Maurocalcine TFA acts as an agonist for ryanodine receptor (RyR) channels 1, 2, and 3, demonstrating cell-penetrating capabilities. It induces binding of [3H]ryanodine to RyR1 with an EC50 of 2558 nM and exhibits an apparent affinity of 14 nM for RyR2. This compound is applicable for in vivo cell tracking or other cellular imaging techniques.

Maurocalcine 在不同浓度和处理时间下表现出特定生物活性。具体来说，Maurocalcine (100 nM, 24 小时) 能够提高 RyR2 对 [Ca 2+] i 激活的敏感性，同时减少其对抑制 [Ca 2+] i 的反应敏感度。另外，Maurocalcine (5 μM, 4 小时/24 小时) 对 HEK293 细胞没有任何细胞毒性。