(S,R,S)-AHPC-C6-PEG3-C4-Cl

Name: (S,R,S)-AHPC-C6-PEG3-C4-Cl
Brand: TargetMol
SKU: T17911
Rating: 4.5 (1 reviews)

还可以

产品编号 T17911Cas号 1835705-55-9

别名 VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8

(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

(S,R,S)-AHPC-C6-PEG3-C4-Cl

还可以

产品编号 T17911 别名 VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8Cas号 1835705-55-9

规格	价格	库存	数量
2 mg	¥ 387	5日内发货
5 mg	¥ 627	期货

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产品介绍

生物活性

产品描述	(S,R,S)-AHPC-C6-PEG3-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker. (S,R,S)-AHPC-C6-PEG3-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
体外活性	(S,R,S)-AHPC-C6-PEG3-C4-Cl uses the cereblon ligand[1]. The linker is 6-2-2-6. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-C6-PEG3-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase [2].
别名	VHL Ligand-Linker Conjugates 12, VH032-C6-PEG3-C4-Cl, E3 ligase Ligand-Linker Conjugates 8

化学信息

分子量	751.42
分子式	C₃₈H₅₉ClN₄O₇S
CAS No.	1835705-55-9
密度	1.174 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (133.08 mM)

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3308 mL	6.6541 mL	13.3081 mL	66.5407 mL
5 mM	0.2662 mL	1.3308 mL	2.6616 mL	13.3081 mL
10 mM	0.1331 mL	0.6654 mL	1.3308 mL	6.6541 mL
20 mM	0.0665 mL	0.3327 mL	0.6654 mL	3.3270 mL
50 mM	0.0266 mL	0.1331 mL	0.2662 mL	1.3308 mL
100 mM	0.0133 mL	0.0665 mL	0.1331 mL	0.6654 mL