FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID)

在FK3311(FK)高剂量组中，存活率显著提高（p<0.05），复灌后30分钟的血清GOT水平显著降低（p<0.05）。复灌4小时后，该组的GPT水平和肝组织流量明显优于对照组（p<0.05）。无论是复灌后30分钟还是4小时，FK高剂量组的血清TxB(2)水平与对照组相比均显著降低（p<0.05）[1]。

Inbred male Lewis rats weighing 200-260 g were used. The donor liver was perfused with cold University of Wisconsin (UW) solution and then stored in the same solution at 4 degrees C for 18 hr. After the preservation period, orthotopic liver transplantation was performed. Animals were divided into three groups: the control group; the FK low-dose group (1 mg/kg FK3311 i.v. 20 min before reperfusion); and the FK high-dose group (3 mg/kg FK3311. 20 min before reperfusion). Survival rate, serum GOT and GPT levels, liver tissue blood flow, and serum thromboxane B(2) (TxB(2)) levels were compared among groups[1].