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(-)-Oxypeucedanin hydrate 是一种呋喃香豆素衍生物,分离自Ducrosia anethifolia 中。
(-)-Oxypeucedanin hydrate 是一种呋喃香豆素衍生物,分离自Ducrosia anethifolia 中。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 695 | 现货 | |
5 mg | ¥ 1,730 | 现货 | |
10 mg | ¥ 2,590 | 现货 | |
25 mg | ¥ 4,290 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,780 | 现货 |
产品描述 | (-)-Oxypeucedanin hydrate is a furanocoumarin. It has a role as a metabolite. |
体外活性 | Oxypeucedanin 对正常成纤维细胞和敏感的亲本小鼠淋巴瘤细胞展现了边缘毒性;对多药耐药淋巴瘤细胞的毒性更低。Oxypeucedanin 表现出中等的多药耐药(MDR)逆转活性。在方格实验中,oxypeucedanin 和 heraclenin 与 doxorubicin 有轻微的协同效应。这些化合物可能增强标准化疗化合物 doxorubicin 的细胞毒效应。 |
细胞实验 | Pure compounds were isolated from the extract of aerial parts of the plant by chromatographic methods.Bioactivities were tested on multidrug resistant and sensitive mouse T-lymphoma cell lines.The inhibition of the cancer MDR efflux pump ABCB1 was evaluated by flow cytometry (at 2 and 20 μM).A checkerboard microplate method was applied to study the interactions of furocoumarins and doxorubicin.Toxicity was studied using normal murine NIH/3T3 fibroblasts. |
别名 | 水合氧化前胡素, OXYPEUCEDANIN HYDRATE |
分子量 | 304.29 |
分子式 | C16H16O6 |
CAS No. | 133164-11-1 |
Smiles | CC(C)(O)[C@@H](O)COc1c2ccoc2cc2oc(=O)ccc12 |
密度 | 1.386 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (180.75 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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