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Burixafor(又名TG-0054)是一种口服可用的CXC趋化因子受体4(CXCR4)抑制剂,具有受体结合和造血干细胞动员活性。Burixafor通过结合到CXCR4化趋受体,阻止基质衍生因子-1(SDF-1或CXCL12)与CXCR4受体的结合及其随后的受体激活,从而可能实现造血干细胞和祖细胞从骨髓释放到血液中的动员。备注:元素分析显示该化合物是含有3个HBr和3个水的盐。
Burixafor(又名TG-0054)是一种口服可用的CXC趋化因子受体4(CXCR4)抑制剂,具有受体结合和造血干细胞动员活性。Burixafor通过结合到CXCR4化趋受体,阻止基质衍生因子-1(SDF-1或CXCL12)与CXCR4受体的结合及其随后的受体激活,从而可能实现造血干细胞和祖细胞从骨髓释放到血液中的动员。备注:元素分析显示该化合物是含有3个HBr和3个水的盐。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | Burixafor (also known as TG-0054) is an orally available inhibitor of the CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell mobilization activities. By binding to the CXCR4 chemokine receptor, Burixafor blocks the binding and subsequent activation of stromal cell-derived factor-1 (SDF-1 or CXCL12) with the CXCR4 receptor, potentially facilitating the mobilization of hematopoietic stem and progenitor cells from the bone marrow into the bloodstream. Note: Elemental analysis shows that this compound is a salt containing 3 HBr and 3 water molecules. |
别名 | TG-0054, TG0054, TG 0054, Burixafor trihydrobromide trihydrate, Burixafor HBr hydrate, Burixafor HBr |
分子量 | 566.72 |
分子式 | C27H51N8O3P |
CAS No. | 1191448-17-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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