723
104
6
44
20
Cat. No. | Product Name | ||
---|---|---|---|
L7400 | 钠通道分子库 | 118 compounds | |
118 种钠通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L7200 | 钙通道分子库 | 140 compounds | |
140 种钙通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2300 | 离子通道库 | 931 compounds | |
931 种与离子通道相关的生物活性小分子化合物的特有集合,用于离子通道相关的疾病和药物研究,可用于高通量筛选和高内涵筛选; | |||
L7300 | 钾通道分子库 | 152 compounds | |
152 种钾通道相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2610 | 神经递质受体化合物库 | 1513 compounds | |
1513 种与神经递质受体相关的化合物,用于高通量、高内涵筛选; | |||
L2800 | 5-羟色胺分子库 | 268 compounds | |
268 种生物活性小分子化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12015 |
Methyl homoveratrate
|
Others | Others |
Methyl homoveratrate 是血浆、尿液和粪便提取物中 McN5691 的代谢物,是电压依赖性钙通道阻滞剂。 | |||
T13177L |
Tocainide
|
Sodium Channel | Membrane transporter/Ion channel |
Tocainide 是口服有活性的 sodium channel 阻滞剂,阻断产生疼痛的病灶中(神经膜上)的钠通道。它是利多卡因 (lignocaine) 的伯胺类似物,可用于研究心律不齐。 | |||
T7603 |
Pinaverium bromide
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Pinaverium bromide 是一种具有解痉作用的钙通道阻滞剂,可有效缓解疼痛、腹泻和肠道不适。 | |||
T23070 |
Nisoxetine hydrochloride
|
Sodium Channel; Monoamine Transporter; Norepinephrine | Membrane transporter/Ion channel; Neuroscience |
Nisoxetine hydrochloride 是一种去甲肾上腺素转运蛋白 (NET) 抑制剂,Kd 值为 0.76 nM。它是抗抑郁药和局部麻药,可以阻断电压门控性钠通道。 | |||
T15423 |
GSK-7975A
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
GSK-7975A 是具有口服活性的高效CRAC 通道抑制剂。 | |||
T8863 |
VK-II-36
|
Others | Others |
VK-II-36 是 carvedilol 的类似物,能够在不阻断 β 受体的情况下抑制肌浆网钙释放。它能够抑制早期和延迟后去极化诱发的触发活动,可用于局灶性室性心律失常的研究。 | |||
T10690 |
Cav 2.2 blocker 1
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cav 2.2 blocker 1 是一种N 型钙离子通道 (Cav 2.2) 的阻断剂,IC50值为 1 nM,可用于治疗疼痛。 | |||
T0916 |
Butamben
Butyl 4-aminobenzoate,4-氨基苯甲酸丁酯 |
Potassium Channel; Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Butamben (Butyl 4-aminobenzoate) 是一种长效局部麻醉剂,用于治疗慢性疼痛。 | |||
T6633 |
Ranolazine
雷诺嗪,CVT 303,Ranexa,RS 43285-003 |
Calcium Channel; Sodium Channel | Membrane transporter/Ion channel; Metabolism |
Ranolazine (RS 43285-003) 具有抗心绞痛和抗缺血的功效,通过抑制内向钠电流的后期作用 (对INa 和IKr 的IC50值分别为 6 μM 和 12 μM) 发挥作用,而不会影响心率或血压。Ranolazine 还是脂肪酸氧化 (FAO) 的部分抑制剂。 | |||
T0275 |
Meticrane
美替克仑,Fontiliz,Arresten,蒲硫杂茶磺胺 |
Chloride channel; Sodium Channel | Membrane transporter/Ion channel |
Meticrane (Arresten) 是一种磺胺类衍生物,具有类似噻嗪类利尿剂的活性,可于研究原发性高血压。 | |||
T7373 |
CDN1163
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
CDN1163 是肌膜/内质网 Ca2+-ATPase (SERCA)的变构激活剂,可改善 Ca2+稳态,可减轻糖尿病和代谢紊乱。 | |||
T15174 |
DSP-2230
|
Sodium Channel | Membrane transporter/Ion channel |
DSP-2230 是有效的Nav1.7/Nav1.8通道选择性阻断剂。 | |||
T16514 |
PF 04531083
|
Others; Sodium Channel | Membrane transporter/Ion channel; Others |
PF 04531083 是 NaV1.8 通道的特异性阻断剂。 PF 04531083 可用于神经性和炎症性疼痛的相关研究。 | |||
T11517 |
GV-58
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
GV-58 是选择性 N 型和 P/Q 型 Ca2+ 通道激动剂,EC50值分别为7.21和8.81uM。它对 CDK 激酶活性的抑制作用减少了 20 倍。 | |||
T12786 |
RY785
|
Potassium Channel | Membrane transporter/Ion channel |
RY785 是电压门控钾 (KV2)通道的选择性抑制剂, KV2.2 的 IC50为 0.05 μM。它在缓解疼痛方面具有研究价值。 | |||
T5324 |
BI 01383298
|
Sodium Channel | Membrane transporter/Ion channel |
BI 01383298 是肝脏中高度表达的柠檬酸钠协同转运蛋白抑制剂。 | |||
TQ0011 |
PF-06869206
|
Sodium Channel | Membrane transporter/Ion channel |
PF-06869206 是口服有效的磷酸钠协同转运蛋白NaPi2a(SLC34A1) 选择性抑制剂,IC50为 380 nM。 | |||
TQ0014 |
GNE-131
|
Sodium Channel | Membrane transporter/Ion channel |
GNE-131 是有效的人类钠离子通道 NaV1.7(hNaV1.7)选择性抑制剂,IC50为 3 nM。 | |||
T4490 |
PF-01247324
|
Sodium Channel | Membrane transporter/Ion channel |
PF01247324是一种选择性的、口服有效的Nav1.8通道阻断物,对人类重组Nav1.8 的IC50为196 nM。 | |||
T14844 |
BX430
|
P2X Receptor; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Neuroscience |
BX430 是一种有效的选择性非竞争性变构人 P2X4 受体通道拮抗剂,IC50 为 0.54 μM。它具有物种特异性,可用于治疗慢性疼痛和心血管疾病。 | |||
T13047 |
Synta66
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Synta66 是一种钙池操纵钙离子通道 Orai 抑制剂,用于神经系统疾病的研究。 | |||
T0924 |
Benzocaine
苯唑卡因,苯佐卡因 |
Others; MRP; Sodium Channel | Immunology/Inflammation; Membrane transporter/Ion channel; Others |
Benzocaine 作用电压门控 Na+通道的共同受体,+30 mV 下的 IC50为0.8 mM。 | |||
T37688 |
Cyfluthrin
|
Reactive Oxygen Species; Sodium Channel | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB |
Cyfluthrin 属于 II 型拟除虫菊酯,对多种昆虫都有杀灭效果。Cyfluthrin 是Nav1.8钠通道调节剂。它可应用于农业、兽医、杀虫剂、拟除虫菊酯和贮存产品等领域。 | |||
T22788 |
FPL64176
FPL 64176 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
FPL64176 是一种非二氢吡啶类L 型钙通道激动剂,EC50值为 16 nM。 | |||
T6848 |
GSK1016790A
GSK101 |
Calcium Channel; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
GSK1016790A (GSK101) 是选择性瞬时受体电位香草酸 4 通道激活剂,可引起 HEK 细胞中 Ca2+流入并升高细胞内 Ca2+。 | |||
T0364 |
Dibucaine
地布卡因,Cinchocaine |
CaMK; Sodium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Dibucaine (Cinchocaine) 是钠通道抑制剂和有效的SChE 抑制剂。 | |||
T3543 |
NS-638
NS 638 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
NS-638 是一种 Ca2+ 通道阻滞剂,可阻断 K+ 刺激的细胞内 Ca2+ 升高,IC50值为3.4 μM。 | |||
T0030 |
Bupivacaine hydrochloride
Vivacaine,Bupivacaine HCl,盐酸布比卡因 |
Sodium Channel | Membrane transporter/Ion channel |
Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂,可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道,还阻断SCN5A 通道,IC50为 69.5 μM。 | |||
T3703 |
ABT-639
ABT 639 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
ABT-639 是一种有效的选择性 T 型钙通道阻滞剂。 | |||
T9685 |
DS-1971a
|
Sodium Channel | Membrane transporter/Ion channel |
DS-1971a 是选择性、口服有效的 NaV1.7抑制剂,对 hNaV1.7 和 mNaV1.7 的 IC50分别为 22.8 和 59.4 nM。DS-1971a 在缓解疼痛方面有研究价值。 | |||
T19644 |
Benzonatate
|
Sodium Channel | Membrane transporter/Ion channel |
Benzonatate 是外周口服镇咳药,对咳嗽延伸受体 (cough stretch receptors) 的活性具有抑制作用。它是丁卡因样代谢物,能够阻断呼吸延伸受体的钠通道并产生局部麻醉作用。 | |||
T7216 |
Mirogabalin
DS5565 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Mirogabalin (DS5565) 是一种高效的、选择性的 α2δ-1 配体,作用于电压敏感性钙通道复合体的α2δ-1亚基。 | |||
T9683 |
VX-150
|
Sodium Channel | Membrane transporter/Ion channel |
VX-150 是一种口服有效的,高选择性的 NaV1.8抑制剂。VX-150 在各种疼痛适应症中有研究的价值。 | |||
T7182 |
Metaflumizone
BAS-320I,氰氟虫腙 |
Sodium Channel; Parasite | Membrane transporter/Ion channel; Microbiology/Virology |
Metaflumizone (BAS-320I) 是一种缩氨基脲杀虫剂,是钠离子通道阻滞剂。 | |||
T0806 |
Flunarizine dihydrochloride
Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪 |
Calcium Channel; Dopamine Receptor; Sodium Channel | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。 | |||
T8960 |
MONNA
|
Chloride channel | Membrane transporter/Ion channel |
MONNA 是 TMEM16A (Anoctamin-1)阻滞剂,IC50为 80 nM。它在氯离子存在或不存在的情况下诱导啮齿动物抵抗动脉的血管舒张。 | |||
T5632 |
Suvecaltamide
MK-8998 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Suvecaltamide (MK-8998) 是一种选择性的 T 型钙通道抑制剂。 | |||
T15192 |
Eact
|
Chloride channel | Membrane transporter/Ion channel |
Eact 是一种选择性和有效的 TMEM16A 激活剂,可直接激活感觉伤害感受器中的 TRPV1 通道,还会产生瘙痒、急性伤害感受和热过敏。 | |||
T11353 |
Gallopamil
Methoxyverapamil,戈洛帕米 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Gallopamil (Methoxyverapamil) 是一种苯烷基胺钙拮抗剂,以浓度依赖性方式抑制酸分泌 (IC50 = 10.9 μM)。Gallopamil 显示出抗心律失常和血管扩张剂的功效。 | |||
T1787 |
Levobupivacaine
|
Sodium Channel | Membrane transporter/Ion channel |
Levobupivacaine 是一种氨基酰胺类局麻药,属于n-alkylsubstituted pipecoloxylidide 家族。它是bupivacaine 的 S-对映异构体。 | |||
T7638 |
NPPB
|
Chloride channel | Membrane transporter/Ion channel |
NPPB 是外向整流氯化物通道阻断剂,IC50 为 80 nM。 | |||
T2519 |
Lercanidipine
乐卡地平,Masnidipine |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Lercanidipine (Masnidipine) 是二氢吡啶类的钙通道阻滞剂,具有持久的降压作用和肾脏保护作用。 | |||
T29201 |
Z944
Z 944,Z-944 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Z944 是有效的 T 型钙通道拮抗剂,对跨模态和视觉识别记忆障碍有缓解作用。 | |||
T7547 |
Ralfinamide mesylate
FCE-26742A (mesylate) |
Sodium Channel | Membrane transporter/Ion channel |
Ralfinamide mesylate (FCE-26742A (mesylate)) 是一种口服有效,来源于 α-aminoamide 的钠离子通道阻滞剂, 在缓解疼痛方面有研究价值。 | |||
T12181 |
NaV1.7 inhibitor-1
|
Sodium Channel | Membrane transporter/Ion channel |
NaV1.7 inhibitor-1 是有效的、选择性的电压门控钠通道 (Nav) 1.7 抑制剂,对于hNaV1.7的IC50为 0.6 nM,其选择性是 hNaV1.5 的 80 倍。 | |||
T5850 |
Benzamil
Benzamil (hydrochloride) |
Na+/Ca2+ Exchanger; Sodium Channel | Membrane transporter/Ion channel |
Benzamil 是 Amiloride 类似物,是 Na+/Ca2+交换体抑制剂,抑制 TRPP3 介导的 Ca2+激活电流,IC50为 1.1 μM。它也是一种非选择性上皮钠通道 (ENaC) 阻滞剂,能增强肌源性血管收缩。 | |||
T0702 |
Gabapentin
Neurontin,Gabapentine,加巴喷丁,Aclonium |
Calcium Channel; GABA Receptor | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Gabapentin (Neurontin) 是GABA 类似物,是一种抗癫痫药,可用于缓解神经性疼痛。 | |||
T6577 |
Manidipine
Iperten,Franidipine,Artedil,马尼地平 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Manidipine (Iperten) 是一种二氢吡啶类钙通道阻滞剂,有降压作用。 | |||
T12421 |
PF-04885614
|
Sodium Channel | Membrane transporter/Ion channel |
PF-04885614是一种有效的NaV1.8抑制剂。PF-04885614有用于神经系统疾病和神经发育疾病研究的潜力。 | |||
T10885 |
CRAC intermediate 2
|
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
CRAC intermediate 2是CRAC 抑制剂合成的中间体化合物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2322 |
Yangambin
|
Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF 受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。 | |||
T6S1418 |
Praeruptorin C
|
Antioxidant; Calcium Channel | Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Praeruptorin C 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.7。 | |||
T2173 |
Veratridine
|
Sodium Channel | Membrane transporter/Ion channel |
Veratridine 是一种生物碱,来自百合科植物。Veratridine 是一种钠通道激动剂, 对 Nav1.7 的峰值电流具有抑制作用,IC50为 18.39 µM。 | |||
T4S1876 |
3-Deoxyaconitine
|
Sodium Channel | Membrane transporter/Ion channel |
3-Deoxyaconitine 是一种二萜类生物碱,对钠离子通道有激活作用。 | |||
T8787 |
Drotaverine hydrochloride
|
PDE | Metabolism |
Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂,也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂,可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果,但无抗胆碱能的效果。 | |||
T0728 |
Ethosuximide
Zarontin,乙琥胺 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Ethosuximide (Zarontin) 是一种抗癫痫药物,可改善多种神经退行性疾病模型的表型,且阻断低电压激活的 T 型钙通道。 | |||
T3904 |
Gomisin J
|
Calcium Channel; AMPK | Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Gomisin J 是在五味子中发现的小分子量木脂素,具有血管舒张活性,在非酒精性脂肪性肝病方面有研究潜力。 它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达,从而抑制脂质积累。 | |||
T8206 |
Cycleanine
|
Others | Others |
Cycleanine 是一种高效血管选择性Ca- 拮抗剂,具有缓解疼痛、肌肉松弛和抗炎作用。它还具有有效的抗菌、抗真菌、抗疟原虫和细胞毒活性。 | |||
T4590 |
(+)-Kavain
醉椒素,Kavain,L-KAWAIN,(R)-KAWAIN |
Calcium Channel; GABA Receptor; Sodium Channel; Monoamine Transporter | Membrane transporter/Ion channel; Metabolism; Neuroscience |
(+)-Kavain ((R)-KAWAIN) 是从卡瓦胡椒中提取的一种主要的卡瓦内酯,可通过电压依赖性的 Na+和 Ca2+通道相互作用,减弱血管平滑肌的收缩,具有抗惊厥作用。它可与α4β2δ GABAA 受体结合,加强 GABA 的功效,用于炎症疾病研究。 | |||
T5723 |
Menthol
薄荷脑,DL-Menthol |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Menthol (DL-Menthol) 是从薄荷或薄荷油中得到的一种天然产物,具有调味和局部麻醉特性。它通过抑制神经元细胞膜的 Ca++电流,刺激冷感受器,从而产生清凉的感觉。 | |||
T10024 |
1-Octanol
Octanol,正辛醇 |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
1-Octanol (Octanol) 是一种饱和脂肪醇,是一种 T 型钙通道抑制剂,对天然 T 电流的IC50为 4 μM。它是一种具有类似柴油特性的极具吸引力的生物燃料。 | |||
T15027 |
Cyclopiazonic acid
环匹阿尼酸,环二氮酸 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM),源于A. flavus,是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA),是植物细胞死亡的有效诱导剂。 | |||
T7056 |
Dronedarone
决奈达隆,SR 33589 |
P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Dronedarone (SR 33589) 是一种胺碘酮类似物,对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂,通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。 | |||
T4S1422 |
Praeruptorin E
白花前胡素 E,白花前胡素E |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Praeruptorin E 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.2。 | |||
T8299 |
Dimethyl lithospermate B
丹酚酸B二甲酯,dmLSB |
Sodium Channel | Membrane transporter/Ion channel |
Dimethyl lithospermate B (dmLSB) 是 Na+通道的选择性激动剂,减缓钠电流 (INa) 失活,导致动作电位 (AP) 早期内向电流增加。 | |||
T3021 |
Bulleyaconitine A
草乌甲素,Bulleyaconi cine A |
Sodium Channel | Membrane transporter/Ion channel |
Bulleyaconitine A (Bulleyaconi cine A) 是一种分离自乌头属植物的抗炎活性化合物,也可用于缓解疼痛的研究。 | |||
TQ0302 |
Thapsigargin
毒胡萝卜素 |
Apoptosis; SARS-CoV; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。 | |||
T6856 |
Halofuginone
卤夫酮,常山酮,Tempostatin,empostatin,RU-19110 |
Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Stem Cells |
Halofuginone (RU-19110) 是Febrifugine 的衍生物,是一种竞争性脯氨酰-tRNA 合成酶抑制剂。它也是肺血管扩张剂,可激活Kv 通道并阻断电压门控、受体操作和存储操作的钙离子通道。它具有抗炎、抗癌、抗疟疾和抗纤维化作用。 | |||
T3013 |
Catharanthine tartrate
Catharanthine hemitartrate,酒石酸长春质碱 |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Catharanthine tartrate (Catharanthine hemitartrate) 是长春花中的一种生物碱,可抑制电压门控 L 型钙离子通道,具有抗肿瘤和降血压活性。 | |||
T7177 |
Capsazepine
|
Apoptosis; TRP/TRPV Channel | Apoptosis; Membrane transporter/Ion channel |
Capsazepine 是一种 TRPV1 受体的拮抗剂, IC50值为 562 nM。 它可阻断由激活 TRPV1 离子通道的辣椒素引起的热痛感,是辣椒素拮抗剂。 | |||
T2782 |
Catharanthine
(+)-3, 4-Didehydrocoronaridine,长春质碱,(+)-3,4-Didehydrocoronaridine |
Calcium Channel; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Catharanthine ((+)-3,4-Didehydrocoronaridine) 是长春花中的一种生物碱,可抑制电压门控 L 型钙离子通道,具有抗肿瘤和降血压活性。 | |||
TN1008 |
Psoralenoside
|
CaMK; Calcium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Psoralenoside 是源于补骨脂中的苯并呋喃苷,具有抗肿瘤、抗菌、促进成骨细胞增殖和雌激素样活性。它对组胺 H1、钙调素和电压门控 l 型钙通道具有较高的亲和力。 | |||
T12514 |
Podocarpic acid
|
Others; TRP/TRPV Channel | Membrane transporter/Ion channel; Others |
Podocarpic acid 是一种天然产物,是一种新型 TRPA1 激活剂。 | |||
T6S1500 |
Ginsenoside Rf
人参皂苷 Rf,Ginsenoside-Rf,Panaxoside Rf |
Calcium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
Ginsenoside Rf (Panaxoside Rf) 是人参根的微量成分,可抑制 N 型 Ca2+通道。 | |||
T4727 |
Taurolithocholic acid sodium salt
牛磺石胆酸钠,Sodium taurolithocholate |
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) 是抑胆剂和 Ca2+激动剂,可抑制放射性配体与毒蕈碱 M1 结合。 | |||
TN7108 |
Urolithin C
|
Apoptosis; Calcium Channel; Reactive Oxygen Species; IGF-1R; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Tyrosine Kinase/Adaptors |
Urolithin C 属于多酚类,是鞣花酸的肠道微生物代谢产物,具有胰岛素分泌的葡萄糖依赖性激活活性。Urolithin C 是 L 型 Ca2+通道开放剂,可增强 Ca2+的流入。它通过线粒体介导的途径诱导细胞凋亡,并刺激活性氧的形成。 | |||
T3524 |
Halofuginone hydrobromide
卤夫酮溴氢酸盐,Tempostatin,RU-19110 (hydrobromide),Stenorol,常山酮溴酸盐 |
Others; Calcium Channel; DNA/RNA Synthesis; Sodium Channel; Parasite; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Others; Stem Cells |
Halofuginone hydrobromid 是Febrifugine 的衍生物,是竞争性脯氨酰-tRNA 合成酶抑制剂。它是 I 型胶原合成的特异性抑制剂,并通过抑制TGF-β活性可减轻骨关节炎。它具有抗疟疾、抗炎、抗癌、抗纤维化作用。 | |||
T4550 |
Ajmaline
Cardiorythmine,Raugalline,阿义吗啉,阿义马林,Tachmalin,(+)-Ajmaline |
Sodium Channel | Membrane transporter/Ion channel |
Ajmaline (Cardiorythmine) 是一种钠通道阻断剂,属于1A 类抗心律失常剂。Ajmaline 阻断 HERG 电流,在 HEK 细胞的 IC50为 1 μM,爪蟾卵母细胞的IC50为 42.3 μM。Ajmaline 在室性心动过速方面具有研究价值。 | |||
T3S1916 |
Heteroclitin D
异型南五味子丁素,异南五味子丁素;异型南五味子丁素 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Heteroclitin D 是异形南五味子中的一种木脂素,可抑制 L 型钙通道,具有抗脂质过氧化作用。 | |||
T5701 |
OPHIOPOGONIN D
麦冬皂苷 D,麦冬皂苷D |
RAAS; Calcium Channel; NF-κB; PPAR | DNA Damage/DNA Repair; Endocrinology/Hormones; Membrane transporter/Ion channel; Metabolism; NF-κB |
Ophiopogonin D 是从麦冬的块茎中分离的一种天然产物,是罕见的天然存在的 C29甾体糖苷。它是一种 CYP2J3 诱导剂,用于炎症和心血管疾病的相关研究。 | |||
T6S1684 |
8-Gingerol
|
Antioxidant; Antibacterial; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction |
8-Gingerol 分离自姜的根状茎,是口服有效的 TRPV1激活剂,EC50值为5.0 µM。8-Gingerol 抑制 COX-2,还能抑制体外 H. pylori 的生长。 | |||
T4S1419 |
(±)-Praeruptorin A
Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A |
p38 MAPK; Calcium Channel; Akt | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分,用于研究伴有厚痰和呼吸困难的咳嗽,非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物,可作为 Ca2+-反流阻滞剂,用于高血压的研究。 | |||
T2807 |
Caffeic Acid
|
Lipoxygenase; Endogenous Metabolite; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
Caffeic acid 是5-脂氧合酶和 TRPV1离子通道的双重抑制剂。 | |||
T8288 |
14-Deoxyandrographolide
去氧穿心莲内酯,14-去氧穿心莲内酯 |
Apoptosis; Others | Apoptosis; Others |
14-Deoxyandrographolide 是穿心莲中的一种天然产物,是一种钙通道阻断剂,具有保肝功效。它通过诱导 TNFRSF1A 的释放,使肝细胞对 TNF-α 介导的凋亡脱敏。 | |||
T1221 |
Acetylcholine chloride
ACh chloride,Pilofrin,氯化乙酰胆碱 |
Calcium Channel; Endogenous Metabolite; AChR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Acetylcholine chloride (Pilofrin) 是一种神经递质,是胆碱能激动剂,通过刺激烟碱乙酰胆碱受体调节多巴胺能神经元活性,在体外抑制 p53 突变肽的聚集。 | |||
T0167 |
Vinpocetine
长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate |
IκB/IKK; NF-κB; Sodium Channel; PDE | Membrane transporter/Ion channel; Metabolism; NF-κB |
Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物,是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂,并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应,已被广泛用于研究脑血管疾病。 | |||
T5S2059 |
Glaucine
|
Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Glaucine 是从海罂粟中分离的一种生物碱,具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂,具有抗氧化和抗病毒活性。 | |||
T11665 |
Ionomycin calcium
SQ23377 calcium,罗红霉素钙盐(链霉菌属载体) |
Apoptosis; Calcium Channel; Antibacterial; Antibiotic; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Ionomycin calcium (SQ23377 calcium) 是选择性钙离子载体,也是一种由 Streptomyces conglobatus 产生的抗生素。它对二价阳离子具有高度特异性,还诱导蛋白激酶 C 激活。Ionomycin 促进细胞凋亡。 | |||
TN6713 |
6-Benzoylheteratisine
Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth,苯甲酰新异乌头碱 |
Sodium Channel | Membrane transporter/Ion channel |
6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) 是乌头碱的拮抗剂,乌头碱是天然 Na+通道激活剂。 | |||
TN4417 |
Larixyl acetate
|
Others | Others |
Larixyl acetate 是一种生物活性化学物质。 | |||
T3915 |
Ginsenoside Ro
人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V |
Calcium Channel; Reductase; Prostaglandin Receptor | Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism |
Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量,较弱降低 COX-1 和 TXAS 活性,具有 Ca2+拮抗剂的抗血小板作用,IC50为 155 μM。 | |||
TN1035 |
Irisolidone
尼泊尔鸢尾异黄酮,葛花苷元 |
IL Receptor; NF-κB; Chloride channel | Immunology/Inflammation; Membrane transporter/Ion channel; NF-κB |
Irisolidone 是葛根花中的一种异黄酮,具有较强的保肝活性。它是一种有效的体积调节阴离子通道 (VRAC) 电流抑制剂,有高效阻断作用,IC50 为 5-13 μM。 | |||
TQ0001 |
1,4-Cineole
Isocineole,1,4-桉叶素 |
Endogenous Metabolite; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
1,4-Cineole (Isocineole) 是天然广泛分布的含氧单萜烯,存在于桉树油中,可激活人TRPM8和TRPA1。 | |||
T2878 |
Ginsenoside Rd
Panaxoside Rd,Sanchinoside Rd,人参皂苷Rd,人参皂苷 Rd,Gypenoside VIII |
P450; Calcium Channel; NF-κB; COX; Endogenous Metabolite | Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
Ginsenoside Rd (Gypenoside VIII) 抑制 TNFα 诱导的NF-κB 转录活性,还抑制COX-2和iNOSmRNA 的表达。它抑制CYP2D6、CYP1A2、CYP3A4和CYP2C9,也抑制Ca2+内流,有可能抑制或阻止肿瘤生长。 | |||
T2996 |
Tetrandrine
NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素 |
Potassium Channel; Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Tetrandrine (Sinomenine A) 是来自粉防己的一种双苯基异喹啉生物碱,可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。 | |||
T37709 |
2,2,2-Trichloroethanol
|
Potassium Channel; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism |
2,2,2-Trichloroethanol 是非经典的 K2P 通道 TREK-1和 TRAAK 的激动剂。 | |||
T3727 |
Methyl syringate
Syringic Acid Methyl Ester,丁香酸甲酯 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Methyl syringate (Syringic Acid Methyl Ester) 是水仙花蜜的化学标记物,是有效的细菌和真菌漆酶酚介质。它也是TRPA1激动剂。 | |||
T2952 |
Camphor
樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa |
Influenza Virus; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Camphor (2-Camphanone) 是一种双环单萜酮,广泛存在于植物中,尤其是樟脑。 它是一种激动剂,局部用作皮肤止痒剂和抗感染剂,具有抗病毒,镇咳和抗癌活性。 | |||
TCS0102 |
Pulegone
胡薄荷酮,(+)-Pulegone,蒲勒酮,胡薄荷酮,长叶薄荷酮 |
Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel | Membrane transporter/Ion channel; Metabolism |
Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分,也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道,并在高浓度下抑制前者但不抑制后者。 | |||
T3377 |
L-Phenylalanine
L-苯丙氨酸,(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine |
Calcium Channel; Endogenous Metabolite; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
L-Phenylalanine (3-Phenyl-L-alanine) 是分离自大肠杆菌的必需氨基酸,是 NMDARs(KB573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂,用于食品香料和药品的生产中。它是一种电压依赖性 α2δ 亚基 Ca2+通道拮抗剂,Ki 为 980 nM。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02245 |
SNAP-25 Protein, Human, Recombinant (His)
synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ106... |
Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp... | |||
TMPH-00837 |
BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc)
Alpha-insect toxin BjaIT,Bj-alpha-IT |
Hottentotta judaicus | E. coli |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against insects (para/tipE). BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.4 kDa and the accession number is Q56TT9. | |||
TMPH-03628 |
Beta-toxin Tz1 Protein, Tityus zulianus, Recombinant (His & Myc)
PT-beta NaTx14.1,Beta-toxin Tz1 |
Tityus zulianus | E. coli |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Strongly affects skeletal muscle channels Nav1.4/SCN4A, poorly affects the neuronal channels Nav1.6/SCN8A and Nav1.2/SCN2A. Induces spastic paralysis of rear limbs, increased salivation, apnea, tachycardia and increased perspiration. Beta-toxin Tz1 Protein, Tityus ... | |||
TMPH-02404 |
LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)
Alpha-insect toxin LqhaIT,Lqh-alpha-IT |
Yellow scorpion | E. coli |
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and ... | |||
TMPH-02308 |
CACNA2D1 Protein, Human, Recombinant (His & SUMO)
MHS3,Voltage-dependent calcium channel subunit alpha-2/delta... |
Human | E. coli |
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. | |||
TMPH-02331 |
GLRA1 Protein, Human, Recombinant (His & Myc)
Glycine receptor subunit alpha-1,GLRA1,Glycine receptor stry... |
Human | E. coli |
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiat... | |||
TMPJ-01363 |
CLIC5 Protein, Human, Recombinant (His)
Chloride Intracellular Channel Protein 5,CLIC5 |
Human | E. coli |
Chloride Intracellular Channel Protein 5 (CLIC5) is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain. Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 can insert into membranes and form selective ion channels regulated by actin that may transport chloride ions. It may play a role in the regulation of transepithelial ion absorption and secretion. CLIC5 specif... | |||
TMPH-03173 |
OprF Protein, Pseudomonas aeruginosa, Recombinant (His)
Outer membrane porin F,oprF |
Pseudomonas aeruginosa | E. coli |
Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium. OprF Protein, Pseudomonas aeruginosa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.3 kDa and the accession number is P13794. | |||
TMPH-01717 |
CHRM5 Protein, Human, Recombinant (His)
CHRM5,Muscarinic acetylcholine receptor M5 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is P08912. | |||
TMPH-01714 |
CHRM1 Protein, Human, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229. | |||
TMPH-00361 |
Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His)
Toxin 2,Beta-mammal toxin Cn2,Toxin II.9.2.2 |
Centruroides noxius | P. pastoris (Yeast) |
Mammal beta-toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the activation voltage to more negative potentials. This toxin is active against mammals. Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 9.6 kDa and the accession number is P01495. | |||
TMPH-01373 |
GJA5 Protein, Human, Recombinant (His)
Gap junction alpha-5 protein,GJA5,Connexin-40 |
Human | E. coli |
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. GJA5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 21.6 kDa and the accession number is P36382. | |||
TMPH-03338 |
CHRM1 Protein, Rat, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1 |
Rat | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482. | |||
TMPH-00267 |
GJD2 Protein, Bovine, Recombinant (His & SUMO)
Gap junction alpha-9 protein,Gap junction delta-2 protein,Co... |
Bovine | E. coli |
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. GJD2 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.1 kDa and the accession number is Q866T7. | |||
TMPH-01716 |
CHRM3 Protein, Human, Recombinant (B2M & His)
Muscarinic acetylcholine receptor M3,CHRM3 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM3 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 40.7 kDa and the accession number is P20309. | |||
TMPJ-00652 |
PSD-95 Protein, Rat, Recombinant (His)
PSD95,SAP90,Disks large homolog 4,SAP-90,PSD-95,Postsynaptic... |
Rat | E. coli |
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain,3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the be... | |||
TMPH-03623 |
Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc)
Toxin Tb2-II,P-Mice-Ins-beta* NaTx5.4 |
Tityus bahiensis | Baculovirus Insect Cells |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. Tb2-II Protein, Tityus bahiensis, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number is P60276. | |||
TMPH-00362 |
Beta-mammal toxin Css4 Protein, Centruroides suffusus, Recombinant (His & SUMO)
Css IV,CssIV,Beta-mammal toxin Css4 |
Centruroides suffusus | E. coli |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on mammals. Beta-mammal toxin Css4 Protein, Centruroides suffusus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.6 kDa and the accession number is P60266. | |||
TMPH-01609 |
LGI1 Protein, Human, Recombinant (His & Myc)
Leucine-rich glioma-inactivated protein 1,Epitempin-1,LGI1 |
Human | E. coli |
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. | |||
TMPY-01854 |
DPP10 Protein, Human, Recombinant (His)
DPPY,DPRP3,DPRP-3,DPL2,dipeptidyl-peptidase 10 (non-function... |
Human | HEK293 Cells |
Inactive dipeptidyl peptidase 1, also known as Dipeptidyl peptidase IV-related protein 3, Dipeptidyl peptidase X, Dipeptidyl peptidase-like protein 2, DPRP-3, DPL2 and DPP1, is a single-pass type II membrane protein which belongs to thepeptidase S9B family.DPPIV subfamily. It may modulate cell surface expression and activity of the potassium channels KCND1 and KCND2. DPP1 / DPRP3 has no detectable protease activity, most likely due to the absence of the conserved serine residue normally p... | |||
TMPH-03624 |
Tb2-II Protein, Tityus bahiensis, Recombinant (E. coli, His & Myc)
Toxin Tb2-II,P-Mice-Ins-beta* NaTx5.4 |
Tityus bahiensis | E. coli |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against both mammals and insects. Tb2-II Protein, Tityus bahiensis, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.0 kDa and the accession number is P... | |||
TMPH-01715 |
CHRM2 Protein, Human, Recombinant (His)
CHRM2,Muscarinic acetylcholine receptor M2 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. CHRM2 Protein, Human, Recombinant (His) is expressed in E. col... | |||
TMPJ-00719 |
CLIC3 Protein, Human, Recombinant (His)
CLIC3,Chloride intracellular channel protein 3 |
Human | E. coli |
Chloride intracellular channel protein 3 (CLIC3) is encoded by the CLIC3 gene. CLIC3 is a single-pass membrane protein which belongs to the chloride channel CLIC family. It contains one GST C-terminal domain and one GST N-terminal domain. Chloride intracellular channel protein 3 high expressed in the placental, lung and heart, low expressed in skeletal muscle, kidney and pancreas. Chloride intracellular channel protein 3 can insert into membranes and forms chloride ion channels, may participate ... | |||
TMPH-02740 |
IL-31R alpha Protein, Mouse, Recombinant (His)
ZcytoR17,Interleukin-31 receptor subunit alpha,Novel cytokin... |
Mouse | E. coli |
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression... | |||
TMPH-02405 |
LqqIT1 Protein, Leiurus quinquestriatus quinquestriatus, Recombinant (His & Myc)
Beta-insect excitatory toxin LqqIT1 |
Egyptian scorpion | E. coli |
Excitatory insect beta-toxins induce a spastic paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin induces a fast excitatory contraction paralysis on fly larvae. It is active only on insects. LqqIT1 Protein, Leiurus quinquestriatus quinquestriatus, Recombinant (His & Myc) is expressed in E. coli expre... | |||
TMPH-01394 |
GRIN1 Protein, Human, Recombinant (His)
N-methyl-D-aspartate receptor subunit NR1,Glutamate [NMDA] r... |
Human | E. coli |
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His)... | |||
TMPY-03384 |
CALM2 Protein, Human, Recombinant (His)
caM,calmodulin 2 (phosphorylase kinase, delta),PHKD,calmodul... |
Human | E. coli |
Calmodulin 2, also known as CALM2, is a calmodulin. Calmodulin 2 mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). It is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Calmodulin 2 gene may be a genetic determinant of hip osteoarthritis (OA). OA is a degenerative disease characterized by gradual loss of articular cartilage and is a leading cause of disability in elderly populations. CALM2 was most... | |||
TMPH-00056 |
Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)
ATX II,Delta-AITX-Avd1c,Toxin II,Delta-actitoxin-Avd1c,Neuro... |
Anemonia sulcata | P. pastoris (Yeast) |
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured... | |||
TMPJ-00587 |
NRCAM Protein, Human, Recombinant (hFc)
gCAM-related cell adhesion molecule,hBravo,Ng-CAM-related,Nr... |
Human | HEK293 Cells |
Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. NrCAM is engaged in such biological processes as axonal fasciculation, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, neuron migration, positive regulation of neuron differentiation, regulation of axon extension, and synaptog... | |||
TMPH-00780 |
CACNA1C Protein, Guinea Pig, Recombinant (His)
CACNA1C,CACNL1A1,CACH2,CACN2,Voltage-dependent L-type calciu... |
Guinea pig | E. coli |
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressur... | |||
TMPY-03613 |
COMMD8 Protein, Human, Recombinant (His)
COMM domain containing 8 |
Human | E. coli |
COMMD8 is a member of the COMMD family. Members of this family are a group of evolutionary conserved proteins that share a common COMM domain at the extreme C-terminus, which provides an interface for protein-protein interactions. Most COMMD proteins play a role in the regulation of NF˚B and, despite their similarities, seem to function in unique and non-redundant pathways. COMMD proteins may also play a role in the function of epithelial sodium channels, cell proliferation, copper homeostasis a... | |||
TMPH-02669 |
GJA1 Protein, Mouse, Recombinant (His & Myc)
Gap junction 43 kDa heart protein,Gja1,Gap junction alpha-1 ... |
Mouse | Baculovirus Insect Cells |
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibi... | |||
TMPJ-00666 |
CLIC2 Protein, Human, Recombinant (His)
CLIC2,XAP121,Chloride Intracellular Channel Protein 2 |
Human | E. coli |
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be d... | |||
TMPJ-00045 |
Podoplanin Protein, Human, Recombinant (hFc)
T1A,PDPN,GP36,Podoplanin,Aggrus,T1-α,PA2.26 Antigen,T1-Alpha... |
Human | HEK293 Cells |
Podoplanin is a type-1 transmembrane protein that belongs to Podoplanin family. PDPN expressed in various specialized cell types throughout the body. It highly expressed in placenta, lung, skeletal muscle and brain, weakly expressed in brain, kidney and liver. In placenta, PDPN expressed on the apical plasma membrane of endothelium, in lung, expressed in alveolar epithelium. PDPN physiological function is related to its mucin-type character. PDPN may be involved in cell migration and/or actin cy... | |||
TMPY-02805 |
GNGT1 Protein, Human, Recombinant (His)
guanine nucleotide binding protein (G protein), γ transducin... |
Human | E. coli |
GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the ... | |||
TMPY-04075 |
CLIC1 Protein, Human, Recombinant (His)
NCC27,G6,chloride intracellular channel 1 |
Human | E. coli |
Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (CLIC1), a newly discovered member of the chloride channel protein family, has been implicated in multiple human cancers. CLIC1 is a Chloride Intracellular Ion Channel protein that exists either in a soluble state in the cytoplasm or as a membrane bound protein. CLIC1 acts as a put... | |||
TMPY-03986 |
PIST Protein, Human, Recombinant (His)
CAL,dJ94G16.2,golgi-associated PDZ and coiled-coil motif con... |
Human | E. coli |
GOPC, also known as PIST, interacts specifically with TC1 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and both polarized and non-polarized MDCK (Madin-Darby canine kidney) cells. The C-terminal SPV (Ser-Pro-Val) motif of Rhotekin binds to the PDZ domain of PIST. The co-localization of PIST and Rhotekin at the Golgi apparatus can be detected in non-polarized fibroblast-like MDCK cells and AJs (adherens junctions) in the fully polarized ce... | |||
TMPY-04561 |
SGK3 Protein, Human, Recombinant (His & GST)
serum/glucocorticoid regulated kinase family, member 3,SGK2,... |
Human | Baculovirus Insect Cells |
Serine / threonine-protein kinase Sgk3, also known as Serum / glucocorticoid-regulated kinase 3, Serum / glucocorticoid-regulated kinase-like and SGK3, is a cytoplasmic vesicle protein that belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. SGK3 contains one AGC-kinase C-terminal domain, one protein kinase domain and one PX (phox homology) domain. Two specific sites of SGK3, one in the kinase domain (Thr-32) and the other in the C-terminal regulatory region (Ser-486... | |||
TMPY-01695 |
CASPR2 Protein, Mouse, Recombinant (His)
5430425M22Rik,Caspr2,contactin associated protein-like 2,mKI... |
Mouse | HEK293 Cells |
CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and media... | |||
TMPY-02802 |
GNG13 Protein, Human, Recombinant (His)
G(gamma)13,h2-35,G(γ)13,guanine nucleotide binding protein (... |
Human | E. coli |
GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. Each G protein is composed of an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding... | |||
TMPH-03037 |
Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc)
Alpha-CT,Alpha-Ctx,Alpha-EPTX-Nk2a,Long neurotoxin 1,Alpha-C... |
Naja kaouthia | E. coli |
Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2)... | |||
TMPY-01890 |
CLIC4 Protein, Human, Recombinant (His)
MTCLIC,chloride intracellular channel 4,p64H1,H1,huH1,CLIC4L |
Human | E. coli |
Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angio... | |||
TMPJ-00055 |
Podoplanin Protein, Mouse, Recombinant (hFc)
T1-alpha,PA2.26 antigen,T1A,Podoplanin,T1-α,Glycoprotein 38,... |
Mouse | HEK293 Cells |
Podoplanin belongs to the podoplanin family, also known as Glycoprotein 38. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. Detected at high levels in lung and brain, at lower levels in kidney, stomach, liver, spleen and esophagus, and not detected in skin and small intestine. Expressed in epithelial cells of choroid plexus, ependyma, glomerulus and ... | |||
TMPH-03753 |
MYLK Protein, Human, Recombinant (His)
MYLK,Myosin light chain kinase, smooth muscle,Telokin,Kinase... |
Human | E. coli |
Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscl... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40376 |
L-Phenylalanine-15N
L-苯丙氨酸 15N,(S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是 15N 标记的 L-Phenylalanine。L-Phenylalanine 是从大肠杆菌中分离出来的一种必需氨基酸。 L-Phenylalanine 广泛用于食品香精和药物的生产。 | |||
TMIJ-0246 |
Tetracaine-d6
|
||
Tetracaine-d6 是 Tetracaine 的氘代化合物。Tetracaine 的 CAS 号为 94-24-6。 | |||
TMID-0070 |
Amiodarone-d10 Hydrochloride
|
||
Amiodarone-d10 Hydrochloride 是 Amiodarone Hydrochloride 的氘代化合物。Amiodarone Hydrochloride 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
TMID-0069 |
Amiodarone-d4 HCl
|
||
Amiodarone-d4 HCl 是 Amiodarone HCl 的氘代化合物。Amiodarone HCl 的 CAS 号为 19774-82-4。Amiodarone hydrochloride是一种抗心绞痛和 III 类抗心律失常药物,通过抑制钾通道和电压门控钠通道来增加心室和心房肌肉作用的持续时间,可导致心率和血管阻力降低。它通过成纤维细胞中的ERK1/2和p38 MAPK信号传导诱导细胞增殖和肌成纤维细胞分化,可研究室上性和室性心律失常。 | |||
T71981 |
Gliclazide-d4
|
||
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin... | |||
T71303 |
Flufenamic Acid-d4
|
||
Flufenamic acid-d4 is intended for use as an internal standard for the quantification of flufenamic acid by GC- or LC-MS. Flufenamic acid is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 3 and 9.3 µM for human COX-1 and COX-2, respectively). Flufenamic acid inhibits TNF-α-induced increases in COX-2 levels and NF-κB activation in HT-29 colon cancer cells in a concentration-dependent manner. It inhibits calcium influx induced by fMLP or A23187 in human polymorphonuclear... | |||
TMIH-0183 |
Dequalinium Chloride-d4
|
||
Dequalinium Chloride-d4 是 Dequalinium Chloride 的氘代化合物。Dequalinium Chloride 的 CAS 号为 522-51-0。Dequalinium chloride 是一种apamin敏感型的钾离子通道选择性阻断剂。 | |||
T11240 |
Ethacrynic acid D5
|
Others | Others |
Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effects, notably reducing retinoid-induced ear edema in mice, and inhibits glutathione S-transferases (GSTs), making it a potent suppressor of the NF-kB signaling pathway. Additionally, ethacrynic acid modulates leukotriene formation. A variant, Ethacrynic acid D5, is distinguished by... | |||
TMIJ-0210 |
Bupivacaine-d9
|
||
Bupivacaine-d9 是 Bupivacaine 的氘代化合物。Bupivacaine 的 CAS 号为 38396-39-3。Bupivacaine 是一种 NMDA 受体抑制剂。Bupivacaine 可以阻断钠、L-钙和钾通道。Bupivacaine 有效阻断 SCN5A 通道,IC50 为 69.5 μM。Bupivacaine 可用于慢性疼痛的研究。 | |||
T68918 |
Phenytoin-d10
|
||
Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fosphenytoin by tissue phosphatases. It inhibits neuronal voltage-gated sodium channels in a voltage-dependent manner. Phenytoin reduces the neuronal firing frequency and decreases the amplitude of excitatory post-synaptic potentials (EPSPs) in electrically stimulated rat corticostriatal... | |||
T37608 |
Riluzole-13C,15N2
Riluzole-13C,15N2 |
||
Riluzole-13C,15N2 is intended for use as an internal standard for the quantification of riluzole by GC- or LC-MS. Riluzole is a benzothiazole derivative with anti-excitotoxic effects that acts by blocking the presynaptic release of glutamate, indirectly antagonizing glutamate receptors, and inactivating neuronal voltage-gated Na+ channels (ED50 = 2.3 μM). Riluzole suppresses glutamate-induced seizures in rats at an ED50 value of 3.2 mg/kg and displays neuroprotective effects in hypoxic animals a... | |||
TMIJ-0074 |
Retigabine-d4
|
||
Retigabine-d4 是 Retigabine 的氘代化合物。Retigabine 的 CAS 号为 150812-12-7。Retigabine dihydrochloride 是一种抗惊厥药,用作有治疗经验的成年患者部分性癫痫的辅助治疗。作用机制涉及神经元 K(V)7.2-7.5(以前的 KCNQ2-5)电压激活 K(+) 通道的开放。 | |||
TMIH-0086 |
Amifampridine-d3 2HCl
|
||
Amifampridine-d3 2HCl 是 Amifampridine 2HCl 的氘代化合物。Amifampridine 2HCl 的 CAS 号为 54-96-6。Amifampridine 可用于罕见肌肉疾病的研究。 | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
||
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
TMID-0299 |
Zonisamide-d4
|
||
Zonisamide-d4 是 Zonisamide 的氘代化合物。Zonisamide 的 CAS 号为 68291-97-4。Zonisamide 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的Ki值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性,在癫痫、癫痫发作和帕金森病的研究中具有价值。 | |||
TMID-0247 |
LacosaMide-d3
|
||
LacosaMide-d3 是 LacosaMide 的氘代化合物。LacosaMide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道:它选择性地增强钠通道缓慢失活,而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用,在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。 | |||
TMIJ-0240 |
Lacosamide-d3 (Acetyl-d3)
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Lacosamide-d3 (Acetyl-d3) 是 Lacosamide 的氘代化合物。Lacosamide 的 CAS 号为 175481-36-4。Lacosamide是一种功能化氨基酸。Lacosamide以一种新的方式调节钠通道:它选择性地增强钠通道缓慢失活,而对快速失活没有影响Lacosamine在不同的啮齿类动物癫痫发作模型中显示出抗癫痫作用,在反映神经性疼痛和慢性炎性疼痛的不同类型和症状的实验动物模型中显示了抗伤害潜力。 | |||
TMID-0120 |
Valproic Acid-d15
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Valproic Acid-d15 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。 | |||
TMIJ-0163 |
Valproic Acid-d4
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Valproic Acid-d4 是 Valproic Acid 的氘代化合物。Valproic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。 | |||
TMIJ-0431 |
2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid
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2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid 是 2-pentanoic Acid 的氘代化合物。2-pentanoic Acid 的 CAS 号为 99-66-1。Valproic acid是一种 HDAC 抑制剂,可抑制HDAC1的活性,同时可诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、双相情感障碍和偏头痛等。 |