|
TMPK-01222
|
APLN Protein, Mouse, Recombinant (hFc)
APJ endogenous ligand,APEL,Apelin
|
Mouse
|
HEK293 Cells
|
|
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Mouse, Recombinant (hFc) is expressed in HE... |
|
TMPK-01236
|
APLN Protein, Human, Recombinant (hFc)
APJ endogenous ligand,Apelin,APEL
|
Human
|
HEK293 Cells
|
|
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Human, Recombinant (hFc) is expressed in HE... |
|
TMPK-01221
|
APLN Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
APEL,APJ endogenous ligand,Apelin
|
Mouse
|
HEK293 Cells
|
|
Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. |
|
TMPH-03271
|
Complement factor D Protein, Rat, Recombinant (His & Myc)
Adn,C3 convertase activator,Properdin factor D,Complement fa...
|
Rat
|
HEK293 Cells
|
|
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038. |
|
TMPH-03272
|
Complement factor D Protein, Rat, Recombinant (His)
Adipsin,Df,Adn,C3 convertase activator,Complement factor D,<...
|
Rat
|
P. pastoris (Yeast)
|
|
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. |
|
TMPH-01291
|
ERVK-7 Protein, Human, Recombinant (His)
Endogenous retrovirus group K member 7 Env polyprot...
|
Human
|
E. coli
|
|
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane. |
|
TMPH-02163
|
Syncytin-1 Protein, Human, Recombinant (His & SUMO)
Endogenous retrovirus group W member 1,Enverin,Env-...
|
Human
|
E. coli
|
|
This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5.; Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor r... |
|
TMPH-01289
|
ERVK-6 Protein, Human, Recombinant (E. coli, His)
HERV-K108 envelope protein,Endogenous retrovirus gr...
|
Human
|
E. coli
|
|
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane... |
|
TMPH-01290
|
ERVK-6 Protein, Human, Recombinant (His)
HERV-K(HML-2.HOM) envelope protein,ERVK-6,HERV-K(C7) envelop...
|
Human
|
Baculovirus Insect Cells
|
|
Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane... |
|
TMPY-02062
|
SULT1A1 Protein, Human, Recombinant (His)
HAST1/HAST2,PST,P-PST,ST1A1,STP,sulfotransferase family, cyt...
|
Human
|
E. coli
|
|
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Pa... |
|
TMPH-02298
|
Urocortin-3 Protein, Human, Recombinant (His & SUMO)
UCN3,Stresscopin,Urocortin III,Urocortin-3
|
Human
|
E. coli
|
|
Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. |
|
TMPY-02128
|
Serpin B1 Protein, Human, Recombinant (His)
HEL57,serpin peptidase inhibitor, clade B (ovalbumin), membe...
|
Human
|
Baculovirus Insect Cells
|
|
SerpinB1 is an endogenous inhibitor of serine proteases recognized for its anti-inflammatory and host-protective properties. Serum SerpinB1 levels are elevated in patients with type 2 diabetes compared with that in healthy subjects and are negatively correlated with serum LDL-C. serpinB1 as an endogenous protein that can potentially be harnessed to enhance functional beta cell mass in patients with diabetes. |
|
TMPY-04121
|
NAGA Protein, Human, Recombinant (His)
D22S674,N-acetylgalactosaminidase, α-,N-acetylgalactosaminid...
|
Human
|
HEK293 Cells
|
|
NAGA (Alpha-N-Acetylgalactosaminidase) is a Protein Coding gene. NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. It belongs to the glycosyl hydrolase 27 family. The antinociceptive effect of NAGA may involve the participation of endogenous opioid peptides and endogenous catecholamines. Normal alpha-NAGA is synthesized as a 52 kDa precursor which matures to a 49 kDa species through phosphorylation and car... |
|
TMPH-02682
|
GSTM3 Protein, Mouse, Recombinant (His & Myc)
GST class-mu 3,Gstm3,Glutathione S-transferase Mu 3,Glutathi...
|
Mouse
|
E. coli
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GSTM3 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.0 kDa and the accession number is P19639. |
|
TMPH-03138
|
GST Protein, Plasmodium falciparum, Recombinant (His)
|
Plasmodium falciparum
|
P. pastoris (Yeast)
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin). GST Protein, Plasmodium falciparum, Recombinant (His) is expressed in yeast with N-10xHis tag. The predicted molecular weight is 27.3 kDa and the accession number is Q8MU52. |
|
TMPH-03483
|
Saxiphilin Protein, Aquarana catesbeiana, Recombinant (His)
Saxiphilin
|
Lithobates catesbeiana
|
HEK293 Cells
|
|
Binds specifically to the neurotoxin saxitoxin. Its physiological role may be to transport or sequester an endogenous organic molecule other than Fe(3+). It may participate in a detoxification mechanism for neutralizing a microbial toxin. Saxiphilin Protein, Aquarana catesbeiana, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 43.7 kDa and the accession number is P31226. |
|
TMPH-03310
|
GUCY2C Protein, Rat, Recombinant (His & Myc)
Guanylyl cyclase C,Gucy2c,Heat-stable enterotoxin receptor,I...
|
Rat
|
HEK293 Cells
|
|
Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin. GUCY2C Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 51.4 kDa and the accession number is P23897. |
|
TMPH-02683
|
GSTP1 Protein, Mouse, Recombinant (His & SUMO)
Gstp1,GST-piB,GST class-pi,Preadipocyte growth factor,GST YF...
|
Mouse
|
E. coli
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. |
|
TMPH-01399
|
GSTP1 Protein, Human, Recombinant (His)
GST class-pi,GSTP1,Glutathione S-transferase P,GSTP1-1
|
Human
|
P. pastoris (Yeast)
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. GSTP1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 25.2 kDa and... |
|
TMPK-00982
|
NTS1 Protein, Cynomolgus, Recombinant (His)
NTR1,NT,NTRR,NTRH,NTS1,NTSR1,NT/N,NTS,NMN-125,NN,NTR
|
Cynomolgus
|
HEK293 Cells
|
|
Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the orthosteric binding pocket of NTS1. NTS1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 18.84 kDa and the accession number is Q2PG57. |
|
TMPY-04934
|
Serpin A3n Protein, Rat, Recombinant (His)
serine (or cysteine) peptidase inhibitor, clade A, member 3N
|
Rat
|
HEK293 Cells
|
|
Serpina3n may represent a circulating biomarker of muscle atrophy associated with GC and, broadly, a reflection of dynamic changes in muscle mass. Serpina3n blocks endogenous increases in the activity of select skeletal muscle resident proteases during injury or dystrophic disease, which stabilizes the sarcolemma leading to less myofiber degeneration and increased regeneration. |
|
TMPH-01298
|
EPHX1 Protein, Human, Recombinant (His)
EPHX1,Microsomal epoxide hydrolase,Epoxide hydratase,Epoxide...
|
Human
|
E. coli
|
|
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol. |
|
TMPK-01162
|
NTS1 Protein, Mouse, Recombinant (hFc)
NTS1,NTRH,NN,NT,NTR1,NMN-125,NT/N,NTSR1,NTR,NTRR
|
Mouse
|
HEK293 Cells
|
|
Crystal structures of neurotensin receptor subtype 1 (NTS1) allowed us to visualize the binding mode of the endogenous peptide hormone neurotensin and its pharmacologically active C-terminal fragment NT(8-13) within the orthosteric binding pocket of NTS1. NTS1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9D3P9. |
|
TMPH-03166
|
Elastase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)
PAE,lasB,Pseudolysin,Neutral metalloproteinase,Elastase
|
Pseudomonas aeruginosa
|
E. coli
|
|
Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. Elastase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.1 kDa and the accession number is P14756. |
|
TMPH-01325
|
FAAH2 Protein, Human, Recombinant (His)
Amidase domain-containing protein,Anandamide amidohydrolase ...
|
Human
|
E. coli
|
|
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. FAAH2 Protein, Human, Recombinant (His) is expressed in E. coli e... |
|
TMPH-01424
|
GUCA2B Protein, Human, Recombinant (His)
Guanylate cyclase activator 2B,GUCA2B
|
Human
|
HEK293 Cells
|
|
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. GUCA2B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 13.5 kDa and the accession number is Q16661. |
|
TMPY-01771
|
Latexin Protein, Mouse, Recombinant (His)
latexin
|
Mouse
|
E. coli
|
|
Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI, and LXN, is a cytoplasm protein that belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in the heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional spe... |
|
TMPK-00592
|
Latexin Protein, Human, Recombinant (His)
ECI,TCI,LXN,MUM
|
Human
|
E. coli
|
|
Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells. |
|
TMPH-01595
|
KMO Protein, Human, Recombinant (His)
Kynurenine 3-monooxygenase,KMO,Kynurenine 3-hydroxylase
|
Human
|
E. coli
|
|
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable). |
|
TMPH-01398
|
GSTP1 Protein, Human, Recombinant (E. coli, His)
GSTP1,Glutathione S-transferase P,GSTP1-1,GST class-pi
|
Human
|
E. coli
|
|
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. GSTP1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted mo... |
|
TMPJ-00816
|
FBPase1 Protein, Human, Recombinant (His)
D-fructose-1,FBP,6-bisphosphate 1-phosphohydrolase 1,FBPase ...
|
Human
|
HEK293 Cells
|
|
Fructose-1,6-bisphosphatase 1(FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes p... |
|
TMPH-02438
|
IL-1 alpha/IL1A Protein, Rhesus macaque, Recombinant (His & SUMO)
Hematopoietin-1,Interleukin-1 alpha,IL1A
|
Rhesus
|
E. coli
|
|
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha/IL1A Protein, Rhesus macaque, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag... |
|
TMPK-01158
|
Kallikrein 5/KLK5 Protein, Mouse, Recombinant (His)
SCTE,KLKL2,KLK5,KLK-L2,Klnc,Kallikrein c
|
Mouse
|
HEK293 Cells
|
|
The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-... |
|
TMPJ-00963
|
CDKN2C Protein, Human, Recombinant (His)
Cyclin-Dependent Kinase 4 Inhibitor C,p18-INK4c,CDKN2C,p18-I...
|
Human
|
E. coli
|
|
Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis,... |
|
TMPH-02648
|
PKDCC Protein, Mouse, Recombinant (His & Myc)
Extracellular tyrosine-protein kinase PKDCC,Vertebrate lones...
|
Mouse
|
Baculovirus Insect Cells
|
|
Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membr... |
|
TMPJ-00473
|
QPRTase Protein, Human, Recombinant (His)
QPRTase,QAPRTase,Nicotinate-Nucleotide Pyrophosphorylase [Ca...
|
Human
|
E. coli
|
|
Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quin... |
|
TMPH-00864
|
RO60 Protein, Human, Recombinant (His)
TROVE domain family member 2,RNA-binding protein RO60,Sjoegr...
|
Human
|
E. coli
|
|
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.; May play roles in cilia formation and/or maintenance. RO60 Protein, Human, Recombinant (His)... |
|
TMPJ-01392
|
IL-1 beta/IL-1F2 Protein, Cavia porcellus, Recombinant (His)
IL-1 β,IL1B,IL-1 beta,Interleukin-1 β,Interleukin-1 beta
|
Cavia porcellus
|
E. coli
|
|
Interleukin-1 beta (IL1B) belongs to the IL-1 family. Interleukin 1 (IL-1) is a family of polypeptide cytokines consisting of two agonists, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2) encoded by two distinct genes and perform identical biological functions. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and... |
|
TMPY-00561
|
Neurotensin Protein, Human, Recombinant (hFc)
NMN-125,NTS1,NN,NT/N,neurotensin,NT
|
Human
|
HEK293 Cells
|
|
NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali... |
|
TMPY-03172
|
Argininosuccinate lyase Protein, Human, Recombinant (His & GST)
ASAL,argininosuccinate lyase,ASL
|
Human
|
Baculovirus Insect Cells
|
|
The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate ... |
|
TMPY-02264
|
LRIG1 Protein, Mouse, Recombinant (His)
LIG-1,D6Bwg0781e,leucine-rich repeats and immunoglobulin-lik...
|
Mouse
|
HEK293 Cells
|
|
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. Leucine-rich repeats and immunoglobulin-like domains containing protein 1 (LRIG1) is an endogenous feedback regulator of receptor tyrosine kinases (RTKs) and was recently shown to inhibit the growth of different types of malignancies. Leucine-rich repeats and immunoglobulin-like domains 1(LRIG1)is a kind of transmembrane glycoprotein, which is induce... |
|
TMPJ-00314
|
ACVR2B Protein, Human, Recombinant (hFc & His)
ACVR2B,Activin Receptor Type IIB,ACTR-IIB,Activin Receptor T...
|
Human
|
HEK293 Cells
|
|
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, ... |
|
TMPY-02885
|
CD1B Protein, Human, Recombinant (hFc)
CD1,CD1A,CD1b molecule,R1,CD1B
|
Human
|
HEK293 Cells
|
|
CD1B contains 1 Ig-like (immunoglobulin-like) domain and belongs to the CD1 family. CD1 family members are transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. During protein synthesis and maturation, they bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface. CD... |
|
TMPY-01842
|
Neuroligin-3/NLGN3 Protein, Human, Recombinant (His)
neuroligin 3,HNL3
|
Human
|
HEK293 Cells
|
|
Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NL... |
|
TMPY-02402
|
WTAP Protein, Human, Recombinant (GST)
Mum2,Wilms tumor 1 associated protein
|
Human
|
E. coli
|
|
Wilms' tumor 1-associating protein (WTAP) was previously identified as a protein associated with Wilms' tumor-1 (WT-1) protein that is essential for the development of the genitourinary system. WT1 was originally identified as a tumor suppressor for Wilms' tumor, but it is also overexpressed in a variety of cancer cells. The WTAP-WT1 axis in vascular cells suggest that WTAP is a vital and multifaceted regulator of vascular remodeling. WTAP has been suggested to function in alternative splicing, ... |
|
TMPJ-00681
|
EDIL3 Protein, Human, Recombinant (His)
EGF-Like Repeats and Discoidin I-Like Domains 3,EDIL3
|
Human
|
HEK293 Cells
|
|
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence a... |
|
TMPJ-00526
|
Langerin/CD207 Protein, Human, Recombinant (His)
C-type lectin domain family 4 member K,langerin,CD207 antige...
|
Human
|
HEK293 Cells
|
|
Langerin (CD207) is a type II transmembrane glycoprotein which is member K of the C-type lectin domain family. Langerin is used as a marker for Langerhans cells (LCs) which represent the immature dendritic cells in the epidermis. Langerin is necessary and sufficient for Birbeck granule formation. Human langerin sequence contains a 43 aa cytoplasmic domain, a 21 aa transmembrane domain and a 264 aa extracellular domain (ECD) that contains a coiled-coil domain and a single C-type lectin domain. Hu... |
|
TMPY-01635
|
PCSK1 Protein, Human, Recombinant (His)
proprotein convertase subtilisin/kexin type 1,SPC3,PC1,BMIQ1...
|
Human
|
HEK293 Cells
|
|
Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleav... |
|
TMPJ-00948
|
Endostatin Protein, Mouse, Recombinant (His)
antiangiogenic agent,type XVIII,collagen α-1(XVIII)chain,col...
|
Mouse
|
HEK293 Cells
|
|
Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End... |
|
TMPY-01383
|
PRMT6 Protein, Human, Recombinant (His & Flag)
protein arginine methyltransferase 6,HRMT1L6
|
Human
|
HEK293 Cells
|
|
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H... |
沪公网安备 31010602006700号