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Targets Recommended: Nucleoside Antimetabolite/Analog Drug Metabolite Endogenous Metabolite P2Y Receptor

1364

抑制剂 & 化合物

1000+

天然产物

9

化合物库

7

重组蛋白

110

同位素标记化合物

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Cat. No.	Product Name
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；
L2500	人内源代谢化合物库		499 compounds
	499 种内源性生物活性化合物的独特集合，用于高通量、高内涵筛选；
L2530	小鼠代谢化合物库		218 compounds
	218 种小鼠代谢化合物的集合，可用于高通量筛选和高内涵筛选；
L5800	药物代谢杂质库		197 compounds
	197 种药物异构体/代谢产物的特有集合，可用于高通量、高内涵筛选；
L6001	Mini真菌代谢天然产物筛选库		Inquiry

L2570	人代谢物化合物库		4454 compounds
	4454 种人代谢物的独特集合，用于高通量、高内涵筛选；
L2501	人内源代谢化合物库 Plus		1283 compounds
	1283种内源性生物活性化合物的独特集合，用于高通量、高内涵筛选。
L5510	肝脏毒性化合物库		1001 compounds
	1001 个肝脏毒性化合物的特有集合，可用于高通量、高内涵筛选，是毒理学研究的良好工具；
L2560	代谢化合物库		2320 compounds
	2320 种代谢途径相关的化合物，可用于高通量和高内涵筛选。

化合物库

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

人内源代谢化合物库

Cat.No: L2500

Compounds: 499

小鼠代谢化合物库

Cat.No: L2530

Compounds: 218

药物代谢杂质库

Cat.No: L5800

Compounds: 197

Mini真菌代谢天然产物筛选库

Cat.No: L6001

Compounds: Inquiry

人代谢物化合物库

Cat.No: L2570

Compounds: 4454

人内源代谢化合物库 Plus

Cat.No: L2501

Compounds: 1283

肝脏毒性化合物库

Cat.No: L5510

Compounds: 1001

代谢化合物库

Cat.No: L2560

Compounds: 2320

Cat. No.	Product Name	Target	Signaling Pathways
T21059	Ticagrelor metabolite M5 Ticagrelor metabolite M5,,T437700,替格瑞洛杂质H,AR-C133913XX	P2Y Receptor	GPCR/G Protein; Neuroscience
	Ticagrelor metabolite M5 (T437700) 是 Ticagrelor 的代谢物，是 P2Y12 受体的第一个可逆口服拮抗剂。与氯吡格雷相比，替格瑞洛对 ADP 受体具有更快和更一致的抑制作用。替格瑞洛用于治疗急性冠状动脉综合征(ACS)。
T16045	Methotrexate metabolite DAMPA,甲喋呤杂质E	Antifolate; Drug Metabolite	Cell Cycle/Checkpoint; Metabolism
	Methotrexate metabolite (DAMPA) (DAMPA)是 Methotrexate 的活性代谢物。Methotrexate 具有拮抗叶酸 (folic acid) 的作用，被用作免疫抑制剂。
T10738	Abemaciclib metabolite M20 CDK4/6-IN-4,LSN3106726	CDK	Cell Cycle/Checkpoint
	Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂，可用于癌症治疗的相关研究。
T13133	Tetrabenazine Metabolite (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ	Monoamine Transporter	Membrane transporter/Ion channel
	Tetrabenazine Metabolite ((-)-β-HTBZ) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂，是 Tetrabenazine 的一种活性代谢物。Tetrabenazine Metabolite 对 VMAT2 具有高亲和力，其Ki 为13.4 nM。Tetrabenazine Metabolite 常常被用于研究与亨廷顿氏病和其他多动障碍相关的舞蹈病。
T10814	Cinacalcet metabolite M4 3-三氟甲基苯丙胺,Rarechem AL BW 1078	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cinacalcet metabolite M4 (Rarechem AL BW 1078) 是 Cinacalcet 的代谢物。Cinacalcet 是具有活性的 Ca receptor 激动剂，可用于心血管疾病。
T5401	GSK2983559 active metabolite GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1	RIP kinase	Apoptosis; NF-κB
	GSK2983559 active metabolite (RIPK2-IN-1) 是一种受体相互作用蛋白-2 激酶抑制剂。
T12309	Omeprazole metabolite Omeprazole sulfone Omeprazole sulphone,Omeprazole sulfone	Others; Proton pump	Membrane transporter/Ion channel; Others
	Omeprazole sulfone 是Omeprazole的代谢物，能够抑制质子泵。
T37181	Avanafil metabolite M4 Avanafil metabolite M4	Others	Others
	Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16 , as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil.
T36662	Imidafenacin Metabolite M4 Imidafenacin Metabolite M4	Others	Others
	Imidafenacin metabolite M4 is a metabolite of the muscarinic acetylcholine receptor antagonist imidafenacin.1It is formed from imidafenacin by the cytochrome P450 (CYP) isoform CYP3A4. 1.Kanayama, N., Kanari, C., Masuda, Y., et al.Drug-drug interactions in the metabolism of imidafenacin: Role of the human cytochrome P450 enzymes and UDP-glucuronic acid transferases, and potential of imidafenacin to inhibit human cytochrome P450 enzymesXenobiotica37(2)139-154(2007)
T36661	Iloperidone metabolite P95 Iloperidone metabolite P95	Others	Others
	Iloperidone metabolite P95 is a metabolite of the atypical antipsychotic iloperidone . It binds to the serotonin (5-HT) receptor subtype 5-HT2A and α1-, α2B-, and α2C-adrenergic receptors with mean Ki values of 7.08, 21.38, 83.18, and 47.86 nM, respectively, but does not cross the blood-brain barrier.
T11445	GNF179 (Metabolite) GNF179 Metabolite	Others	Others
	GNF179 Metabolite, the derivative of GNF179—an optimized 8,8-dimethyl IP analog—demonstrates significant potency (4.8 nM against the multidrug-resistant W2 strain) alongside in vitro metabolic stability and in vivo oral bioavailability.
T10220	LSN2839567 Abemaciclib metabolite M2	CDK	Cell Cycle/Checkpoint
	LSN2839567 (Abemaciclib metabolite M2) 是 Abemaciclib 的活性代谢物，是一种强效的 CDK4 和 CDK6 抑制剂（IC50s：1-3 nM），具有抗癌活性。LSN2839567 抑制 CDK9。LSN2839567 以浓度依赖性方式抑制细胞生长和细胞周期进程，可用于研究乳腺癌和肺癌。
T12229	Niraparib metabolite M1 尼拉帕尼代谢物,M1 metabolite of niraparib,Niraparib carboxylic acid metabolite M1	Others	Others
	Niraparib metabolite M1 is niraparib metabolite, niraparib is a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.
T20723	LGE-899 Sonidegib metabolite M48,LGE 899	Drug Metabolite	Metabolism
	LGE-899 (Sonidegib metabolite M48) 是 Sonidegib 的主要代谢物，是一种刺猬通路抑制剂。 LGE-899 (60 h) 的 Tmax 比 Sonidegib 长得多。
T37638	Tofacitinib metabolite-1	Others	Others
	Tofacitinib metabolite-1, a derivative of Tofacitinib, which is a JAK inhibitor, is employed in studies focused on the pharmacokinetics and metabolism of tofacitinib[1][2].
T68375	KD026-metabolite	Others	Others
	KD026-metabolite, is a metabolite of KD-026. KD026, also known as SLx-4090, is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes.
T37180	Avanafil metabolite M16	Others	Others
	Avanafil metabolite M16 is a major inactive metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil . Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M16 and avanafil metabolite M4 , as well as minor metabolites.
T11893L	Lurasidone metabolite 14326 hydrochloride Lurasidone metabolite 14326 hydrochloride (186204-33-1 free base)	Others	Others
	Lurasidone metabolite 14326 hydrochloride, an active metabolite of the atypical antipsychotic Lurasidone, maintains its significant function in pharmacological efficacy.
T39345	Lopinavir Metabolite M-1	Others	Others
	Lopinavir Metabolite M-1, an active metabolite derived from Lopinavir, effectively inhibits the HIV protease enzyme with a Ki value of 0.7 pM. Additionally, in vitro studies have revealed notable antiviral properties associated with Lopinavir Metabolite M-1.
T70178	Sonidegib metabolite M25	Others	Others
	Sonidegib metabolite M25 is a smoothened (SMO) antagonist.
T2687	Omeprazole sulfide Omeprazole metabolite Omeprazole sulfide,Ufiprazole,奥美拉唑硫醚	Proton pump; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	Omeprazole sulfide (Ufiprazole) 是 Omeprazole 的代谢物。
T12735	Ritonavir metabolite Desthiazolylmethyloxycarbonyl Ritonavir,利托那韦代谢物	Others	Others
	Ritonavir metabolite is a Ritonavir metabolite, which is a inhibitor of HIV protease.
T11893	Lurasidone metabolite 14326	Others	Others
	Lurasidone metabolite 14326, an active metabolite of the atypical antipsychotic Lurasidone, functions effectively in the body.
T37645	Dasatinib metabolite M6 达沙替尼羧酸	Others	Others
	Dasatinib metabolite M6 (Dasatinib carboxylic acid) is an oxidative metabolite of Dasatinib, a potent and orally active inhibitor of both Bcr-Abl and Src family tyrosine kinases[1].
T35815	Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)	Others	Others
	Vildagliptin carboxylic acid metabolite is the major metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor vildagliptin in humans. Vildagliptin carboxylic acid metabolite has an IC50 value of 477 μM for DPP-4 in human Caco-2 cells. It is formed from hydrolysis of the cyano group on vildagliptin.
T23950	Dacomitinib metabolite M2 Dacomitinib cysteine conjugate,UNII-SOA52D3NLL	Others	Others
	Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.
T12689	Ramelteon metabolite M-II	Others	Others
	Ramelteon metabolite M-II is the major Ramelteon metabolite(human melatonin receptors (MT1 or MT2) with IC50s of 208 pM, 1470 pM). Ramelteon is an agonist of selective melatonin.
T10358L	AR-13324 M1 metabolite	Others	Others
	AR-13324 M1 metabolite is a hydrolysis metabolite of AR-13324 mesylate.
T33659	Nicardipine pyridine metabolite II	Others	Others
	Nicardipine pyridine metabolite II is a biaoctive chemical.
T11641	N-Desmethyl imatinib Imatinib metabolite N-Desmethyl imatinib,Norimatinib,N-去甲基伊马替尼	Bcr-Abl; PDGFR; c-Kit; Drug Metabolite	Angiogenesis; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors
	N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) 是 Imatinib 的代谢物。Imatinib 是一个靶向 c-Kit、v-Abl 和 PDGFR 的多靶点抑制剂。
T71932	MAM2201 N-pentanoic acid metabolite	Others	Others
	MAM2201 N-pentanoic acid metabolite is a potential phase 1 metabolite of MAM2201 -- a cannabinoid receptor agonist.
T13525	Abiraterone metabolite 1 3β-OH-5α-Abi	Others	Others
	Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone. Abiraterone inhibits CYP17A1, blocks androgen synthesis, and prolongs survival in prostate cancer.
T13760	Lurasidone Metabolite 14283 hydrochloride	Others	Others
	Lurasidone Metabolite 14283 hydrochloride is a major active metabolite of Lurasidone.
T12211	Netupitant metabolite Monohydroxy Netupitant Monohydroxy Netupitant	Others	Others
	Monohydroxy Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.
T12213	Netupitant metabolite Netupitant N-oxide Netupitant N-oxide	Others	Others
	Netupitant N-oxide is a highly selective antagonist of NK1 receptor, is Netupitant metabolite.
T12212	Netupitant metabolite N-desmethyl Netupitant N-desmethyl Netupitant	Others	Others
	N-desmethyl Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite.
T11637	Iloperidone metabolite Hydroxy Iloperidone P88,伊潘立酮代谢物,Hydroxy Iloperidone	Others	Others
	Iloperidone metabolite Hydroxy Iloperidone is an atypical antipsychotic. It is a metabolite of Iloperidone.
T10686	Carvedilol metabolite 4-Hydroxyphenyl Carvedilol 4-Hydroxyphenyl Carvedilol,4-Hydroxycarvedilol	Others	Others
	4-Hydroxyphenyl Carvedilol is a metabolite of Carvedilol. Carvedilol is a beta-blocker/alpha-1 blocker.
T11114	Duloxetine metabolite Para-Naphthol Duloxetine 度洛西汀代谢物,Para-Naphthol duloxetine	Others	Others
	Para-Naphthol Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI),is a metabolite of Duloxetine.
T73909	Abemaciclib metabolite M18 LSN3106729	Ligands for Target Protein for PROTAC	PROTAC
	Abemaciclibmetabolite M18 (LSN3106729) 是一种CDK抑制剂，具有抗肿瘤活性。作为Abemaciclib的代谢物，Abemaciclibmetabolite M18 能与CRBN配体结合，用于设计PROTAC CDK4/6降解剂。
T19175	Acetaminophen metabolite 3-hydroxy-acetaminophen 对乙酰氨基酚代谢物,3-Hydroxyacetaminophen	Others	Others
	3-hydroxy-acetaminophen is a metabolite of Acetaminophen. Acetaminophen is a pain medicine.
T83676	Tianeptine Metabolite MC5 sodium
	Tianeptine metabolite MC5是一种来自非典型抗抑郁化合物tianeptine的活性代谢物，通过β-氧化形成。此代谢物在使用表达人类μ-阿片受体（MOR）而非人类δ-阿片受体（DOR；EC50s = 0.454和 >100 µM, 分别）的HEK293T细胞进行的生物发光共振能量转移(BRET)试验中，特异性诱导G蛋白激活。在野生型小鼠上，30 mg/kg剂量的Tianeptine metabolite MC5可减少强迫游泳测试中的静止时间，但在MOR敲除小鼠中则不会，表明其具有MOR依赖的抗抑郁样活性。
T19667	R-138727 Prasugrel active metabolite	Others	Others
	R-138727 is a novel P2Y12 receptor inhibitor.
T84724	γ-CEHC γ-Tocopherol Metabolite	Others	Others
	γ-CEHC, a metabolite of γ-tocopherol, is predominantly excreted through urine, primarily in its conjugated form as glucuronide [1], rather than through bile.
T84618	tetranor-PGFM tetranor-Prostaglandin F Metabolite	Others	Others
	Tetranor-PGFM, the principal urinary metabolite of PGF2α, is excreted at rates of 7-13 µg per day in healthy females and 11-59 µg per 24 hours in healthy males. During pregnancy, female urinary levels of tetranor-PGFM increase 2 to 5-fold, returning to normal shortly after childbirth.
T32000	GSK-1071306 Pazopanib metabolite M27	Others	Others
	GSK-1071306 is a bio-active chemical.
T32828	LNC-119 Sonidegib metabolite M16,LNC119	Others	Others
	LNC-119 is an aminosteroid.
T30191	Atecegatran metabolite of AZD0837,atecegatran metoxil	Others	Others
	Atecegatran 常被当作一种抗凝血剂属于，可用来治疗心血管疾病。
T30302	BAY-751098 UNII-58I22S7HYD,Regorafenib metabolite M4;UNII-58I22S7HYD,Regorafenib metabolite M4,BAY751098	Others	Others
	BAY-751098 is a bio-active chemical.
T11987	Mebeverine alcohol Mebeverine metabolite Mebeverine alcohol	Others	Others
	Mebeverine alcohol is a metabolite of Mebeverine.

化合物

Ticagrelor metabolite M5

Cat.No: T21059

Synonym: Ticagrelor metabolite M5,,T437700,替格瑞洛杂质H,AR-C133913XX

Target: P2Y Receptor

Methotrexate metabolite

Cat.No: T16045

Synonym: DAMPA,甲喋呤杂质E

Target: Antifolate, Drug Metabolite

Abemaciclib metabolite M20

Cat.No: T10738

Synonym: CDK4/6-IN-4,LSN3106726

Target: CDK

Tetrabenazine Metabolite

Cat.No: T13133

Synonym: (-)-β-Dihydrotetrabenazine,(-)-β-HTBZ

Target: Monoamine Transporter

Cinacalcet metabolite M4

Cat.No: T10814

Synonym: 3-三氟甲基苯丙胺,Rarechem AL BW 1078

Target: Calcium Channel

GSK2983559 active metabolite

Cat.No: T5401

Synonym: GSK2983559,RIPK2 inhibitor 1,RIPK2-IN-1

Target: RIP kinase

Omeprazole metabolite Omeprazole sulfone

Cat.No: T12309

Synonym: Omeprazole sulphone,Omeprazole sulfone

Target: Others, Proton pump

Avanafil metabolite M4

Cat.No: T37181

Synonym: Avanafil metabolite M4

Target: Others

Imidafenacin Metabolite M4

Cat.No: T36662

Synonym: Imidafenacin Metabolite M4

Target: Others

Iloperidone metabolite P95

Cat.No: T36661

Synonym: Iloperidone metabolite P95

Target: Others

GNF179 (Metabolite)

Cat.No: T11445

Synonym: GNF179 Metabolite

Target: Others

Cat.No: T10220

Synonym: Abemaciclib metabolite M2

Target: CDK

Niraparib metabolite M1

Cat.No: T12229

Synonym: 尼拉帕尼代谢物,M1 metabolite of niraparib,Niraparib carboxylic acid metabolite M1

Target: Others

Cat.No: T20723

Synonym: Sonidegib metabolite M48,LGE 899

Target: Drug Metabolite

Tofacitinib metabolite-1

Cat.No: T37638

Target: Others

KD026-metabolite

Cat.No: T68375

Target: Others

Avanafil metabolite M16

Cat.No: T37180

Target: Others

Lurasidone metabolite 14326 hydrochloride

Cat.No: T11893L

Synonym: Lurasidone metabolite 14326 hydrochloride (186204-33-1 free base)

Target: Others

Lopinavir Metabolite M-1

Cat.No: T39345

Target: Others

Sonidegib metabolite M25

Cat.No: T70178

Target: Others

Omeprazole sulfide

Cat.No: T2687

Synonym: Omeprazole metabolite Omeprazole sulfide,Ufiprazole,奥美拉唑硫醚

Target: Proton pump, Drug Metabolite

Ritonavir metabolite

Cat.No: T12735

Synonym: Desthiazolylmethyloxycarbonyl Ritonavir,利托那韦代谢物

Target: Others

Lurasidone metabolite 14326

Cat.No: T11893

Target: Others

Dasatinib metabolite M6

Cat.No: T37645

Synonym: 达沙替尼羧酸

Target: Others

Vildagliptin carboxylic acid metabolite (trifluoroacetate salt)

Cat.No: T35815

Target: Others

Dacomitinib metabolite M2

Cat.No: T23950

Synonym: Dacomitinib cysteine conjugate,UNII-SOA52D3NLL

Target: Others

Ramelteon metabolite M-II

Cat.No: T12689

Target: Others

AR-13324 M1 metabolite

Cat.No: T10358L

Target: Others

Nicardipine pyridine metabolite II

Cat.No: T33659

Target: Others

N-Desmethyl imatinib

Cat.No: T11641

Synonym: Imatinib metabolite N-Desmethyl imatinib,Norimatinib,N-去甲基伊马替尼

Target: Bcr-Abl, PDGFR, c-Kit, Drug Metabolite

MAM2201 N-pentanoic acid metabolite

Cat.No: T71932

Target: Others

Abiraterone metabolite 1

Cat.No: T13525

Synonym: 3β-OH-5α-Abi

Target: Others

Lurasidone Metabolite 14283 hydrochloride

Cat.No: T13760

Target: Others

Netupitant metabolite Monohydroxy Netupitant

Cat.No: T12211

Synonym: Monohydroxy Netupitant

Target: Others

Netupitant metabolite Netupitant N-oxide

Cat.No: T12213

Synonym: Netupitant N-oxide

Target: Others

Netupitant metabolite N-desmethyl Netupitant

Cat.No: T12212

Synonym: N-desmethyl Netupitant

Target: Others

Iloperidone metabolite Hydroxy Iloperidone

Cat.No: T11637

Synonym: P88,伊潘立酮代谢物,Hydroxy Iloperidone

Target: Others

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

Cat.No: T10686

Synonym: 4-Hydroxyphenyl Carvedilol,4-Hydroxycarvedilol

Target: Others

Duloxetine metabolite Para-Naphthol Duloxetine

Cat.No: T11114

Synonym: 度洛西汀代谢物,Para-Naphthol duloxetine

Target: Others

Abemaciclib metabolite M18

Cat.No: T73909

Synonym: LSN3106729

Target: Ligands for Target Protein for PROTAC

Acetaminophen metabolite 3-hydroxy-acetaminophen

Cat.No: T19175

Synonym: 对乙酰氨基酚代谢物,3-Hydroxyacetaminophen

Target: Others

Tianeptine Metabolite MC5 sodium

Cat.No: T83676

Cat.No: T19667

Synonym: Prasugrel active metabolite

Target: Others

Cat.No: T84724

Synonym: γ-Tocopherol Metabolite

Target: Others

Cat.No: T84618

Synonym: tetranor-Prostaglandin F Metabolite

Target: Others

Cat.No: T32000

Synonym: Pazopanib metabolite M27

Target: Others

Cat.No: T32828

Synonym: Sonidegib metabolite M16,LNC119

Target: Others

Cat.No: T30191

Synonym: metabolite of AZD0837,atecegatran metoxil

Target: Others

Cat.No: T30302

Synonym: UNII-58I22S7HYD,Regorafenib metabolite M4;UNII-58I22S7HYD,Regorafenib metabolite M4,BAY751098

Target: Others

Mebeverine alcohol

Cat.No: T11987

Synonym: Mebeverine metabolite Mebeverine alcohol

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T16338	Norgestimate metabolite Norelgestromin 17-Deacetyl norgestimate,17-Deacylnorgestimate,甲基孕酮	Drug Metabolite	Metabolism
	Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) 是norgestimate 的一种活性代谢物。它是用于避孕贴片的甾体孕激素，与雌激素乙炔雌二醇结合使用。
Fr13756	Isonicotinic acid	Endogenous Metabolite; Drug Metabolite	Metabolism
	Isonicotinic acid 是 Isoniazid 的代谢产物。Isoniazid 通过肼解转化为 Isonicotinic acid。 Isoniazid 向 Isonicotinic acid 的生物转化可以通过细胞色素 P450 酶催化。
T10815	Cinnamoylglycine	Endogenous Metabolite	Metabolism
	Cinnamoylglycine 是肉桂酸和的甘氨酸结合物，是人体尿液代谢物。它被用作的尿液标志物，能够作为在抗生素研究期之后定殖耐药性的标志物。
T13539	Allopurinol riboside	Others; Endogenous Metabolite; Parasite; Drug Metabolite	Metabolism; Microbiology/Virology; Others
	Allopurinol riboside 是别嘌醇的代谢产物，具有抗寄生虫作用。 Allopurinol riboside 竞争性抑制嘌呤核苷磷酸化酶对肌苷的作用，Ki 为 277 μM。
T12287	Octadecanedioic acid	Endogenous Metabolite	Metabolism
	Octadecanedioic acid 是内源性代谢物的一种，是一种长链二羧酸，曾在雷氏综合征的血清游离脂肪酸中被发现。
T10021	1-Methylxanthine	Endogenous Metabolite	Metabolism
	1-Methylxanthine 是咖啡因衍生物，是咖啡因和茶碱 (1,3-二甲基黄嘌呤，TP) 在人体尿代谢产物，能够提高肿瘤细胞的放射敏感性。
T8153	glycohyodeoxycholic acid	Others; Endogenous Metabolite	Metabolism; Others
	Glycohyodeoxycholic acid 是一种人体次级胆汁酸猪去氧胆酸的主要代谢物，能够预防胆结石的形成。
T13719	Hexadecanal Palmitaldehyde,十六醛	Endogenous Metabolite	Metabolism
	Hexadecanal (Palmitaldehyde) 是存在于动物体内的游离脂肪醛。
T0647	Tryptamine	Dehydrogenase; 5-HT Receptor; Endogenous Metabolite; TRP/TRPV Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Tryptamine 是一种在动物、植物和真菌中发现的单胺生物碱。它含有吲哚环结构，结构类似于色氨酸。在哺乳动物的大脑中发现了微量这种物质，并被认为是一种神经递质或神经调节剂。
T0069	Uracil	Others; Endogenous Metabolite	Metabolism; Others
	Uracil 是普遍存在的天然嘧啶衍生物，是 RNA 核酸中的四个碱基之一。
T8165	Erythrodiol	Endogenous Metabolite; ABC	Membrane transporter/Ion channel; Metabolism
	Erythrodiol 是一种橄榄油的成分，能够选择性抑制ABCA1蛋白的降解来促进胆固醇外流，有用于动脉粥样硬化的研究潜力。
TN1740	Homoeriodictyol 高胜草酚,高圣草酚	5-HT Receptor; transporter; Sodium Channel; Drug Metabolite	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Homoeriodictyol 是 Eriocitrin 的代谢物，属于黄酮类。Eriocitrin 是强效抗氧化剂。
T0586	Lactose	Others; Endogenous Metabolite	Metabolism; Others
	Lactose 是半乳糖和葡萄糖衍生的二糖，是大多数物种乳汁中的主要糖分，能够调节人类肠道的微生物菌群。
TN1490	Chrysoeriol	ERK; p38 MAPK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Chrysoeriol 是一种天然黄酮，可从热带植物Coronopus didymus 中提取获得，具有强大的抗氧化功能，能够抑制脂质的过氧化。
T8272	Trierucin	Others; Endogenous Metabolite	Metabolism; Others
	Trierucin 是一种从种子油中提取的三芥酸甘油三酯。
T20446	Creosol	Endogenous Metabolite	Metabolism
	Creosol 是内源性代谢产物的一种。
T4799	Indole	Others; Endogenous Metabolite	Metabolism; Others
	Indole 它具有双环结构，由一个六元苯环和一个五元含氮吡咯环融合而成。它可以由细菌作为氨基酸色氨酸的降解产物产生。它自然存在于人类粪便中，有强烈的粪便气味。然而，在非常低的浓度下，它有一种花香，是许多花香(如橙花)和香水的成分。
T15720	Lathosterol	Endogenous Metabolite	Metabolism
	Lathosterol 是胆固醇样分子，其血清浓度是全身胆固醇合成的指标。
T19792	1,3,7-Trimethyluric acid	Others	Others
	1,3,7-Trimethyluric acid 是咖啡因的代谢产物。其与咖啡因的代谢比可以反映 CYP3A 活性的变化情况。
T4776	Glycerol Glycerin,甘油	Endogenous Metabolite	Metabolism
	Glycerol 是甘油三酯（即脂肪和油）和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。
T5352	GLYCODEOXYCHOLIC ACID	Others; Endogenous Metabolite	Metabolism; Others
	Glycodeoxycholic Acid 是内源性代谢产物的一种,是一种存在于黑链霉菌、布氏锥虫和隐单胞菌中的天然产物,可诱导阻塞性胆汁淤积症患者的肝细胞坏死和自噬。
TN6833	octanal	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	octanal 是一种具有抗氧化和抗菌活性的天然产物。
T37508	Meconin	Endogenous Metabolite	Metabolism
	Meconine 是一种人内源性代谢产物。
T8068	o-Toluic acid	Others	Others
	O-toluic acid 是一种在 2 号位被甲基取代的苯甲酸，可用作一种外源性的代谢物。
T2228	Adipic acid	Others; Endogenous Metabolite	Metabolism; Others
	Adipic acid 是一种生产尼龙的前体。它被发现与 HMG-CoA 裂解酶缺乏症，肉毒碱激酶缺乏症，中链酰基脱氢酶缺乏症相关，这些都是天生代谢异常导致的。
T2724	Caryophyllene oxide	Others; Endogenous Metabolite	Metabolism; Others
	Caryophyllene oxide 是一种天然产物，源自Annona squamosa L. bark. ，有缓解疼痛和抗炎特性。
T8086	Decyl aldehyde	Others; Endogenous Metabolite	Metabolism; Others
	Decyl aldehyde 是细菌荧光素酶底物，是十碳醛。
T5665	Geraniol	Others; Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology; Others
	Geraniol 对糖尿病引起的心脏功能障碍起保护作用，抑制氧化应激。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
T8049	Pentadecanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Pentadecanoic acid 是一个具有 15 个碳主链的饱和脂肪酸。
T5812	Zinc Phytate	Others	Others
	Zinc Phytate 存在于食物中，对人类吸收营养有重要意义。
T8031	Terephthalic acid	Others; Endogenous Metabolite	Metabolism; Others
	Terephthalic acid 是一种三种酞酸盐的异构体，是聚酯 PET 的前体，能够用于制作服装和塑料。
T5228	Nicotinuric acid	Others; Endogenous Metabolite	Metabolism; Others
	Nicotinuric acid 是一种酰基甘氨酸，通常是脂肪酸的次要代谢物。酰基甘氨酸是通过甘氨酸 N-酰基转移酶的作用产生的。
T4794	Glutaric acid	Endogenous Metabolite	Metabolism
	Glutaric acid 是一种 C5 二羧酸，是色氨酸和赖氨酸分解代谢途径中的中间体。Glutaric acid 影响周细胞的收缩性和迁移。Glutaric acid 是 I 型戊二酸尿症的生物指标。
T4809	Pyrimidine 嘧啶,Metadiazine	Others; Endogenous Metabolite	Metabolism; Others
	Pyrimidine (Metadiazine) 是内源性代谢产物的一种。
T12095	Monomethyl fumarate	GPR; Drug Metabolite	Endocrinology/Hormones; GPCR/G Protein; Metabolism
	Monomethyl fumarate 是 Dimethyl fumarate 的活性代谢产物。Monomethyl fumarate 是一种 GPR109A 激动剂。Monomethyl fumarate 是一种 GPR109A 激动剂具有用于多种神经保护途径和其他视网膜疾病模型的潜力。
TN6752	Dimethyl sulfone	Endogenous Metabolite	Metabolism
	Dimethyl sulfone 是内源性代谢产物的一种。
T13581	Biotin sulfone	Endogenous Metabolite	Metabolism
	Biotin sulfone 是一个被分离的天然生物素代谢物。
T36790	(Ethoxymethyl)benzene	Endogenous Metabolite	Metabolism
	(Ethoxymethyl)benzene 是一种人内源性代谢产物。
T37501	Ethoxyacetic acid	Endogenous Metabolite	Metabolism
	Ethoxyacetic acid 是一种人内源性代谢产物。
T5565	Undecanedioic acid	Others; Endogenous Metabolite	Metabolism; Others
	Undecanedioic acid 是存在于人体主动脉的部分区域中，其中晚期动脉粥样硬化病变与细胞间基质大分子相关，特别是与弹性蛋白相关。
T19418	Methionine sulfoxide	Endogenous Metabolite	Metabolism
	Methionine sulfoxide 是具有特性氧的甲硫氨酸的氧化产物，能够用作体内氧化应激的生物标记。
T7331	Ursocholic acid	Endogenous Metabolite	Metabolism
	Ursocholic acid 是存在于哺乳动物胆汁中的胆酸，通过小鼠肠道菌群转化为脱氧胆酸。脱氧胆酸是7α-羟化类固醇脱氢酶和肝细胞核因子1α的抑制剂。
T5985	Glycolic acid	Tyrosinase; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Glycolic acid 是一种酪氨酸酶抑制剂，可以抑制黑色素的形成，从而减淡皮肤的颜色。
TQ0284	Hydroxyphenyllactic acid	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	Hydroxyphenyllactic acid 是具有抗真菌活性的代谢物。
T7602	Theaflavin	Influenza Virus; Endogenous Metabolite	Metabolism; Microbiology/Virology
	Theaflavin 是在红茶中发现的一种多酚类黄酮，具有如抗氧化、抗癌、抗炎和抗病毒多种生物活性。
T8034	Dimethyl Trisulfide	Others; Endogenous Metabolite	Metabolism; Others
	Dimethyl trisulfide 是存在于大蒜，洋葱，西兰花和类似植物中的有机三硫化物。它是一种氰化物解毒剂。
T5074	Cholesteryl palmitate	Others; Endogenous Metabolite	Metabolism; Others
	Cholesteryl palmitate 是一种慢性间质性肺炎的有用预后生物标志物。
T5737	euphol	Others; Lipase; Endogenous Metabolite	Metabolism; Others
	Euphol 是从Euphorbia tirucalli 的汁液中分离出来的四环三萜醇，具有抗炎和免疫调节作用，口服具有活力。它通过能够逆机制抑制单酰基甘油脂肪酶 (MGL) 的特性，IC50=315 nM。外周 MGL 抑制能够调节内源性大麻素系统从而阻止炎症性疼痛的发展。
T4761	Pyridoxal hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Pyridoxal hydrochloride 是内源性代谢产物的一种。
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天然产物

Norgestimate metabolite Norelgestromin

Cat.No: T16338

Synonym: 17-Deacetyl norgestimate,17-Deacylnorgestimate,甲基孕酮

Target: Drug Metabolite

Isonicotinic acid

Cat.No: Fr13756

Target: Endogenous Metabolite, Drug Metabolite

Cinnamoylglycine

Cat.No: T10815

Target: Endogenous Metabolite

Allopurinol riboside

Cat.No: T13539

Target: Others, Endogenous Metabolite, Parasite, Drug Metabolite

Octadecanedioic acid

Cat.No: T12287

Target: Endogenous Metabolite

1-Methylxanthine

Cat.No: T10021

Target: Endogenous Metabolite

glycohyodeoxycholic acid

Cat.No: T8153

Target: Others, Endogenous Metabolite

Cat.No: T13719

Synonym: Palmitaldehyde,十六醛

Target: Endogenous Metabolite

Cat.No: T0647

Target: Dehydrogenase, 5-HT Receptor, Endogenous Metabolite, TRP/TRPV Channel

Cat.No: T0069

Target: Others, Endogenous Metabolite

Cat.No: T8165

Target: Endogenous Metabolite, ABC

Homoeriodictyol

Cat.No: TN1740

Synonym: 高胜草酚,高圣草酚

Target: 5-HT Receptor, transporter, Sodium Channel, Drug Metabolite

Cat.No: T0586

Target: Others, Endogenous Metabolite

Cat.No: TN1490

Target: ERK, p38 MAPK, Akt

Cat.No: T8272

Target: Others, Endogenous Metabolite

Cat.No: T20446

Target: Endogenous Metabolite

Cat.No: T4799

Target: Others, Endogenous Metabolite

Cat.No: T15720

Target: Endogenous Metabolite

1,3,7-Trimethyluric acid

Cat.No: T19792

Target: Others

Cat.No: T4776

Synonym: Glycerin,甘油

Target: Endogenous Metabolite

GLYCODEOXYCHOLIC ACID

Cat.No: T5352

Target: Others, Endogenous Metabolite

Cat.No: TN6833

Target: Endogenous Metabolite, Antibacterial

Cat.No: T37508

Target: Endogenous Metabolite

Cat.No: T8068

Target: Others

Cat.No: T2228

Target: Others, Endogenous Metabolite

Caryophyllene oxide

Cat.No: T2724

Target: Others, Endogenous Metabolite

Cat.No: T8086

Target: Others, Endogenous Metabolite

Cat.No: T5665

Target: Others, Endogenous Metabolite, Antifungal

Cat.No: T37298

Target: Endogenous Metabolite

Pentadecanoic acid

Cat.No: T8049

Target: Others, Endogenous Metabolite

Cat.No: T5812

Target: Others

Terephthalic acid

Cat.No: T8031

Target: Others, Endogenous Metabolite

Nicotinuric acid

Cat.No: T5228

Target: Others, Endogenous Metabolite

Cat.No: T4794

Target: Endogenous Metabolite

Cat.No: T4809

Synonym: 嘧啶,Metadiazine

Target: Others, Endogenous Metabolite

Monomethyl fumarate

Cat.No: T12095

Target: GPR, Drug Metabolite

Dimethyl sulfone

Cat.No: TN6752

Target: Endogenous Metabolite

Cat.No: T13581

Target: Endogenous Metabolite

(Ethoxymethyl)benzene

Cat.No: T36790

Target: Endogenous Metabolite

Ethoxyacetic acid

Cat.No: T37501

Target: Endogenous Metabolite

Undecanedioic acid

Cat.No: T5565

Target: Others, Endogenous Metabolite

Methionine sulfoxide

Cat.No: T19418

Target: Endogenous Metabolite

Ursocholic acid

Cat.No: T7331

Target: Endogenous Metabolite

Cat.No: T5985

Target: Tyrosinase, Endogenous Metabolite

Hydroxyphenyllactic acid

Cat.No: TQ0284

Target: Endogenous Metabolite, Antifungal

Cat.No: T7602

Target: Influenza Virus, Endogenous Metabolite

Dimethyl Trisulfide

Cat.No: T8034

Target: Others, Endogenous Metabolite

Cholesteryl palmitate

Cat.No: T5074

Target: Others, Endogenous Metabolite

Cat.No: T5737

Target: Others, Lipase, Endogenous Metabolite

Pyridoxal hydrochloride

Cat.No: T4761

Target: Others, Endogenous Metabolite

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00844	HSD11B2 Protein, Human, Recombinant (His) HSD11B2,11-beta-hydroxysteroid dehydrogenase type 2,Short ch...	Human	P. pastoris (Yeast)
	Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. HSD11B2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession number is P80365.
TMPY-03414	ABHD10 Protein, Human, Recombinant (aa 53-306, His) ABHD10,abhydrolase domain containing 10	Human	Baculovirus Insect Cells
	Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is primarily metabolized by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AcMPAG). It is known that AcMPAG, which may be an immunotoxic metabolite, is deglucuronidated in human liver. AcMPAG deglucuronidation activity was detected in both human liver cytosol (HLC) and microsomes (HLM). By purification from HLC with column chromatographic purification steps, the en...
TMPH-00843	HSD11B1 Protein, Human, Recombinant (His & SUMO) 7-oxosteroid reductase,11-beta-hydroxysteroid dehydrogenase ...	Human	E. coli
	Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol. HSD11B1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P28845.
TMPY-00320	APOA1BP Protein, Human, Recombinant (His) YJEFN1,apolipoprotein A-I binding protein,AIBP	Human	HEK293 Cells
	APOA1BP, now renamed NAXE, encodes an epimerase essential in the cellular metabolite repair for NADHX and NADPHX. The enzyme catalyzes the epimerization of NAD(P)HX, thereby avoiding the accumulation of toxic metabolites.Pathogenic biallelic mutations in NAXE in children from four families with (sub-) acute-onset ataxia, cerebellar edema, spinal myelopathy, and skin lesions.
TMPH-02615	CBS Protein, Mouse, Recombinant (His) Cystathionine beta-synthase,Serine sulfhydrase,Beta-thionase...	Mouse	E. coli
	Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
TMPH-01597	KYAT1 Protein, Human, Recombinant (His & SUMO) Kynurenine aminotransferase 1,KYAT1,Glutamine--phenylpyruvat...	Human	E. coli
	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cl...
TMPY-02420	HEMK2 Protein, Human, Recombinant (His) N-6 adenine-specific DNA methyltransferase 1 (putative),HEMK...	Human	E. coli
	N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to the eukaryotic/archaeal PrmC-related family. The encoded enzyme may be involved in the methylation of release factor I during translation termination. N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity because of its specific activi...

重组蛋白

HSD11B2 Protein, Human, Recombinant (His)

Cat.No: TMPH-00844

Species: Human

Expression System: P. pastoris (Yeast)

ABHD10 Protein, Human, Recombinant (aa 53-306, His)

Cat.No: TMPY-03414

Species: Human

Expression System: Baculovirus Insect Cells

HSD11B1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-00843

Species: Human

Expression System: E. coli

APOA1BP Protein, Human, Recombinant (His)

Cat.No: TMPY-00320

Species: Human

Expression System: HEK293 Cells

CBS Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02615

Species: Mouse

Expression System: E. coli

KYAT1 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01597

Species: Human

Expression System: E. coli

HEMK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02420

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T23983	Deutetrabenazine metabolite M4 SD-1018,Deuterated monohydroxy tetrabenazine,D6-tetrabenazine metabolite M4
	Deutetrabenazine metabolite M4 is believed to be related to its effect as a reversible depletion of monoamines from nerve terminals. The major circulating metabolites of Deutetrabenazine, are reversible inhibitors of VMAT2, resulting in decreased uptake
T19407	Lurasidone Metabolite 14326 D8	Others	Others
	Lurasidone Metabolite 14326 D8 is the deuterium labeled Lurasidone Metabolite 14326.
T19406	Lurasidone Metabolite 14283 D8	Others	Others
	Lurasidone Metabolite 14283 D8 is the deuterium labeled Lurasidone Metabolite 14283.
TMIH-0519	Selexipag Active Metabolite-d7
	Selexipag Active Metabolite-d7 是 Selexipag Active Metabolite 的氘代化合物。Selexipag Active Metabolite 的 CAS 号为 475085-57-5。MRE269 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。
TMIH-0067	Acalabrutinib Metabolite 27-d4
	Acalabrutinib Metabolite 27-d4 是 Acalabrutinib Metabolite 27 的氘代化合物。
TMIH-0316	Lurasidone Inactive Metabolite 14326-d8 5β/6β-Hydroxy Lurasidone-d8 Hydrochloride (Mixture of Diastereomers)
	Lurasidone Inactive Metabolite 14326-d8 是 Lurasidone Inactive Metabolite 14326 的氘代化合物。Lurasidone Inactive Metabolite 14326 的 CAS 号为 186204-33-1。
TMIH-0155	Prasugrel Metabolite Derivative-13C-d3 Mixture of Diastereomers-13C-d3
	Prasugrel Metabolite Derivative-13C-d3 是 Prasugrel Metabolite Derivative 的 13C 和氘代化合物。
TMIH-0315	Lurasidone Inactive Metabolite 14283-d8 5α/6α-Hydroxy Lurasidone-d8 Hydrochloride (Mixture of Diastereomers)
	Lurasidone Inactive Metabolite 14283-d8 是 Lurasidone Inactive Metabolite 14283 的氘代化合物。Lurasidone Inactive Metabolite 14283 的 CAS 号为 186204-31-9。
TMIH-0198	DM-3411-d8 Brexpiprazole Metabolite
	DM-3411-d8 是 DM-3411 的氘代化合物。DM-3411 的 CAS 号为 913611-97-9。Brexpiprazole是人5-HT1A和多巴胺受体的部分激动剂，Ki分别为0.12 和 0.3 nM。它也是5-HT2A受体的拮抗剂，Ki为 0.47 nM，可作为非典型抗精神病药。
TMIH-0023	1-[3-carboxypropyl]-3,7-dimethylxanthine-d6 pentoxyfylline metabolite 1-d6
	1-[3-carboxypropyl]-3,7-dimethylxanthine-d6 是 1-[3-carboxypropyl]-3,7-dimethylxanthine 的氘代化合物。
TMIH-0021	1-(5-hydroxyhexyl)-3,7-dimethylxanthine-d6 pentoxyfylline metabolite 2-d6
	1-(5-hydroxyhexyl)-3,7-dimethylxanthine-d6 是 1-(5-hydroxyhexyl)-3,7-dimethylxanthine 的氘代化合物。
T12571	PSI-6206 13C,d3 Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3	Others	Others
	PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor.
T19451	N-Desmethyl imatinib-d8 Norimatinib D8,Imatinib metabolite N-Desmethyl imatinib D8,N-Desmethyl imatinib D8	Others	Others
	N-Desmethyl imatinib D8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
T9087	Creatine-d3 hydrate CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物	Endogenous Metabolite	Metabolism
	Creatine-d3 hydrate (CREATINE-(METHYL-D3) MONOHYDRATE) 是一种氘标记的肌酸水合物。其中肌酸水合物在肌肉和脑细胞的能量代谢中起着关键作用。
T71142	Tebuconazole-d9
	Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per...
T40376	L-Phenylalanine-15N L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。
T19442	N-acetyl Dapsone (D4') MADDS D4'	Others	Others
	N-acetyl Dapsone (D4') is the deuterium-labeled metabolite of Dapsone.
T19275	Desbutyl Lumefantrine D9 Desbutyl-benflumetol D9	Others	Others
	Desbutyl Lumefantrine D9, a deuterium-labeled metabolite of Lumefantrine, exhibits the incorporation of deuterium atoms.
T19441	N-acetyl Dapsone D4 MADDS D4	Others	Others
	N-Acetyl Dapsone D4 is a deuterium-labeled metabolite of N-Acetyl Dapsone, derived from Dapsone.
T12445	Phenolic acid	Others	Others
	Phenolic acid is an endogenous metabolite.
T12144	N-Desethyl Oxybutynin-d5 hydrochloride N-Desethyl Oxybutynin D5 hydrochloride	Others	Others
	N-Desethyl Oxybutynin D5 hydrochloride is the the active metabolite Oxybutynin, is deuterium labeled N-Desethyl Oxybutynin hydrochloride.
T19434	Monohydroxy Netupitant D6	Others	Others
	Monohydroxy Netupitant D6 is a metabolite of Netupitant.
T19452	N-desmethyl Netupitant D6	Others	Others
	N-desmethyl Netupitant D6 is the deuterium labeled N-desmethyl Netupitant, which is a Netupitant metabolite.
TMID-0140	2-Methoxyestrone-1,4,16,16-d4
	2-Methoxyestrone-1,4,16,16-d4 是 2-Methoxyestrone 的氘代化合物。2-Methoxyestrone 的 CAS 号为 362-08-3。2-Methoxyestrone 是甲氧基苯二酚雌激素，也是雌酮代谢物，其 pKa=10.81。
T19109	25-Hydroxy VD2-D6	Others	Others
	25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2.
T19273	Debutyldronedarone D7 SR-35021 D7	Others	Others
	Debutyldronedarone D7 is deuterium-labeled Debutyldronedarone, which is the main circulating active metabolite of dronedarone in the body.
T19162	7-Desmethyl-agomelatine D3	Others	Others
	7-Desmethyl-agomelatine D3 is a deuterium labeled 7-Desmethyl-agomelatine. 7-Desmethyl-agomelatine is a metabolite of Agomelatine.
T11036	Diacetolol D7	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Diacetolol D7 is deuterium-labeled diacetone Roller. Diacetol is the main metabolite of Acetolol. Diacetololβ-adrenoceptor shielding and anti-arrhythmic agent.
T19474	Netupitant N-oxide D6	Others	Others
	Netupitant N-oxide D6 is a Netupitant metabolite, is the deuterium labeled Netupitant N-oxide.
T11585	Hydroxy Itraconazole D8 R-63373 D8	Others	Others
	Hydroxy Itraconazole D8 is the deuterium-labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole, which is a triazole antifungal agent.
T31109	CTP-499
	CTP499, a selective PDE inhibitor, and the deuterium-containing agent is an HDX analogue and a metabolite of hexantheobromine that slows the progression of type 2 diabetic nephropathy in patients with macroalbuminuria.
T10663	Calcitriol-d6 Calcitriol D6,骨化三醇 D6	Others	Others
	Calcitriol D6 is the deuterated form of Calcitriol, which is the hormonally active form of vitamin D. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor.
T19447	N-Demethyl Ivabradine D6 Hydrochloride	Others	Others
	N-Demethyl Ivabradine D6 Hydrochloride salt is the deuterium labeled N-Demethyl Ivabradine, which is a Ivabradine metabolite.
TMIJ-0093	Keto Pioglitazone-d4
	Keto Pioglitazone-d4 是 Keto Pioglitazone 的氘代化合物。Keto Pioglitazone 的 CAS 号为 146062-45-5。
T19489	O-Desmethyl gefitinib D8	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma.
T19088	13-cis Acitretin D3 Isoacitretin D3,13-cis Acitretin D3	Others	Others
	13-cis Acitretin D3 (Isoacitretin D3) is a deuterium-labeled 13-cis Acitretin. 13-cis Acitretin is the metabolite of Acitretin after chronic administration. Acitretin is a second-generation, systemic retinoid.
T10149	4-Hydroxypropranolol-d7 hydrochloride (±)-4-hydroxy Propranolol D7 hydrochloride,4-Hydroxypropranolol D7 hydrochloride	Others	Others
	4-Hydroxypropranolol D7 hydrochloride is deuterium-labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors
T19311	Enzalutamide carboxylic acid D6 MDV3100 carboxylic acid D6	Others	Others
	Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide. Enzalutamide carboxylic acid D6 is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid).
T11817	Lansoprazole Sulfide D4	Proton pump	Membrane transporter/Ion channel
	Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole.
T10144	4-Hydroxyatomoxetine D3	Others	Others
	4-Hydroxyatomoxetine D3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.
TMID-0062	Ethyl-β-D-glucuronide-d5
	Ethyl-β-D-glucuronide-d5 是 Ethyl-β-D-glucuronide 的氘代化合物。Ethyl-β-D-glucuronide 的 CAS 号为 17685-04-0。
T10113	3-Hydroxy agomelatine D3	5-HT Receptor	GPCR/G Protein; Neuroscience
	3-Hydroxy agomelatine D3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is an Agomelatine metabolite and a 5-HT2C receptor antagonist (IC50: 3.2 μM; Ki: 1.8 μM).
TMIJ-0128	4’-Hydroxy Diclofenac-d4
	4’-Hydroxy Diclofenac-d4 是 4’-Hydroxy Diclofenac 的氘代化合物。4’-Hydroxy Diclofenac 的 CAS 号为 64118-84-9。
T19119	3-Hydroxy Midostaurin-D5 CGP52421-D5	Others	Others
	3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).
T10118	3-O-Methyltolcapone D7 Ro 40-7591 D7	Transferase	Metabolism
	3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of P
TMIJ-0008	3-Amino-2-Oxazolidinone-d4 Aoz-d4
	3-Amino-2-Oxazolidinone-d4 是 3-Amino-2-Oxazolidinone 的氘代化合物。3-Amino-2-Oxazolidinone 的 CAS 号为 80-65-9。3-Amino-2-oxazolidinone 是一种呋喃唑烷酮的代谢物 (metabolite)，可用作检测呋喃唑烷酮残留的一个指标。
T10351	Aprocitentan D4 ACT-132577 D4	Others	Others
	Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5).
TMID-0220	4’-Hydroxy Diclofenac-d4 (Major)
	4’-Hydroxy Diclofenac-d4 (Major) 是 4’-Hydroxy Diclofenac 的氘代化合物。4’-Hydroxy Diclofenac 的 CAS 号为 64118-84-9。
T10611	Brexpiprazole S-oxide D8 DM-3411 D8	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole. Brexpiprazole is a partial agonist of human 5-HT1A and dopamine receptors (Kis: 0.12 nM and 0.3 nM).
TMID-0039	Hydroxy Dimetridazole-d3
	Hydroxy Dimetridazole-d3 是 Hydroxy Dimetridazole 的氘代化合物。Hydroxy Dimetridazole 的 CAS 号为 936-05-0。Hydroxy Dimetridazole 是Dimetridazol的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物，可用于对抗原生动物感染。
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同位素标记化合物

Deutetrabenazine metabolite M4

Cat.No: T23983

Synonym: SD-1018,Deuterated monohydroxy tetrabenazine,D6-tetrabenazine metabolite M4

Lurasidone Metabolite 14326 D8

Cat.No: T19407

Target: Others

Lurasidone Metabolite 14283 D8

Cat.No: T19406

Target: Others

Selexipag Active Metabolite-d7

Cat.No: TMIH-0519

Acalabrutinib Metabolite 27-d4

Cat.No: TMIH-0067

Lurasidone Inactive Metabolite 14326-d8

Cat.No: TMIH-0316

Synonym: 5β/6β-Hydroxy Lurasidone-d8 Hydrochloride (Mixture of Diastereomers)

Prasugrel Metabolite Derivative-13C-d3

Cat.No: TMIH-0155

Synonym: Mixture of Diastereomers-13C-d3

Lurasidone Inactive Metabolite 14283-d8

Cat.No: TMIH-0315

Synonym: 5α/6α-Hydroxy Lurasidone-d8 Hydrochloride (Mixture of Diastereomers)

Cat.No: TMIH-0198

Synonym: Brexpiprazole Metabolite

1-[3-carboxypropyl]-3,7-dimethylxanthine-d6

Cat.No: TMIH-0023

Synonym: pentoxyfylline metabolite 1-d6

1-(5-hydroxyhexyl)-3,7-dimethylxanthine-d6

Cat.No: TMIH-0021

Synonym: pentoxyfylline metabolite 2-d6

PSI-6206 13C,d3

Cat.No: T12571

Synonym: Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3

Target: Others

N-Desmethyl imatinib-d8

Cat.No: T19451

Synonym: Norimatinib D8,Imatinib metabolite N-Desmethyl imatinib D8,N-Desmethyl imatinib D8

Target: Others

Creatine-d3 hydrate

Cat.No: T9087

Synonym: CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物

Target: Endogenous Metabolite

Tebuconazole-d9

Cat.No: T71142

L-Phenylalanine-15N

Cat.No: T40376

Synonym: L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N

Target: Calcium Channel

N-acetyl Dapsone (D4')

Cat.No: T19442

Synonym: MADDS D4'

Target: Others

Desbutyl Lumefantrine D9

Cat.No: T19275

Synonym: Desbutyl-benflumetol D9

Target: Others

N-acetyl Dapsone D4

Cat.No: T19441

Synonym: MADDS D4

Target: Others

Cat.No: T12445

Target: Others

N-Desethyl Oxybutynin-d5 hydrochloride

Cat.No: T12144

Synonym: N-Desethyl Oxybutynin D5 hydrochloride

Target: Others

Monohydroxy Netupitant D6

Cat.No: T19434

Target: Others

N-desmethyl Netupitant D6

Cat.No: T19452

Target: Others

2-Methoxyestrone-1,4,16,16-d4

Cat.No: TMID-0140

25-Hydroxy VD2-D6

Cat.No: T19109

Target: Others

Debutyldronedarone D7

Cat.No: T19273

Synonym: SR-35021 D7

Target: Others

7-Desmethyl-agomelatine D3

Cat.No: T19162

Target: Others

Cat.No: T11036

Target: Adrenergic Receptor

Netupitant N-oxide D6

Cat.No: T19474

Target: Others

Hydroxy Itraconazole D8

Cat.No: T11585

Synonym: R-63373 D8

Target: Others

Cat.No: T31109

Cat.No: T10663

Synonym: Calcitriol D6,骨化三醇 D6

Target: Others

N-Demethyl Ivabradine D6 Hydrochloride

Cat.No: T19447

Target: Others

Keto Pioglitazone-d4

Cat.No: TMIJ-0093

O-Desmethyl gefitinib D8

Cat.No: T19489

Target: EGFR

13-cis Acitretin D3

Cat.No: T19088

Synonym: Isoacitretin D3,13-cis Acitretin D3

Target: Others

4-Hydroxypropranolol-d7 hydrochloride

Cat.No: T10149

Synonym: (±)-4-hydroxy Propranolol D7 hydrochloride,4-Hydroxypropranolol D7 hydrochloride

Target: Others

Enzalutamide carboxylic acid D6

Cat.No: T19311

Synonym: MDV3100 carboxylic acid D6

Target: Others

Lansoprazole Sulfide D4

Cat.No: T11817

Target: Proton pump

4-Hydroxyatomoxetine D3

Cat.No: T10144

Target: Others

Ethyl-β-D-glucuronide-d5

Cat.No: TMID-0062

3-Hydroxy agomelatine D3

Cat.No: T10113

Target: 5-HT Receptor

4’-Hydroxy Diclofenac-d4

Cat.No: TMIJ-0128

3-Hydroxy Midostaurin-D5

Cat.No: T19119

Synonym: CGP52421-D5

Target: Others

3-O-Methyltolcapone D7

Cat.No: T10118

Synonym: Ro 40-7591 D7

Target: Transferase

3-Amino-2-Oxazolidinone-d4

Cat.No: TMIJ-0008

Synonym: Aoz-d4

Aprocitentan D4

Cat.No: T10351

Synonym: ACT-132577 D4

Target: Others

4’-Hydroxy Diclofenac-d4 (Major)

Cat.No: TMID-0220

Brexpiprazole S-oxide D8

Cat.No: T10611

Synonym: DM-3411 D8

Target: Dopamine Receptor, 5-HT Receptor

Hydroxy Dimetridazole-d3

Cat.No: TMID-0039

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