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Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 μg | ¥ 1,260 | 35日内发货 | |
1 mg | ¥ 2,360 | 35日内发货 | |
5 mg | ¥ 7,420 | 35日内发货 |
产品描述 | Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM). |
靶点活性 | FXR:40 μM |
体外活性 | In the CRC cell line HT29, T-βMCA sodium inhibits FXR reporter activity (EC50 ~10 μM)[3].In HT29 and HCT116 cells, T-βMCA sodium dose-dependently increases WNT signaling [3]. T-βMCA sodium induces proliferation and DNA damage in Lgr5+ cells[3]. |
体内活性 | T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3]. |
别名 | T-βMCA sodium |
分子量 | 537.69 |
分子式 | C26H44NNaO7S |
CAS No. | 145022-92-0 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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