PROTAC ERα Degrader-2

Name: PROTAC ERα Degrader-2
Brand: TargetMol
SKU: T18605
Rating: 4.5 (1 reviews)

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产品编号 T18605Cas号 1351169-29-3

PROTAC ERα Degrader-2 comprises a cIAP1 ligand binding group, a linker and an estrogen receptor α (ERα) binding group. PROTAC ERα Degrader-2 is an ERα degrader. Maximal ERα degradation at 30 μM concentration in human mammary tumor MCF7 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

PROTAC ERα Degrader-2

还可以

产品编号 T18605Cas号 1351169-29-3

规格	价格	库存	数量
100 mg	询价	期货
500 mg	询价	期货

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生物活性

产品描述

PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].

化学信息

分子量	763.96
分子式	C₄₂H₆₁N₅O₈
CAS No.	1351169-29-3
密度	1.29 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 200 mg/mL (261.79 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3090 mL	6.5448 mL	13.0897 mL	65.4485 mL
5 mM	0.2618 mL	1.3090 mL	2.6179 mL	13.0897 mL
10 mM	0.1309 mL	0.6545 mL	1.3090 mL	6.5448 mL
20 mM	0.0654 mL	0.3272 mL	0.6545 mL	3.2724 mL
50 mM	0.0262 mL	0.1309 mL	0.2618 mL	1.3090 mL
100 mM	0.0131 mL	0.0654 mL	0.1309 mL	0.6545 mL