Beclomethasone 17-propionate

Name: Beclomethasone 17-propionate
Brand: TargetMol
SKU: T10494
Rating: 4.5 (1 reviews)

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产品编号 T10494Cas号 5534-18-9

别名 Beclomethasone-17-monopropionate, 17-BMP

Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.

Beclomethasone 17-propionate

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产品编号 T10494 别名 Beclomethasone-17-monopropionate, 17-BMPCas号 5534-18-9

规格	价格	库存	数量
2 mg	¥ 399	5日内发货

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生物活性

产品描述	Beclomethasone 17-propionate is an active metabolite of Beclomethasone dipropionate and an agonist of the glucocorticoid receptor (GR). It exhibits greater affinity for GR than Beclomethasone dipropionate. Beclomethasone 17-propionate effectively suppresses cytokine production in COPD lung macrophages.
体外活性	Beclomethasone 17-propionate inhibits LPS-stimulated CXCL8, TNFα, and IL-6. The EC50 values of Beclomethasone 17-propionate for IL-6, TNFα, and CXCL8 were 0.05 nM, 0.01 nM, and 0.1 nM, respectively. Beclomethasone 17-propionate evokes the upregulation of the GR dependent genes FKBP51 and GILZ [3].
别名	Beclomethasone-17-monopropionate, 17-BMP