LUF7244

Name: LUF7244
Brand: TargetMol
SKU: T61421
Price: 333 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T61421Cas号 1821638-43-0

LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].

LUF7244

还可以

产品编号 T61421Cas号 1821638-43-0

LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].
体外活性	LUF7244 (0-10 μM; HEK293 cells) binds K v 11.1 channels and increases I Kv11.1 by inhibiting inactivation in a dose-dependent manner [1]. LUF7244 (0-10 μM; cardiomyocytes) reduces action potential duration (APD) by approximately 50% and dofetilide-induced early afterdepolarization (EAD) in isolated ventricular CMCs from SR and CAVB dogs [1]. LUF7244 (10 μM) had no effects on I KIR2.1, I Nav1.5, I Ca-L, and I Ks but doubled I Kr [1].
体内活性	LUF7244 (2.5 mg/kg; i.v.; for 15 min) decreases repolarization parameters. LUF7244 has antiarrhythmic effects against dofetilide-induced TdP arrhythmias in CAVB dogs [1].