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Atosiban (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。
Atosiban (RW22164) 是一种脱氨基催产素类似物,是一种九肽,也是竞争性的催产素受体拮抗剂。它是一种宫缩抑制剂,可用于自发早产的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 270 | 5日内发货 | |
5 mg | ¥ 587 | 5日内发货 | |
10 mg | ¥ 840 | 5日内发货 | |
25 mg | ¥ 1,250 | 5日内发货 | |
50 mg | ¥ 1,510 | 5日内发货 | |
100 mg | ¥ 2,260 | 5日内发货 | |
1 mL x 10 mM (in DMSO) | ¥ 919 | 5日内发货 |
产品描述 | Atosiban (RW22164) is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence. |
别名 | 阿托西班, RWJ22164, RW22164 |
分子量 | 994.19 |
分子式 | C43H67N11O12S2 |
CAS No. | 90779-69-4 |
Smiles | C(=O)(N1[C@H](C(N[C@H](C(NCC(N)=O)=O)CCCN)=O)CCC1)[C@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@@H](CC3=CC=C(OCC)C=C3)NC(=O)CCSSC2)[H])[H] |
密度 | 1.254 g/cm3 |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | H2O: 16.67 mg/mL (16.77 mM), Sonication is recommended. DMSO: 16.67 mg/mL (16.77 mM) | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
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