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ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂,可抑制海马突触可塑性。
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ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂,可抑制海马突触可塑性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 497 | 现货 | |
2 mg | ¥ 738 | 现货 | |
5 mg | ¥ 1,180 | 现货 | |
10 mg | ¥ 2,120 | 现货 | |
25 mg | ¥ 3,630 | 现货 | |
50 mg | ¥ 5,230 | 现货 | |
100 mg | ¥ 7,380 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,320 | 现货 |
产品描述 | ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity. |
体外活性 | ZD7288以浓度依赖的方式减弱了谷氨酸诱导的[Ca(2+)]i上升,并且逆转了8-Br-cAMP介导的这种谷氨酸诱导的[Ca(2+)]i上升的促进作用。ZD7288抑制了大鼠海马神经元中谷氨酸释放及其引起的[Ca(2+)]i增加,影响海马突触可塑性。 |
细胞实验 | Cultured hippocampal neurons were incubated with 1 μM Fura-2 acetoxy-methylol ester for 30 minutes at 37°C, washed three times with artificial cerebrospinal fluid (containing 140 mM NaCl, 5 mM KCl, 2 mM CaCl2, 1 mM MgCl2, 10 mM glucose and 10 mM hydroxyethyl piperazine ethanesulfonic acid, pH 7.3), and then incubated at room temperature in the dark for 30 minutes.?Fura-2 fluorescence was observed by a Ratio Vision digital fluorescence microscopy system.?Fluorescence signals were evoked by 340 and 380 nm excitation wavelengths and collected at 510 nm by TILLvisION 4.0 software.?The 340:380 nm fluorescence ratio was used to represent [Ca2+]i.?Peak calcium change was represented as the percentage increase from baseline.?Neurons were incubated in ZD7288 (25, 50 or 100 μM) or 8-Br-cAMP (5 or 50 μM) for 15 minutes prior to stimulation with 50 μM glutamate.?All experiments were repeated in triplicate, using different batches of cells across 4–5 dishes[1]. |
别名 | N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐, ICI D7288 |
分子量 | 292.81 |
分子式 | C15H21ClN4 |
CAS No. | 133059-99-1 |
Smiles | Cl.CCN(c1ccccc1)c1cc(=NC)n(C)c(C)n1 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (170.76 mM) H2O: 50 mg/mL (170.76 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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