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(E/Z)-4-Hydroxytamoxifen (Afimoxifene) 是一种新的雌激素抑制剂,多用于多种雌激素依赖性疾病的研究,包括周期性乳房疼痛和男性乳房发育症。
(E/Z)-4-Hydroxytamoxifen (Afimoxifene) 是一种新的雌激素抑制剂,多用于多种雌激素依赖性疾病的研究,包括周期性乳房疼痛和男性乳房发育症。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 218 | 现货 | |
5 mg | ¥ 492 | 现货 | |
10 mg | ¥ 747 | 现货 | |
25 mg | ¥ 1,320 | 现货 | |
50 mg | ¥ 2,160 | 现货 | |
100 mg | ¥ 3,320 | 现货 | |
200 mg | ¥ 4,750 | 现货 | |
500 mg | ¥ 7,290 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 547 | 现货 |
产品描述 | (E/Z)-4-Hydroxytamoxifen (Afimoxifene) is a novel estrogen inhibitor, commonly used in research for various estrogen-dependent conditions, including cyclic mastalgia and gynecomastia. |
靶点活性 | ER: |
体外活性 | 方法:乳腺癌细胞系 用 (E/Z)-4-Hydroxytamoxifen 处理 4 h,检测细胞生长。 结果:(E/Z)-4-Hydroxytamoxifen 能够抑制四种乳腺癌细胞系 MCF-7、MCF-7/Adr、MDA-MB-231 和 MDA-MB-435 的生长,IC50 分别为 300 nM、40000 nM、30000 nM 和 20000 nM 。[1] 方法:HepG2 或 MCF-7 细胞用 (E/Z)-4-Hydroxytamoxifen (5-50 µM) 在标记培养基中孵育 18 h,测定人 SULT 催化硫酸化的动力学参数。 结果:(E/Z)-4-Hydroxytamoxifen 可以通过 HepG2 和 MCF-7 细胞的硫酸化进行代谢。[2] |
细胞实验 | Cell lines: Adult Rat and Mouse Cardiac MyocytesConcentrations: 0, 0.5, 1, 3, 5, and 10 μMIncubation Time: 15-45 minMethod:For sarcomere length measurements, cells are covered in Tyrode's containing 4OHT, allowed to reach 36 ± 1°C, and then stimulated at 0.2 Hz. |
动物实验 | Animal Models: Sprague-Dawley ratsFormulation: dissolved in 200 μl tricaprylinDosages: 21 mg/kg, 54 μmol/kgAdministration: oral administration |
别名 | 4-羟基他莫昔芬, Afimoxifene, 4-Hydroxytamoxifen, (E/Z)-4-羟基他莫昔芬 |
分子量 | 387.51 |
分子式 | C26H29NO2 |
CAS No. | 68392-35-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 60 mg/mL (154.83 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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