|
TMPH-03613
|
NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)
nblA,Phycobilisome degradation protein NblA
|
Synechococcus elongatus
|
E. coli
|
|
Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions. NblA Protein, Synechococcus elongatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.5 kDa and the accession number is P35087. |
|
TMPY-03870
|
EDEM2 Protein, Human, Recombinant (His)
UNQ573/PRO1135,ER degradation enhancer, mannosidase...
|
Human
|
HEK293 Cells
|
|
EDEM2, also known as C2orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome. Early in this pathway, a proposed lumenal ER lectin, EDEM, recognizes misfolded glycoproteins in the ER, disengages the nascent molecules from the folding pathway, and facilitates their targeting for disposal. In humans there are a total of three EDEM ... |
|
TMPY-03390
|
LSM1 Protein, Human, Recombinant (His)
LSM1 homolog, mRNA degradation associated,CASM,YJL1...
|
Human
|
E. coli
|
|
LSM1 is an Sm-like protein. Sm-like proteins can be detected in a variety of organisms based on sequence homology with the Sm protein family. Sm-like proteins include the Sm sequence motif, which consists of two regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM1 has a role in replication-dependent histone mRNA degradation and binds specif... |
|
TMPH-00176
|
PucL Protein, Bacillus subtilis, Recombinant (His & Myc)
Uric acid degradation bifunctional protein PucL,puc...
|
Bacillus subtilis
|
E. coli
|
|
Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. PucL Protein, Bacillus subtilis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 64.0 kDa and the accession number is O32141. |
|
TMPJ-01172
|
IL-17 Protein, Mouse, Recombinant (His)
CTLA8,IL-17,IL-17A,Interleukin-17A,CTLA-8,Cytotoxic T-Lympho...
|
Mouse
|
HEK293 Cells
|
|
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato... |
|
TMPY-00541
|
LON PROTEASE Protein, E. coli, Recombinant (His)
|
E. coli
|
E. coli
|
|
Lon protease, an ATP-dependent mitochondrial protease, is important in mitochondrial protein maintenance. Lon protease is a multifunctional enzyme, and its functions include the degradation of damaged proteins and naturally short-lived proteins, ATPase and chaperone-like activities, as well as DNA binding. Lon protease plays a major role in the protein quality control system in mammalian cell mitochondria. It is present in the mitochondrial matrix and degrades oxidized and misfolded proteins, th... |
|
TMPY-02078
|
HtrA2/Omi Protein, Human, Recombinant (His)
PARK13,OMI,HtrA serine peptidase 2,PRSS25
|
Human
|
E. coli
|
|
Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor... |
|
TMPY-00828
|
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
MPS2,IDS,SIDS,iduronate 2-sulfatase
|
Human
|
HEK293 Cells
|
|
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, an... |
|
TMPY-00150
|
IGF2/IGF-II Protein, Human, Recombinant
PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2
|
Human
|
P. pastoris (Yeast)
|
|
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br... |
|
TMPH-02271
|
BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-protein kina...
|
Human
|
Baculovirus Insect Cells
|
|
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... |
|
TMPJ-01386
|
STUB1 Protein, Human, Recombinant
Carboxy Terminus of Hsp70-Interacting Protein,STIP1 Homology...
|
Human
|
E. coli
|
|
E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation.... |
|
TMPH-01273
|
TRIP12 Protein, Human, Recombinant (His & Myc)
Thyroid receptor-interacting protein 12,E3 ubiquitin-protein...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag... |
|
TMPH-03455
|
Polyphosphatase/PPX1 Protein, S. cerevisiae, Recombinant (His)
Polyphosphatase,Exopolyphosphatase,PPX1,Metaphosphatase
|
Saccharomyces cerevisiae
|
E. coli
|
|
Degradation of inorganic polyphosphates. |
|
TMPH-02131
|
SKP2 Protein, Human, Recombinant (His & SUMO)
S-phase kinase-associated protein 2,SKP2,F-box protein Skp2,...
|
Human
|
E. coli
|
|
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB... |
|
TMPH-02432
|
Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc)
Legumain,Protease, cysteine 1,LGMN,Asparaginyl endopeptidase
|
Cynomolgus
|
E. coli
|
|
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg... |
|
TMPH-01259
|
AMFR Protein, Human, Recombinant (His)
Autocrine motility factor receptor,AMF receptor,gp78,RNF45,R...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add... |
|
TMPH-02844
|
Properdin Protein, Mouse, Recombinant (His)
Cfp,Properdin,Complement factor P
|
Mouse
|
E. coli
|
|
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b). |
|
TMPH-02845
|
Properdin Protein, Mouse, Recombinant (His & Myc)
Properdin,Complement factor P,Cfp
|
Mouse
|
HEK293 Cells
|
|
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b). |
|
TMPH-02634
|
TRIM63 Protein, Mouse, Recombinant (His & Myc)
Trim63,Muscle-specific RING finger protein 1,Tripartite moti...
|
Mouse
|
E. coli
|
|
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... |
|
TMPH-01269
|
SMURF2 Protein, Human, Recombinant (His)
SMAD ubiquitination regulatory factor 2,E3 ubiquitin-protein...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com... |
|
TMPH-02149
|
ALDH5A1 Protein, Human, Recombinant (His)
Succinate-semialdehyde dehydrogenase, mitochondrial,NAD(+)-d...
|
Human
|
P. pastoris (Yeast)
|
|
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). |
|
TMPH-03282
|
TRIM63 Protein, Rat, Recombinant (His & Myc)
Muscle-specific RING finger protein 1,Tripartite motif-conta...
|
Rat
|
E. coli
|
|
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... |
|
TMPJ-00823
|
UBB Protein, Human, Recombinant
UBB,Polyubiquitin-B
|
Human
|
E. coli
|
|
Polyubiquitin-B(UBB) is one of Ubiquitins. Ubiquitin is one of the most conserved proteins known in eukaryotic organisms. Ubiquitin is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. |
|
TMPH-02431
|
Legumain Protein, Cynomolgus, Recombinant (His & Myc)
Legumain,Protease, cysteine 1,Asparaginyl endopeptidase,LGMN
|
Cynomolgus
|
Baculovirus Insect Cells
|
|
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg... |
|
TMPJ-01035
|
UBE2G2 Protein, Human, Recombinant (GST)
Ubiquitin-Conjugating Enzyme E2 G2,Ubiquitin-Protein Ligase ...
|
Human
|
E. coli
|
|
Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60% and 100% sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked ... |
|
TMPH-01260
|
AMFR Protein, Human, Recombinant (hFc)
gp78,RNF45,AMF receptor,RING finger protein 45,E3 ubiquitin-...
|
Human
|
HEK293 Cells
|
|
E3 ubiquitin-protein ligase that mediates the polyubiquitination of lysine and cysteine residues on target proteins, such as CD3D, CYP3A4, CFTR, INSIG1, SOAT2/ACAT2 and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG1 complex at the ER membrane. In add... |
|
TMPH-00520
|
Host-nuclease inhibitor protein gam Protein, Enterobacteria phage lambda, Recombinant (His & Myc)
Host-nuclease inhibitor protein gam,gam
|
Escherichia phage lambda
|
E. coli
|
|
Binds to host RecBCD nuclease and inhibits it thereby protecting the viral DNA against recBCD mediated degradation. |
|
TMPH-01271
|
TRIM63 Protein, Human, Recombinant (His & Myc)
TRIM63,Striated muscle RING zinc finger protein,RING-type E3...
|
Human
|
E. coli
|
|
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striate... |
|
TMPH-02641
|
ECEL1 Protein, Mouse, Recombinant (His & Myc)
Ecel1,Endothelin-converting enzyme-like 1,Dine,Xce,Damage-in...
|
Mouse
|
E. coli
|
|
May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. |
|
TMPH-00868
|
ADAMTS7 Protein, Human, Recombinant (His & SUMO)
ADAM-TS7,ADAMTS-7,ADAM-TS 7,A disintegrin and metalloprotein...
|
Human
|
E. coli
|
|
Metalloprotease that may play a role in the degradation of COMP. ADAMTS7 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.1 kDa and the accession number is Q9UKP4. |
|
TMPH-00869
|
ADAMTS7 Protein, Human, Recombinant (His)
ADAM-TS7,ADAM-TS 7,COMPase,ADAMTS-7,A disintegrin and metall...
|
Human
|
P. pastoris (Yeast)
|
|
Metalloprotease that may play a role in the degradation of COMP. ADAMTS7 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.1 kDa and the accession number is Q9UKP4. |
|
TMPH-01280
|
EGLN1 Protein, Human, Recombinant (His & Myc)
HPH-2,EGLN1,PHD2,SM-20,HIF-prolyl hydroxylase 2,HIF-PH2,C1or...
|
Human
|
E. coli
|
|
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquiti... |
|
TMPH-02136
|
SPSB1 Protein, Human, Recombinant (His)
SPSB1,SPRY domain-containing SOCS box protein 1
|
Human
|
E. coli
|
|
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. |
|
TMPH-02847
|
CNPY2 Protein, Mouse, Recombinant (His & Myc)
MIR-interacting saposin-like protein,Tmem4,Transmembrane pro...
|
Mouse
|
E. coli
|
|
Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation. |
|
TMPH-00618
|
Exopolyphosphatase Protein, E. coli, Recombinant (His & SUMO)
ppx,Metaphosphatase,Exopolyphosphatase
|
E. coli
|
E. coli
|
|
Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has a strong preference for long-chain polyphosphates and has only weak affinity for smaller size polyP of about 15 residues. |
|
TMPH-00209
|
CLPP2 Protein, Borrelia burgdorferi, Recombinant (His & Myc)
clpP-2,Endopeptidase Clp 2,ATP-dependent Clp protease proteo...
|
Borrelia burgdorferi
|
E. coli
|
|
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. |
|
TMPH-02581
|
Chymase 1 Protein, Mouse, Recombinant (His)
Mast cell protease 5,Mast cell protease I,Alpha-chymase,Chym...
|
Mouse
|
E. coli
|
|
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Chymase 1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.2 kDa and the accession number is P21844. |
|
TMPH-00582
|
Endopeptidase Clp Protein, E. coli, Recombinant (His & Myc)
clpP,ATP-dependent Clp protease proteolytic subunit,Endopept...
|
E. coli
|
E. coli
|
|
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. |
|
TMPY-02950
|
WWP2 Protein, Human, Recombinant (His & GST)
WW domain containing E3 ubiquitin protein ligase 2,AIP2,WWp2...
|
Human
|
Baculovirus Insect Cells
|
|
WWP2 contains 1 C2 domain, 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain and 4 WW domains. It is an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. WWP2 can be detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. It is also expressed in spleen and peripheral blood leukocytes. WWP2 polyubiquitinates POU5F1 by 'Lys-6... |
|
TMPH-02594
|
MMP-13 Protein, Mouse, Recombinant (His)
Matrix metalloproteinase-13,Collagenase 3,Mmp13
|
Mouse
|
E. coli
|
|
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone develop... |
|
TMPH-02651
|
Fbxo3 Protein, Mouse, Recombinant (His & Myc)
Muscle atrophy F-box protein,Atrogin-1,Fbxo32,F-box only pro...
|
Mouse
|
E. coli
|
|
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. |
|
TMPH-02282
|
Ubiquilin-1 Protein, Human, Recombinant (His & Myc)
Ubiquilin-1,UBQLN1,Protein linking IAP with cytoskeleton 1
|
Human
|
E. coli
|
|
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its in... |
|
TMPH-03401
|
Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc)
Azgp1,Zinc-alpha-2-glycoprotein
|
Rat
|
E. coli
|
|
Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. Zinc Alpha 2 Glycoprotein/AZGP1 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.7 kDa and the accession number is Q63678. |
|
TMPH-01062
|
Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc)
CTSO1,CTSO,Cathepsin O
|
Human
|
E. coli
|
|
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.5 kDa and the accession number is P43234. |
|
TMPH-01650
|
PRAME Protein, Human, Recombinant (E. coli, His)
Opa-interacting protein 4,Preferentially expressed antigen o...
|
Human
|
E. coli
|
|
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation. The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding. In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role... |
|
TMPJ-01249
|
ASB13 Protein, Human, Recombinant (His)
ASB13,Ankyrin repeat and SOCS box protein 13
|
Human
|
E. coli
|
|
Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. ASB13 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex... |
|
TMPH-03415
|
Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)
Non-structural protein S,NSS
|
RVFV
|
E. coli
|
|
Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool binds to host FBXO3 to target TFIIH subunit GTF2H1 for proteasomal degradation. Forms filaments in the nucleus that may sequester NSs binding partners, causing cell cycle arrest. Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc) is expressed... |
|
TMPH-01063
|
Cathepsin O Protein, Human, Recombinant (His & Myc)
CTSO1,CTSO,Cathepsin O
|
Human
|
HEK293 Cells
|
|
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover. Cathepsin O Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 28.5 kDa and the accession number is P43234. |
|
TMPH-01522
|
HIV-2 (subtype A, isolate ROD) Protein Vpx (His)
vpx,Viral protein X,X ORF protein,Protein Vpx
|
HIV-2
|
P. pastoris (Yeast)
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Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by... |
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TMPH-01535
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INSIG2 Protein, Human, Recombinant (His & Myc)
Insulin-induced gene 2 protein,INSIG2
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Human
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E. coli
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Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycho... |
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