Salusin-β, an endogenous bioactive peptide, exhibits significant hemodynamic and mitotic activities. It can stimulate the proliferation of quiescent vascular smooth muscle cells (VSMCs) and fibroblasts, leading to a rapid and marked decrease in blood pressure and heart rate. Additionally, in rat models, Salusin-β stimulates the pituitary release of arginine vasopressin. This positions Salusin-β as a valuable compound in cardiovascular disease research.