Fulvic Acid is a natural product of humus produced by microorganisms in soil, sediment or aquatic environments. Fulvic acid is a phenolic acid and fungal metabolite isolated from Penicillium for the first time. Fulvic Acid inhibits the dimerization of amyloid b (17-42) (AB17-42), destroys the pre-formed trimer of AB17-42, and binds to the catalytic site of phosphodiesterase 5A (PDE5A), which can regulate the body's immune system, affect the oxidation state of cells, and improve gastrointestinal function. Fulvic Acid can be used as an oxidant or reducing agent and has the potential to study chronic inflammatory diseases such as diabetes.

Fulvic Acid（15 mg/L）促进了进化硅藻的生长，并实现了最高的EPA含量（13.9%）。Fulvic Acid增强了抗氧化潜力，并前所未有地调控了PUFA和脂质生物合成基因的表达。此研究证明了Fulvic Acid通过适应性进化增强的功效。[1] Abies cephalonica的胚性细胞团（ECM）在Fulvic Acid（FA）存在和缺席的情况下在增殖培养基上生长，FA特别是在早期取样天增加了增殖率，并且在它们的高级发展阶段增加了PEM的百分比。在成熟阶段，富里物质也诱导了体胚形成的延迟。这里观察到的结构-活性关系表明，FA对ECM的影响可能归因于从FA松散超结构中优先释放的特定生物活性分子。[2]