Rimtuzalcap

产品编号 T9522Cas号 2167246-24-2

别名 CAD-1883

Rimtuzalcap (CAD-1883) 是首创的，选择性的小电导钙激活钾通道 (SK 通道) 正变构调节剂。Rimtuzalcap 可用于运动障碍的研究，包括脊髓小脑性共济失调 (SCA)和特发性震颤 (ET)。

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产品编号 T9522别名 CAD-1883Cas号 2167246-24-2

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生物活性

产品描述	Rimtuzalcap (CAD-1883) (CAD-1883), a pioneering selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels), is employed in the study of movement disorders such as spinocerebellar ataxia (SCA) and essential tremor (ET).
体外活性	Rimtuzalcap (Compound 1) is a small molecule modulator of potassium ion channels. It shows great therapeutic potential for treating a variety of diseases characterized by dysfunction of potassium ion channels and dysfunction from other causes which influence these potassium channels[1].
体内活性	Rimtuzalcap (CAD-1883) reduces the firing rate of Purkinje cells by approximately 40% which is consistent with the anticipated therapeutic mechanism of positive allosteric modulation of SK channels. Sequential bath application of 1 or 3 µM CAD-1883 results in a partial reversal of the increased coefficient of variation of the interspike interval which is seen in cerebellar slices from 11-month-old spinocerebellar ataxia-2 58Q mice[1].
别名	CAD-1883

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 250 mg/mL (660.64 mM), Sonication is recommended.

溶液配制表

DMSO