brk Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 78 kDa and the accession number is Q13882-1.
TMPY-03299	FLT1 Protein, Rat, Recombinant (His) fms-related tyrosine kinase 1	Rat	HEK293 Cells
	FLT1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84 kDa and the accession number is P53767.
TMPJ-01143	MERTK/Mer Protein, Human, Recombinant (aa 1-323, His) MER,Receptor tyrosine kinase MerTK,Tyr...	Human	HEK293 Cells
	Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that t...
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重组蛋白

BTK Protein, Human, Recombinant (His)

Cat.No: TMPH-02271

Species: Human

Expression System: Baculovirus Insect Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-00548

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-00636

Species: Cynomolgus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-01944

Species: Rat

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Rhesus, Recombinant

Cat.No: TMPY-00246

Species: Rhesus

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03024

Species: Rat

Expression System: HEK293 Cells

ErbB4 Protein, Human, Rhesus, Recombinant (His)

Cat.No: TMPY-02813

Species: Human,Rhesus

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-02477

Species: Rhesus

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Canine, Recombinant (His)

Cat.No: TMPY-03719

Species: Canine

Expression System: HEK293 Cells

VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00412

Species: Human

Expression System: HEK293 Cells

FLT3 Ligand Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03066

Species: Mouse

Expression System: HEK293 Cells

FLT3 Ligand Protein, Human, Recombinant (His)

Cat.No: TMPY-03215

Species: Human

Expression System: Baculovirus Insect Cells

FLT3 Ligand Protein, Human, Recombinant

Cat.No: TMPY-06873

Species: Human

Expression System: E. coli

AXL Protein, Human, Recombinant (His)

Cat.No: TMPY-01601

Species: Human

Expression System: HEK293 Cells

ROR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04649

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00930

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01064

Species: Human

Expression System: HEK293 Cells

ROR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-05394

Species: Human

Expression System: HEK293 Cells

FLT1 Protein, Human, Recombinant (aa 1-328, His)

Cat.No: TMPY-00637

Species: Human

Expression System: HEK293 Cells

HGFR/c-Met Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01896

Species: Mouse

Expression System: HEK293 Cells

FLT3 Protein, Human, Recombinant (T227M, His)

Cat.No: TMPY-01247

Species: Human

Expression System: HEK293 Cells

Mer Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00882

Species: Human

Expression System: HEK293 Cells

Mer Protein, Human, Recombinant

Cat.No: TMPY-04330

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00778

Species: Human

Expression System: HEK293 Cells

TrkB Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02231

Species: Mouse

Expression System: HEK293 Cells

VEGFR3/FLT4 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01936

Species: Mouse

Expression System: HEK293 Cells

Src Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04384

Species: Human

Expression System: Baculovirus Insect Cells

TrkA Protein, Human, Recombinant (His)

Cat.No: TMPY-01084

Species: Human

Expression System: HEK293 Cells

TrkB Protein, Human, Recombinant (His)

Cat.No: TMPY-00751

Species: Human

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02365

Species: Mouse

Expression System: HEK293 Cells

HGFR/c-Met Protein, Human, Recombinant (His)

Cat.No: TMPY-01296

Species: Human

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02469

Species: Mouse

Expression System: HEK293 Cells

HER2/ERBB2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02314

Species: Mouse

Expression System: HEK293 Cells

VEGFR3/FLT4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00949

Species: Human

Expression System: HEK293 Cells

DDR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01289

Species: Human

Expression System: HEK293 Cells

C-ABL/ABL1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04396

Species: Human

Expression System: Baculovirus Insect Cells

HER3/ERBB3 Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04956

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-02508

Species: Rat

Expression System: HEK293 Cells

TIE2 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-05049

Species: Rhesus

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Human, Recombinant

Cat.No: TMPY-00399

Species: Human

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01389

Species: Human

Expression System: HEK293 Cells

Dtk Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01017

Species: Mouse

Expression System: HEK293 Cells

Dtk Protein, Human, Recombinant (His)

Cat.No: TMPJ-01081

Species: Human

Expression System: HEK293 Cells

Dtk Protein, Mouse, Recombinant (mFc)

Cat.No: TMPJ-01018

Species: Mouse

Expression System: HEK293 Cells

AXL Protein, Rat, Recombinant (His)

Cat.No: TMPY-06552

Species: Rat

Expression System: HEK293 Cells

CSK Protein, Human, Recombinant (GST)

Cat.No: TMPY-04383

Species: Human

Expression System: Baculovirus Insect Cells

TIE2 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-03563

Species: Cynomolgus

Expression System: HEK293 Cells

Brk Protein, Human, Recombinant (GST)

Cat.No: TMPY-04377

Species: Human

Expression System: Baculovirus Insect Cells

FLT1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03299

Species: Rat

Expression System: HEK293 Cells

MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)

Cat.No: TMPJ-01143

Species: Human

Expression System: HEK293 Cells

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Cat. No.	Product Name	Target	Signaling Pathways
T10766	Ceritinib D7 LDK378 D7	Others	Others
	Ceritinib D7 (LDK378 D7) is a deuterium-labeled Ceritinib. Ceritinib is an ATP-competitive inhibitor of ALK tyrosine kinase.
TMIH-0610	Zanubrutinib-d5
	Zanubrutinib-d5 是 Zanubrutinib 的氘代化合物。Zanubrutinib 的 CAS 号为 1691249-45-2。Zanubrutinib 是 Bruton tyrosine kinase(Btk) 的选择性抑制剂。
T10962	Dasatinib-d8 BMS-354825 D8	Others	Others
	Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
T12698	Regorafenib-d3 Regorafenib D3,BAY 73-4506 D3	Others	Others
	Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.
T11639	Imatinib D4 CGP-57148B D4,STI571 D4	Others	Others
	Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.
T11384	Gefitinib-d8 ZD1839 D8,Gefitinib D8	Others	Others
	Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.
T12224	Nilotinib-d6 AMN107 D6	Others	Others
	Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity.
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...
T11640	Imatinib-d8 CGP-57148B D8,STI571 D8	Others	Others
	Imatinib D8 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.
T13039	Sunitinib-d10 Sunitinib D10,SU 11248 D10	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively).
T11229	Erlotinib-d6 OSI-774 D6,NSC 718781 D6,CP-358774 D6	Others	Others
	Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib .
TMIJ-0330	Gilteritinib-d8
	Gilteritinib-d8 是 Gilteritinib 的氘代化合物。Gilteritinib 的 CAS 号为 1254053-43-4。Gilteritinib 是一种 FLT3 抑制剂 (IC50:0.29 nM)，也是一种 AXL 抑制剂 (IC50:0.73 nM)，具有ATP 竞争性。
T19119	3-Hydroxy Midostaurin-D5 CGP52421-D5	Others	Others
	3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).
TMID-0073	Alectinib-d8
	Alectinib-d8 是 Alectinib 的氘代化合物。Alectinib 的 CAS 号为 1256580-46-7。Alectinib 是一种有效的、选择性的、口服具有活力的、ATP 竞争性的ALK抑制剂，其IC50=1.9 nM，Kd=2.4 nM，并且还抑制ALK F1174L和ALK R1275Q，其IC50分别为 1 nM 和 3.5 nM。它还有中枢神经系统渗透能力。
TMIJ-0154	Lenvatinib-d4
	Lenvatinib-d4 是 Lenvatinib 的氘代化合物。Lenvatinib 的 CAS 号为 417716-92-8。Lenvatinib 是一种口服具有活性的，多靶点酪氨酸激酶抑制剂，能够抑制血管内皮生长因子受体(VEGFR1-3)，成纤维细胞生长因子受体(FGFR1-4)，干细胞因子受体(KIT)，血小板衍生生长因子受体(PDGFR)，转染期间重排(RET)，具有效抗癌的作用。
TMIJ-0124	Regorafenib-13C-d3
	Regorafenib-13C-d3 是 Regorafenib 的 13C 和氘代化合物。Regorafenib 的 CAS 号为 755037-03-7。Regorafenib 是一种多靶点受体酪氨酸激酶抑制剂，对 RET、C-RAF、VEGFR2、c-Kit、VEGFR1和PDGFRβ 的 IC50为1.5、2.5、4.2、7、13和22 nM。
TMIH-0413	Osimertinib-d6
	Osimertinib-d6 是 Osimertinib 的氘代化合物。Osimertinib 的 CAS 号为 1421373-65-0。Osimtinib 是一种小分子酪氨酸激酶受体抑制剂和抗肿瘤剂，用于治疗选定形式的晚期非小细胞肺癌，其有效抑制 L858R 和 L858R/T790M EGFR，IC50 为 12 和 1 nM。
TMIJ-0147	Gefitinib-d6
	Gefitinib-d6 是 Gefitinib 的氘代化合物。Gefitinib 的 CAS 号为 184475-35-2。Gefitinib 是一种有口服活性的EGFR酪氨酸激酶抑制剂，可诱导细胞自噬，有抗肿瘤活性。它选择性抑制 EGF 刺激的肿瘤细胞生长，并阻断 EGF 刺激的肿瘤细胞中EGFR自磷酸化。
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
TMIH-0124	Brivanib Alaninate-d4
	Brivanib Alaninate-d4 是 Brivanib Alaninate 的氘代化合物。Brivanib Alaninate 的 CAS 号为 649735-63-7。Brivanib alaninate 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐，IC50值为 25 nM，具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制，对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。

同位素标记化合物

Cat.No: T10766

Synonym: LDK378 D7

Target: Others

Zanubrutinib-d5

Cat.No: TMIH-0610

Cat.No: T10962

Synonym: BMS-354825 D8

Target: Others

Cat.No: T12698

Synonym: Regorafenib D3,BAY 73-4506 D3

Target: Others

Cat.No: T11639

Synonym: CGP-57148B D4,STI571 D4

Target: Others

Cat.No: T11384

Synonym: ZD1839 D8,Gefitinib D8

Target: Others

Cat.No: T12224

Synonym: AMN107 D6

Target: Others

Cat.No: T35915

Synonym: Erlotinib-13C6

Cat.No: T11640

Synonym: CGP-57148B D8,STI571 D8

Target: Others

Cat.No: T13039

Synonym: Sunitinib D10,SU 11248 D10

Target: VEGFR, PDGFR

Cat.No: T11229

Synonym: OSI-774 D6,NSC 718781 D6,CP-358774 D6

Target: Others

Gilteritinib-d8

Cat.No: TMIJ-0330

3-Hydroxy Midostaurin-D5

Cat.No: T19119

Synonym: CGP52421-D5

Target: Others

Cat.No: TMID-0073

Cat.No: TMIJ-0154

Regorafenib-13C-d3

Cat.No: TMIJ-0124

Cat.No: TMIH-0413

Cat.No: TMIJ-0147

Acalabrutinib-d4

Cat.No: TMIH-0065

Brivanib Alaninate-d4

Cat.No: TMIH-0124

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