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Targets Recommended: PPAR

472

抑制剂 & 化合物

20

天然产物

10

化合物库

13

重组蛋白

19

同位素标记化合物

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Cat. No.	Product Name
LF1000	多样性核心预制库		50000 compounds
	For your convenience, there are Diversity Sets of 5,000, 10,000, 15,000, and 20,000 compounds with no structure overlap.
L7820	高溶解性微型片段化合物库		1081 compounds
	高溶解性微型片段化合物库由 1081 个低分子量片段组成。
CB1100	EXP多样性库		50000 compounds
	For hit finding across different targets, against novel targets, or for the discovery of new chemical series against existing targets, ChemBridge offers up to 150,000 DIVERSet Library compounds in economical, pre-plated format. The DIVERSet Libraries are suitable for biochemical assays, phenotypic and other cell based assays, and assays using model organisms such as bacteria, yeast, c. elegans, zebrafish, or arabidopsis. DIVERSet Libraries have been used across many disease areas resulting in hu...
VM1400	多样性核心库Part2		25920 compounds
	分子量<500，主要集中于250-450之间，方便后续的改造优化；
L4520	抗菌活性库		904 compounds
	904 种具有抗菌活性的化合物，是抗菌药物研发的有力工具；
L9820	β-内酰胺类化合物库		97 compounds
	97 种β-内酰胺类化合物的集合，可以用于高通量和高内涵筛选；
L9830	抗帕金森病化合物库		857 compounds
	857 种帕金森病相关的化合物集合，可用于高通量和高内涵筛选；
L6020	天然产物单体化合物库		16627 compounds
	16627 种精选天然产物集合，结构多样，遍布多种动植物与微生物；
L6800	中国药典收录天然产物库		2051 compounds
	2051 种中国药典收录的天然产物，是药物开发、药理研究等领域的有力工具；
DF4500	多样性核心库Part1		50000 compounds
	绝大部分分子量<500，主要集中于250-450之间，方便后续的改造优化；

化合物库

多样性核心预制库

Cat.No: LF1000

Compounds: 50000

高溶解性微型片段化合物库

Cat.No: L7820

Compounds: 1081

EXP多样性库

Cat.No: CB1100

Compounds: 50000

多样性核心库Part2

Cat.No: VM1400

Compounds: 25920

抗菌活性库

Cat.No: L4520

Compounds: 904

β-内酰胺类化合物库

Cat.No: L9820

Compounds: 97

抗帕金森病化合物库

Cat.No: L9830

Compounds: 857

天然产物单体化合物库

Cat.No: L6020

Compounds: 16627

中国药典收录天然产物库

Cat.No: L6800

Compounds: 2051

多样性核心库Part1

Cat.No: DF4500

Compounds: 50000

Cat. No.	Product Name	Target	Signaling Pathways
T11339	Furegrelate sodium U-63557A	PPAR	DNA Damage/DNA Repair; Metabolism
	Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。
T9865	Almonertinib mesylate	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib mesylate 是一种不可逆的 EGFR 酪氨酸激酶抑制剂，对 EGFR 敏感突变和 T790M 耐药突变具有高选择性。它可用于非小细胞肺癌研究。
T1457	Deferasirox ICL 670,CGP-72670,地拉罗司	Others; Ferroptosis; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Deferasirox (CGP-72670) 是一种口服铁螯合剂，用于治疗慢性铁过载。
T2923	Apremilast 阿普斯特,CC-10004,阿普司特	Apoptosis; TNF; PDE	Apoptosis; Metabolism
	Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂，IC50为 74 nM。它抑制脂多糖释放TNF-α，IC50为 104 nM。
T16841	SAR-260301	PI3K	PI3K/Akt/mTOR signaling
	SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).
T15198	Edasalonexent CAT-1004	NF-κB	NF-κB
	Edasalonexent (CAT-1004) 是一种可口服的 NF-κB 抑制剂，可用于改善杜氏肌营养不良症。
T13997	AU-224	Others	Others
	AU-224 是一种可口服的苯甲酰胺衍生物，是一种强效的胃肠促动力活性。
T27632	Isomazole	PDE	Metabolism
	Isomazole 是一种可口服的具有钙敏特性的新型磷酸二酯酶（PDE）抑制剂，对PDE3 和 PDE4 有抑制作用。
T17226	Vericiguat 维利西呱,BAY1021189	Guanylate cyclase	GPCR/G Protein
	Vericiguat (BAY1021189) 是一种有效的口服鸟苷酸环化酶刺激剂。
T31668	Eribaxaban PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292	Factor Xa	Metabolism
	Eribaxaban (PD348292) 是一种可口服的 Xa 因子抑制剂，可用于预防和治疗静脉血栓栓塞。
T3218	Napabucasin BBI608	STAT	JAK/STAT signaling; Stem Cells
	Napabucasin (BBI608) 是一种口服的 Stat3 和 Y 干细胞活性抑制剂。
T6153	Icotinib BPI-2009,埃克替尼,BPI-2009H,Conmana	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Icotinib (Conmana) 是一种口服的基于喹唑啉的表皮生长因子受体 (EGFR) 抑制剂，IC50值为5 nM，具有潜在的抗肿瘤活性。
T27812	Leminoprazole	ATPase	Membrane transporter/Ion channel
	Leminoprazole 是一种可口服的 H+，K（+）-ATPase 抑制剂，可保护胃黏膜细胞免受各种细胞损伤，可用于治疗胃溃疡。
T68050L	Dazolicin HCl Dazolicine HCl,Dazolicine hydrochloride	Others	Others
	Dazolicin HCl (Dazolicine HCl) 是一种可口服的抗心律失常化合物。
T6585	SAR405838 MI773,MI 773,MI-77301,MI-773	Mdm2; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SAR405838 (MI 773) 是 MI-773 的类似物，具有抗肿瘤活性。它是一种高效、选择性的MDM2-p53相互作用抑制剂，与 MDM2 结合的Ki 值为 0.88 nM。
T33421	MK-0686 MK0686	Bradykinin Receptor	GPCR/G Protein
	MK-0686 是一种可口服的缓激肽 B1 受体拮抗剂，具有潜在的抗炎活性。
T5605	EZM 2302 GSK3359088	Histone Methyltransferase	Chromatin/Epigenetic
	EZM 2302 (GSK3359088) 是选择性口服精氨酸甲基转移酶 CARM1 抑制剂，IC50值为 6 nM。
T16785	Ropidoxuridine IPdR	Others	Others
	Ropidoxuridine (IPdR) 是一种新型的、可口服的卤化胸苷类似物，有望成为人类肿瘤的增敏剂。Ropidoxuridine 是一种可口服且具有生物可利用的IUdR(5-碘-2'-脱氧尿苷)前药。
T15423	GSK-7975A	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	GSK-7975A 是具有口服活性的高效CRAC 通道抑制剂。
T67963	Teniloxazine	Others	Others
	Teniloxazine 是一种可口服的抗抑郁化合物，具有抗缺氧特性。
T25006	AGI-14100 AGI 14100	Dehydrogenase	Metabolism
	AGI-14100 是一种新型且可口服的 mIDH1 抑制剂。AGI-14100 用于治疗原发性人类髓性白血病。
T28911	Tafetinib SIM-010603,SIM010603,SIM 010603	Tyrosine Kinases	Tyrosine Kinase/Adaptors
	Tafetinib (SIM-010603) 是一种新型有效且可口服的酪氨酸激酶抑制剂，具有抗血管生成和抗肿瘤活性。
T27176	Dimethandrolone Undecanoate DMAU	Others	Others
	Dimethandrolone Undecanoate (DMAU) 是一种新型可口服的雄激素，具有孕激素活性，是有潜力的男性避孕化合物。
T67960	Recainam	Others	Others
	Recainam 是一种可口服的新型且具有有效的 I 类抗心律失常活性的化合物。
T33836L	Oxamisole TFA Oxamisole TFA（99258-56-7 Free base)	Antiviral	Immunology/Inflammation
	Oxamisole TFA 是一种可口服且具有选择性的 T 细胞免疫调节剂，可用于研究病毒感染。
T16781	Rogaratinib BAY1163877	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Rogaratinib (BAY1163877) 选择性抑制成纤维细胞生长因子受体。
T17235	Voclosporin ISAtx-247	Phosphatase	Metabolism
	Voclosporin (ISAtx-247) 是一种新型且可口服钙调磷酸酶(CN; PP2B)抑制剂和免疫抑制剂，可用于治疗狼疮性肾炎。
T39707	AS-1763	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	AS-1763 是一种有效的、选择性的、非共价的、可口服的抑制剂，IC50 为 0.85 nM。
T2614	GSK2606414	Apoptosis; PERK; Autophagy	Apoptosis; Autophagy
	GSK2606414 是可渗透细胞且有口服活性的蛋白激酶 R 样内质网激酶抑制剂，IC50值为 0.4 nM。
T13111	Tegadifur 40497S,FD 1	Others	Others
	Tegadifur (40497S) 是一种可口服的抗肿瘤化合物，具有抗新陈代谢作用，常与尿嘧啶林和治疗直肠腺癌。
TQ0266	MSC2530818	CDK	Cell Cycle/Checkpoint
	MSC2530818 是一种有效的、选择性的、可口服的 CDK8 抑制剂，IC50值为2.6 nM。
T68139	Scio-323	p38 MAPK	MAPK
	Scio-323是一种可口服的 p38丝裂原活化蛋白（MAPK）激酶抑制剂。
TP1399	Fmoc-N-Me-Leu-OH	Others	Others
	Fmoc-N-Me-Leu-OH 是 N-Fmoc-N-甲基氨基酸的一种，能够用于肽偶联反应。
T3723	Dioxopromethazine hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dioxopromethazine hydrochloride 是一种基于目标的药物分类，在全球许多国家都有销售。
T23297	(S)-(+)-Dimethindene maleate	AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(S)-(+)-Dimethindene maleate 是一种可口服且具有选择性毒蕈碱 M2 受体和组胺 H1 受体拮抗剂，抑制毒蕈碱 M1，M3 和 M4 受体。
T23711	WAY-260022 WAY 260022,NRI 022,NRI022,NRI-022,WAY260022	Dopamine Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	WAY-260022 是一种可口服且具有选择性去甲肾上腺素转运蛋白抑制剂，对血清素和多巴胺转运蛋白显示出抑制作用。
TQ0042	BAY-1436032	Dehydrogenase; Isocitrate Dehydrogenase (IDH)	Metabolism
	BAY-1436032 是一种选择性泛突变异柠檬酸脱氢酶 1 新型口服抑制剂。
T14089	AC-261066 AC 261066	Retinoid Receptor	Metabolism
	AC-261066是一种口服的RARβ2的同型选择性激动剂，pEC50为8.0。
T69356	Cindunistat Cindunistat free base,SD6010,SD-6010	NOS	Immunology/Inflammation
	Cindunistat (free base) 是一种可口服的选择性 iNOS 抑制剂，可用于研究关节炎。
T68122L	Oxmetidine FA Oxmetidine FA(72830-39-8 Free base)	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Oxmetidine FA 是一种可口服的特异性组胺 H2 受体拮抗剂，具有抗溃疡作用。
T6076	EPZ015666 GSK3235025	Histone Methyltransferase	Chromatin/Epigenetic
	EPZ015666 (GSK3235025) 是一种口服有效的 PRMT5 酶活性抑制剂，IC50为 22 nM。
T27271	Enzaplatovir BTAC585,BTA 585,BTA585,BTA-C585,BTA-585	RSV	Microbiology/Virology
	Enzaplatovir (BTA-585) 是一种可口服的融合 (fusion) 抑制剂，具有抗病毒活性，可用于研究呼吸道合胞病毒感染和冠状病毒病（COVID-19）感染。
T6511	Ravoxertinib GDC-0994	ERK	MAPK
	Ravoxertinib (GDC-0994) 是可口服的ERK 激酶抑制剂，抑制ERK1和ERK2的IC50分别为 6.1 和 3.1 nM。
T7547	Ralfinamide mesylate FCE-26742A (mesylate)	Sodium Channel	Membrane transporter/Ion channel
	Ralfinamide mesylate (FCE-26742A (mesylate)) 是一种口服有效，来源于 α-aminoamide 的钠离子通道阻滞剂, 在缓解疼痛方面有研究价值。
T30787	Cefetamet sodium Ro 15-8074/001,Ro15-8074/001,Ro-15-8074/001	Antibiotic	Microbiology/Virology
	Cefetamet sodium (Ro 15-8074/001) 是一种可口服的头孢类抗生素，具有抗菌活性，可用于研究肝硬化和肺部感染。
T12717	Basimglurant CTEP Derivative,RG7090	GluR	Neuroscience
	Basimglurant (CTEP Derivative) 是一种高效，选择性，可口服的 mGlu5负变构调节剂，Kd 值为1.1 nM。
T16114	Pavinetant MLE-4901,AZD4901,AZD2624	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Pavinetant (MLE-4901) 是一种可口服的神经激肽-3 受体 (NK3R) 拮抗剂，可用于改善更年期症状。
T15575	Indeglitazar PPM 204	PPAR	DNA Damage/DNA Repair; Metabolism
	Indeglitazar (PPM 204) 是 PPAR 的泛激动剂，包括亚型 alpha (α)、delta (δ) 和 gamma (γ)。
T10983L	DDP-38003 dihydrochloride	Histone Demethylase	Chromatin/Epigenetic
	DDP-38003 dihydrochloride 是具有口服活性的KDM1A/LSD1抑制剂，IC50 值为 84 nM。
T25982	Pramiconazole R-126638,R126638,R 126638,Azoline	Antifungal	Microbiology/Virology
	Pramiconazole (R126638) 是一种可口服的抗真菌化合物。Pramiconazole 是治疗皮肤癣菌和皮肤酵母菌感染的候选化合物，可用于治疗脂溢性皮炎。

化合物

Furegrelate sodium

Cat.No: T11339

Synonym: U-63557A

Target: PPAR

Almonertinib mesylate

Cat.No: T9865

Target: EGFR

Cat.No: T1457

Synonym: ICL 670,CGP-72670,地拉罗司

Target: Others, Ferroptosis, Antibacterial

Cat.No: T2923

Synonym: 阿普斯特,CC-10004,阿普司特

Target: Apoptosis, TNF, PDE

Cat.No: T16841

Target: PI3K

Cat.No: T15198

Synonym: CAT-1004

Target: NF-κB

Cat.No: T13997

Target: Others

Cat.No: T27632

Target: PDE

Cat.No: T17226

Synonym: 维利西呱,BAY1021189

Target: Guanylate cyclase

Cat.No: T31668

Synonym: PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292

Target: Factor Xa

Cat.No: T3218

Synonym: BBI608

Target: STAT

Cat.No: T6153

Synonym: BPI-2009,埃克替尼,BPI-2009H,Conmana

Target: EGFR

Cat.No: T27812

Target: ATPase

Cat.No: T68050L

Synonym: Dazolicine HCl,Dazolicine hydrochloride

Target: Others

Cat.No: T6585

Synonym: MI773,MI 773,MI-77301,MI-773

Target: Mdm2, E1/E2/E3 Enzyme

Cat.No: T33421

Synonym: MK0686

Target: Bradykinin Receptor

Cat.No: T5605

Synonym: GSK3359088

Target: Histone Methyltransferase

Cat.No: T16785

Synonym: IPdR

Target: Others

Cat.No: T15423

Target: Calcium Channel

Cat.No: T67963

Target: Others

Cat.No: T25006

Synonym: AGI 14100

Target: Dehydrogenase

Cat.No: T28911

Synonym: SIM-010603,SIM010603,SIM 010603

Target: Tyrosine Kinases

Dimethandrolone Undecanoate

Cat.No: T27176

Synonym: DMAU

Target: Others

Cat.No: T67960

Target: Others

Cat.No: T33836L

Synonym: Oxamisole TFA（99258-56-7 Free base)

Target: Antiviral

Cat.No: T16781

Synonym: BAY1163877

Target: FGFR

Cat.No: T17235

Synonym: ISAtx-247

Target: Phosphatase

Cat.No: T39707

Target: BTK

Cat.No: T2614

Target: Apoptosis, PERK, Autophagy

Cat.No: T13111

Synonym: 40497S,FD 1

Target: Others

Cat.No: TQ0266

Target: CDK

Cat.No: T68139

Target: p38 MAPK

Fmoc-N-Me-Leu-OH

Cat.No: TP1399

Target: Others

Dioxopromethazine hydrochloride

Cat.No: T3723

Target: Histamine Receptor

(S)-(+)-Dimethindene maleate

Cat.No: T23297

Target: AChR, Histamine Receptor

Cat.No: T23711

Synonym: WAY 260022,NRI 022,NRI022,NRI-022,WAY260022

Target: Dopamine Receptor, Serotonin Transporter, Norepinephrine

Cat.No: TQ0042

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

Cat.No: T14089

Synonym: AC 261066

Target: Retinoid Receptor

Cat.No: T69356

Synonym: Cindunistat free base,SD6010,SD-6010

Target: NOS

Cat.No: T68122L

Synonym: Oxmetidine FA(72830-39-8 Free base)

Target: Histamine Receptor

Cat.No: T6076

Synonym: GSK3235025

Target: Histone Methyltransferase

Cat.No: T27271

Synonym: BTAC585,BTA 585,BTA585,BTA-C585,BTA-585

Target: RSV

Cat.No: T6511

Synonym: GDC-0994

Target: ERK

Ralfinamide mesylate

Cat.No: T7547

Synonym: FCE-26742A (mesylate)

Target: Sodium Channel

Cefetamet sodium

Cat.No: T30787

Synonym: Ro 15-8074/001,Ro15-8074/001,Ro-15-8074/001

Target: Antibiotic

Cat.No: T12717

Synonym: CTEP Derivative,RG7090

Target: GluR

Cat.No: T16114

Synonym: MLE-4901,AZD4901,AZD2624

Target: Neurokinin receptor

Cat.No: T15575

Synonym: PPM 204

Target: PPAR

DDP-38003 dihydrochloride

Cat.No: T10983L

Target: Histone Demethylase

Cat.No: T25982

Synonym: R-126638,R126638,R 126638,Azoline

Target: Antifungal

Cat. No.	Product Name	Target	Signaling Pathways
TN5073	Strophanthidin 毒毛旋花子甙元,Strophanthidine,葡萄球菌素	ATPase; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Strophanthidin (Strophanthidine) 是黄花夹竹桃中的一种类固醇，可增加舒张期和收缩期胞内 Ca2+浓度。它在 0.1 和 1 nmol/L 增加Na+/K+-ATPase 活性，1到100 μ mol/L 抑制Na+/K+-ATPase 活性，10 和 100 nmol/L 对Na+/K+-ATPase 活性无影响。
T5368	Eicosapentaenoic Acid	Histone Demethylase; Others; Endogenous Metabolite	Chromatin/Epigenetic; Metabolism; Others
	Eicosapentaenoic Acid 是一种 ω-3 脂肪酸。
T3428	Helicid Hilicidum,4-formylphenyl-O-β-d-allopyranoside,Helicide,豆腐果苷	Others	Others
	Helicid (Helicide) 是 Helicia nilgirica Bedd 的主要组成部分。它被用于精神神经症的相关研究，可用于促进安定、睡眠和缓解疼痛。
TQ0024	3-Hydroxyglutaric acid	Endogenous Metabolite	Metabolism
	3-Hydroxyglutaric acid 是一种戊二酸的衍生物。
T2933	Wogonin Vogonin,汉黄芩素	Apoptosis; Wnt/beta-catenin; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Wogonin (Vogonin) 是一种具有细胞渗透性的口服类黄酮，具有抗炎和抗癌特性，能够抑制 CDK8和 Wnt 的活性。
T3S2007	MRE-269 3-氧代-12-烯-28-乌苏酸,MRE 269,ACT-333679,MRE269	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	MRE-269 (ACT-333679) 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。
T2947	Indole-3-carbinol 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol	E1/E2/E3 Enzyme; NF-κB; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p53	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; Ubiquitination
	Indole-3-carbinol (I3C) 是樟子松中的一种天然产物，是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂，可抑制 NF-κB 和 IκBα 激酶活化。
T1045	Trimipramine maleate Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐	Dopamine Receptor; 5-HT Receptor; Antibacterial; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Trimipramine maleate (Surmontil maleate) 是一种 5-HT 受体拮抗剂，对 5-HT1C、5-HT2和 5-HT1A 受体的 pKi 值分别为 6.39、8.10和 4.66。
T5253	3-Methyladipic acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Methyladipic acid 是 ω 氧化途径的终产物。它是植烷酸分解代谢的代谢物。
T3O2749	L-Leucine (S)-Leucine,Leu,L-亮氨酸,亮氨酸	mTOR	PI3K/Akt/mTOR signaling
	L-Leucine ((S)-Leucine) 是必需的支链氨基酸，能够激活 mTOR 信号通路。
T0978	Pantethine LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine	Endogenous Metabolite	Metabolism
	D-Pantethine (Pantomin) 是泛酸的二聚体形式, 是生产辅酶 A 的中间体。D-Pantethine 能够作为膳食补充剂，用于改善血液胆固醇和研究痤疮。
T20643	Cefoxitin Rephoxitin,Cefoxitinum	Cell wall; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology
	Cefoxitin (Rephoxitin) 是一种广谱的、可口服的第二代头孢霉素类抗生素。Cefoxitin 干扰细菌细胞壁的合成。其活性谱包括革兰氏阴性和革兰氏阳性菌，通常用于腹腔感染、盆腔感染和某些类型的妇科感染等腹部，对厌氧菌具有高效性。
T15248	Estetrol Donesta	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用，但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。
T3746	Dimethyl phthalate 邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯	Others	Others
	Dimethyl phthalate (Fermine) 是一种邻苯二甲酸酯 (PAEs)，是一种已知的内分泌干扰物，也是一种普遍存在的污染物。它常作为增塑剂，赋予硬质聚氯乙烯 (PVC) 树脂以柔韧性。
TN1056	Mogroside IIe	IL Receptor	Immunology/Inflammation
	Mogroside IIe 是一种天然来源的三萜糖苷，作为非糖类甜味剂，Mogroside 比蔗糖更甜。Mogroside 具有抗氧化，抗糖尿病和抗癌活性。
TN6550	New compound 2
	New compound 2 可用于生命科学领域的相关研究，其产品编号为 TN6550。
TN6578	Dihydromarein
	Dihydromarein 可用于生命科学领域的相关研究，其产品编号为 TN6578。
TN6654	cis-Aegineoside
	cis-Aegineoside 可用于生命科学领域的相关研究，其产品编号为 TN6654。
TN3405	Amaronol B	Others	Others
	Amaronol B 是在 Pseudolarix amabilis 和 Larix kaempferi 中发现的一种天然产物，有可用的数据。
TN6479	13-Dehydroxyindaconintine
	13-Dehydroxyindaconintine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 TN6479。

天然产物

Cat.No: TN5073

Synonym: 毒毛旋花子甙元,Strophanthidine,葡萄球菌素

Target: ATPase, Calcium Channel

Eicosapentaenoic Acid

Cat.No: T5368

Target: Histone Demethylase, Others, Endogenous Metabolite

Cat.No: T3428

Synonym: Hilicidum,4-formylphenyl-O-β-d-allopyranoside,Helicide,豆腐果苷

Target: Others

3-Hydroxyglutaric acid

Cat.No: TQ0024

Target: Endogenous Metabolite

Cat.No: T2933

Synonym: Vogonin,汉黄芩素

Target: Apoptosis, Wnt/beta-catenin, CDK, Autophagy

Cat.No: T3S2007

Synonym: 3-氧代-12-烯-28-乌苏酸,MRE 269,ACT-333679,MRE269

Target: Prostaglandin Receptor

Indole-3-carbinol

Cat.No: T2947

Synonym: 吲哚-3-甲醇,I3C,3-Indolemethanol,3-吲哚甲醇,Indole-3-Methanol

Target: E1/E2/E3 Enzyme, NF-κB, Aryl Hydrocarbon Receptor, Endogenous Metabolite, p53

Trimipramine maleate

Cat.No: T1045

Synonym: Surmontil maleate,马来酸三甲丙咪嗪,三甲丙咪嗪马来酸盐

Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor

3-Methyladipic acid

Cat.No: T5253

Target: Others, Endogenous Metabolite

Cat.No: T3O2749

Synonym: (S)-Leucine,Leu,L-亮氨酸,亮氨酸

Target: mTOR

Cat.No: T0978

Synonym: LBF disulfide,Pantosin,Pantetina,Bis-pantethine,泛硫乙胺(维生素B5),泛硫乙胺,Pantomin,D-Pantethine

Target: Endogenous Metabolite

Cat.No: T20643

Synonym: Rephoxitin,Cefoxitinum

Target: Cell wall, Antibacterial, Antibiotic

Cat.No: T15248

Synonym: Donesta

Target: Estrogen Receptor/ERR, Endogenous Metabolite

Dimethyl phthalate

Cat.No: T3746

Synonym: 邻苯二甲酸二甲酯,Solvanom,Avolin,Fermine,避蚊酯

Target: Others

Cat.No: TN1056

Target: IL Receptor

Cat.No: TN6550

Cat.No: TN6578

cis-Aegineoside

Cat.No: TN6654

Cat.No: TN3405

Target: Others

13-Dehydroxyindaconintine

Cat.No: TN6479

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00369	LY6D Protein, Human, Recombinant (mFc) E48,lymphocyte antigen 6 complex, locus D,Ly-6D	Human	HEK293 Cells
	LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification. The expression of LY6D is induced in MCF10A cells by X-ray irradiation. The induction of LY6D expression is triggered through a pathway regulated by ATM, CHK2, and p53. This method is a new Ab-directed proteomic strategy for the analysis of membrane protein...
TMPY-02157	GST Protein, Schistosoma japonicum, Recombinant	Schistosoma japonicum	Baculovirus Insect Cells
	Genetic engineers have used glutathione S-transferase to create the GST gene fusion system. This system is used to purify and detect proteins of interest. In a GST gene fusion system, the GST sequence is incorporated into an expression vector alongside the gene sequence encoding the protein of interest. Induction of protein expression from the vector's promoter results in expression of a fusion protein: the protein of interest fused to the GST protein. This GST-fusion protein can then be purifie...
TMPH-00771	Ferritin-2 Protein, Glycine max, Recombinant (His & SUMO) Ferritin-2, chloroplastic,SFerH-2	Glycine max	E. coli
	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
TMPK-01125	FAM19A5 Protein, Mouse, Recombinant (His) Fam19a5,QLLK5208,Tafa5,Chemokine-like protein TAFA-5,UNQ5208	Mouse	E. coli
	FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain. FAM19A5 plays a role in nervous system development from an early stage and increases its expression in response to pathological conditions in subsets of neurons and OPCs of the brain. FAM19A5 Protein, Mouse, Recombinant (His) is expressed in E. coli ...
TMPK-00906	PSCA Protein, Mouse, Recombinant (hFc) UNQ206,PSCA,PRO232	Mouse	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Mouse, Recomb...
TMPK-00699	FAM19A5 Protein, Human, Recombinant (His) Chemokine-like protein TAFA-5,UNQ5208,Tafa5,QLLK5208,Fam19a5	Human	E. coli
	FAM19A5 is a secretory protein that is predominantly expressed in the brain. Although the FAM19A5 gene has been found to be associated with neurological and/or psychiatric diseases, only limited information is available on its function in the brain. FAM19A5 plays a role in nervous system development from an early stage and increases its expression in response to pathological conditions in subsets of neurons and OPCs of the brain. FAM19A5 Protein, Human, Recombinant (His) is expressed in E. coli ...
TMPK-00728	PSCA Protein, Human, Recombinant (hFc) UNQ206,PRO232,PSCA	Human	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Human, Recomb...
TMPY-00561	Neurotensin Protein, Human, Recombinant (hFc) NMN-125,NTS1,NN,NT/N,neurotensin,NT	Human	HEK293 Cells
	NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali...
TMPJ-00696	NOL3 Protein, Human, Recombinant Apoptosis Repressor With CARD,Nucleolar Protein of 30 kDa,Nu...	Human	E. coli
	Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ...
TMPJ-00761	FTH Protein, Human, Recombinant (His) FTHL6,Cell proliferation-inducing gene 15 protein,Ferritin h...	Human	E. coli
	Ferritin heavy polypeptide 1(FTH1), is a ubiquitous intracellular protein which stores iron in a soluble, non-toxic, readily available form. FTH1 has ferroxidase activity and is important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Ferritin is composed of 24 subunits of the light and heavy ferritin chains. It plays a role in delivery of iron to cells and mediates iron uptake in capsule cells of the developing kidney. Variation of...
TMPY-02711	Ferritin heavy chain 1/FTH1 Protein, Human, Recombinant FHC,FTHL6,FTH,PIG15,PLIF,ferritin, heavy polypeptide 1,HFE5	Human	E. coli
	FTH1 (ferritin, heavy polypeptide 1) is the heavy subunit of ferritin which is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative dis...
TMPH-02524	Arginase-1/ARG1 Protein, Mouse, Recombinant (His) Arginase-1,Type I arginase,Liver-type arginase,Arg1	Mouse	P. pastoris (Yeast)
	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available i...
TMPH-00651	Lpp Protein, E. coli, Recombinant (His & KSI) Major outer membrane lipoprotein Lpp,Braun lipoprotein,Murei...	E. coli	E. coli
	An outer membrane lipoprotein that controls the distance between the inner and outer membranes; adding residues to Lpp increases the width of the periplasm. The only protein known to be covalently linked to the peptidoglycan network (PGN). Also non-covalently binds the PGN. The link between the cell outer membrane and PGN contributes to the maintenance of the structural and functional integrity of the cell envelope, and maintains the correct distance between the PGN and the outer membrane. The m...

重组蛋白

LY6D Protein, Human, Recombinant (mFc)

Cat.No: TMPY-00369

Species: Human

Expression System: HEK293 Cells

GST Protein, Schistosoma japonicum, Recombinant

Cat.No: TMPY-02157

Species: Schistosoma japonicum

Expression System: Baculovirus Insect Cells

Ferritin-2 Protein, Glycine max, Recombinant (His & SUMO)

Cat.No: TMPH-00771

Species: Glycine max

Expression System: E. coli

FAM19A5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01125

Species: Mouse

Expression System: E. coli

PSCA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00906

Species: Mouse

Expression System: HEK293 Cells

FAM19A5 Protein, Human, Recombinant (His)

Cat.No: TMPK-00699

Species: Human

Expression System: E. coli

PSCA Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00728

Species: Human

Expression System: HEK293 Cells

Neurotensin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00561

Species: Human

Expression System: HEK293 Cells

NOL3 Protein, Human, Recombinant

Cat.No: TMPJ-00696

Species: Human

Expression System: E. coli

FTH Protein, Human, Recombinant (His)

Cat.No: TMPJ-00761

Species: Human

Expression System: E. coli

Ferritin heavy chain 1/FTH1 Protein, Human, Recombinant

Cat.No: TMPY-02711

Species: Human

Expression System: E. coli

Arginase-1/ARG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02524

Species: Mouse

Expression System: P. pastoris (Yeast)

Lpp Protein, E. coli, Recombinant (His & KSI)

Cat.No: TMPH-00651

Species: E. coli

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T12224	Nilotinib-d6 AMN107 D6	Others	Others
	Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity.
T13121	Teneligliptin D8 MP-513 D8	Others	Others
	Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.
T10350	Apremilast-d5 Apremilast D5,CC-10004 D5	TNF; PDE	Apoptosis; Metabolism
	Apremilast D5 (CC-10004 D5) is a deuterium-labeled Apremilast. Apremilast is an orally available inhibitor of PDE-4 (IC50: 74 nM). Apremilast inhibits TNF-α release by lipopolysaccharide (IC50: 104 nM).
TMIH-0595	Vericiguat-d3
	Vericiguat-d3 是 Vericiguat 的氘代化合物。Vericiguat 的 CAS 号为 1350653-20-1。Vericiguat 是一种有效的口服鸟苷酸环化酶刺激剂。
TMIJ-0379	Eicosapentaenoic Acid-d5
	Eicosapentaenoic Acid-d5 是 Eicosapentaenoic Acid 的氘代化合物。Eicosapentaenoic Acid 的 CAS 号为 10417-94-4。Eicosapentaenoic Acid 是一种 ω-3 脂肪酸。
TMIJ-0207	(S)-Ketoprofen-d3
	(S)-Ketoprofen-d3 是 (S)-Ketoprofen 的氘代化合物。(S)-Ketoprofen 的 CAS 号为 22161-81-5。S-(+)-Ketoprofen 抑制COX-1和COX-2的IC50值分别为 1.9 和 27 nM。
TMIH-0117	Binimetinib-13C-d3
	Binimetinib-13C-d3 是 Binimetinib 的 13C 和氘代化合物。Binimetinib 的 CAS 号为 606143-89-9。Binimetinib 是一种可口服的选择性MEK1/2抑制剂，抑制MEK的IC50为 12 nM。
TMID-0021	Fruquintinib-d3
	Fruquintinib-d3 是 Fruquintinib 的氘代化合物。Fruquintinib 的 CAS 号为 1194506-26-7。Fruquintinib 是一种选择性的VEGFR 1/2/3抑制剂，它们的IC50值分别为33 nM、0.5 nM、35 nM。
TMIH-0609	Zafirlukast-d7
	Zafirlukast-d7 是 Zafirlukast 的氘代化合物。Zafirlukast 的 CAS 号为 107753-78-6。Zafirlukast 是一种可口服的白三烯 D4受体拮抗剂，具有平喘、抗炎和抗菌作用。
TMIJ-0295	Flubendazole-d3 (methyl-d3)
	Flubendazole-d3 (methyl-d3) 是 Flubendazole 的氘代化合物。Flubendazole 的 CAS 号为 31430-15-6。Flubendazole 是用于治疗人类蠕虫感染的驱虫药。它通过抑制微管功能等机制发挥抗癌作用。它诱导p53介导的细胞凋亡，抑制 G2/M 细胞周期。
TMID-0073	Alectinib-d8
	Alectinib-d8 是 Alectinib 的氘代化合物。Alectinib 的 CAS 号为 1256580-46-7。Alectinib 是一种有效的、选择性的、口服具有活力的、ATP 竞争性的ALK抑制剂，其IC50=1.9 nM，Kd=2.4 nM，并且还抑制ALK F1174L和ALK R1275Q，其IC50分别为 1 nM 和 3.5 nM。它还有中枢神经系统渗透能力。
TMIH-0519	Selexipag Active Metabolite-d7
	Selexipag Active Metabolite-d7 是 Selexipag Active Metabolite 的氘代化合物。Selexipag Active Metabolite 的 CAS 号为 475085-57-5。MRE269 是一种口服的长效前列环素受体激动剂前药，是 Selexipag 的活性代谢物，用于治疗肺动脉高压。
TMIJ-0329	Montelukast-d6
	Montelukast-d6 是 Montelukast 的氘代化合物。Montelukast 的 CAS 号为 158966-92-8。Montelukast 是可口服的半胱氨酸白三烯受体1 选择性拮抗剂，可用于研究预防哮喘和肝损伤。它还可减少心脏损伤，在肠缺血-再灌注损伤中也具有抗氧化作用。
TMIJ-0374	L-Leucine-d3
	L-Leucine-d3 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸，能够激活mTOR信号通路。
TMIJ-0081	L-Leucine-d10
	L-Leucine-d10 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸，能够激活mTOR信号通路。
TMIH-0235	Finerenone-d5
	Finerenone-d5 是 Finerenone 的氘代化合物。Finerenone 的 CAS 号为 1050477-31-0。Finerenone 是一种选择性、具有口服活性的、非甾体类盐皮质激素受体拮抗剂 (IC50=18 nM)。与糖皮质激素受体、雄激素受体和孕酮受体相比，它表现出良好的选择性 (>500-fold)。它在心肾疾病研究中具有潜在的应用前景，如 2 型糖尿病和慢性肾脏疾病。
TMIH-0109	Bempedoic acid-d4
	Bempedoic acid-d4 是 Bempedoic acid 的氘代化合物。Bempedoic acid 的 CAS 号为 738606-46-7。ETC-1002 是一种 ATP-柠檬酸裂解酶抑制剂，可激活AMPK。它是脂质和碳水化合物代谢的调节剂。
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
TMIJ-0268	Relugolix-d6
	Relugolix-d6 是 Relugolix 的氘代化合物。Relugolix 的 CAS 号为 737789-87-6。Relugolix 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的IC50值分别为0.33 nM和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。

同位素标记化合物

Cat.No: T12224

Synonym: AMN107 D6

Target: Others

Teneligliptin D8

Cat.No: T13121

Synonym: MP-513 D8

Target: Others

Cat.No: T10350

Synonym: Apremilast D5,CC-10004 D5

Target: TNF, PDE

Cat.No: TMIH-0595

Eicosapentaenoic Acid-d5

Cat.No: TMIJ-0379

(S)-Ketoprofen-d3

Cat.No: TMIJ-0207

Binimetinib-13C-d3

Cat.No: TMIH-0117

Fruquintinib-d3

Cat.No: TMID-0021

Cat.No: TMIH-0609

Flubendazole-d3 (methyl-d3)

Cat.No: TMIJ-0295

Cat.No: TMID-0073

Selexipag Active Metabolite-d7

Cat.No: TMIH-0519

Cat.No: TMIJ-0329

Cat.No: TMIJ-0374

Cat.No: TMIJ-0081

Cat.No: TMIH-0235

Bempedoic acid-d4

Cat.No: TMIH-0109

Acalabrutinib-d4

Cat.No: TMIH-0065

Cat.No: TMIJ-0268

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