VCP/p97 inhibitor-1, a highly effective compound, inhibits VCP/p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

VCP/p97:54.7 nM

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC 50 s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1]. Cell Viability Assay[1]Cell Line: A549, RPMI8226 cells Concentration: 3-fold serial dilutions with the highest concentration at 10 μM Incubation Time: 72 hours Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC 50 = 2.9 and 0.86 μM, respectively).